Dr Sophie Whyte

MMath (Warwick), PhD (Birmingham)

School of Medicine and Population Health

Senior Research Fellow

sophie.whyte@sheffield.ac.uk
+44 114 222 0859

Full contact details

Dr Sophie Whyte
School of Medicine and Population Health
Regent Court (ScHARR)
30 Regent Street
Sheffield
S1 4DA
Profile

I joined the HEDS section of ScHARR as a mathematical modeller in September 2007. Previous to this, I obtained a Masters in Mathematics from the University of Warwick and a PhD in Pure Mathematics (Group Theory) from Birmingham University.

Research interests

My broad research is focused on mathematical modelling within health economics. I have gained significant expertise and experience in two related areas:

  • Bayesian calibration of cancer natural history models: This is my main methodological research theme, please see MDM publication  and Example Excel model using the Metropolis Hastings algorithm to calibrate a state transition model available to down load from the Downloads box)
  • Early diagnosis of bowel cancer: I have substantial experience in early diagnosis of cancer generally having worked on more than 15 projects in this area of applied research. My main expertise lies in the modelling bowel cancer screening to inform national bowel cancer screening policy.

In addition to these main research themes I have undertaken research to inform policy making: Health Technology Assessment (HTA) for NICE, and research as part of the Policy Research Unit in Economic Evaluation of Health and Care Interventions (EEPRU) for DH ()

Publications

Show: Featured publications All publications

Journal articles

  • Whyte S, Thomas C, Chilcott J & Kearns B (2022) . Value in Health, 25(6), 954-964.
  • Rutter MD, East J, Rees CJ, Cripps N, Docherty J, Dolwani S, Kaye PV, Monahan KJ, Novelli MR, Plumb A , Saunders BP et al (2019) . Gut, 69(2), 201-223.
  • Kearns B, Chilcott J, Relton C, Whyte S, Woods HB, Nickerson C & Loban A (2018) . Cancer Management and Research, 10, 637-645.
  • Asaria M, Griffin S, Cookson R, Whyte S & Tappenden P (2015) . Health Economics, 24(6), 742-754.
  • Kearns B, Whyte S, Chilcott J & Patnick J (2014) . British Journal of Cancer, 111(9), 1734-1741.
  • Whyte S & Harnan S (2014) . Cancer Causes Control, 25(6), 647-658.
  • Whyte S, Pandor A & Stevenson M (2012) . Pharmacoeconomics, 30(12), 1119-1132.
  • Whyte S, Chilcott J & Halloran S (2012) . Colorectal Dis, 14(9), e547-e561.
  • Sharp L, Tilson L, Whyte S, O'Ceilleachair A, Walsh C, Usher C, Tappenden P, Chilcott J, Staines A, Barry M & Comber H (2012) . Br J Cancer, 106(5), 805-816.
  • Madan J, Stevenson MD, Cooper KL, Ades AE, Whyte S & Akehurst R (2011) . Value Health, 14(6), 953-960.
  • Whyte S, Cooper KL, Stevenson MD, Madan J & Akehurst R (2011) . Value Health, 14(4), 465-474.
  • Whyte S, Walsh C & Chilcott J (2011) . Medical Decision Making, 31(4), 625-641.
  • Whyte S, Pandor A, Stevenson M & Rees A (2010) . Health Technol Assess, 14(Suppl. 2), 47-53.
  • Whyte S, Walsh C, Sharp L, O'Ceilleachair A, Tilson L, Usher C, Chilcott J, Tappenden P, Staines A, Comber H & Barry M (2009) . Value in Health, 12(7), A395-A395.

