Diana Papaioannou

BChD, MSc

School of Medicine and Population Health

Senior Research Fellow/Portfolio Lead

CTRU Deputy Director

Diana Papaioannou
Profile picture of Diana Papaioannou
d.papaioannou@sheffield.ac.uk
+44 114 222 0766

Full contact details

Diana Papaioannou
School of Medicine and Population Health
Barber House
Sheffield
S10 2HQ
Profile

Diana Papaioannou is an Assistant Director of the Clinical Trials Research Unit (CTRU) and a Senior Research Fellow with expertise in trial conduct and methodology and CTIMP trials (Clinical Trials of Investigational Medicinal Products).

Diana has extensive experience in designing and implementing large multi-centre trials, particularly CTIMP trials. Since 2014, she has been co-applicant on 8 NIHR funded trials. Diana also held a Clinical Trials Unit (CTU) Efficient Trials award to develop recommendations for recording harms in behaviour change interventions. Diana was the Quality Assurance Lead for Sheffield CTRU between 2014 to 2024.

Diana is CTRU lead, providing senior CTRU oversight, for the following studies: EXPERTS-ALS (NIHR158515), MISSION-EB (NHSE/NIHR EME: 127963), PRAISE (NIHR153170) and MAP (NIHR167171).

Diana previously provided CTRU senior oversight and a co-applicant on the MAGIC trial (NIHR HTA: 16/80/08) and STAR-MS trials (NIHR EME: 16/126/26). I provided CTIMP expertise to the ASTIClite trial (NIHR EME: 15/178/09).

In 2019, Diana became Assistant Director at CTRU, responsible for the CTRU management with the CTRU Director and the CTRU management group and coordinating the CTRU
Diana joined the CTRU in May 2011 as the Trial Co-ordinator for a multi-centre randomised controlled trial, REPOSE (The Relative Effectiveness of Pumps over MDI and Structured Education for Type-1 diabetes).

Prior to joining CTRU, she worked with the ScHARR Technology Assessment Group from July 2006, as an Information Specialist and Systematic Reviewer undertaking health technology assessments for the National Institute for Health and Clinical Excellence (NICE) and the NIHR Evaluation, Trials and Studies Coordinating Centre (NETSCC).
 

Research interests
  • Clinical trial design
  • Clinical trials of Investigational Medicinal Products
  • Adverse event recording in behavioural trials
  • Systematic reviews
Publications

Show: Featured publications All publications

Books

  • Booth A, Papaioannou D & Sutton A (2012) Systematic Approaches to a Successful Literature Review. Sage Publications Limited.

Journal articles

  • Hyslop MC, Papaioannou DE, Bolt R, Wilson MJ, Bradburn M, Clarkson J, Herbert E, Ireland N, Kettle J, Loban A , Norrington AC et al (2025) . BJA Open, 13.
  • Kettle J, Bolt R, Deery C, Papaioannou D, Rodd H, Hyslop MC, Totton N & Marshman Z (2024) . Trials, 25(1).
  • Papaioannou D, Hamer-Kiwacz S, Mooney C, Sprange K, Cooper C & O’Cathain A (2024) . BMJ, 387.
  • Papaioannou D, Sprange K, Hamer-Kiwacz S, Mooney C, Moody G & Cooper C (2024) . Trials, 25.
  • Papaioannou D, Brazier J & Paisley S (2013) . Value in Health, 16(4), 686-695.
  • Papaioannou D, Brazier J & Parry G (2013) . J Pers Disord, 27(3), 383-401.
  • Papaioannou D, Rafia R, Rathbone J, Stevenson M, Buckley Woods H & Stevens J (2012) . Health Technol Assess, 16(37), 1-iv.
  • Kaltenthaler E, Papaioannou D, Boland A & Dickson R (2011) . Value Health, 14(8), 1158-1165.
  • Papaioannou D, Brazier J & Parry G (2011) . Value Health, 14(6), 907-920.
  • Papaioannou D, Rafia R, Stevenson MD, Stevens JW & Evans P (2011) . Health Technol Assess, 15 Suppl 1, 69-75.
  • Carroll C, Papaioannou D, Rees A & Kaltenthaler E (2011) . Health Technol Assess, 15(16), iii-62.
  • Papaioannou D, Cooper KL, Carroll C, Hind D, Squires H, Tappenden P & Logan RF (2011) . Colorectal Dis, 13(10), 1085-1099.
  • Cooper K, Squires H, Carroll C, Papaioannou D, Booth A, Logan RF, Maguire C, Hind D & Tappenden P (2010) . Health Technol Assess, 14(32), 1-206.
  • Papaioannou D, Sutton A, Carroll C, Booth A & Wong R (2010) . HEALTH INFO LIBR J, 27(2), 114-122.
  • Wilkinson A, Papaioannou D, Keen C & Booth A (2009) . Health Info Libr J, 26(2), 118-125.

