Professor Alan Brennan
BSc (London), MSc (London), PhD (Sheffield)
School of Medicine and Population Health
Professor of Health Economics and Decision Modelling
+44 114 222 0684
Full contact details
School of Medicine and Population Health
Regent Court (ScHARR)
30 Regent Street
Sheffield
S1 4DA
- Profile
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I am Professor of Health Economics and Decision Modelling at ScHARR, University of Sheffield, England.
I studied for BSc Mathematics at Imperial College London and then MSc Operational Research at the London School of Economics before joining the NHS to work in and then lead the Trent Operational Research Unit. Since 1994 I have been leading the modelling team at ScHARR.
I lead a large group of around 35 academic staff, undertaking methodological and applied research and consultancy using mathematical modelling in health and healthcare.
I have been developing and applying modelling in support of healthcare decision-making nationally and internationally, across a large range of diseases, interventions, service planning and policy issues for over 25 years. Together we have now built a large, high-quality team of around 35 or more health economic modelling researchers.
I am a regular expert on several panels, providing input to the design of phase III studies from an economic/NICE perspective, usually for global pharmaceutical and device manufacturers.
I lead programmes of research on mathematical modelling in health and healthcare focusing on health economics and decision modelling.
I lead and contribute to the strategic development of research collaborations and programmes within the University, the White Rose, nationally and internationally for funders including NIH (US), MRC, ESRC, NICE, DH and EU.
I undertake substantial applied research/consultancy with healthcare organisations around public health, service development and policy, and with the pharmaceutical industry in the UK and internationally on the cost-effectiveness of interventions.
I contribute to PhD and Masters programmes in ScHARR including the and working on new courses and curriculum development around MSc Health Economics and Decision Modelling, and the online course MSc International Health Technology Assessment and Reimbursement.
- Research interests
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My fundamental interest is in mathematical modelling approaches to inform decision making in health and healthcare.
I am currently principal investigator or co-investigator involved in over 19 research programmes and projects. Current government / national policy research.
Alcohol Policy
I have been involved in modelling alcohol behaviours and policy since 2008, when we began a programme of research for UK research bodies and policy makers. With Prof Meier, we have developed the Sheffield Alcohol Research Group, a leading international centre for alcohol policy and epidemiological modelling research. Our work has influenced government policy on minimum unit pricing for alcohol; shaping and informing policy in UK, Scotland, Canada, Wales, EU Commission, and Republic of Ireland.Public Health - Health Economics and Decision Modelling
I am co-applicant (Health Economics and Decision Modelling leader) on large research grants for the and the .I have a wider portfolio of public health work including work around screening and prevention of diabetes, linking smoking and alcohol behaviours and developing a joint smoking and alcohol policy analysis model, encouraging behaviours in physical activity and general lifestyle risk reductions. This entire programme relates to the central methodological interest which is in developing and using novel mathematical modelling approaches to support and inform decision making around health and healthcare for international impact.
Health Technology Assessment
I have been heavily involved in health technology assessment and health economic evaluation of pharmaceuticals and interventions for both government bodies in the UK eg and internationally, and also with the pharmaceutical industry.
I direct a programme of research in Health Economic Modelling / Health Technology Assessment which involves a large team of modelling staff and their collaborators. We are recognized as a leading national and international centre for HTA modelling research. I have been involved in direct leadership of over 30 research projects within the last five years, working closely with ScHARR-TAG and DSU.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . Addiction, 115(12), 2268-2279.
- . Addiction, 115(11), 2021-2031.
- . Value in Health, 23(6), 734-742.
- . Health Education and Behavior, 47(2), 224-234.
- . Trials, 21(1).
- . PharmacoEconomics, 38(2), 193-204.
- . Population Health Metrics, 18(1).
- . Journal of Studies on Alcohol and Drugs(Sup 18), 96-109.
- . BMJ Open, 8.
- . PharmacoEconomics, 35(1), 1287-1296.
- . Journal of Public Health, 38(4), 679-687.
- . International Journal of Technology Assessment in Health Care, 32(4), 203-211.
- . PLoS One, 11(9).
- . BMC Public Health, 16, 917.
- . Health and Place, 41, 11-18.
- . BMC Public Health, 16.
- . PLoS Medicine, 13(2).
- . British Journal of General Practice , 66(642), e1-e9.
- . Medical Decision Making, 35(5), 570-583.
- . Health Economics.
- . Addiction, 109(12), 1994-2002.
- . BMJ, 349(-), ---.
- . Lancet, 383(9929), 1655-1664.
- . J Health Econ, 34(100), 96-103.
- . Medical Decision Making, 32(5), 701-711.
- . Lancet, 375(9723), 1355-1364.
- . Med Decis Making, 27(4), 448-470.
- . Rheumatology (Oxford), 46(8), 1345-1354.
- . Health Econ, 16(11), 1205-1225.
- . J Health Econ, 26(1), 122-148.
- . Health Econ, 15(12), 1295-1310.
- . Health Technology Assessment, 19(33), 1-80.
All publications
Journal articles
- . BMJ Open, 15(10), e100490-e100490.