Reports

  • Whyte S, Chilcott J, Essat M, Stevens J, Wong R & Kalita N (2011) Reappraisal of the options for colorectal cancer screening

All publications

Journal articles

  • Harnan S, Navega Biz A, Hamilton J, Whyte S, Simpson E, Ren S, Cooper K, Clowes M, Abulafi M, Ball A , Benton SC et al (2025) . Health Technology Assessment, 29(46).
  • Mandrik O, Whyte S, Kunst N, Rayner A, Harden M, Dias S, Payne K, Palmer S & Soares MO (2025) . Medical Decision Making, 45(8), 1013-1024.
  • Thomas C, Heathcote L, Sun Y, Callister MEJ, Kitt J, Rossi SH, Shinkins B, Usher-Smith JA, Whyte S & Stewart GD (2025) . British Journal of Cancer, 133(2), 239-247.
  • Whyte S & Heathcote L (2025) Model estimation of the impact of delayed diagnosis of colorectal cancer and advanced adenomas on long- term outcomes and costs. HEDS Discussion Paper Series(25.01), 1-13.
  • Harnan S, Hamilton J, Simpson E, Clowes M, Navega Biz A, Whyte S, Ren S, Cooper K, Abulafi M, Ball A , Beton S et al (2025) . Colorectal Disease, 27(1).
  • Harnan S, Hamilton J, Simpson E, Clowes M, Biz AN, Whyte S, Ren S, Cooper K, Ball A, Benton S , Carten R et al (2024) . International Journal of Technology Assessment in Health Care, 40(S1), S56-S57.
  • Biz AN, Stevenson M, Whyte S, Hamilton J, Ren S, Heathcote L, Simpson E, Cooper K, Clowes M, Ball A , Benton S et al (2024) . International Journal of Technology Assessment in Health Care, 40(S1), S7-S7.
  • Harnan S, Hamilton J, Simpson E, Clowes M, Biz AN, Whyte S, Ren K, Cooper K, Abulafi M, Ball A , Benton S et al (2024) . Value in Health, 27(12).
  • Mandrik L, Whyte S, Kunst N, Palmer S & Soares M (2024) . Value in Health, 27(12), S450-S451.
  • Needham KJ, Tappenden P, Gillespie D & Whyte S (2023) . Journal of Thoracic Oncology, 18(11), S134-S134.
  • Thomas C, Mandrik O & Whyte S (2022) . Preventive Medicine, 162.
  • Mandrik O, Thomas C, Whyte S & Chilcott J (2022) . PharmacoEconomics, 40(4), 359-366.
  • Whyte S, Thomas C, Chilcott J & Kearns B (2022) . Value in Health, 25(6), 954-964.
  • Thomas C, Mandrik O, Saunders CL, Thompson D, Whyte S, Griffin S & Usher-Smith JA (2021) . Cancer Prevention Research, 14(8), 811-822.
  • Rubin G, Walter FM, Emery J, Hamilton W, Hoare Z, Howse J, Nixon C, Srivastava T, Thomas C, Ukoumunne OC , Usher-Smith JA et al (2021) . BMJ Open, 11(3).
  • Thomas C, Mandrik O, Whyte S, Saunders CL, Griffin SJ & Usher-Smith JA (2021) . Cancer Reports, 4(4).
  • Rutter MD, Bretthauer M, Hassan C, Jover R, Adami H-O, Corley DA, Cubiella J, Cross AJ, Evelien Dekker PD, Gupta S , Kalager M et al (2020) . Gastroenterology, 158(6), 1529-1533.e4.
  • Rutter MD, East J, Rees CJ, Cripps N, Docherty J, Dolwani S, Kaye PV, Monahan KJ, Novelli MR, Plumb A , Saunders BP et al (2019) . Gut, 69(2), 201-223.
  • Thomas C, Whyte S, Kearns B & Chilcott J (2019) . Value in Health, 22(10), 1154-1161.
  • Kearns B, Chilcott J, Relton C, Whyte S, Woods HB, Nickerson C & Loban A (2018) . Cancer Management and Research, 10, 637-645.
  • Picot J, Rose M, Cooper K, Pickett K, Lord J, Harris P, Whyte S, Bohning D & Shepherd J (2017) . Health Technology Assessment, 21(79).
  • Ren S, Minton J, Whyte S, Latimer N & Stevenson M (2017) . Value in Health, 20(9), a758-a758.