Book chapters

  • Brazier J, Papaioannou D, Cantrell A, Paisley S & Herrmann K (2010) Identifying and reviewing health state utility values for populating decision models In Shemilt I, Mugford M, Vale L, Donaldson C & Marsh K (Ed.), Evidence-Based Decisions and Economics: Health Care, Social Welfare, Education and Criminal Justice (pp. 93-105). Wiley-Blackwell

Conference proceedings

  • Papaioannou D, Peasgood T, Brazier J & Parry G (2011) . VALUE IN HEALTH, Vol. 14(7) (pp A239-A239)

All publications

Books

  • Booth A, Sutton A & Papaioannou D (2016) Systematic Approaches to a Successful Literature Review. London: Sage.
  • Booth A, Papaioannou D & Sutton A (2012) Systematic Approaches to a Successful Literature Review. Sage Publications Limited.

Journal articles

  • Bageta ML, Lopez-Balboa P, Bursnall M, Glover R, Hutchence K, Papaioannou D, Biggs K, Julious S, Wilson I, Tappenden P , Turton E et al (2025) . EClinicalMedicine.
  • Deery C, Bolt R, Papaioannou D, Wilson M, Hyslop M, Herbert E, Totton N, Marshman Z, Young T, Kettle J , Albadri S et al (2025) . Health Technology Assessment, 29(29).
  • Bageta ML, López-Balboa P, Dimairo M, Glover R, Hutchence K, Papaioannou D, Cooper C, Biggs K, Tappenden P, Ennis K , Ogboli M et al (2025) . BMJ Open, 15(5).
  • Hyslop MC, Papaioannou DE, Bolt R, Wilson MJ, Bradburn M, Clarkson J, Herbert E, Ireland N, Kettle J, Loban A , Norrington AC et al (2025) . BJA Open, 13.
  • Kettle J, Bolt R, Deery C, Papaioannou D, Rodd H, Hyslop MC, Totton N & Marshman Z (2024) . Trials, 25(1).
  • Papaioannou D, Hamer-Kiwacz S, Mooney C, Sprange K, Cooper C & O’Cathain A (2024) . BMJ, 387.
  • Brittain G, Cooper C, Glover R, Loban A, Muraro P, Papaioannou D, Roldan E, Sharrack B & Snowden J (2024) . Neurology, 102(7_supplement_1).
  • Papaioannou D, Sprange K, Hamer-Kiwacz S, Mooney C, Moody G & Cooper C (2024) . Trials, 25.
  • Lindsay JO, Hind D, Swaby L, Berntsson H, Bradburn M, Bannur C U, Byrne J, Clarke C, Desoysa L, Din S , Emsley R et al (2024) . Efficacy and Mechanism Evaluation, 11(3).
  • Herbert E, Papaioannou D, Loban A, Totton N, Hyslop M, Bolt R & Deery C (2024) . Trials, 25(1).
  • Lindsay JO, Hind D, Swaby E, Berntsson H, Bradburn M, Bannur U, Byrne J, Clarke C, Desoysa L, Dickins B , Din S et al (2024) . The Lancet Gastroenterology and Hepatology.
  • Papaioannou D, Hamer-Kiwacz S, Mooney C, Cooper C, O'Cathain A, Sprange K & Moody G (2024) . Journal of Clinical Epidemiology, 169.
  • Brittain G, Petrie J, Duffy KEM, Glover R, Hullock K, Papaioannou D, Roldan E, Beecher C, Bursnall M, Ciccarelli O , Coles AJ et al (2024) . BMJ Open, 14(2).
  • Bolt R, Hyslop MC, Herbert E, Papaioannou DE, Totton N, Wilson MJ, Clarkson J, Evans C, Ireland N, Kettle J , Marshman Z et al (2024) . British Journal of Anaesthesia, 132(1), 76-85.
  • Brittain G, Roldan E, Glover R, Cooper C, Papaioannou D, Muraro P, Sharrack B & Snowden AJ (2023) . Journal of the Neurological Sciences, 455, 121832-121832.
  • Bageta ML, Balboa PL, Glover R, Cooper C, Papaioannou DE, Julious S, Dimairo M, Biggs K, Petrof G & Martinez AE (2023) . British Journal of Dermatology, 189(3), e42-e43.