- . NIHR Open Research, 5.
- . NIHR Open Research.
- . Tobacco Control.
- . NIHR Open Research, 5.
- . Appetite, 213, 108071-108071.
- . Contemporary Clinical Trials, 157, 108050-108050.
- . Wellcome Open Research, 10, 455-455.
- . Journal of Geriatric Oncology, 16(7).
- . Diabetes, Obesity and Metabolism.
- . Tobacco Control.
- . BMC Medical Research Methodology, 25(1).
- . Value in Health Regional Issues, 49.
- . International Journal of Obesity, 49(8), 1598-1607.
- . BMJ Open, 15(4).
- . Diabetic Medicine, 42(6).
- . Obesity Science & Practice, 11(2).
- . Programme Grants for Applied Research, 13(2), 1-72.
- . Diabetologia, 68(5), 969-980.
- . Tobacco Control.
- . BMC Public Health, 25(1).
- . Value in Health, 28(3), 326-335.
- . Value in Health, 27(12), S471-S472.
- . The Lancet, 404(Supplement 1), S13-S13.
- . European Journal of Public Health, 34(Supplement_3).
- . BMC Public Health, 24(1).
- . The Lancet Public Health, 9(10), e719-e728.
- . Addiction, 119(10), 1726-1736.
- . Value in Health, 27(10), 1328-1337.
- . Diabetes Care, 47(7), 1239-1239.
- . BMC Primary Care, 25.
- . BMJ Open Diabetes Research and Care, 12(2).
- . BMC Public Health, 24.
- . BMJ Open, 14(3).
- . Diabetes Care, 47(4), 739-746.
- . Tobacco Control.
- . Environmental Modelling & Software, 173.
- . Drug and Alcohol Review, 43(1), 315-324.
- . Value in Health, 26(12), S544-S544.
- . The Lancet, 402(1), S75-S75.
- . International Journal of Drug Policy, 122.
- . NIHR Open Research, 3(26).
- . NIHR Open Research, 3(26).
- . Appetite, 189, 106907-106907.
- . JMIR Diabetes, 8(1).
- . Appetite, 189, 106933-106933.
- . Public Health, 220, 43-49.
- . NIHR Open Research, 3.
- . Tobacco Prevention & Cessation, 9(Supplement), 57-57.
- . Health Economics, 32(7), 1603-1625.
- . Journal of Artificial Societies and Social Simulation, 26(2).
- . International Journal of Alcohol and Drug Research, 10(1), 24-33.
- . Addiction.
- . The Lancet Public Health, 7(10), e866-e875.
- . BMJ Open Diabetes Research and Care, 10(4).
- . International Journal of Behavioral Nutrition and Physical Activity, 19.
- . Quality of Life Research, 31(11), 3283-3292.
- . Programme Grants for Applied Research, 10(6), 1-114.
- . Diabetic Medicine, 39(9).
- . BMJ Open, 12(4).
- . Drug and Alcohol Review, 41(5), 1161-1173.
- . BMC Public Health, 22(1).
- . BMJ Open, 12(2).
- . Jmir Formative Research, 6(1).
- . Addictive Behaviors, 124.
- . Medical Decision Making, 42(5), 599-611.
- . Medical Decision Making, 42(4), 461-473.
- . Addiction, 117(5), 1392-1403.
- . Annals of Behavioral Medicine, 56(1), 64-77.
- . BMJ Open, 8(2).
- . Health Technology Assessment, 25(77).
- . Journal of Public Health, 43(3), 639-646.
- . Radiotherapy and Oncology, 161, 166-176.
- . Addiction, 116(10), 2709-2711.
- . BMC Medicine, 19.
- . British Journal of Cancer, 125(2), 209-219.
- . Value in Health, 24(6), 770-779.
- . Drug and Alcohol Review, 40(7), 1377-1386.
- . British Journal of Surgery, 108(3), 315-325.
- . Addiction, 116(9), 2372-2384.
- . Drug and Alcohol Review, 40(6), 1061-1070.
- . Public Health Research, 9(4).
- . Addiction, 116(9), 2538-2547.
- . European Journal of Cancer, 144, 269-280.
- . The European Journal of Health Economics, 22(3), 381-392.
- . BMJ Open, 11(1).
- . Wellcome Open Research, 6.
- . BMC Public Health, 21.
- . European Journal of Cancer, 142, 48-62.
- . Emergency Medicine Journal, 38(7), 504-510.
- . Tobacco Control, 30(e1), e27-e32.
- . Addiction, 115(12), 2268-2279.
- . Public Health, 189, 48-53.
- . Addiction, 115(11), 2021-2031.
- . Journal of Epidemiology and Community Health, 74(11), 942-949.
- . Medical Decision Making, 40(7), 912-923.
- . Public Health Research, 8(14).
- . BMJ Open, 10(9).
- . Value in Health, 23(9), 1163-1170.
- . Statistical Methods in Medical Research, 29(9), 2637-2646.
- . International Journal of Microsimulation, 13(2), 21-60.
- . Health Services and Delivery Research, 8(24).
