Dr Andrew Grierson

PhD

School of Medicine and Population Health

Senior Lecturer in Neuroscience

a.j.grierson@sheffield.ac.uk
+44 114 222 2277
+44 114 22 22290 (fax)
Room B25, Sheffield Institute for Translational Neuroscience (SITraN)

Full contact details

Dr Andrew Grierson
School of Medicine and Population Health
Room B25
Sheffield Institute for Translational Neuroscience (SITraN)
385a Glossop Road
Sheffield
S10 2HQ
Qualifications

2009 –present: Senior Lecturer
2001 - 2008: Lecturer, University of Sheffield
1997 - 2001: Postdoctoral Research Associate, Institute of Psychiatry, Kings College London
1994 - 1997: Postdoctoral Research Associate, University of Amsterdam, Netherlands
1991 - 1994: PhD (Molecular Genetics) University of Sheffield
1988 - 1991: BSc (Genetics) University of Sheffield

Research interests

Research in my laboratory concerns identifying the molecular mechanisms underlying the regulation of axonal transport in health and disease. In particular we are investigating the involvement of axonal transport in diseases including motor neurone disease (MND) and hereditary spastic paraplegia (HSP).

In addition we are developing and characterising novel vertebrate models of neurodegeneration in zebrafish and mouse. With support from the NC3Rs we are refining the widely used SOD1G93A model of motor neuron disease.

Current projects

  • Preclinical testing of HDAC6 inhibition in a zebrafish model of CMT2A (Hereditary Neuropathy Foundation)Investigating the function of the C9ORF72 protein in motor neuron disease (University Studentship)

  • Preclinical assessment of histone deacetylase 6 (HDAC6) inhibition as a therapy for hereditary spastic paraplegia (Spastic Paraplegia Foundation)

  • ANIMPACT: An ethical, legal and practical perspective on the impact of a new regulatory framework for the scientific use of animals on research and innovation (European Union) Zebrafish C9orf72 loss of function models of ALS (MND Association)

  • Role of C9ORF72 in proteostasis. (De Vos PI) (Thierry Latran Foundation) ROLE OF MITOCHONDRIA IN C9ORF72-RELATED ALS/MND (De Vos is PI) (MND Association)

  • Preclinical assessment of spastin gene replacement therapy as a treatment for hereditary spastic paraplegia (Spastic Paraplegia Foundation)

Research collaborations

  • Pamela Shaw, Academic Neurology Unit, University of Sheffield
  • , University of Sheffield
Publications

