Professor Arshad Majid
School of Medicine and Population Health
Professor of Cerebrovascular Neurology
Consultant Neurologist, Royal Hallamshire Hospital
Chief Investigator, TRICEPS Trial (NIHR EME · Association of British Neurologists · Stroke Association)
Co Chief Investigator, RICFAST Trial (Stroke Association)
  
  +44 114 222 2290
Full contact details
School of Medicine and Population Health
Sheffield Institute for Translational Neuroscience (SITraN)
385a Glossop Road
Sheffield
S10 2HQ
- Profile
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My professional mission is to translate cutting‑edge neuroscience into effective therapies for patients with cerebrovascular and other neurological diseases. Following medical graduation from the University of Glasgow, specialist training in Neurology at the University of Pennsylvania, and fellowship training at Washington University in St Louis and the Medical College of Wisconsin, I have pursued a career that bridges bench science and bedside care.
I am honoured to hold the title of NIHR Senior Investigator and to lead major UK multicentre trials:
- TRICEPS (TRanscutaneous Vagus Nerve Stimulation to enhance limb rECovery PoSt‑Stroke) – evaluating whether pairing task‑specific upper‑limb rehabilitation with movement‑activated transcutaneous vagus nerve stimulation improves arm function after stroke.
 - RICFAST (Remote Ischaemic Conditioning For fATigue after STroke) – investigating whether repeated brief episodes of limb ischaemia and reperfusion can reduce debilitating post‑stroke fatigue.
 
Previously I founded the Division of Cerebrovascular Diseases at Michigan State University and the William & Claire Dart Stroke Center at Sparrow Health System before joining the University of Sheffield and Royal Hallamshire Hospital in 2013.
I serve as Director of the Comprehensive Cerebrovascular Research Unit (CCRU). My research has been funded by the NIH, American Heart Association, MRC, NIHR and industry.
 
- Research interests
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Key research areas:
- Neuroprotection and Neuroregeneration
 - Electroceuticals
 - Stroke Clinical Trials,
 - Animal and Cellular Models of Stroke and Neuroinflammation
 - Novel Drug Delivery (nanotechnology and exosomes)
 - Remote Conditioning, Vagus Nerve Stimulation.
 - Gene editing, gene blocking & gene replacement for hereditary cerebral small‑vessel diseases — including vascular dementia, COL4A1/COL4A2 mutation‑related angiopathy and CADASIL
 
Trial / Project Role Focus TRICEPS Chief Investigator Movement-activated tVNS paired with upper-limb rehab to improve arm recovery post-stroke RICFAST Co-Chief Investigator RIC as a home-based intervention for alleviating post-stroke fatigue Gene-block & replacement therapy Principal Investigator CRISPR/Cas-based editing and AAV-mediated replacement for COL4A1/2 disease, CADASIL & vascular dementia Stroke vaccine development Lead Immunomodulatory vaccine to mitigate secondary neuroinflammation after stroke Donations
Help Us Beat Rare Genetic Stroke Disorders
Vascular dementia, CADASIL, and COL4A1/2-related diseases are often inherited, progressive, and devastating. These disorders can cause strokes, cognitive decline, and long-term disability in both children and adults.
No disease-modifying treatments currently exist. Our lab is developing world-first gene-block and gene-replacement therapies that offer real hope to affected families. Traditional research funding often overlooks rare conditions, making philanthropic support absolutely vital to accelerate these breakthroughs.
How You Can Help
- Fund a PhD student or postdoc working on CADASIL or COL4A1 therapy
 - Support development of gene therapy vectors for testing in preclinical models
 - Sponsor patient registries and biobank infrastructure
 - Partner with us to launch early-phase clinical trials
 
If you or your organisation would like to make a contribution or explore partnership opportunities, please email me directly at arshad.majid@sheffield.ac.uk.
Every contribution, large or small, drives innovation and hope for people affected by genetic stroke disorders.
 
- Publications
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Edited books
- . Cham: Springer.
 