- . Complexity, 2020.
- . Value in Health, 23(6), 743-750.
- . Health Technology Assessment, 24(28).
- . Value in Health, 23(6), 734-742.
- . Journal of Artificial Societies and Social Simulation, 23(3).
- . Addiction, 115(6), 1038-1049.
- . Diabetic Medicine, 37(5), 735-746.
- . BMJ Open, 10(4).
- . BMJ Open Diabetes Research & Care, 8(1).
- . Health Education and Behavior, 47(2), 224-234.
- . Trials, 21(1).
- . PharmacoEconomics, 38(2), 193-204.
- . Population Health Metrics, 18(1).
- . Medical Decision Making, 40(1), 90-105.
- . The Lancet, 394, S54-S54.
- . Wellcome Open Research, 4.
- . Energy Policy, 130, 206-217.
- . BMJ Open, 9(6).
- . Value in Health, 22(4), 391-398.
- . Addiction, 114(4), 607-608.
- . Journal of Studies on Alcohol and Drugs(Sup 18), 96-109.
- . BMC Medical Research Methodology, 19.
- . European Journal of Public Health, 29(2), 219-225.
- . Addiction, 114(4), 590-600.
- . Health & Place, 57, 358-364.
- . Addiction, 113(12), 2225-2232.
- . Alcohol and Alcoholism, 53(5), 548-559.
- . Journal of Medical Economics (JME), 21(7), 666-675.
- . Journal of Epidemiology and Community Health, 72(9), 864-864.
- . Value in Health, 21(6), 724-731.
- . PLoS One, 13(5).
- . BMJ Open, 8.
- . Addiction, 113(2), 203-204.
- . Addiction, 113(2), 372-373.
- . PharmacoEconomics, 35(1), 1287-1296.
- . BMJ, 359.
- . Pharmacoeconomics, 35, 989-1006.
- . Journal of Epidemiology and Community Health, 71(9), 912-918.
- . PharmacoEconomics, 35, 937-949.
- . BMJ Open, 7.
- . Diabetic Medicine, 34(8), 1136-1144.
- . Alcohol and Alcoholism, 52(3), 372-381.
- . Diabetic Medicine, 34(5), 632-640.
- . International Journal of Environmental Research and Public Health, 14(4).
- . Addiction, 112(5), 808-817.
- . Health Technology Assessment, 21(20), 1-278.
- . European Journal of Public Health, 27(2), 345-351.
- . BMJ, 356.
- . Journal of Epidemiology and Community Health, 71, 137-145.
- . Journal of Public Health, 38(4), 679-687.
- . Medical Decision Making, 38(8), 1020-1033.
- . Journal of Public Health & Epidemiology, 8(10), 191-203.
- . International Journal of Technology Assessment in Health Care, 32(4), 203-211.
- . PLoS One, 11(9).
- . BMC Public Health, 16, 917.
- . Health and Place, 41, 11-18.
- . Addiction, 111(9), 1616-1627.
- . Addiction, 111(9), 1568-1579.
- . Pharmacoeconomics, 34(8), 815-827.
- . BMC Public Health, 16.
- . Value in Health, 19(4), 404-412.
- . Journal of Epidemiology and Community Health, 70(3), 231-237.
- . PLoS Medicine, 13(2).
- . British Journal of General Practice , 66(642), e1-e9.
- . Diabetic Medicine, 33(8), 1155-1163.
- . Diabetic Medicine, 33(2), 192-203.
- . Diabetic Medicine, 33(2), 243-251.
- . Trials, 16(1).
- . Medical Decision Making, 35(7), 872-887.
- . Health Economics, 24(10), 1368-1388.
- . Medical Decision Making, 35(5), 570-583.
- . Pilot and Feasibility Studies, 1.
- . Journal of Artificial Societies and Social Simulation, 18(3).
- . Rheumatology, 54(4), 623-632.
- . Health Economics.
- . Programme Grants for Applied Research, 2(5).
- . Addiction, 109(12), 1994-2002.
- . The Lancet, 384, S52-S52.
- . Drug and Alcohol Review, 33(6), 596-603.
- . Diabetes Research and Clinical Practice, 106(3), 443-450.
- . BMJ, 349(-), ---.
- . Drug and Alcohol Review, 33(5), 515-525.
- . Proceedings of the 2014 Annual Conference on Genetic and Evolutionary Computation, 1159-1166.
- . Diabet Med, 31(7), 847-853.
- . Acta Veterinaria Scandinavica, 563-563.
- . Appl Health Econ Health Policy, 12(3), 239-253.
- . Lancet, 383(9929), 1655-1664.
- . Medical Decision Making, 34(3), 311-326.
- . Diabet Med, 31(4), 477-486.
- . J Health Econ, 34(100), 96-103.
- . BMC Fam Pract, 15, 26.
- . Addiction, 109(2), 206-215.
- . Annals of Surgical Innovation and Research, 14.
- . Drug and Alcohol Dependence, 134(1), 136-143.
- . Trials, 14(S1).
- . Trials, 14(S1).
- . BMJ Open, 3(9), e003250.
