Professor Oliver Bandmann
MD, PhD
School of Medicine and Population Health
Professor of Movement Disorders Neurology
Honorary Consultant Neurologist
Co-Director, Neuroscience Institute
  
  +44 114 222 2237
Full contact details
School of Medicine and Population Health
Room B32
Sheffield Institute for Translational Neuroscience (SITraN)
385a Glossop Road
Sheffield
S10 2HQ
- Profile
 - 
    
- 2002-present: University of Sheffield/Royal Hallamshire Hospital, Sheffield, UK
 - 1997-2002: Specialist Training in Neurology, Marburg, Germany;
 - 1993-1997: Research Fellow, Institute of Neurology. Queen Square London. PhD on "Genetic Aspects of Parkinsonian Disorders" (Supervisors: Prof A.E. Harding, Prof C.D. Marsden, Prof N.W. Wood)
 - 1992-1993: House officer, Dept Neurology, Klinikum Grosshadern, Munich (Head: Prof T. Brandt)
 - 1991: Qualification at Ludwig Maximilian´s University Munich, Germany
 
 
- Research interests
 - 
    
My research focuses on movement disorders, in particular Parkinson´s Disease (PD) but also Huntington´s Disease, Wilson Disease and dystonia. I’m particularly interested in working towards disease-modifying therapy for PD which would slow down disease progression.
The main areas of research within my group are as follows:
1. Mitochondrial dysfunction and compound screen with identification of neuroprotective compounds as candidates for disease-modifying treatment in Parkinson’s Disease:
We were the first group worldwide to undertake detailed assessment of mitochondrial function and morphology in both and . We subsequently undertook the mutant patient tissue. 2000 drugs were assessed for their rescue effect on mitochondrial function. A clear mode of action (MOA) was identified for a group of compounds which includes the FDA-licensed drug ursodeoxycholic acid (UDCA).For interested members of the public: Please have a look at the official for more information on this project. You may also be interested in listening to a .
Fig1. The image shows a fibroblast from a patient with Parkinson’s Disease due to mutations in the parkin gene. The fibroblast has been stained to show the mitochondria in the cell. We see increased branching and interconnectedness of the mitochondrial network in the fibroblasts from patients with parkin mutations compared to controls; this change in morphology of the mitochondria correlates with changes in function.
2. Bench to bedside – early clinical trials in Parkinson’s disease
There is emerging evidence of a “Parkinson Epidemic” with a predicted global doubling in the number of people with Parkinson’s from 6 million to 12 million between 2015 and 2014 (PMID:30584159).
We have now taken UDCA as the top hit of our drug screen into an early clinical trial, called the UP study (short for: UDCA in Parkinson’s disease). The UP study will predominantly focus on investigating the safety and tolerability of UDCA in PD. However, we will also use novel techniques (in particular 31P-MR-Spectroscopy and sensor-based objective quantification of motor impairment) to gain some insight into the neuroprotective potential of UDCA.
MR Spectroscopy of a human brain with focussed analysis of the basal ganglia (the area most affected in Parkinson’s disease)
My group is also participating in two other multicentre neuroprotection trials, testing statins and antibodies against alpha-synuclein for their neuroprotective effect.
For interested members of the public: Please have a look at the official University of Sheffield Press release for more information on this project
This link will take you to a webpage of the Cure Parkinson’s Trust - it provides additional information on UDCA for Parkinson’s:
You may also find this video interesting during which we describe our journey from the bench at SITraN to the clinical trial carried out at the NIHR-funded Clinical Research facility at the Royal Hallamshire Hospital:
3. Zebrafish as a new vertebrate animal model for Parkinson’s Disease:
We were the first group worldwide to establish a at Bateson Centre of the University of Sheffield ().
We subsequently demonstrated that Parkin-deficient zebrafish share key features with human parkin-mutant Parkinson’s Disease patients, namely . Most recently, we have identified as novel mechanism leading to mitochondrial dysfunction and dopaminergic cell loss in PINK1 deficiency. Inhibition of TIGAR prevents loss of dopaminergic neurons by normalizing mitochondrial function. TIGAR is therefore a promising novel target for disease-modifying therapy in early onset Parkinson’s Disease. We are now also using zebrafish to study genetic risk factors for sporadic Parkinson’s and how they may interact with ageing.
For interested members of the public: Please have a look at the
official for more information on this project.4. Mitochondrial biomarkers in Parkinson’s Disease:
We have just completed a detailed assessment of mitochondrial and lysosomal dysfunction in patients with sporadic Parkinson’s Disease. This will hopefully allow to eventually identify those patients with Parkinson’s Disease who are most likely to benefit from medication with mitochondrial rescue drugs.5. Huntington's Disease (HD)
We are recruiting patients for the Enroll-HD study at our multidisciplinary Huntington’s Disease clinic. As part of this, we have been frequently recruiting patients for HD drug trials and other HD studies.6. Wilson Disease (WD)
I have previously contributed to the development of the . More recently, we have conducted the first study on the genetic prevalence of Wilson Disease in the UK in collaboration with the Welcome Sanger Institute, Cambridge, UK. This study demonstrated a surprisingly high ATP7B carrier frequency which suggests that WD may be considerably more common than previously thought. In collaboration with the Sheffield Diagnostic Genetics Service, we also identified .In close collaboration with the Wilson disease patient self-help group, we have helped to establish a UK-wide, interdisciplinary Wilson disease network. This network will hopefully allow us to develop national standards for the care of Wilson disease patients and facilitate future research projects.
 