Journal articles

  • Bauer CS, Webster CP, Shaw AC, Kok JR, Castelli LM, Lin Y-H, Smith EF, Illanes-Álvarez F, Higginbottom A, Shaw PJ , Azzouz M et al (2022) . Frontiers in Cellular Neuroscience, 16.
  • Bauer CS, Cohen RN, Sironi F, Livesey MR, Gillingwater TH, Highley JR, Fillingham DJ, Coldicott I, Smith EF, Gibson YB , Webster CP et al (2022) . Acta Neuropathologica, 144(3), 437-464.
  • Marchi PM, Marrone L, Brasseur L, Coens A, Webster CP, Bousset L, Destro M, Smith EF, Walther CG, Alfred V , Marroccella R et al (2022) . Life Science Alliance, 5(9).
  • Bauer CS, Webster CP, Shaw AC, Kok JR, Castelli LM, Lin Y-H, Smith EF, Illanes-Álvarez F, Higginbottom A, Shaw PJ , Azzouz M et al (2022) Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation. Frontiers in cellular neuroscience, 16.
  • Derrick CJ, Pollitt EJG, Sevilla Uruchurtu AS, Hussein F, Grierson AJ & Noël ES (2021) . Development, 148(20).
  • Keerie A, Brown-Wright H, Kirkland I, Grierson A, Alix JJP, Holscher C & Mead RJ (2021) . Scientific Reports, 11.
  • Łysyganicz PK, Pooranachandran N, Liu X, Adamson KI, Zielonka K, Elworthy S, van Eeden FJ, Grierson AJ & Malicki JJ (2021) . Frontiers in Cell and Developmental Biology, 9.
  • Ciervo Y, Gatto N, Allen C, Grierson A, Ferraiuolo L, Mead RJ & Shaw PJ (2021) . Molecular Therapy — Methods & Clinical Development, 21, 413-433.
  • Gibson JF, Prajsnar TK, Hill CJ, Tooke AK, Serba JJ, Tonge RD, Foster SJ, Grierson AJ, Ingham PW, Renshaw SA & Johnston SA (2021) . Autophagy, 17(6), 1448-1457.
  • Sardinia F, Pisciottani A, Ferrara M, Valente D, Casella M, Crescenzi M, Peschiaroli A, Casali C, Soddu S, Grierson A & Rinaldo C (2020) . Life Science Alliance, 3(12).
  • Fernandes JG, Franco NH, Grierson AJ, Hultgren J, Furley A & Olsson IAS (2019) . BMJ Open Science, 3(1).
  • Webster CP, Smith EF, Grierson AJ & De Vos K (2018) . Small GTPases, 9(5).
  • Higginbottom A (2016) . EMBO Journal.
  • Lukashchuk V, Lewis K, Coldicott I, Grierson A & Azzouz M (2016) . Molecular Therapy — Methods & Clinical Development, 2016(3).
  • Allen SP, Duffy LM, Shaw PJ & Grierson AJ (2015) . Neurobiology of Aging, 36(10), 2893-2903.
  • Bennett EJ, Mead RJ, Azzouz M, Shaw PJ & Grierson AJ (2014) . PLoS ONE, 9(9), e107918-e107918.
  • Grant RA, Sharp PS, Kennerley AJ, Berwick J, Grierson A, Ramesh T & Prescott TJ (2014) . Behav Brain Res, 259, 274-283.
  • Allen SP, Rajan S, Duffy L, Mortiboys H, Higginbottom A, Grierson AJ & Shaw PJ (2014) . Neurobiol Aging, 35(6), 1499-1509.
  • Richardson K, Allen SP, Mortiboys HJ, Grierson AJ, Wharton SB, Ince PG, Shaw PJ & Heath PR (2013) . Plos One, 6(8), e68256-e68256.
  • Chapman AL, Bennett EJ, Ramesh TM, De Vos KJ & Grierson AJ (2013) . PLoS One, 8(6), e67276.
  • Mead RJ, Higginbottom A, Allen SP, Kirby J, Bennett E, Barber SC, Heath PR, Coluccia A, Patel N, Gardner I , Brancale A et al (2013) . Free Radic Biol Med, 61, 438-452.