  • Mellor K, Papaioannou D, Thomason A, Bolt R, Evans C, Wilson M & Deery C (2022) . BMC Pediatrics, 22(1).
  • Kettle J, Deery C, Bolt R, Papaioannou D & Marshman Z (2021) . Trials, 22(1).
  • Papaioannou D, Cooper C, Mooney C, Glover R & Coates E (2021) . Journal of Clinical Epidemiology, 136, 64-76.
  • Biggs K, Hind D, Gossage-Worrall R, Sprange K, White D, Wright J, Chatters R, Berry K, Papaioannou D, Bradburn M , Walters SJ et al (2020) . Trials, 21.
  • Snowden JA, Hawkey C, Hind D, Swaby L, Mellor K, Emsley R, Mandefield L, Lee E, Badoglio M, Polge E , Labopin M et al (2019) . BMC Gastroenterology, 19(1).
  • Pollard DJ, Brennan A, Dixon S, Waugh N, Elliott J, Heller S, Lee E, Campbell M, Basarir H & White D (2018) . BMJ Open, 8.
  • Heller S, White D, Lee E, Lawton J, Pollard D, Waugh N, Amiel S, Barnard K, Beckwith A, Brennan A , Campbell M et al (2017) . Health Technology Assessment, 21(20), 1-278.
  • Heller S, Amiel S, Campbell M, Choudhary P, Cooper C, Dimairo M, Elliott J, Hammond P, Lee E, Lindsay R , Waugh N et al (2017) . BMJ, 356.
  • Jarvis D, Mooney C, Cohen J, Papaioannou D, Bradburn M, Sutton A & Griffiths PD (2016) . European Radiology.
  • Lawton J, Kirkham J, Rankin D, White DA, Elliott J, Jaap A, Smithson WH, Heller S, Gianfrancesco C, Gordon V , Greaves L et al (2016) . Diabetic Medicine, 33(2), 243-251.
  • Lawto J, Kirkham J, Rankin D, Barnard K, Cooper CL, Taylor C, Heller S, Elliott J & the REPOSE Group (2014) . Diabetes Research and Clinical Practice, 106(3), 443-450.
  • Brazier J, Connell J, Papaioannou D, Mukuria C, Mulhern B, Peasgood T, Lloyd MJ, Paisley S, O’Cathain A, Barkham M , Knapp M et al (2014) . Health Technology Assessment, 18(34).
  • Holmes M, Carroll C & Papaioannou D (2013) . Pharmacoeconomics Italian Research Articles, 15(2), 83-90.
  • Papaioannou D, Brazier J & Paisley S (2013) . Value in Health, 16(4), 686-695.
  • Rafia R, Simpson E, Stevenson M & Papaioannou D (2013) . Pharmacoeconomics, 31(6), 471-478.
  • Papaioannou D, Brazier J & Parry G (2013) . J Pers Disord, 27(3), 383-401.
  • Holmes M, Carroll C & Papaioannou D (2012) . Pharmacoeconomics, 30(2), 137-146.
  • Papaioannou D, Rafia R, Rathbone J, Stevenson M, Buckley Woods H & Stevens J (2012) . Health Technol Assess, 16(37), 1-iv.
  • Kaltenthaler EC, Dickson R, Boland A, Carroll C, Fitzgerald P, Papaioannou D & Akehurst R (2012) . BMJ Open, 2(1), e000562.
  • Brazier J, Mulhern B, Alonso J, Connell J, Papaioannou D & Vilagut G (2012) Are generic preference-based measures valid in mental health? A mixed methods enquiry. QUALITY OF LIFE RESEARCH, 21, 1-1.
  • Kaltenthaler E, Papaioannou D, Boland A & Dickson R (2011) . Value Health, 14(8), 1158-1165.
  • Harnan SE, Cooper KL, Meng Y, Ward SE, Fitzgerald P, Papaioannou D, Ingram C, Lorenz E, Wilkinson ID & Wyld L (2011) . Eur J Surg Oncol, 37(11), 928-936.
  • Papaioannou D, Brazier J & Parry G (2011) . Value Health, 14(6), 907-920.
  • Papaioannou D, Rafia R, Stevenson MD, Stevens JW & Evans P (2011) . Health Technol Assess, 15 Suppl 1, 69-75.