- Publications
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Journal articles
- . Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 17(3).
 - . Neurology and Therapy, 14(5), 1747-1767.
 - . npj Parkinson's Disease, 11(1).
 - . Movement Disorders, 40(7), 1307-1317.
 - . npj Parkinson's Disease, 10.
 - . Annals of Neurology, 96(1), 133-149.
 - . Brain, 147(1), 267-280.
 - . Journal of Parkinson's Disease, 13(6), 1011-1033.
 - . Nature Communications, 14.
 - . Journal of Parkinson’s Disease, 13(6), 851-864.
 - . Nature Reviews Drug Discovery, 22(9), 681-682.
 - . Movement Disorders, 38(8), 1493-1502.
 - . Disease Models & Mechanisms, 16(6).
 - . Brain, 146(7), 2717-2722.
 - . Biomolecules, 13(1).
 - . Bone, 168.
 - . Journal of Neurology, Neurosurgery & Psychiatry, 93(9), e2.2-e2.2.
 - . Movement Disorders, 37(8), 1728-1738.
 - . The Lancet Gastroenterology & Hepatology, 7(6), 560-575.
 - . The Journal of Neuroscience, 42(4), 702-716.
 - . Brain, 145(1), 263-275.
 - . Journal of Neurology, Neurosurgery & Psychiatry, 92(10), 1053-1061.
 - . The Lancet Neurology, 20(7), 559-572.
 - . Neuroscience & Biobehavioral Reviews, 128, 367-382.
 - . Cortex, 142, 74-83.
 - . Scientific Reports, 11(1).
 - . Neural Regeneration Research, 16(3), 500-501.
 - . Movement Disorders, 36(2), 503-508.
 - . Neuron, 109(3), 448-460.e4.
 - . Practical Neurology, 20(6), 435.2-445.
 - . BMJ Open, 10(8).
 - . Neurology, 94(21), 907-908.
 - . Progress in Neurobiology, 187.
 - . Neurology Clinical Practice, 10(1), 40-46.
 - . Brain, 1-20.
 - . Journal of Neurology, Neurosurgery & Psychiatry, 90(12), e38.2-e38.
 - . Biology Open, 8(10).
 - . Movement Disorders, 34(9), 1307-1314.
 - . Neurobiology of Disease, 127, 563-569.
 - . Value in Health, 22(6), 712-720.
 - . Journal of Huntington's Disease, 8(2), 181-193.
 - . Scientific Reports, 9.
 - . Brain Research, 1706, 218-223.
 - . American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 180(3), 232-245.
 - . Parkinsonism & Related Disorders, 61, 101-105.
 - . Journal of Cerebral Blood Flow and Metabolism, 40(2), 298-313.
 - . Journal of Molecular Biology, 430(21).
 - . Journal of Huntington's Disease, 7(3), 209-222.
 - . Journal of Neurochemistry, 146(4), 356-373.
 - . Cell Reports, 23(10), 2976-2988.
 - . Journal of Movement Disorders, 11(2), 53-64.
 - . EJNMMI Research, 8(1).
 - . Practical Neurology, 18(5), 352-358.
 - . FEBS Letters, 592(5), 776-792.
 - . Nuclear Medicine Communications, 39(3), 268-275.
 - . Journal of Neurology, Neurosurgery & Psychiatry, 88(Suppl 1), A31.4-A32.
 - . The Lancet Neurology, 16(9), 701-711.
 - . Cortex, 95, 51-62.
 - . Sleep, 40(8), ---.
 - . Brain Sciences, 7(7).