Journal articles
- . Antioxidants, 14(10).
 - . Nutrients, 17(13).
 - . Brain Research, 1863, 149754-149754.
 - . Pharmaceuticals, 18(5).
 - . Atherosclerosis, 404.
 - . BMJ Open, 15(3).
 - . Journal of Cardiovascular Development and Disease, 12(2).
 - . Journal of Cerebral Blood Flow & Metabolism, 45(6), 1048-1058.
 - . Annals of Neurology, 97(4), 709-719.
 - . Neural Regeneration Research, 20(12), 3388-3399.
 - . Neural Regeneration Research, 20(11), 3213-3214.
 - . Neuropharmacology, 262, 110192-110192.
 - . Systematic Reviews, 13(1).
 - . Current Medical Research and Opinion, 40(12), 2223-2236.
 - . Food Science & Nutrition, 12(6), 3819-3833.
 - . International Journal of Molecular Sciences, 25(5).
 - . Nutrition Reviews, 82(10), 1372-1385.
 - . Alzheimer's & Dementia, 19(S21).
 - . Current Neurology and Neuroscience Reports, 23(12), 947-962.
 - . Journal of Stroke and Cerebrovascular Diseases, 32(12).
 - . Stroke, 54(10), 2676-2687.
 - . Life, 13(4).
 - . Life Sciences in Space Research, 36, 105-115.
 - . Neurorehabilitation and Neural Repair.
 - . Annals of Pharmacotherapy, 56(12), 1386-1387.
 - . Toxicological Research, 38(4), 479-486.
 - . Stroke, 53(Suppl_1).
 - . Annals of Pharmacotherapy, 56(10), 1159-1173.
 - . International Journal of Peptide Research and Therapeutics, 28(1).
 - . Autonomic Neuroscience, 237.
 - . International Journal of Environmental Research and Public Health, 18(15).
 - . International Journal of Molecular Sciences, 22(14).
 - . Stroke, 52(7), 2445-2455.
 - . Stroke and Vascular Neurology, 6(2).
 - . The Lancet, 397(10284), 1545-1553.
 - . Frontiers in Human Neuroscience, 14.
 - . International Journal of Molecular Sciences, 22(5).
 - . Arteriosclerosis, Thrombosis, and Vascular Biology, 41(3), 1127-1145.
 - . Scientific Reports, 10(1).
 - . Journal of Extracellular Vesicles, 10(1).
 - . BMJ Open Sport & Exercise Medicine, 6(1).
 - . International Journal of Molecular Sciences, 21(9).
 - . Journal of Neurology, Neurosurgery & Psychiatry, 91(4), 396-401.
 - . Fluids and Barriers of the CNS, 17(1).
 - . Efficacy and Mechanism Evaluation, 7(1).
 - . Journal of Pharmaceutical Investigation, 50(4), 373-381.
 - . Journal of Stroke and Cerebrovascular Diseases, 28(12).
 - . Cerebrovascular Diseases, 48(3-6), 184-192.
 - . Safety Science, 118, 881-886.
 - . Nutrients, 11(6).
 - . Basic Science, A155.2-A155.
 - . The FASEB Journal, 33(S1).
 - . Multiple Sclerosis Journal, 25(3), 306-324.
 - . Frontiers in Cell and Developmental Biology, 6.
 - . The Lancet, 393(10168), 265-274.