  • Hewamadduma CAA, Grierson AJ, Ma TP, Pan L, Moens CB, Ingham PW, Ramesh T & Shaw PJ (2013) . Hum Mol Genet, 22(12), 2376-2386.
  • Hameed A, Bennett E, Ciani B, Hoebers LPC, Milner R, Lawrie A, Francis SE & Grierson AJ (2013) . PLoS One, 8(1), e54636.
  • Rocca RA, Magoon G, Reynolds DF, Krahn T, Tilroe VO, Op den Velde Boots PM & Grierson AJ (2012) . Plos One, 7(7).
  • Ferraiuolo L, Kirby J, Grierson AJ, Sendtner M & Shaw PJ (2011) . Nat Rev Neurol, 7(11), 616-630.
  • Mead RJ, Bennett EJ, Kennerley AJ, Sharp P, Sunyach C, Kasher P, Berwick J, Pettmann B, Battaglia G, Azzouz M , Grierson A et al (2011) . PLoS One, 6(8), e23244.
  • Duffy LM, Chapman AL, Shaw PJ & Grierson AJ (2011) . Neuropathol Appl Neurobiol, 37(4), 336-352.
  • Kasher PR, Namavar Y, van Tijn P, Fluiter K, Sizarov A, Kamermans M, Grierson AJ, Zivkovic D & Baas F (2011) . Hum Mol Genet, 20(8), 1574-1584.
  • Mahmood QA, Whitworth A & Grierson A (2010) Role of Mitochondrial Dynamics in Neurodegeneration. J NEUROGENET, 24, 64-65.
  • Valori CF, Ning K, Wyles M, Mead RJ, Grierson AJ, Shaw PJ & Azzouz M (2010) . Sci Transl Med, 2(35), 35ra42.
  • Cox LE, Ferraiuolo L, Goodall EF, Heath PR, Higginbottom A, Mortiboys H, Hollinger HC, Hartley JA, Brockington A, Burness CE , Morrison KE et al (2010) . PLoS One, 5(3), e9872.
  • Kasher PR, De Vos KJ, Wharton SB, Manser C, Bennett EJ, Bingley M, Wood JD, Milner R, McDermott CJ, Miller CCJ , Shaw PJ et al (2009) . J Neurochem, 110(1), 34-44.
  • Hewamadduma C, McDermott C, Kirby J, Grierson A, Panayi M, Dalton A, Rajabally Y & Shaw P (2009) . Neurogenetics, 10(2), 105-110.
  • Zhan L, Liu B, Jose-Lafuente M, Chibalina MV, Grierson A, Maclean A & Nasir J (2008) . Eur J Neurosci, 27(7), 1626-1633.
  • De Vos KJ, Grierson AJ, Ackerley S & Miller CCJ (2008) . Annu Rev Neurosci, 31, 151-173.
  • De Vos KJ, Chapman AL, Tennant ME, Manser C, Tudor EL, Lau K-F, Brownlees J, Ackerley S, Shaw PJ, McLoughlin DM , Shaw CE et al (2007) . Hum Mol Genet, 16(22), 2720-2728.
  • Sathasivam S, Grierson AJ & Shaw PJ (2005) . Neuropathol Appl Neurobiol, 31(5), 467-485.
  • Connell JW, Rodriguez-Martin T, Gibb GM, Kahn NM, Grierson AJ, Hanger DP, Revesz T, Lantos PL, Anderton BH & Gallo J-M (2005) . Brain Res Mol Brain Res, 137(1-2), 104-109.
  • De Vos KJ, Allan VJ, Grierson AJ & Sheetz MP (2005) . Curr Biol, 15(7), 678-683.
  • Ackerley S, Grierson AJ, Banner S, Perkinton MS, Brownlees J, Byers HL, Ward M, Thornhill P, Hussain K, Waby JS , Anderton BH et al (2004) . Mol Cell Neurosci, 26(2), 354-364.
  • Saha AR, Hill J, Utton MA, Asuni AA, Ackerley S, Grierson AJ, Miller CC, Davies AM, Buchman VL, Anderton BH & Hanger DP (2004) . J Cell Sci, 117(Pt 7), 1017-1024.
  • Grierson AJ & Shaw PJ (2003) . Blue Books of Practical Neurology, 28(C), 237-257.