 - . Alzheimer's & Dementia, 13(7S_Part_26).
 - . Handb Clin Neurol, 142, 7-17.
 - . European Journal of Neuroscience, 45(4), 528-535.
 - . Neurology.
 - . Neuroscience Letters, 630, 23-29.
 - . Human Molecular Genetics, 24(23), 6640-6652.
 - . Neurology, 85(10), 846-852.
 - . Neurology, 84(14_supplement).
 - . The Lancet Neurology, 14(1), 103-113.
 - . ACS Nano, 8(5), 4650-4661.
 - . Neurology, 82(10_supplement).
 - . Neurology, 82(10_supplement).
 - . Neurogenetics, 15(1), 19-21.
 - . Ann Neurol, 74(6), 837-847.
 - . Front Cell Neurosci, 7, 178.
 - . J Neurol Neurosurg Psychiatry, 84(11), e2.
 - . Brain, 136(Pt 10), 3038-3050.
 - . Neurology, 81(9), 808-811.
 - . PLoS ONE, 8(7).
 - . Journal of Affective Disorders, 151(1), 248-258.
 - . Neurology, 80(19), 1740-1745.
 - . J Huntingtons Dis, 2(1), 107-124.
 - . Brain, 136(Pt 5), 1476-1487.
 - . Pract Neurol, 13(2), 114-119.
 - . Journal of Huntington's Disease, 2(1), 107-124.
 - . Neurology, 80(7), 608-609.
 - . Neurosci Lett, 532, 55-58.
 - . PLoS Curr, 4, e4f8606b742ef3.
 - Prolonged generalized dystonia after chronic cerebellar application of kainic acid. Brain Research.
 - . Brain Research, 1464, 82-88.
 - . Neurology, 78(10), 690-695.
 - . Neurology, 78(11), 772-773.
 - . European Journal of Human Genetics, 20(1), 20-26.
 - . Zebrafish, 8(3), 103-108.
 - . Journal of Neurology, Neurosurgery & Psychiatry, 82(12), 1409-1412.
 - . Neurology, 75(22), 2017-2020.
 - . Neurobiol Dis, 40(1), 58-65.
 - . Hum Mol Genet, 19(R1), R21-R27.
 - . AM J NEURORADIOL, 31(5), 856-861.
 - . Neurology, 73(16), 1280-1285.
 - . Nat Neurosci, 12(9), 1129-1135.
 - . Brain, 132(Pt 6), 1613-1623.
 - . Mitochondrion, 9(1), 63-63.
 - . Ann Neurol, 64(5), 555-565.
 - . Neurology, 71(8), 542-543.
 - . J Neurochem, 106(5), 1991-1997.
 - . Eur J Neurol, 15(7), 749-753.
 - . Neurology, 70(16 Pt 2), 1375-1376.
 - . Mov Disord, 23(1), 54-62.
 - Unified Wilson's Disease Rating Scale - a proposal for the neurological scoring of Wilson's disease patients.. Neurol Neurochir Pol, 41(1), 1-12.
 - Unified Wilson's Disease Rating Scale (UWDRS) - a proposal for the neurological scoring of Wilson's disease patients. PARKINSONISM RELAT D, 13, S80-S80.
 - . J Neurochem, 100(6), 1626-1635.
 - . Neurology, 67(12), 2250-2252.
 - . Mov Disord, 21(10), 1789-1790.
 - . Mov Disord, 21(6), 881-883.
 - . Neurology, 66(6), 951-952.
 - . J Neurol Neurosurg Psychiatry, 76(8), 1058-1063.
 - . Brain, 128(Pt 8), 1855-1860.
 - . Neurogenetics, 6(1), 55-56.
 - Advances in dystonia. EUR J NEUROL, 11, 1-1.
 - . Mov Disord, 19(11), 1279-1284.
 - . Exp Neurol, 187(1), 199-202.
 - . Neurosci Lett, 359(3), 195-197.
 - . Neurology, 62(3), 357-358.
 - . Mov Disord, 19(2), 192-196.