 - . British Journal of Sports Medicine, 53(24), 1515-1525.
 - . Frontiers in Cellular Neuroscience, 12.
 - . Brain Stimulation, 11(6), 1225-1238.
 - . Journal of Stroke and Cerebrovascular Diseases , 27(7), 1998-2005.
 - . Current Opinion in Supportive & Palliative Care, 12(2), 142-147.
 - . Stroke, 49(6), 1571-1579.
 - . Journal of Toxicology and Environmental Health, Part A, 81(9), 266-277.
 - . Topics in Stroke Rehabilitation, 25(3), 214-223.
 - . International Journal of Pharmaceutics, 525(1), 92-100.
 - . Molecular Neurobiology, 54(8), 6061-6073.
 - . Journal of Cerebral Blood Flow and Metabolism, 36(10), 1686-1694.
 - . European Journal of Pharmaceutics and Biopharmaceutics, 108, 187-195.
 - . Chemico-Biological Interactions, 256, 102-110.
 - . Stroke, 47(suppl_1).
 - . International Journal of Molecular Sciences , 16(10), 24048-24058.
 - . Molecular Neurobiology, 53(4), 2579-2593.
 - . Neurology, 84(14_supplement).
 - Ethnic minority recruitment into stroke research trials at a university teaching hospital in the UK.. CEREBROVASCULAR DISEASES, 39, 287-287.
 - The role of relatives in help-seeking for patients with stroke/TIA: Results from Stroke and TIA Awareness and Response to Symptoms (STARS) study. INTERNATIONAL JOURNAL OF STROKE, 10, 121-121.
 - . Biological and Pharmaceutical Bulletin, 37(8), 1397-1401.
 - . Stroke, 45(8), 2438-2443.
 - . Stroke, 45(2), 520-526.
 - . ISRN Neurology, 2014(2014).
 - Post stroke cognitive and mood screening: The Sheffield experience. INTERNATIONAL JOURNAL OF STROKE, 9, 42-42.
 - . International Journal of Networking and Virtual Organisations, 14(4), 377-377.
 - . International Journal of Stroke, 9(7), 939-942.
 - . J Neuroimaging, 23(4), 495-501.
 - . Brain Res, 1527, 246-254.
 - . Stroke, 44(1), 205-212.
 - . AJNR Am J Neuroradiol, 34(5), 1049-S1.
 - . International Journal of Stroke, 7(8), E15.
 - . Neurology, 79(13 SUPPL. 1), S167-S173.
 - . J Neurosci, 32(21), 7278-7286.
 - . Stroke, 43(6), 1632-1638.
 - . Stroke, 43(suppl_1).
 - Systematic review and meta-analysis of newly detected atrial fibrillation after ischaemic stroke/TIA using non-invasive and invasive cardiac monitoring. INTERNATIONAL JOURNAL OF STROKE, 7, 17-17.
 - . The Neurohospitalist, 2(1), 12-17.
 - . Expert Rev Cardiovasc Ther, 9(10), 1315-1330.
 - . Neurosci Lett, 500(3), 157-161.
 - . Stroke Res Treat, 2011, 172074.
 - . Stroke Res Treat, 2010, 245715.
 - . Front Neurol, 1, 160.
 - . AJNR Am J Neuroradiol, 31(8), 1395-1402.
 - . Stroke, 41(8), 1630-1635.