- . DIABETIC MEDICINE, 30(10), 1236-1244.
- . Health Technol Assess, 17(32), 1-vi.
- . Value in Health.
- . Alcohol Alcohol, 48(2), 241-249.
- . Alcohol Alcohol, 48(2), 180-188.
- . BMC Public Health, 13, 107.
- . BMJ Open, 3(1).
- Innovation in Health Economic Modelling of Service Improvements for Longer-Term Depression: Demonstration in a Local Health Community. JOURNAL OF MENTAL HEALTH POLICY AND ECONOMICS, 16, S34-S35.
- The cost-effectiveness of Dose Adjustment for Normal Eating (DAFNE) structured education in Type 1 diabetes: an update using the Sheffield Type 1 diabetes policy model. DIABETIC MEDICINE, 30, 133-134.
- A theory-based online intervention to promote health behaviour in new university students: One-month follow-up data. PSYCHOLOGY & HEALTH, 28, 132-132.
- . BMC Health Serv Res, 13, 150.
- . Eur J Health Econ, 14(6), 887-899.
- . Value Health, 15(8), 1127-1136.
- . Medical Decision Making, 32(5), 701-711.
- . Value in Health, 15(6), 821-827.
- . Health Technol Assess, 16(33), 1-iv.
- . Drug and Alcohol Dependence, 123(1-3), 7-14.
- . Rheumatology (Oxford), 50 Suppl 4, iv26-iv31.
- . Journal of Epidemiology and Community Health, 65(Suppl 1), A47.4-A47.
- . Med Decis Making, 31(6), 839-852.
- . Int J Geriatr Psychiatry, 26(5), 483-494.
- . BRIT MED J, 341.
- . BMJ, 341, c4093.
- . MED DECIS MAKING, 30(3), E20-E22.
- . Lancet, 375(9723), 1355-1364.
- . J Health Econ, 29(3), 468-477.
- . Addiction, 105(3), 400-401.
- . Addiction, 105(3), 383-393.
- . INT J CARDIOL, 140(3), 315-322.
- . Int J Technol Assess Health Care, 25(4), 470-478.
- . Aktuelle Neurologie, 36(S 02).
- . Aktuelle Neurologie, 36(S 02).
- . Med Decis Making, 29(6), 678-689.
- . PHARM STAT, 8(4), 371-389.
- . PHARM STAT, 8(2), 150-162.
- . Alzheimer's & Dementia, 4(4S_Part_14).
- . RHEUMATOLOGY, 47(7), 1107-1107.
- . BJOG-INT J OBSTET GY, 115(6), 749-757.
- . Arthritis Rheum, 58(4), 939-946.
- . Value Health, 11(2), 160-171.
- . Med Decis Making, 27(4), 448-470.
- . Med Decis Making, 27(4), 491-499.
- . DIABETES CARE, 30(6), 1638-1646.
- . Rheumatology (Oxford), 46(8), 1345-1354.
- . RHEUMATOLOGY, 46(7), 1140-1147.
- Screening for type 2 diabetes: Literature review and economic modelling. Health Technology Assessment, 11(17).
- Screening for type 2 diabetes: literature review and economic modelling. HEALTH TECHNOL ASSES, 11(17), 1-+.
- . Health Econ, 16(11), 1205-1225.
- . Obes Rev, 8(4), 363-371.
- . Value Health, 10(1), 32-41.
- . J Health Econ, 26(1), 122-148.
- . STAT MED, 26(6), 1237-1254.
- . Eur J Health Econ, 7(4), 276-284.
- . Health Econ, 15(12), 1295-1310.
- A prognostic model for functional outcome in early rheumatoid arthritis. Journal of Rheumatology, 33(8), 1503-1510.
- Accurate, practical and cost-effective assessment of carotid stenosis in the UK. Health Technology Assessment, 10(30).
- Accurate, practical and cost-effective assessment of carotid stenosis in the UK. HEALTH TECHNOL ASSES, 10(30), 1-+.
- . Rheumatology (Oxford), 45(8), 1029-1038.
- . Int J Cardiol, 109(3), 307-316.
- . Expert Rev Pharmacoecon Outcomes Res, 5(5), 519-529.
- . Pharmacoeconomics, 23(8), 851-853.
- Incorporation of uncertainty in health economic modelling studies - The authors' reply. PHARMACOECONOMICS, 23(8), 853-853.
- . Pharmacoeconomics, 23(6), 529-536.
- . Drugs, 65(4), 473-496.
- . Appl Health Econ Health Policy, 4(4), 201-208.
- . Health Serv Manage Res, 18(4), 265-276.
- The Authors' Reply. PharmacoEconomics, 23(8), 853-853.
- . Curr Med Res Opin, 21(1), 101-112.
- . Ann Rheum Dis, 64(7), 995-1002.
- . RHEUMATOLOGY, 44(1), 3-4.
- THE COST-EFFECTIVENESS OF ADALIMUMAB (HUMIRA (TM)) IN PATIENTS WITH RHEUMATOID ARTHRITIS: A UK ANALYSIS. RHEUMATOLOGY, 43, 77-77.
