Diana Papaioannou
BChD, MSc
School of Medicine and Population Health
Senior Research Fellow/Portfolio Lead
CTRU Deputy Director
+44 114 222 0766
Full contact details
School of Medicine and Population Health
Barber House
Sheffield
S10 2HQ
- Profile
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Diana Papaioannou is an Assistant Director of the Clinical Trials Research Unit (CTRU) and a Senior Research Fellow with expertise in trial conduct and methodology and CTIMP trials (Clinical Trials of Investigational Medicinal Products).
Diana has extensive experience in designing and implementing large multi-centre trials, particularly CTIMP trials. Since 2014, she has been co-applicant on 8 NIHR funded trials. Diana also held a Clinical Trials Unit (CTU) Efficient Trials award to develop recommendations for recording harms in behaviour change interventions. Diana was the Quality Assurance Lead for Sheffield CTRU between 2014 to 2024.
Diana is CTRU lead, providing senior CTRU oversight, for the following studies: EXPERTS-ALS (NIHR158515), MISSION-EB (NHSE/NIHR EME: 127963), PRAISE (NIHR153170) and MAP (NIHR167171).
Diana previously provided CTRU senior oversight and a co-applicant on the MAGIC trial (NIHR HTA: 16/80/08) and STAR-MS trials (NIHR EME: 16/126/26). I provided CTIMP expertise to the ASTIClite trial (NIHR EME: 15/178/09).
In 2019, Diana became Assistant Director at CTRU, responsible for the CTRU management with the CTRU Director and the CTRU management group and coordinating the CTRU
Diana joined the CTRU in May 2011 as the Trial Co-ordinator for a multi-centre randomised controlled trial, REPOSE (The Relative Effectiveness of Pumps over MDI and Structured Education for Type-1 diabetes).
Prior to joining CTRU, she worked with the ScHARR Technology Assessment Group from July 2006, as an Information Specialist and Systematic Reviewer undertaking health technology assessments for the National Institute for Health and Clinical Excellence (NICE) and the NIHR Evaluation, Trials and Studies Coordinating Centre (NETSCC).
- Research interests
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- Clinical trial design
- Clinical trials of Investigational Medicinal Products
- Adverse event recording in behavioural trials
- Systematic reviews
- Publications
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Show: Featured publications All publications
Featured publications
Books
- Systematic Approaches to a Successful Literature Review. Sage Publications Limited.
Journal articles
- . BJA Open, 13.
- . Trials, 25(1).
- . BMJ, 387.
- . Trials, 25.
- . Value in Health, 16(4), 686-695.
- . J Pers Disord, 27(3), 383-401.
- . Health Technol Assess, 16(37), 1-iv.
- . Value Health, 14(8), 1158-1165.
- . Value Health, 14(6), 907-920.
- . Health Technol Assess, 15 Suppl 1, 69-75.
- . Health Technol Assess, 15(16), iii-62.
- . Colorectal Dis, 13(10), 1085-1099.
- . Health Technol Assess, 14(32), 1-206.
- . HEALTH INFO LIBR J, 27(2), 114-122.
- . Health Info Libr J, 26(2), 118-125.
Book chapters
- Identifying and reviewing health state utility values for populating decision models In Shemilt I, Mugford M, Vale L, Donaldson C & Marsh K (Ed.), Evidence-Based Decisions and Economics: Health Care, Social Welfare, Education and Criminal Justice (pp. 93-105). Wiley-Blackwell
Conference proceedings
- . VALUE IN HEALTH, Vol. 14(7) (pp A239-A239)
All publications
Books
- Systematic Approaches to a Successful Literature Review. London: Sage.
- Systematic Approaches to a Successful Literature Review. Sage Publications Limited.
Journal articles
- . EClinicalMedicine.
- . Health Technology Assessment, 29(29).
- . BMJ Open, 15(5).
- . BJA Open, 13.
- . Trials, 25(1).
- . BMJ, 387.
- . Neurology, 102(7_supplement_1).
- . Trials, 25.
- . Efficacy and Mechanism Evaluation, 11(3).
- . Trials, 25(1).
- . The Lancet Gastroenterology and Hepatology.
- . Journal of Clinical Epidemiology, 169.
- . BMJ Open, 14(2).
- . British Journal of Anaesthesia, 132(1), 76-85.
- . Journal of the Neurological Sciences, 455, 121832-121832.
- . British Journal of Dermatology, 189(3), e42-e43.
- . BMC Pediatrics, 22(1).
- . Trials, 22(1).
- . Journal of Clinical Epidemiology, 136, 64-76.
- . Trials, 21.
- . BMC Gastroenterology, 19(1).
- . BMJ Open, 8.
- . Health Technology Assessment, 21(20), 1-278.
- . BMJ, 356.
- . European Radiology.
- . Diabetic Medicine, 33(2), 243-251.
- . Diabetes Research and Clinical Practice, 106(3), 443-450.
- . Health Technology Assessment, 18(34).
- . Pharmacoeconomics Italian Research Articles, 15(2), 83-90.
- . Value in Health, 16(4), 686-695.
- . Pharmacoeconomics, 31(6), 471-478.