  • Kaltenthaler E, Boland A, Carroll C, Dickson R, Fitzgerald P & Papaioannou D (2011) . Health Technol Assess, 15(22), 1-iv.
  • Carroll C, Papaioannou D, Rees A & Kaltenthaler E (2011) . Health Technol Assess, 15(16), iii-62.
  • Jones R, Everson-Hock ES, Papaioannou D, Guillaume L, Goyder E, Chilcott J, Cooke J, Payne N, Duenas A, Sheppard LM & Swann C (2011) . Child Care Health Dev, 37(5), 613-622.
  • Cooper KL, Harnan S, Meng Y, Ward SE, Fitzgerald P, Papaioannou D, Wyld L, Ingram C, Wilkinson ID & Lorenz E (2011) . Eur J Surg Oncol, 37(3), 187-198.
  • Cooper KL, Meng Y, Harnan S, Ward SE, Fitzgerald P, Papaioannou D, Wyld L, Ingram C, Wilkinson ID & Lorenz E (2011) . Health Technol Assess, 15(4), iii-134.
  • Papaioannou D, Cooper KL, Carroll C, Hind D, Squires H, Tappenden P & Logan RF (2011) . Colorectal Dis, 13(10), 1085-1099.
  • Cooper K, Squires H, Carroll C, Papaioannou D, Booth A, Logan RF, Maguire C, Hind D & Tappenden P (2010) . Health Technol Assess, 14(32), 1-206.
  • Papaioannou D, Sutton A, Carroll C, Booth A & Wong R (2010) . HEALTH INFO LIBR J, 27(2), 114-122.
  • Simpson EL, Rafia R, Stevenson MD & Papaioannou D (2010) . Health Technol Assess, 14 Suppl 1, 63-67.
  • Carroll C, Cooper K, Papaioannou D, Hind D, Pilgrim H & Tappenden P (2010) . CLIN THER, 32(5), 789-803.
  • Chilcott J, Tappenden P, Rawdin A, Johnson M, Kaltenthaler E, Paisley S, Papaioannou D & Shippam A (2010) . Health Technol Assess, 14(25), iii-107.
  • Carroll C, Cooper K, Papaioannou D, Hind D, Tappenden P, Pilgrim H & Booth A (2010) . Aliment Pharmacol Ther, 31(7), 708-718.
  • Stevenson MD, Simpson EL, Rawdin AC & Papaioannou DE (2010) A review of discrete event simulation in National Coordinating Centre for Health Technology Assessment-funded work and a case study exploring the cost-effectiveness of testing for thrombophilia in patients presenting with an initial idiopathic venous thromboembolism.. J. Simulation, 4, 14-23.
  • Pandor A, Fitzgerald P, Stevenson M & Papaioannou D (2009) . HEALTH TECHNOL ASSES, 13, 55-60.
  • Stevenson M, Lloyd-Jones M & Papaioannou D (2009) Vitamin K to prevent fractures in older women: systematic review and economic evaluation.. Health technology assessment (Winchester, England), 13(45).
  • Holmes M, Carroll C & Papaioannou D (2009) . Health Technol Assess, 13 Suppl 2, 55-62.
  • Stevenson M, Lloyd-Jones M & Papaioannou D (2009) . Health Technol Assess, 13(45), iii-134.
  • Wilkinson A, Papaioannou D, Keen C & Booth A (2009) . Health Info Libr J, 26(2), 118-125.
  • Booth A, Carroll C, Papaioannou D, Sutton A & Wong R (2009) . Health Info Libr J, 26(1), 4-21.
  • Simpson EL, Duenas A, Holmes MW, Papaioannou D & Chilcott J (2009) . Health Technol Assess, 13(17), iii-154.
  • Simpson EL, Stevenson MD, Rawdin A & Papaioannou D (2009) . Health Technol Assess, 13(2), iii-91.
  • Carroll C, Booth A, Papaioannou D, Sutton A & Wong R (2009) . J Contin Educ Health Prof, 29(4), 235-241.
  • Dawett B, Deery C, Banerjee A, Papaioannou D & Marshman Z () . British Dental Journal.