  • Uttley L, Whyte S, Gomersall T, Ren S, Wong R, Chambers D & Tappenden P (2017) . PharmacoEconomics , 35(7), 717-726.
  • Faria R, Walker S, Whyte S, Dixon S, Palmer S & Sculpher M (2017) . Medical Decision Making, 37(2), 148-161.
  • Kearns B, Chilcott J, Whyte S, Preston L & Sadler S (2017) . BMC Medicine, 15(1).
  • Kearns B, Chilcott J, Whyte S, Preston L & Sadler S (2016) . BMC Medicine, 14(1).
  • Moore HJ, Nixon C, Tariq A, Emery J, Hamilton W, Hoare Z, Kershenbaum A, Neal RD, Ukoumunne OC, Usher-Smith J , Walter FM et al (2016) . Trials, 17(1).
  • Kearns B, Whyte S, Seaman HE, Snowball J, Halloran SP, Butler P, Patnick J, Nickerson C & Chilcott J (2016) . British Journal of Cancer, 114(3), 327-333.
  • Rowen D, Brazier J, Mukuria C, Keetharuth A, Risa Hole A, Tsuchiya A, Whyte S & Shackley P (2016) . Medical Decision Making, 36(2), 210-222.
  • Hinde S, McKenna C, Whyte S, Peake MD, Callister MEJ, Rogers T & Sculpher M (2015) . British Journal of Cancer, 113(1), 135-141.
  • Asaria M, Griffin S, Cookson R, Whyte S & Tappenden P (2015) . Health Economics, 24(6), 742-754.
  • Kearns B, Whyte S, Chilcott J & Patnick J (2014) . British Journal of Cancer, 111(9), 1734-1741.
  • Whyte S & Harnan S (2014) . Cancer Causes Control, 25(6), 647-658.
  • Asaria M, Griffin S, Cookson R, Tappenden P & Whyte S (2013) . VALUE IN HEALTH, 16(7), A426-A426.
  • Sharp L, Tilson L, Whyte S, Ceilleachair AO, Walsh C, Usher C, Tappenden P, Chilcott J, Staines A, Barry M & Comber H (2013) . BMC Health Serv Res, 13, 105.
  • Sharp L, Walsh C, Whyte S, Tilson L, O'Ceilleachair A, Usher C, Tappenden P, Chilcott J, Staines A, Barry M & Comber H (2013) . British Journal of Cancer, 108(5), 1211-1212.
  • Whyte S, Pandor A & Stevenson M (2012) . Pharmacoeconomics, 30(12), 1119-1132.
  • Whyte S, Chilcott J & Halloran S (2012) . Colorectal Dis, 14(9), e547-e561.
  • Sharp L, Tilson L, Whyte S, O'Ceilleachair A, Walsh C, Usher C, Tappenden P, Chilcott J, Staines A, Barry M & Comber H (2012) . Br J Cancer, 106(5), 805-816.
  • Tilson L, Sharp L, Usher C, Walsh C, Whyte S, O'Ceilleachair A, Stuart C, Mehigan B, Kennedy MJ, Tappenden P , Chilcott J et al (2012) . European Journal of Health Economics, 13(4), 511-524.
  • Cooper KL, Madan J, Whyte S, Stevenson MD & Akehurst RL (2011) . BMC Cancer, 11.
  • Madan J, Stevenson MD, Cooper KL, Ades AE, Whyte S & Akehurst R (2011) . Value Health, 14(6), 953-960.
  • Whyte S, Cooper KL, Stevenson MD, Madan J & Akehurst R (2011) . Value Health, 14(4), 465-474.
  • Whyte S, Walsh C & Chilcott J (2011) . Medical Decision Making, 31(4), 625-641.
  • Whyte S, Pandor A, Stevenson M & Rees A (2010) . Health Technol Assess, 14(Suppl. 2), 47-53.
  • Whyte S, Walsh C, Sharp L, O'Ceilleachair A, Tilson L, Usher C, Chilcott J, Tappenden P, Staines A, Comber H & Barry M (2009) . Value in Health, 12(7), A395-A395.
  • Sharp L, Tilson L, Whyte S, O'Ceilleachair A, Walsh C, Usher C, Tappenden P, Chilcott J, Staines A, Comber H & Barry M (2009) COST-EFFECTIVENESS OF A POPULATION-BASED COLORECTAL CANCER SCREENING PROGRAMME IN IRELAND. VALUE HEALTH, 12(7), A280-A280.
  • Whyte S, Dixon S, Faria R, Walker S, Palmer S, Sculpher M & Radford S () . Value in Health, 19(2), 138-144.
  • Whyte S, Pandor A, Stevenson M & Rees A () . Health Technology Assessment, 14(Suppl 2), 47-53.