 - . Neurology, 61(8), 1097-1101.
 - . Neurology, 60(4), 700-702.
 - . Ann Neurol, 53(2), 278-279.
 - . Am J Med Genet B Neuropsychiatr Genet, 119B(1), 60-64.
 - Myoclonic encephalopathy caused by chronic bismuth abuse.. Epileptic Disord, 4(4), 229-233.
 - . Neurology, 59(5), 782-783.
 - . J Neural Transm (Vienna), 109(4), 503-512.
 - . Neuropediatrics, 33(1), 1-5.
 - Spectrum of mutations in the gene for epsilon-sarcoglycan (SGCE) in myoclonus-dystonia syndrome (MDS, DYT11). NEUROLOGY, 58(7), A17-A17.
 - Detailed genotyping demonstrates association between the slow acetylator genotype for N-acetyltransferase 2 (NAT2) and familial Parkinson's disease.. Mov Disord, 15(1), 30-35.
 - . Dtsch Med Wochenschr, 124(8), 219-222.
 - . Eur J Neurol, 6(5), 549-554.
 - . J Neurol Neurosurg Psychiatry, 66(5), 665-667.
 - . J Neurol Neurosurg Psychiatry, 66(1), 86-89.
 - . J Neural Transm Suppl, 56, 155-164.
 - Toxins, genetics, and Parkinson's disease: the role of N-acetyltransferase 2.. Adv Neurol, 80, 199-204.
 - . Mov Disord, 13(2), 203-211.
 - . Ann Neurol, 44(2), 270-273.
 - . Ann Neurol, 44(4), 649-656.
 - . Lancet, 351(9096), 141-142.
 - Acetylator genotype and Parkinson's disease - Reply. LANCET, 351(9096), 142-142.
 - Mental disorders in movement disorders. CURR OPIN PSYCHIATR, 11(3), 315-319.
 - Atypical presentations of dopa-responsive dystonia.. Adv Neurol, 78, 283-290.
 - . Lancet, 350(9085), 1136-1139.
 - . J Neurol Neurosurg Psychiatry, 63(3), 304-308.
 - . J Neurol, 244(4), 262-265.
 - . Neurology, 49(6), 1598-1604.
 - . J Neurol Sci, 141(1-2), 27-32.
 - . J Neurol Neurosurg Psychiatry, 60(5), 588.
 - . Hum Mol Genet, 5(3), 403-406.
 - . J Neurol Neurosurg Psychiatry, 60(1), 98-101.
 - Peripheral markers in Parkinson's disease. An overview.. Adv Neurol, 69, 283-291.
 - . Neuroscience, 72(4), 877-879.
 - . Mov Disord, 10(3), 277-278.
 - Epidemiological, genetic, pharmacological, kinesiological, nuclear medical (IBZM-SPECT), standard and functional MRI studies on Parkinson's disease and related disorders and economic evaluation of Parkinson's disease therapy--clinical projects in the BMFT-research program Munich: "Parkinson's disease and other basal ganglia disorders".. J Neural Transm Suppl, 46, 325-337.
 - . J Neurol Neurosurg Psychiatry, 59(5), 557.
 - . J Neurol Neurosurg Psychiatry, 59(1), 90-91.
 - . Mol Cell Probes, 8(6), 519-525.
 - . Headache, 33(8), 446-448.
 - . J Neural Transm Park Dis Dement Sect, 5(2), 107-116.
 - . Neurology, 87(3), 247-248.
 - The common PARK8 mutation LRRK2 G2019S is not a risk factor for breast cancer in the absence of Parkinson's disease.. Journal of Neurology.
 - . PLoS Currents, 3, RRN1247-RRN1247.
 