 - Peripheral neuropathy: differential diagnosis and management.. Am Fam Physician, 81(7), 887-892.
 - . J Neuroimaging, 20(1), 74-77.
 - . Stroke, 40(12), e713.
 - . Epilepsy Res, 87(2-3), 268-271.
 - . Int J Stroke, 4(5), 381-389.
 - . Stroke, 40(7), 2594-2600.
 - . Cerebrovasc Dis, 28(1), 45-48.
 - . Stroke, 40(7), 2560-2563.
 - . Cell Tissue Res, 337(1), 45-61.
 - . J Neurosci Res, 87(11), 2541-2550.
 - . Nat Clin Pract Neurol, 5(3), 163-169.
 - . Am J Health Syst Pharm, 66(6), 541-561.
 - . Stroke, 40(6), 2244-2250.
 - . Neurol Sci, 30(3), 241-245.
 - . VASCULAR MEDICINE, 14(1), 63-71.
 - . J Neuroimaging, 19(1), 68-71.
 - Hypothermia Decreases The Fibrinolytic Activity Of Tissue Plasminogen Activator. STROKE, 40(4), E243-E243.
 - . Stroke, 39(11), e171.
 - . Clin Neuropharmacol, 31(6), 353-362.
 - . Neurosurgery, 63(5), 874-878.
 - The WHO STEPwise Approach to Stroke Surveillance. JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN, 18(10), 665-665.
 - . J Neuroimaging, 18(3), 336-339.
 - . J Neurosci Res, 86(13), 2984-2991.
 - . Neurocritical Care, 9(3), 412.
 - Periodic lateralized epileptiform discharges: an initial electrographic pattern in reversible posterior leukoencephalopathy syndrome.. Neurol Neurochir Pol, 42(1), 55-59.
 - . Neurocrit Care, 9(3), 357-360.
 - . Stroke, 39(6), 1779-1785.
 - . Cerebrovasc Dis, 25(1-2), 107-110.
 - . Cerebrovasc Dis, 25(1-2), 12-20.
 - . J Headache Pain, 8(5), 289-293.
 - . Stroke, 38(11), 3023-3031.
 - . Stroke, 38(9), e80.
 - . VASCULAR MEDICINE, 12(3), 243-249.
 - . ACADEMIC EMERGENCY MEDICINE, 14(11), 1114-1119.
 - . Journal of Headache and Pain, 8(2), 143-144.
 - . Neurocrit Care, 7(1), 36-39.
 - . Drug ¾Ã²Ý¸£Àû Perspect, 20(8), 495-499.
 - . J Am Board Fam Med, 20(1), 65-71.
 - . CURRENT MEDICINAL CHEMISTRY, 14(1), 103-112.
 - . Neurology, 66(3), 306-312.
 - . Stroke, 36(12), 2705-2711.
 - . Journal of Cerebral Blood Flow & Metabolism, 25(1_suppl), S313-S313.
 - . ANNALS OF PHARMACOTHERAPY, 39(2), 387-388.
 - . STROKE, 36(12), 2705-2711.
 - . Neurotoxicology, 25(6), 895-904.
 - . Clin Neuropharmacol, 27(6), 293-298.
 - . Vasc Med, 9(3), 225-226.
 - . Brain, 125(1), 159-165.
 - . Stroke, 31(11), 2707-2714.
 - . Journal of Clinical Pathology, 49(12), 1019-1020.
 - . Seizure, 5(3), 229-234.
 - Involvement of alpha 1-adrenoceptors in the depolarizing but not the hyperpolarizing responses of motorneurones in the neonate rat to noradrenaline. Neuropharmacology, 1399-404.
 - . Advances in Clinical Neuroscience & Rehabilitation.
 