Conference proceedings

  • Mandrik L, Whyte S, Kunst N, Palmer S & Soares M (2024) COMPARISON OF MULTI-CANCER EARLY DETECTION MODELLING APPROACHES: APPRAISAL OF THE METHODS. VALUE IN HEALTH, Vol. 27(12) (pp S450-S451)
  • Needham KJ, Tappenden P, Gillespie D & Whyte S (2023) Model-based Evaluations of the Cost-effectiveness of Interventions for Lung Cancer: A Systematic Review. JOURNAL OF THORACIC ONCOLOGY, Vol. 18(11) (pp S134-S134)
  • Kearns B, Chilcott & whyte (2016) Flexible parametric survival models and time-series analysis for extrapolating time-varying treatment effects in health technology assessment. Flexible parametric survival models and time-series analysis for extrapolating time-varying treatment effects in health technology assessment, 5 September 2016 - 8 September 2016.
  • Faria R, Walker S, Whyte S, Dixon S, Sculpher M & Palmer S (2015) The value of implementation: how to invest in getting cost-effective technologies into practice. Framework and application to novel oral anticoagulants in the prevention of stroke and systemic embolism. HESG. Leeds
  • Faria R, Whyte S, Palmer S & Hoomans T (2014) WORKSHOP 2999: From evaluation to implementation: how to ensure efficient investment in implementation of cost-effective technologies in clinical practice?. ISPOR. Amsterdam, 9 November 2014 - 12 November 2014.
  • Rowen D, Brazier J, Mukuria C, Whyte S, Keetharuth A, Risa Hole A, Tsuchiya A & Shackley P (2014) Rowen D, Brazier J, Mukuria C, Whyte S, Keetharuth A, Risa Hole A, Tsuchiya A, Shackley P. Eliciting societal preferences for burden of illness, therapeutic improvement and end of life for value based pricing.. HESG. Sheffield, UK, 8 January 2014.
  • Asaria M, Griffin S, Cookson R, Whyte S & Tappenden P (2013) A framework for the cost-equality analysis of health care programmes. ISPOR. Dublin
  • Bessey A, Whyte S, Minton J & Chilcott J (2013) Economic evaluation of an electrical impedance spectroscopy (EIS) device used as an adjunct to colposcopy. VALUE IN HEALTH, Vol. 16(7) (pp A407-A407)
  • Whyte S (2013) Cost effectiveness analysis of an early awareness campaign for colorectal cancer. Cancer Outcomes Conference. Brighton
  • Whyte S (2013) Effectiveness and cost effectiveness of an awareness campaign for colorectal cancer: A mathematical modelling study. Cancer Research UK NAEDI conference. Cambridge, UK
  • Whyte S (2012) The cost effectiveness of an early awareness campaign for colorectal cancer. SMDM. Oslo, Norway, 10 June 2012 - 12 June 2012.
  • Whyte S, Scope A & Tappenden P (2012) The cost effectiveness of an early awareness campaign for colorectal cancer. SMDM. Oslo, Norway
  • Whyte S & Chilcott J (2010) Using a natural history model in combination with screening data to estimate the test characteristics of the FOB test in the English bowel cancer screening programme. Methods for evaluating medical tests and biomarkers. Birmingham, UK
  • Whyte S (2009) Bayesian calibration of a natural history model for colorectal cancer. ISPOR. Paris
  • Whyte S, Dixon S, Faria R, Walker S, Sculpher M & Palmer S ()