  • Wharton SB, McDermott CJ, Grierson AJ, Wood JD, Gelsthorpe C, Ince PG & Shaw PJ (2003) . J Neuropathol Exp Neurol, 62(11), 1166-1177.
  • McDermott CJ, Grierson AJ, Wood JD, Bingley M, Wharton SB, Bushby KMD & Shaw PJ (2003) . Ann Neurol, 54(6), 748-759.
  • Ackerley S, Thornhill P, Grierson AJ, Brownlees J, Anderton BH, Leigh PN, Shaw CE & Miller CCJ (2003) . J Cell Biol, 161(3), 489-495.
  • Miller CCJ, Ackerley S, Brownlees J, Grierson AJ, Jacobsen NJO & Thornhill P (2002) . Cell Mol Life Sci, 59(2), 323-330.
  • Menzies FM, Grierson AJ, Cookson MR, Heath PR, Tomkins J, Figlewicz DA, Ince PG & Shaw PJ (2002) . J Neurochem, 82(5), 1118-1128.
  • Brownlees J, Ackerley S, Grierson AJ, Jacobsen NJO, Shea K, Anderton BH, Leigh PN, Shaw CE & Miller CCJ (2002) . Hum Mol Genet, 11(23), 2837-2844.
  • Gibb G, Hanger D, Anderton B, Connell J, Grierson A, De Silva R & Revesz T (2002) Comparision of tau protein expression in AD, FTDP-17, PSP and Pick's disease. NEUROBIOL AGING, 23(1), S505-S505.
  • Standen CL, Brownlees J, Grierson AJ, Kesavapany S, Lau KF, McLoughlin DM & Miller CC (2001) . J Neurochem, 76(1), 316-320.
  • Grierson AJ, Shaw CE & Miller CC (2001) . Biochim Biophys Acta, 1536(1), 13-20.
  • Grierson AJ, Johnson GV & Miller CC (2001) . Neurosci Lett, 298(1), 9-12.
  • Ackerley S, Grierson AJ, Brownlees J, Thornhill P, Anderton BH, Leigh PN, Shaw CE & Miller CC (2000) . J Cell Biol, 150(1), 165-176.
  • Utton MA, Killick R, Grierson A, Ackerly S, Lovestone S & Miller C (2000) . Neurobiology of Aging, 21, 113-113.
  • Grierson AJ, Mootoosamy RC & Miller CC (1999) . Neurosci Lett, 277(1), 9-12.
  • Grierson AJ (1999) Corrigendum: An integrated map of chromosome 18 CAG trinucleotide repeat loci (European Journal of Human Genetics (1999) 7 (12-19)). European Journal of Human Genetics, 7(8), 944.
  • Grierson AJ, van Groenigen M, Groot NP, Lindblad K, Hoovers JM, Schalling M, de Belleroche J & Baas F (1999) . Eur J Hum Genet, 7(1), 12-19.
  • Guidato S, McLoughlin DM, Grierson AJ & Miller CC (1998) . J Neurochem, 70(1), 335-340.
  • Meijerink PH, Yanakiev P, Zorn I, Grierson AJ, Bikker H, Dye D, Kalaydjieva L & Baas F (1998) . Eur J Biochem, 254(2), 297-303.
  • Grierson AJ, Hodgkins MA, Hancock BW, Goepel JR, Royds J & Goyns MH (1996) . Leuk Lymphoma, 23(3-4), 353-363.
  • Lorigan PC, Grierson AJ, Goepel JR, Coleman RE & Goyns MH (1996) . Cancer Lett, 104(1), 27-30.
  • Grierson A, van Groenigen M & Baas F (1996) . Psychiatric Genetics, 6(3), 148-148.
  • Grierson AJ, Hammond DW, Goepel JR, Hancock BW & Goyns MH (1994) . Ann Oncol, 5 Suppl 1, 47-50.
  • Grierson A (1928) . Public Administration, 6(3), 211-220.
  • Martins RR, Besse S, Ellis PS, Sevil R, Hartopp N, Purse C, Everett‐Brown G, Evans O, Mughal N, Wahib MHF , Yazigan Z et al () . Aging Cell.
  • Rocca RA, Magoon G, Reynolds DF, Krahn T, Tilroe VO, Op den Velde Boots PM & Grierson AJ () . PLoS ONE, 7(8).