Book chapters
- , Acute Brain Impairment (pp. 82-104). The Royal Society of Chemistry
 - , Electroceuticals (pp. 55-73). Springer International Publishing
 - , Food and Nutritional Components in Focus (pp. 412-431). Royal Society of Chemistry
 
Conference proceedings
- Modulating The Role And Function Of Macrophages In Human Symptomatic Carotid Stenosis: Potential Mechanisms For Stabilisation Of Atherosclerotic Carotid Plaques. INTERNATIONAL JOURNAL OF STROKE, Vol. 19(3_SUPPL) (pp 39-39)
 - Quality, not quantity, of walking correlates with deep grey matter in progressive Multiple Sclerosis. MULTIPLE SCLEROSIS JOURNAL, Vol. 29 (pp 317-318)
 - . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 93(9) (pp e2.160-e2.160)
 - . Basic science (pp A156.1-A156)
 - INTERVENTIONS TO PREVENT AND TREAT POST STROKE FATIGUE: A SYSTEMATIC REVIEW AND META-ANALYSIS. INTERNATIONAL JOURNAL OF STROKE, Vol. 15(1_SUPPL) (pp 660-660)
 - EFFECT OF EXERCISE INTERVENTIONS ON HEALTH-RELATED QUALITY OF LIFE AFTER STROKE AND TRANSIENT ISCHAEMIC ATTACK: A SYSTEMATIC REVIEW AND META-ANALYSIS.. INTERNATIONAL JOURNAL OF STROKE, Vol. 15(1_SUPPL) (pp 657-657)
 - A COMMUNITY-BASED EXERCISE REFERRAL PROGRAMME TO PROMOTE CARDIOVASCULAR HEALTH IN STROKE AND TIA PATIENTS: A PILOT FEASIBILITY STUDY. INTERNATIONAL JOURNAL OF STROKE, Vol. 15(1_SUPPL) (pp 142-142)
 - UNDERSTANDING THE FACILITATORS AND BARRIERS TO EXERCISE AFTER STROKE AMONG PATIENTS, EXERCISE PROFESSIONALS AND CLINICIANS.. INTERNATIONAL JOURNAL OF STROKE, Vol. 15(1_SUPPL) (pp 260-260)
 - PHYSIOLOGICAL RESPONSE AND PERCEIVED EXERTION DURING RECUMBENT AEROBIC CYCLING FOLLOWING ACUTE STROKE. INTERNATIONAL JOURNAL OF STROKE, Vol. 15(1_SUPPL) (pp 212-212)
 - . Cardiovascular Research, Vol. 114(suppl_2) (pp S5-S6)
 - . Basic Science (pp A90.1-A90)
 - Stroke and TIA awareness and response to symptoms study (STARSS): assessing the relationship between stroke knowledge and help-seeking behaviour. INTERNATIONAL JOURNAL OF STROKE, Vol. 13 (pp 21-21)
 - Microglial activation in recent ischemic stroke: comparison of two TSPO tracers. JOURNAL OF NUCLEAR MEDICINE, Vol. 58
 - Difference in Acute Ischemic Post Thrombolytic Stroke Outcomes in Pre Comprehensive and Post Comprehensive Status: Single Center Experience. STROKE, Vol. 47
 - Inter-rater Reliability of Transient Ischemic Attack Diagnosis in the Emergency Department. STROKE, Vol. 41(4) (pp E203-E203)
 - Stroke Symptoms and Risk Factor Awareness Amongst High School Children in Pakistan. STROKE, Vol. 41(4) (pp E291-E291)
 - Concordance Between Patient Bedside Dysphagia Assessment Results Obtained From Neurological Nurses and Speech Pathologists. STROKE, Vol. 41(4) (pp E230-E230)
 - Predictors of discharge disposition for TIA cases presenting to community-based emergency departments. STROKE, Vol. 39(2) (pp 704-704)
 - Ability of the ABCD2 clinical prediction rule to identify low-risk TIA cases in community-based emergency departments. STROKE, Vol. 39(2) (pp 558-558)
 - BLOOD PRESSURE CHANGES AFTER INTRAVENOUS LOADING WITH FOSPHENYTOIN AND LEVETIRACETAM IN PATIENTS WITH ACUTE CEREBRAL INSULTS. EPILEPSIA, Vol. 49 (pp 430-431)
 - . ANNALS OF EMERGENCY MEDICINE, Vol. 50(3) (pp S102-S102)
 - Effect of pre-existing statin use on in-hospital mortality and functional status at discharge in stroke patients: A propensity-based analysis. CIRCULATION, Vol. 115(21) (pp E581-E582)
 - The effect of hypoxic preconditioning on the mTOR pathway. STROKE, Vol. 37(2) (pp 682-682)
 - Inhibition of brain GTP cyclohydrolase I and tetrahydrobiopterin attenuates cerebral infarction via reducing iNOS and peroxynitrite in ischemic stroke. JOURNAL OF THE NEUROLOGICAL SCIENCES, Vol. 238 (pp S388-S389)
 - Factors associated with IV tPA use in eligible acute stroke patients in Michigan. STROKE, Vol. 35(1) (pp 335-335)
 
Preprints
- , Cold Spring Harbor Laboratory.
 - , Springer Science and Business Media LLC.
 - , MDPI AG.
 
 
- Research group
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Doctoral Students
Professor Majid welcomes enquiries from students interested in pursuing a doctorate in translational and clinical research. Several projects, preclinical (translational) and clinical are available. These include development of vaccines for neurological diseases, remote conditioning, development of exosome technologies for therapeutics and development of novel neurotherapeutics.
Post-Doctoral Scientists (short and long-term):
Several preclinical and clinical projects are available.
 
- Teaching activities
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Professor Majid is the Phase 3a Neurology Lead for Sheffield Medical school.