Reports

  • Thomas C, Mandrik O & Whyte S (2020) Development of the Microsimulation Model in Cancer of the Bowel (MiMiC-Bowel), an Individual Patient Simulation Model for Investigation of the Cost-effectiveness of Personalised Screening and Surveillance Strategies
  • Srivastava T, Chambers D, Thomas C & Whyte S (2019) ECASS health economic feasibility study
  • Whyte S, Thomas C, Kearns B, Webster M & Chilcott J (2017) Optimising Bowel Cancer Screening Phase 1: Optimising the cost effectiveness of repeated FIT screening and screening strategies combining bowel scope and FIT screening
  • Whyte S, Pollard D & Cree I (2016) Generic Cancer Screen - Economic modelling report
  • Whyte S, Chambers D & Wong R (2015) Degarelix for treating advanced hormone-dependent Prostate cancer [ID590] Spinal cord compression associated with hormonal therapy in men with hormone-dependent metastatic prostate cancer: a systematic review and economic assessment
  • Faria R, Walker S, Whyte S, Dixon S, Palmer S & Sculpher M (2014) Getting cost-effective technologies into practice: the value of implementation An application to novel anticoagulants in the prevention of stroke and systemic embolism
  • Whyte S, Dixon S, Faria R, Walker S, Palmer S & Sculpher M (2014) Getting cost-effective technologies into practice: the value of implementation. An application to B-type natriuretic peptide (BNP) testing in diagnosing chronic heart failure
  • Walker S, Faria R, Whyte S, Dixon S, Palmer S & Sculpher M (2014) Getting cost-effective technologies into practice: the value of implementation. Report on framework for valuing implementation initiatives
  • Rowen D, Brazier J, Mukuria C, Keetharuth A, Rise Hole A, Tsuchiya A, Whyte S & Shackley P (2014) Update: Eliciting societal preferences for weighting QALY's according to burden of illness, size of gain and end of life
  • Brazier J, Rowen D, Mukuria C, Whyte S, Keetharuth A, RiseHole A, Tsuchiya A & Shackley P (2013) Eliciting societal preferences for burden of illness, therapeutic improvement and end of life for value based pricing: a report of the main survey
  • Hinde S, McKenna C, Whyte S, Peake M, Callister M, Rogers T & Sculpher M (2012) Modelling the cost-effectiveness of early awareness interventions for the early detection of lung cancer
  • Whyte S, Harnan S, Scope A, Simpson E, Tappenden P, Duffy S, Rachet B, Sculpher M, Hinde S, McKenna C & Wong R (2012) Early awareness interventions for cancer: Colorectal cancer
  • Whyte S, Chilcott J, Essat M, Stevens J, Wong R & Kalita N (2011) Reappraisal of the options for colorectal cancer screening
  • Sharp L, Whyte S, Ceillachair A, Comber H, Tilson L, Usher C, Walsh C, Barry M, Tappenden P, Chilcott J & Staines A (2009) Options for a population-based colorectal cancer screening programme in Ireland: a health technology assessment
  • Whyte S, Cooper KL, Stevenson MD, Madan J & Akehurst R () Cost-effectiveness of granulocyte colony-stimulating factor prophylaxis for febrile neutropenia in breast cancer in the United Kingdom
  • Cooper KL, Madan J, Whyte S, Stevenson MD & Akehurst R () Granulocyte colony-stimulating factors for prevention of febrile neutropenia following chemotherapy: systematic review and meta-analysis

Posters

  • Whyte S, Dixon S, Faria R, Walker S, Sculpher M & Palmer S The value of investing in implementation activities: A case study in natriuretic peptide testing for diagnosing suspected heart failure (SMDM 15th Biennial European Meeting 8-10 June 2015).

Preprints

  • Mandrik O, Whyte S, Kunst N, Rayner A, Harden M, Dias S, Payne K, Palmer S & Soares M (2025) , arXiv.
  • Mandrik O, Thomas C, Strong M & Whyte S (2021) Calibration and Validation of the Microsimulation Model in Cancer of the Bowel (MiMiC-Bowel), an Individual Patient Simulation Model for Investigation of the Cost-effectiveness of Personalised Screening and Surveillance Strategies.
Research group

If you are interested in pursuing a PhD which may fit with my research areas described above please contact me regarding PhD supervision.

Teaching interests

I am module lead for the Dissertation on the MSc in Health Economics and Decision Modelling.