Book chapters

  • Brazier J, Papaioannou D, Cantrell A, Paisley S & Herrmann K (2010) Identifying and reviewing health state utility values for populating decision models In Shemilt I, Mugford M, Vale L, Donaldson C & Marsh K (Ed.), Evidence-Based Decisions and Economics: Health Care, Social Welfare, Education and Criminal Justice (pp. 93-105). Wiley-Blackwell

Conference proceedings

  • Brittain G, Glover R, Roldan E, Papaioannou D, Cooper C, Muraro P, Snowden J & Sharrack B (2022) A changing target - adapting ongoing autologous haematopoietic stem cell transplantation clinical trials to evolving clinical practice in the treatment of highly active relapsing remitting multiple sclerosis. MULTIPLE SCLEROSIS JOURNAL, Vol. 28(3_SUPPL) (pp 843-843)
  • Papaioannou D, Peasgood T, Brazier J & Parry G (2011) . VALUE IN HEALTH, Vol. 14(7) (pp A239-A239)
  • Rafia R, Papaioannou D, Stevenson M, Rathbone J & Woods HB (2011) . VALUE IN HEALTH, Vol. 14(7) (pp A445-A445)

Reports

  • Ara R, Keetharuth D, Papaioannou D, Cantrell A & Brazier J (2011) Evaluating public health interventions for obesity from the perspective of local health authorities

Posters

  • Biggs K, Hind D, Gossage-Worrall R, Sprange K, White D, Wright J, Chatters R, Berry K, Papaioannou D, Bradburn M , Walters SJ et al (2019) Challenges in the design, planning and implementation of trials evaluating group interventions. 5th International Clinical Trials Methodology Conference (ICTMC 2019).
  • Rafia R, Papaioannou D, Stevenson M, Rathbone J & Woods H Evaluating the cost-effectiveness of the addition of rituximab to chemotherapy in the first-line treatment of Follicular Lymphoma patients in the UK.
  • Harnan S, Cooper K, Meng Y, Ward S, Fitzgerald P, Papaioannou D, Wyld L, Ingram C, Wilkinson I & Lorenz E Magnetic resonance imaging (MRI) for assessment of axillary lymph node metastases in breast cancer: systematic review.
  • Carroll C, Papaioannou D & Harnan S Surgical interventions for the primary prophylaxis of retinal detachment in Stickler Syndrome: a systematic review.
Research group

CTRU, DTS

Grants

Metformin and Psychosis Weight Prevention Trial (MAP Trial). NIHR HTA.
Coapplicant. £3million

EXPErimental medicine Route To Success in Amyotrophic Lateral Sclerosis
(EXPERTS-ALS) NIHR EME and NIHR BRC. Coapplicant. £4,796,266.62. Start date:
1 Sep 2023.

Recording Harms in Behavioural change Intervention Trials (RHABIT) Project. NIHR CTU support funding for Efficient trials. Principal Investigator. £79,015

MissionEB trial: Double blinded placebo control study of Mesenchymal Intravenous
Stromal cell Infusions in children with recessive dystrophic Epidermolysis Bullosa.
Coapplicant. £2,539,714. Start date Aug 2020

STAR-MS trial: Autologous Stem Cell Transplantation versus Alemtuzumab in
Relapsing Remitting MS. Coapplicant. £2,350,322. Start date Jan 2019

The MAGIC trial: Melatonin for Anxiety prior to General Anaesthesia. HTA 16/80/08,
Coapplicant.£1.65million. Dec 2017 to September 2024.

Autologous Stem Cell Transplantation In refractory Crohns disease - Low Intensity
Therapy Evaluation (ASTIC-LITE). Sep 2017 to 2021

SCRATCH trial (Induced Endometrial Trauma in IVF). HTA 14/08/05, Coapplicant.
£1.25million. Dec 2015 to Sep 2020

Teaching interests

I am interested in supervising research students in areas such as RCT methodology and evaluation of health technologies.