Dr Jen-Yu (Amy) Chang

BSc (Pharm), MSc (ClinPharm), PhD

School of Medicine and Population Health

Research Fellow in Statistics

Amy Chang
Profile picture of Amy Chang
jy.a.chang@sheffield.ac.uk
Regent Court (ScHARR)

Full contact details

Dr Jen-Yu (Amy) Chang
School of Medicine and Population Health
Regent Court (ScHARR)
30 Regent Street
Sheffield
S1 4DA
Profile

I joined SCHARR as a staff member after completing my PhD here, where I specialised in treatment sequences in health economic evaluations and the incorporation of advanced causal inference methods. My research focuses on applying these techniques—such as Target Trial Emulation and g-methods—to generate real-world evidence on the comparative effectiveness of treatment sequences using secondary databases. My research addresses the challenges in evaluating treatment sequences within HTA due to the lack of clinical evidence, as trials typically do not compare treatment sequences. Importantly, merging evidence from different treatment lines of trials requires making population exchangeability assumptions, which may not always hold.


Prior to my PhD, I obtained a BSc and an MSc in Pharmacy/Clinical Pharmacy, during which I developed a cost-effectiveness model that informed the national reimbursement of a pharmacist-led anticoagulation service in Taiwan. I then worked in an academic role with consultancy responsibilities, supporting local HTA submissions for pharmaceutical companies by adapting oncology economic models and generating local evidence using national claims data. Alongside this core responsibility, I contributed to the construction of the Taiwan EQ-5D-5L tariff model and healthcare utilisation and pharmacoepidemiology studies using Taiwan national health insurance claims and US NHIS survey data. Additionally, I worked as a pharmacist from time to time.

Research interests

My current research interests lie in health economic modelling and related research methodologies with an emphasis on the comparison of treatment sequences. From a wider perspective, I am interested in applying causal inference methods and using real-world data to inform economic evaluation. 

I am an active learner and keen on having exposure to innovative analytical methods and interdisciplinary research.

Publications

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Journal articles

  • Chang J-YA, Chilcott JB & Latimer NR (2024) . PharmacoEconomics, 42(5), 487-506.
  • Chang J-YA, Hsu C-N, Ramos-Goñi JM, Luo N, Lin H-W & Lin F-J (2024) . The European Journal of Health Economics, 25(6), 1041-1055.
  • Peasgood T, Chang J-Y, Mir R, Mukuria C & Powell P (2021) . Quality of Life Research, 30(7), 2097-2108.
  • Chan H-J, Chang J-Y, Erickson SR & Wang C-C (2019) . Journal of Women's Health, 28(7), 965-975.
  • Lin H-W, Li C-I, Lin F-J, Chang J-Y, Gau C-S, Luo N, Pickard AS, Ramos Goñi JM, Tang C-H & Hsu C-N (2018) . PLoS ONE, 13(12).
  • Chang J-Y, Wang C-C, Kang H-C, Shen L-J & Huang C-F (2017) . International Journal for Quality in Health Care, 29(6), 817-825.

Conference proceedings

  • Liu Y-H, Gulas I, Tyas E, Tan YZ, Chang A, Kearns B & Westley T (2025) . Value in Health, Vol. 28(6) (pp S285-S286)
  • Hickey C, Sidovar M, Garcia A, Kramer K, Chang A, Kupas K, Telukuntla V & Cutler AJ (2025) . Value in Health, Vol. 28(6) (pp S39-S39)
  • Chang JYA, Rex SS, Chilcott JB & Latimer NR (2024) . Value in Health, Vol. 27(12) (pp S450-S450)
  • Rex S, Chang JY, Bradburn M, Akehurst R & Latimer N (2022) . Value in Health, Vol. 25(12). Vienna, 6 November 2022 - 6 November 2022.
  • Amy J-YC, Latimer NR, Gillespie D & Chilcott J (2020) PREVALENCE, CHARACTERISTICS AND KEY ISSUES OF MODELLING TREATMENT SEQUENCES IN HEALTH ECONOMIC EVALUATIONS: A SYSTEMATIC REVIEW OF NICE TECHNOLOGY APPRAISALS. VALUE IN HEALTH, Vol. 23 (pp S606-S606)
  • (2019) . Quality of Life Research, Vol. 28(S1) (pp 1-190)
  • Powell P, Chang J-Y, Mukuria C & Peasgood T (2019) The role of context and label in participants' quantitative interpretation of common quality of life PROM response options. QUALITY OF LIFE RESEARCH, Vol. 28 (pp S136-S137)
  • Lin H, Li C, Lin F, Chang J, Gau C, Luo N, Pickard AS, Ramos-Goñi JM, Tang C & Hsu C (2018) . Value in Health, Vol. 21 (pp S91-S91)
  • Chang J, Lin H, Hsu C, Li C, Ramos-Goñi JM, Tang C & Lin F (2018) . Value in Health, Vol. 21 (pp S89-S89)
  • Chan H, Chang J, Erickson SR & Wang C (2017) . Value in Health, Vol. 20(9) (pp A797-A797)
  • Chang J, Wang C & Lin F (2017) . Value in Health, Vol. 20(9) (pp A463-A464)
  • Chang J, Kang H, Shen L & Wang C (2016) . Value in Health, Vol. 19(7) (pp A612-A613)
Research group

SCHARR-TAG: 

Professor

PhD Supervisors:

Professor Nicholas Latimer

Professor Jim Chilcott

Teaching interests

I currently support the survival analysis component in R for HAR6178: Further Statistical Methods for Health Economic Analysis. I've led tutorials for an MBChB module on medical research design and the critical appraisal of RCTs and systematic reviews. I’ve also served as a peer mentor for new PhD students.

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