Book chapters
- , Neuroscience for Neurologists (pp. 181-200). PUBLISHED BY IMPERIAL COLLEGE PRESS AND DISTRIBUTED BY WORLD SCIENTIFIC PUBLISHING CO.
 
Conference proceedings
- . I: Experimental therapeutics – preclinical (pp A152.1-A152)
 - Repurposing Anti-Gout Medications for the Treatment of Parkinson's disease (PD). MOVEMENT DISORDERS, Vol. 39 (pp S402-S402)
 - Treatment Selection in Multi-Arm Multi-Stage Clinical Trials in Parkinson Disease: The Search for the Ideal Neuroprotective Drug. MOVEMENT DISORDERS, Vol. 37 (pp S329-S329)
 - Multimodal mechanistic disease stratification in sporadic Parkinson's disease. MOVEMENT DISORDERS, Vol. 37 (pp S113-S113)
 - Developing 31-phosphorus magnetic resonance spectroscopy (31P-MRS) as an imaging biomarker to identify mitochondrial dysfunction in Parkinson's disease. MOVEMENT DISORDERS, Vol. 36 (pp S370-S371)
 - 31Phosphorus Magnetic Resonance Spectroscopy as a Tool to Identify Mitochondrial Dysfunction in Parkinson's Disease In-Vivo. ANNALS OF NEUROLOGY, Vol. 90 (pp S152-S153)
 - The UP study - Ursodeoxycholic acid (UDCA) as neuroprotective treatment for Parkinson's disease. MOVEMENT DISORDERS, Vol. 35 (pp S413-S414)
 - Disease-modifying treatment in Parkinson's disease - opportunities and obstacles. FEBS OPEN BIO, Vol. 9 (pp 40-40)
 - . Movement Disorders, Vol. 33(S2) (pp S605-S605). Hong Kong, China
 - Acid sphingomyelinase deficiency rescues mitochondrial dysfunction in gba-/- zebrafish (Danio rerio). MOVEMENT DISORDERS, Vol. 33 (pp S615-S615)
 - Impact of Computer Aided Diagnosis (CAD) on DaTSCAN reporting: a pilot study. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol. 44 (pp S611-S611)
 - The role of TIGAR in Parkinson's disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42 (pp 34-35)
 - . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 86(11) (pp e4.93-e4)
 - . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 86(11) (pp e4.46-e4)
 - . 2015 IEEE 12th International Symposium on Biomedical Imaging (ISBI) (pp 772-776), 16 April 2015 - 19 April 2015.
 - . 2014 22nd International Conference on Pattern Recognition (pp 865-870), 24 August 2014 - 28 August 2014.
 - TIGAR inactivation rescues dopaminergic neurons in parkin deficiency. MOVEMENT DISORDERS, Vol. 29(14) (pp 1839-1840)
 - TIGAR inactivation rescues dopaminergic neurons in parkin deficiency. MOVEMENT DISORDERS, Vol. 29 (pp S3-S3)
 - Neurodegeneration caused by intronic expansions of C9ORF72 is a clinically heterogeneous but pathologically distinct disease. LANCET, Vol. 381 (pp 32-32)
 - . JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 83
 - Mitochondrial Impairment in Manifesting LRRK2-G2019S Carriers. NEUROLOGY, Vol. 74(9) (pp A255-A255)
 - Bone marrow transplantation in adult cerebral X-linked adrenoleukodystrophy: an update. BONE MARROW TRANSPLANTATION, Vol. 43 (pp S182-S183)
 - Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio). MOVEMENT DISORDERS, Vol. 24 (pp S135-S135)
 - Abnormal mitochondrial function and morphology in fibroblasts of patients with early onset Parkinson's disease and two parkin mutations. NEUROLOGY, Vol. 70(11) (pp A485-A485)
 - Mitochondrial function and morphology in parkin mutant fibroblasts. MOVEMENT DISORDERS, Vol. 23(1) (pp S49-S49)
 - P53 dependent neuronal cell death in a DJ-1 deficient zebrafish model of Parkinson disease. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 78(9) (pp 1024-1024)
 - Proximal and central myelin damage of cranial nerves in hereditary neuropathy with liability to pressure palsies. NEUROLOGY, Vol. 64(6) (pp A376-A376)
 - Immunocytological analysis of B-, T-, and natural killer cell subsets in Tourette syndrome. MOVEMENT DISORDERS, Vol. 19 (pp S439-S439)
 - The Va166Met polymorphism of the brain derived neurotrophic factor (BDNF): A shared genetic risk factor for obsessive-compulsive behaviour and Gilles de la Tourette syndrome?. MOVEMENT DISORDERS, Vol. 19 (pp S354-S354)
 - Prevalence of UCHL1, DJ1 and NR4A2 gene mutations in young-onset Parkinson's disease (YOPD) patients. MOVEMENT DISORDERS, Vol. 19 (pp S358-S358)
 - The role of the epsilon-sarcoglycan gene (SGCE) in Gilles de la Tourette patients. MOVEMENT DISORDERS, Vol. 19 (pp S363-S363)
 - Evaluation of the epsilon-sarcoglyan (SGCE) promoter region in myoclonus-dystonia (M-D). MOVEMENT DISORDERS, Vol. 19 (pp S96-S97)
 - Gene expression studies in a novel rat dystonia model. MOVEMENT DISORDERS, Vol. 19 (pp S98-S98)
 - The role of CNS dopaminergic, serotonergic and hypocretin (Orexin) systems in restless legs syndrome. SLEEP, Vol. 26 (pp A325-A326)
 - Tourette syndrome and attention deficit hyperactivity disorder: Are there shared genetic susceptibility factors?. MOVEMENT DISORDERS, Vol. 17 (pp S342-S342)
 - Dopamine receptor and hypocretin gene polymorphisms in Parkinson's disease (PD) patients reporting "sleep attacks". MOVEMENT DISORDERS, Vol. 17 (pp S138-S138)
 - Candidate gene research in focal dystonia excludes involvement of ATP7A, ATP7B, ATOX, HLA-DR and MTHFR. MOVEMENT DISORDERS, Vol. 17 (pp S278-S279)
 