- WHICH PATIENTS WITH EARLY RA DEVELOP FAST PROGRESSIVE DISEASE? PROGNOSTIC FACTORS FOR SEVERE FUNCTIONAL LOSS FROM AN INCEPTION COHORT WITH 9 YEAR FOLLOW UP. RHEUMATOLOGY, 43, 137-137.
- . RHEUMATOLOGY, 43(5), 677-678.
- . Med Decis Making, 24(1), 9-19.
- . Rheumatology (Oxford), 43(1), 62-72.
- . Eur J Health Econ, 4(3), 239-240.
- The role of modelling in prioritising and planning clinical trials.. Health technology assessment (Winchester, England), 7(23).
- . Journal of Health Services Research & Policy, 8(1), 18-24.
- . J Health Serv Res Policy, 8(1), 18-24.
- MODELLING THE COST-EFFECTIVENESS OF ETANERCEPT IN ADULTS WITH RHEUMATOID ARTHRITIS IN THE UK. RHEUMATOLOGY, 41, 91-91.
- . Vaccine, 20(13-14), 1778-1786.
- . J Epidemiol Community Health, 55(7), 521-527.
- . Injury, 32(4), 267-274.
- . Pharmacoeconomics, 17(5), 445-459.
- . Applied Health Economics and Health Policy.
- Breast cancer screening using clinical breast examination: A cost-effectiveness analysis for South Africa. Value in Health Regional Issues.
- A model based cost-utility analysis of embedding referral to structured self-management education into standard practice (Embedding) compared to usual care for people with type 2 diabetes diagnosis in the last 12 months in England.. BMJ Open.
- . Annals of Operations Research, 236(1), 149-176.
- . Public Health.
- . Health Technology Assessment, 19(33), 1-80.
Book chapters
- , Value of Information for Healthcare Decision Making (pp. 251-263).
- , Value of Information for Healthcare Decision-Making (pp. 251-264). Chapman and Hall/CRC
- Supporting purchasing in acute specialties in the trent region, Controlling Costs Strategic Issues in Health Care Management (pp. 118-130).
- Chapman and Hall/CRC
Conference proceedings
- . International Journal of Obesity, Vol. 49(Suppl 1) (pp 1-45). Aberdeen, Scotland, 10 September 2025 - 10 September 2025.
- . 2024 Winter Simulation Conference (WSC) (pp 252-263). Orlando, Florida, 15 December 2024 - 15 December 2024.
- . SSM Annual Scientific Meeting (pp A63.1-A63)
- HEALTH TECHNOLOGY DECISION-MAKING IN AN IMPERFECT WORLD: A UNIFYING FRAMEWORK OF VALUE OF INFORMATION AND IMPLEMENTATION METRICS BASED ON A NARRATIVE REVIEW. VALUE IN HEALTH, Vol. 27(12) (pp S471-S472)
- . Obesity, Vol. 31(S2) (pp 47-48). Dallas, Texas, 14 October 2023 - 14 October 2023.
- . SSM Annual Scientific Meeting (pp A18.2-A19)
- PUBLIC HEALTH ECONOMIC MODELLING IN EVALUATIONS OF SALT AND ALCOHOL POLICIES: A SCOPING REVIEW. VALUE IN HEALTH, Vol. 26(12) (pp S544-S544)
- WHEN IS A SIMPLE MODEL GOOD ENOUGH? TOWARDS GREATER USE OF FORMAL METHODS FOR EVALUATING STRUCTURAL UNCERTAINTY IN COST-EFFECTIVENESS ANALYSIS. VALUE IN HEALTH, Vol. 25(7) (pp S350-S351)
- . The Lancet, Vol. 398(Supplement 2) (pp S53-S53). Virtual conference, 25 November 2021 - 25 November 2021.
- . The Lancet, Vol. 398(Supplement 2) (pp 23-23). Virtual conference, 26 November 2021 - 26 November 2021.
- . The Lancet, Vol. 398(Supplement 2) (pp S27-S27). Online, 26 November 2021 - 26 November 2021.
- . Annals of the Rheumatic Diseases, Vol. 80 (pp 617-618)
- . Evolutionary Multi-Criterion Optimization : EMO 2021 Proceedings, Vol. 12654 (pp 721-733). Shenzhen, China, 28 March 2021 - 28 March 2021.
- . Medical Decision Making, Vol. 40(1) (pp E1-E379)
- . Medical Decision Making, Vol. 40(1) (pp E63-E64). Portland, Oregon, 20 October 2019 - 20 October 2019.
- METHODS FOR CHOOSING THE BEST DESIGN OF A CLINICAL TRIAL: IMPLEMENTING EXPECTED VALUE OF SAMPLE INFORMATION AND ADJUSTING FOR BIAS INDUCED BY A GROUP SEQUENTIAL DESIGN. MEDICAL DECISION MAKING, Vol. 40(1) (pp E188-E189)
- . The Lancet, Vol. 394(Suppl 2) (pp S51-S51). London, UK, 29 November 2019 - 29 November 2019.