Book chapters

  • Miller CCJ, Ackerley S, Brownlees J, Grierson AJ & Thornhill P (2003) , Neuroinflammation (pp. 89-97). Humana Press
  • Miller CCJ, Ackerley S, Brownlees J, Grierson AJ & Thornhill P () , Neuroinflammation (pp. 089-097). Humana Press

Conference proceedings

  • Mohammedeid A, Bhargava A, Godena VK, Kong S, Tennore R, Grierson AJ, Xu J, Shaw PJ, Azzouz M & Ning K (2019) Arfaptin-2 as a therapeutic target for amyotrophic lateral sclerosis (ALS). HUMAN GENE THERAPY, Vol. 30(8) (pp A19-A20)
  • Hewamadduma C, Grierson A, Higginbottom A & Shaw P (2015) . Journal of the Neurological Sciences, Vol. 357 (pp e49-e49)
  • Adamson KI & Grierson AJ (2015) FISH ON DRUGS: A ZEBRAFISH PRECLINICAL MODEL FOR CMT2A. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, Vol. 20(2) (pp 92-93)
  • Mohammedeid A, Ning K, Kong SC, Azzouz M & Grierson A (2014) Regulation of protein aggregation by Arfaptin2 in amyotrophic lateral sclerosis. HUMAN GENE THERAPY, Vol. 25(5) (pp A14-A14)
  • Hewamadduma C, Grierson A, Moens C, Pan L, Ma T, Ingham P, Ramesh T & Shaw P (2012) A novel alternative splicing event rescues the mutant tardbp phenotype in a zebrafish model of TDP-43 related Amyotrophic Lateral Sclerosis (ALS). NEUROLOGY, Vol. 78
  • Hewamadduma C, Grierson A, Moens C, Pan L, Ma T, Ingham P, Ramesh T & Shaw P (2012) A novel alternative splicing event rescues the mutant tardbp phenotype in a zebrafish model of TDP-43 related Amyotrophic Lateral Sclerosis (ALS). NEUROLOGY, Vol. 78
  • Hewamadduma C, Higgenbottom CAA, Moens C, Helde K, Raman R, Tennore R, Grierson A & Shaw PJ (2012) . JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 83(3)
  • Eckmann J, Eckert SH, Leuner K, Bordet T, Pruss R, Grierson A, Shaw P, Clemens L, Nguyen HP, Mueller WE & Eckert GP (2011) Impact of Olesoxime on disease related mitochondrial membrane properties in mouse models of neurodegenerative diseases. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, Vol. 383 (pp 51-51)
  • Clemens LE, Grierson A, De Vos K, Riess O & Nguyen HP (2010) . JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 81 (pp A5-A5)
  • Valori CF, Ning K, Wyles M, Mead RJ, Grierson AJ, Shaw PJ & Azzouz M (2010) Systemic delivery of scAAV9 expressing SMN prolongs survival in a mouse model of SMA. HUMAN GENE THERAPY, Vol. 21(10) (pp 1424-1425)
  • Sathasivam S, Grierson AJ & Shaw PJ (2005) Alterations of the Bcl-2 family oncoprotein members in a cell culture model of familial SOD1-related motor neurone disease. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 76(1) (pp 157-157)
  • McDermott CJ, Grierson A, Wood J & Shaw PJ (2003) Hereditary spastic paraparesis associated with mutation in spastin (SPG4): A disorder of axonal transport?. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 74(10) (pp 1453-1453)

Preprints

  • Butler L, Adamson KI, Johnson SL, Jestice LH, Price CJ, Stavish D, Pooranachandran N, Malicki JJ, Tsakiridis A, Grierson AJ & Barbaric I (2022) , Cold Spring Harbor Laboratory.
  • Martins RR, Besse S, Ellis PS, Sevil R, Hartopp N, Purse C, Everett-Brown G, Evans O, Mughal N, Wahib MHF , Yazigan Z et al (2022) , Cold Spring Harbor Laboratory.
  • Marchi PM, Marrone L, Brasseur L, Bousset L, Webster CP, Destro M, Smith EF, Walther CG, Alfred V, Marroccella R , Robinson D et al (2021) , Cold Spring Harbor Laboratory.
  • Magoon GR, Banks RH, Rottensteiner C, Schrack BE, Tilroe VO, Robb T & Grierson AJ (2013) , Cold Spring Harbor Laboratory.
Research group
  • Natalie Rounding (PhD student)
  • Khlood Mehdar (PhD student)
  • Gary Shaw (Research Technician)
  • Katie Adamson (Research Technician)
  • Yolanda Gibson (PhD student)
Grants

Links