Preprints
- , Springer Science and Business Media LLC.
 - , Cold Spring Harbor Laboratory.
 - , Cold Spring Harbor Laboratory.
 - , Cold Spring Harbor Laboratory.
 - , Research Square Platform LLC.
 - , Cold Spring Harbor Laboratory.
 - , Center for Open Science.
 
 
- Research group
 - 
    
- Clinical Fellows: Dr Tom Payne, Dr Emily Reed
 - UP study Trial Manager: Sarah Moll (co-funded by Sheffield Neuroscience BRC)
 - Post-doctoral scientists: Dr Lisa Watson (ne Trollope), Dr Deepak Ailandi
 - PhD students as primary supervisor: Mohammed Karami, Hannah Larbalestier, Emma White
 
Co-supervision with Dr Heather Mortiboys:
- Postdoctoral scientist: Dr Helen Rowland
 - PhD students: Chris Hastings, Ruby McDonald, Rachel Hughes
 - Technician: Sarah Roscoe
 
 
- Grants
 - 
    
The UP Study is predominantly funded by the JP Moulton Foundation, but also supported by Cure Parkinson’s UK and the Sheffield Neuroscience BRC.
My research is also supported by the Medical Research Council (MRC), the Michael J Fox Foundation (MJFF) and the University of Sheffield. In the past, I’ve also had substantial funding from Parkinson’s UK.
 
- Teaching interests
 - 
    
I was the Dept Neuroscience Undergraduate Teaching Lead/Director for Teaching and Learning for 15 years (2002-2017). I was also the University of Sheffield BMedSci Programme Director for 5 years (2013-2018).
I twice won the “Consultant Teacher of the Year" award of the Sheffield Medical Student Society MedSoc.
I continue to contribute to all undergraduate phases of our MBChB course and also contribute to SITRaN-based MSc courses.
I am now the academic training lead for the STH Neuroscience Directorate and also the Training Lead for our NIHR-funded Sheffield Neuroscience BRC.
 
- Professional activities and memberships
 - 
    
- Member of the Editorial Board of the clinical Neuroscience Journals NEUROLOGY and Parkinsonism& Related Disorders
 - Member of the MRC-DPFS Panel
 - Deputy Chair of Association of British Neurologists (ABN) Research Committee
 - Chair of the ABN Movement Disorders Advisory Group
 - Movement Disorders Theme Lead of STH Academic Neuroscience Directorate and the NIHR-funded Sheffield Neuroscience BRC
 
Awards and esteem factors
- 1984-1991: Bavarian Scholarship for highly gifted students
 - 1986-1991: German Scholarship for highly gifted students ("Studienstiftung des Deutschen Volkes")
 - 1993-1997: Training Fellowship of Deutsche Forschungsgemeinschaft (DFG)
 - 1996: Presidents Prize of Royal Society of Medicine
 - 1997: Queen Square Prize of Institute of Neurology
 - 2000: Oppenheim Prize of German Dystonia Society
 - 2006: "Consultant Teacher of the Year" Prize of "Med Soc" (organization of medical students at UoS Medical School)