- . European Journal of Public Health, Vol. 29(Supplement_4)
- . Value in Health, Vol. 22 (pp S584-S584)
- . Value in Health, Vol. 22 (pp S577-S577)
- . The Lancet, Vol. 394 (pp S35-S35)
- . Trials, Vol. 20(Supplement 1) (pp 99-99). Brighton, UK, 6 October 2019 - 6 October 2019.
- . Trials, Vol. 20(Supplement 1) (pp 109-109). Brighton, UK, 6 October 2019 - 6 October 2019.
- . Proceedings of the Genetic and Evolutionary Computation Conference (pp 1356-1363)
- . Value in Health, Vol. 22 (pp S374-S374)
- ALCOHOL POLICY MODELING USING THEORY - A NEW COMPUTATIONAL PLATFORM FOR DEVELOPING MECHANISM-BASED EXPLANATORY MODELS. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, Vol. 43 (pp 142A-142A)
- SYNTHESIZING THE RATIONAL ADDICTION AND MYOPIC CHOICE ECONOMIC MODELS TO EXPLAIN POPULATION ALCOHOL USE AND UNDERSTAND PRICING POLICIES: AN AGENT-BASED SIMULATION. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, Vol. 43 (pp 141A-141A)
- PRETRIAL MODELLING METHODS TO JUSTIFY AND INFORM THE DESIGN OF LARGE RCTS - EXPECTED VALUE OF SAMPLE INFORMATION FOR THE DAFNEPLUS DIABETES EDUCATION CLUSTER RCT. VALUE IN HEALTH, Vol. 22 (pp S584-S584)
- A HEALTH ECONOMIC AND DECISION MODELLING ANALYSIS PLAN FOR AN INTEGRATED DATABASE OF OVER 100 CLINICAL TRIALS MEASURING HYPOGLYCAEMIC ATTACKS FOR PEOPLE WITH DIABETES: A HEDMAP FOR HYPORESOLVE. VALUE IN HEALTH, Vol. 22 (pp S577-S577)
- . Value in Health, Vol. 21 (pp S206-S206)
- A CONCEPTUAL FRAMEWORK FOR MODELING ALCOHOL USE DYNAMICS OVER OPULATION HEALTH TIME HORIZONS. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, Vol. 42 (pp 331A-331A)
- PLATFORM FOR CALIBRATED, SYSTEM-BASED MODELS OF ALCOHOL USE DYNAMICS. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, Vol. 42 (pp 331A-331A)
- . Value in Health, Vol. 20(9) (pp A776-A776)
- . BMC Public Health, Vol. 17(825)
- . Value in Health, Vol. 20(9) (pp A733-A733)
- . Value in Health, Vol. 20(9) (pp A732-A732)
- . Addiction science & clinical practice, Vol. 12(Suppl 1)
- A comparison of approaches to model migraine day frequency in migraine. CEPHALALGIA, Vol. 37 (pp 102-103)
- MODELING MIGRAINE DAY FREQUENCY USING THE BETA-BINOMIAL DISTRIBUTION: A CASE STUDY OF ERENUMAB AS MIGRAINE PROPHYLAXIS. VALUE IN HEALTH, Vol. 20(5) (pp A329-A329)
- A Systematic Review of Psychological Interventions to Improve Glycaemic Control in Type 1 Diabetes. DIABETES, Vol. 66 (pp A214-A214)
- . Value in Health, Vol. 19(7) (pp A853-A853)
- . Value in Health, Vol. 19(7) (pp A361-A361)
- . Posters (pp A83.1-A83)
- . The Lancet, Vol. 386 (pp S33-S33)
- . Value in Health, Vol. 18(7) (pp A423-A423)
- . Value Health, Vol. 18(7) (pp A725-A726). Milan, Italy, 7 November 2015 - 7 November 2015.