- . J Pers Disord, 27(3), 383-401.
- . Pharmacoeconomics, 30(2), 137-146.
- . Health Technol Assess, 16(37), 1-iv.
- . BMJ Open, 2(1), e000562.
- Are generic preference-based measures valid in mental health? A mixed methods enquiry. QUALITY OF LIFE RESEARCH, 21, 1-1.
- . Value Health, 14(8), 1158-1165.
- . Eur J Surg Oncol, 37(11), 928-936.
- . Value Health, 14(6), 907-920.
- . Health Technol Assess, 15 Suppl 1, 69-75.
- . Health Technol Assess, 15(22), 1-iv.
- . Health Technol Assess, 15(16), iii-62.
- . Child Care Health Dev, 37(5), 613-622.
- . Eur J Surg Oncol, 37(3), 187-198.
- . Health Technol Assess, 15(4), iii-134.
- . Colorectal Dis, 13(10), 1085-1099.
- . Health Technol Assess, 14(32), 1-206.
- . HEALTH INFO LIBR J, 27(2), 114-122.
- . Health Technol Assess, 14 Suppl 1, 63-67.
- . CLIN THER, 32(5), 789-803.
- . Health Technol Assess, 14(25), iii-107.
- . Aliment Pharmacol Ther, 31(7), 708-718.
- A review of discrete event simulation in National Coordinating Centre for Health Technology Assessment-funded work and a case study exploring the cost-effectiveness of testing for thrombophilia in patients presenting with an initial idiopathic venous thromboembolism.. J. Simulation, 4, 14-23.
- . HEALTH TECHNOL ASSES, 13, 55-60.
- Vitamin K to prevent fractures in older women: systematic review and economic evaluation.. Health technology assessment (Winchester, England), 13(45).
- . Health Technol Assess, 13 Suppl 2, 55-62.
- . Health Technol Assess, 13(45), iii-134.
- . Health Info Libr J, 26(2), 118-125.
- . Health Info Libr J, 26(1), 4-21.
- . Health Technol Assess, 13(17), iii-154.
- . Health Technol Assess, 13(2), iii-91.
- . J Contin Educ Health Prof, 29(4), 235-241.
- . British Dental Journal.
Book chapters
- Identifying and reviewing health state utility values for populating decision models In Shemilt I, Mugford M, Vale L, Donaldson C & Marsh K (Ed.), Evidence-Based Decisions and Economics: Health Care, Social Welfare, Education and Criminal Justice (pp. 93-105). Wiley-Blackwell
Conference proceedings
- A changing target - adapting ongoing autologous haematopoietic stem cell transplantation clinical trials to evolving clinical practice in the treatment of highly active relapsing remitting multiple sclerosis. MULTIPLE SCLEROSIS JOURNAL, Vol. 28(3_SUPPL) (pp 843-843)
- . VALUE IN HEALTH, Vol. 14(7) (pp A239-A239)
- . VALUE IN HEALTH, Vol. 14(7) (pp A445-A445)
Reports
- Evaluating public health interventions for obesity from the perspective of local health authorities
Posters
- Challenges in the design, planning and implementation of trials evaluating group interventions. 5th International Clinical Trials Methodology Conference (ICTMC 2019).
- Evaluating the cost-effectiveness of the addition of rituximab to chemotherapy in the first-line treatment of Follicular Lymphoma patients in the UK.
- Magnetic resonance imaging (MRI) for assessment of axillary lymph node metastases in breast cancer: systematic review.
- Surgical interventions for the primary prophylaxis of retinal detachment in Stickler Syndrome: a systematic review.
- Research group
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CTRU, DTS
- Grants
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Metformin and Psychosis Weight Prevention Trial (MAP Trial). NIHR HTA.
Coapplicant. £3million
EXPErimental medicine Route To Success in Amyotrophic Lateral Sclerosis
(EXPERTS-ALS) NIHR EME and NIHR BRC. Coapplicant. £4,796,266.62. Start date:
1 Sep 2023.
Recording Harms in Behavioural change Intervention Trials (RHABIT) Project. NIHR CTU support funding for Efficient trials. Principal Investigator. £79,015
MissionEB trial: Double blinded placebo control study of Mesenchymal Intravenous
Stromal cell Infusions in children with recessive dystrophic Epidermolysis Bullosa.
Coapplicant. £2,539,714. Start date Aug 2020
STAR-MS trial: Autologous Stem Cell Transplantation versus Alemtuzumab in
Relapsing Remitting MS. Coapplicant. £2,350,322. Start date Jan 2019
The MAGIC trial: Melatonin for Anxiety prior to General Anaesthesia. HTA 16/80/08,
Coapplicant.£1.65million. Dec 2017 to September 2024.
Autologous Stem Cell Transplantation In refractory Crohns disease - Low Intensity
Therapy Evaluation (ASTIC-LITE). Sep 2017 to 2021
SCRATCH trial (Induced Endometrial Trauma in IVF). HTA 14/08/05, Coapplicant.
£1.25million. Dec 2015 to Sep 2020
- Teaching interests
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I am interested in supervising research students in areas such as RCT methodology and evaluation of health technologies.