- . The Lancet, Vol. 384 (pp S51-S51)
- Minimum unit pricing for alcohol: policy appraisal modelling of income and socioeconomic group-specific effects on consumption, spending, and health harms. LANCET, Vol. 382 (pp 47-47)
- . VALUE IN HEALTH, Vol. 16(7) (pp A530-A530)
- . Value Health, Vol. 16(3) (pp A290). United States
- . Value Health, Vol. 16(3) (pp A29). United States
- . VALUE IN HEALTH, Vol. 16(3) (pp A284-A284)
- The cost-effectiveness of five week vs one week DAFNE structured education in Type 1 diabetes: a preliminary evaluation using the Sheffield Type 1 diabetes policy model. DIABETIC MEDICINE, Vol. 30 (pp 131-131)
- . VALUE IN HEALTH, Vol. 15(7) (pp A360-A360)
- . VALUE IN HEALTH, Vol. 15(4) (pp A181-A182)
- Validation of an individual patient level simulation of the natural history of systemic Lupus erythematosus against an alternative longitudinal cohort. 2012 Operational Research Society Simulation Workshop Sw 2012 (pp 19-24)
- . VALUE IN HEALTH, Vol. 14(7) (pp A469-A470)
- . VALUE IN HEALTH, Vol. 14(7) (pp A243-A243)
- The Natural History and Predictive Factors of Long Term Outcomes in Systemic Lupus Erythematosus.. ARTHRITIS AND RHEUMATISM, Vol. 63(10) (pp S951-S951)
- MODELLING GENERAL AND TARGETED PRICE POLICY OPTIONS: ESTIMATION OF EFFECTS ON DIFFERENT SUBGROUPS OF THE POPULATION. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, Vol. 34(6) (pp 251A-251A)
- MODELLING COST EFFECTIVENESS OF BEHAVIOUR MODIFICATION PROGRAMMES AND EFFECTS ON MEDICATION: CASE STUDY OF EDUCATION PROGRAMMES IN DIABETES. VALUE HEALTH, Vol. 13(3) (pp A59-A59)
- Cost effectiveness of the DESMOND structured education programme for patients newly diagnosed with type 2 diabetes. DIABETOLOGIA, Vol. 52 (pp S12-S12)
- ESTIMATING THE COST EFFECTIVENESS IN THE UK OF VILDAGLIPTIN COMPARED TO PIOGLITAZONE AS ADD-ON THERAPY TO METFORMIN USING THE SHEFFIELD TYPE 2 DIABETES MODEL. VALUE HEALTH, Vol. 11(6) (pp A501-A501)
- Clopidogrel is cost-effective compared with aspirin in United Kingdom patients with a myocardial infarction who subsequently sustain an ischaemic stroke or peripheral arterial disease event. VALUE HEALTH, Vol. 11(3) (pp A194-A195)
- The cost-utility of exelon patch in the management of patients with moderate Alzheimer's disease in the United Kingdom. VALUE HEALTH, Vol. 10(6) (pp A384-A384)
- Using mixed treatment comparisons and meta-regression to perform indirect comparisons to estimate the efficacy of biologic treatments in rheumatoid arthritis. VALUE HEALTH, Vol. 10(3) (pp A121-A121)
- Economic evaluation of the use of lanthanum carbonate from an Australian perspective. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 22 (pp 186-186)
- The cost effectiveness of etanercept in patients with severe as in the UK. ANNALS OF THE RHEUMATIC DISEASES, Vol. 65 (pp 273-274)
- The cost effectiveness of anti-TNF antagonists in rheumatoid arthritis: Results from the British Society for Rheumatology Biologics Registry. ANNALS OF THE RHEUMATIC DISEASES, Vol. 65 (pp 179-179)
- A simple prognostic index in early rheumatoid arthritis for predicting functional outcome at 5 years follow up. RHEUMATOLOGY, Vol. 44 (pp I97-I97)
- Lanthanum carbonate for the treatment of hyperphosphataemia: Development of a cost effectiveness model. VALUE HEALTH, Vol. 7(6) (pp 805-805)
- The cost effectiveness of adalimumab (HUMIRA (R)) in patients with RA: A Finnish analysis. ANNALS OF THE RHEUMATIC DISEASES, Vol. 63 (pp 513-514)
- A prognostic model for progressive disease in early rheumatoid arthritis. ANNALS OF THE RHEUMATIC DISEASES, Vol. 63 (pp 110-110)
- The cost effectiveness of adalimumab (HUMIRA((R))) in UK patients with moderate to severe RA. ANNALS OF THE RHEUMATIC DISEASES, Vol. 63 (pp 512-513)
- Cost effectivness of obesity treatment with sibutramine in combination with diet and lifestyle advice in Germany. INTERNATIONAL JOURNAL OF OBESITY, Vol. 28 (pp S152-S152)
- Cost-effectiveness of adalimumab (Humira (TM)) in the treatment of US patients with rheumatoid arthritis (RA). VALUE HEALTH, Vol. 7(3) (pp 241-241)
- Cost effectiveness of adalimumab (HUMIRA (TM), Abbott) in the treatment of patients with moderate to severe rheumatoid arthritis (RA). ARTHRITIS AND RHEUMATISM, Vol. 48(9) (pp S215-S215)
- The cost-effectiveness of adalimumab (HUMIRA (TM), Abbott) in patients with rheumatoid arthritis: A Swedish analysis.. ARTHRITIS AND RHEUMATISM, Vol. 48(9) (pp S611-S611)
- Identifing groups of RA patients who are fast Progressors from early clinical and radiological. ARTHRITIS AND RHEUMATISM, Vol. 48(9) (pp S110-S110)
- Costing the impact of the cancer service guidance. Journal of Clinical Excellence, Vol. 4(1 SUPPL.) (pp 209-210)
- A threshold cost-effectiveness comparison of infliximab and etanercept in adults with rheumatoid arthritis in the UK.. ARTHRITIS AND RHEUMATISM, Vol. 46(9) (pp S582-S582)
- Methods to analyse the economic benefits of a pharmacogenetic (PGt) test to predict response to biologic therapy in RA, and to prioritise further research.. ARTHRITIS AND RHEUMATISM, Vol. 46(9) (pp S92-S92)
- Modelling the cost-effectiveness of etanercept in adults with rheumatoid arthritis (RA) in the UK.. ARTHRITIS AND RHEUMATISM, Vol. 44(9) (pp S157-S157)
- In rheumatoid arthritis (RA) utility calculations should be derived from EQ5D rather than SF-36 due to floor effects.. ARTHRITIS AND RHEUMATISM, Vol. 44(9) (pp S311-S311)
- . PharmacoEconomics, Vol. 17(5) (pp 443-444)
- Breast Cancer Screening Using Clinical Breast Examination: A Cost-Effectiveness Analysis for South Africa. TBA, 18 July 2025 - 23 July 2025.
- . Endocrine Abstracts
- . International Journal of Integrated Care, Vol. 13(7)
- Accounting for Psychological Determinants of Treatment Response in Health Economic Simulation Models of Behavioural Interventions: A Case Study in Type 1 Diabetes. ISPOR 17th Annual International Meeting. Washington DC, June 2012.
Reports
- Report for the EcoNomics of Adaptive Clinical Trials (ENACT) project : Application of a Bayesian Value-Based Sequential Model of a Clinical Trial to the CACTUS and HERO Case Studies (with Guidance Material for Clinical Trials Units)
- Summary report of the Health and Labour Outcomes (HaLO) Tool
- A feasibility study for building a health and work model. Report prepared for Public Health England
- Estimates of alcohol dependence in England based on APMS 2014, including estimates of children living in a household with an adult with alcohol dependence. Prevalence, trends, and amenability to treatment
- Model-based appraisal of the comparative impact of Minimum Unit Pricing and taxation policies in Scotland. An adaptation of the Sheffield Alcohol Policy Model version 3,
- Mortality and morbidity risks from alcohol consumption in the UK: Analyses using the Sheffield Alcohol Policy Model (v.2.7) to inform the UK Chief Medical Officers’ review of the UK lower risk drinking guidelines
- SPHR Diabetes Prevention Model: Detailed Description of Model Background, Methods, Assumptions and Parameters
- A new approach to measuring drinking cultures in Britain
- Injury Alcohol-Attributable Fractions: Methodological Issues and Developments
- Fuel Poverty: Perspectives from the front line
- An evidence-based model for estimating requirements for specialist alcohol treatment capacity in England: The Specialist Treatment for Alcohol Model (STreAM) Version 1.0
Posters
- Health Economic Modelling of the Service of Care in Sheffield for Patients with Long-Term Depression.
- Cost-Utility of the Rivastigmine Transdermal Patch in the Management of Patients with Moderate Alzheimer's Disease in the US.
- Comparing socioeconomic gradients in alcohol-related harm between the four UK countries (PHE Applied Epidemiology Scientific Meeting 18-19 March 2015).
- Using real world data to structure and populate Markov models - a case study of telemonitoring for heart failure.
- Telemonitoring after discharge with heart failure - costeffectiveness modelling of alternative service designs (2012).
- The Cost-Effectiveness of 5-week versus 1-week DAFNE Structured Education in Type 1 Diabetes: A Preliminary Evaluation Using the Sheffield Type 1 Diabetes Policy Model (Diabetes UK Professional Conference 13-15 March 2013).
- The Cost-Effectiveness of Dose Adjustment For Normal Eating (DAFNE) Structured Education in Type 1 Diabetes: An Update using the Sheffield Type 1 Diabetes Policy Model (Diabetes UK Professional Conference 13-15 March 2013).
- Modelling cost effectiveness of behaviour modification programmes and effects on medication: case study of education programmes in diabetes.
- Using Whole Disease Modelling to inform economic recommendations for the detection, diagnosis, treatment and followup of colorectal cancer.
Datasets
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Other
- .
- .
Preprints
- , Cold Spring Harbor Laboratory.
- , Springer Science and Business Media LLC.
- , Springer Science and Business Media LLC.
- , Cold Spring Harbor Laboratory.
- Value-adaptive clinical trial designs for efficient delivery of research – actions, opportunities and challenges for publicly funded trials.
- , JMIR Publications Inc..
- , arXiv.
- .
- .
- Research group
- Grants
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Current and Recent Research Grants
NIHR
- including leadership of the cross cutting theme on efficient and equitable public health systems
UK Prevention Research Programme
UK Prevention Research Programme (led by and )
US National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIHR
With results available here:- )
Innovative Medicines Initiative
ESRC
MRC
MRC Skills Development Fellowship
MRC Skills Development Fellowship
MRC Skills Development Fellowship on tobacco econometrics
NIHR (led by )
Department of Health Policy Research Programme via NIHR (led by )
NIHR Programme Grant (led by , Sheffield)
NHS Health Scotland (led by , Sheffield)
MRC
. - Funding completed May 2018 but ongoing work on other grants especially and
This work has developed the Sheffield Tobacco and Alcohol Policy Model (STAPM) led by
NIHR (led by , Leicester)
NIHR (led by Tom Yates Leicester)
.
Public Health England
Support to Non Communicable Disease Modelling Unit
Public Health England
Health and Work - estimating the impact of 11 chronic conditions on labour market outcomes
- Professional activities and memberships
-
I am a member of ,,,,,, and .
I am currently a co-editor for the journal .