Professor Thushan de Silva

MBChB BSc (Hons) DTM&H MRCP FRCPath PhD

School of Medicine and Population Health

Professor of Infectious Diseases

Honorary Consultant Physician in Infectious Diseases

Dr Thushan de Silva
Dr Thushan de Silva
Profile picture of Dr Thushan de Silva
t.desilva@sheffield.ac.uk
+44 114 215 9532
The Medical School

Full contact details

Professor Thushan de Silva
School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

I am an Infectious Diseases Clinician Scientist with a programme of research centred around clinical discovery science in the UK and Africa. Our group applies a broad range of methods including human immunology, epidemiology, molecular diagnostics and genomics, to establish how pathogens interact with human hosts at population and individual levels. We work primarily on respiratory viruses such as influenza and SARS-CoV-2, and Streptococcus pyogenes (Group A Streptococcus), investigating the natural history of infection and immunity to inform the design of diagnostic tools, vaccines, and other preventative measures. A specific area of interest is also how immunocompromising conditions such as HIV and haematopoietic stem cell transplantation impact the clinical risk and vaccine-induced immunity to respiratory viruses. 

I am part of the Clinical Infection Research Group (CIRG) in the Medical School at the University of Sheffield and am an Honorary Consultant Physician in Infectious Diseases in the South Yorkshire Regional Department of Infection and Tropical Medicine in Sheffield. I am co-director of the and lead the host-pathogen interactions theme. I am also a Principal Investigator in the Vaccines and Immunity Theme at the Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine.

I completed my undergraduate medical training at the University of Bristol in 2000. Following postgraduate clinical training in General Internal Medicine, Infectious Diseases and HIV in Oxford and London, I moved to Sheffield for higher specialist training in Infectious Diseases & Microbiology in 2004. After relocating to The MRC Unit The Gambia in 2007, I was awarded a British Infection Society Research Fellowship (2007-8), followed by a MRC Clinical Research Training Fellowship and PhD (2008 – 11) under the supervision of and , to study the pathogenesis of HIV-2 infection and the molecular epidemiology of HIV-1 and HIV-2 in West Africa.

I joined the University of Sheffield in 2013 as an NIHR Academic Clinical Lecturer in Infectious Diseases & Microbiology. I was awarded a Wellcome Trust Intermediate Clinical Fellowship (2016 -2021), based between Imperial College London and the MRC Unit The Gambia, to study the immunogenicity of intranasal Live Attenuated Influenza Vaccine in children and bidirectional interactions with nasopharyngeal microbiota. I returned to the University of Sheffield as a Senior Clinical Lecturer in 2020 and led a programme of SARS-CoV-2 research through the COVID-19 pandemic, including roles as lead PI in Sheffield for the and the study. I was awarded an MBE in 2021 for services to COVID-19 research.

Publications

Show: Featured publications All publications

Journal articles

  • Sanyang B, Dabrowska MB, Amenyogbe N, Camara B, Beloum N, Jammeh M, Bojang D, Goodall J, Mohammed N, Sesay AK , Roca A et al (2025) . Nature Communications, 16.
  • Keeley AJ, Camara FE, Armitage EP, de Crombrugghe G, Sillah J, Fofana ML, Rollinson V, Senghore E, Jammeh M, Whitcombe AL , Bittaye A et al (2025) . Nature Medicine, 31(10), 3360-3371.
  • Hao S, Tomic I, Lindsey BB, Jagne YJ, Hoschler K, Meijer A, Carreño Quiroz JM, Meade P, Sano K, Peno C , Costa-Martins AG et al (2025) . Journal of Clinical Investigation, 135(18).
  • Armitage EP, Senghore E, Camara FE, Jarju S, Jagne S, Ceesay E, Darboe FF, de Crombrugghe G, Keeley AJ, Hall JN , Angyal A et al (2025) . Journal of Infection, 91(2), 106546-106546.
  • Colton H, Barratt N, Temperton N, Hornsby H, Angyal A, Grouneva I, Lindsey BB, Kearns P, Barnes E, Goodyear CS , Richter A et al (2024) . British Journal of Haematology, 205(6), 2206-2218.
  • Armitage EP, de Crombrugghe G, Keeley AJ, Senghore E, Camara FE, Jammeh M, Bittaye A, Ceesay H, Ceesay I, Samateh B , Manneh M et al (2024) . The Lancet Microbe, 5(7), 679-688.
  • Jarju S, Wenlock RD, Danso M, Jobe D, Jagne YJ, Darboe A, Kumado M, Jallow Y, Touray M, Ceesay EA , Gaye H et al (2024) . Nature Communications, 15(1).
  • Hornsby H, Nicols AR, Longet S, Liu C, Tomic A, Angyal A, Kronsteiner B, Tyerman JK, Tipton T, Zhang P , Gallis M et al (2023) . Nature Communications, 14(1).
  • Barnes E, Goodyear CS, Willicombe M, Gaskell C, Siebert S, I de Silva T, Murray SM, Rea D, Snowden JA, Carroll M , Pirrie S et al (2023) . Nature Medicine, 29(7), 1760-1774.
  • Miller PDE, Patel SR, Skinner R, Dignan F, Richter A, Jeffery K, Khan A, Heath PT, Clark A, Orchard K , Snowden JA et al (2023) . Journal of Infection, 86(1), 1-8.
  • Longet S, Hargreaves A, Healy S, Brown R, Hornsby HR, Meardon N, Tipton T, Barnes E, Dunachie S, Duncan CJA , Klenerman P et al (2022) . Frontiers in Immunology, 13.
  • Costa-Martins AG, Mane K, Lindsey BB, Ogava RLT, Castro I, Jagne YJ, Sallah HJ, Armitage EP, Jarju S, Ahadzie B , Ellis-Watson R et al (2022) . CELL REPORTS MEDICINE, 3(2).
  • Lindsey BB, Villabona-Arenas CJ, Campbell F, Keeley AJ, Parker MD, Shah DR, Parsons H, Zhang P, Kakkar N, Gallis M , Foulkes BH et al (2022) . Nature Communications, 13(1).
  • Angyal A, Longet S, Moore SC, Payne RP, Harding A, Tipton T, Rongkard P, Ali M, Hering LM, Meardon N , Austin J et al (2022) . The Lancet Microbe, 3(1), e21-e31.
  • Minter A, Hoschler K, Jagne YJ, Sallah H, Armitage E, Lindsey B, Hay JA, Riley S, de Silva TI & Kucharski A (2022) . The Journal of Infectious Diseases, 225(10), 1750-1754.
  • de Silva TI, Liu G, Lindsey BB, Dong D, Moore SC, Hsu NS, Shah D, Wellington D, Mentzer AJ, Angyal A , Brown R et al (2021) . iScience, 24(11).
  • Payne RP, Longet S, Austin JA, Skelly DT, Dejnirattisai W, Adele S, Meardon N, Faustini S, Al-Taei S, Moore SC , Tipton T et al (2021) . Cell, 184(23), 5699-5714.e11.
  • Peno C, Armitage EP, Clerc M, Balcazar Lopez C, Jagne YJ, Drammeh S, Jarju S, Sallah H, Senghore E, Lindsey BB , Camara J et al (2021) . The Lancet Microbe, 2(12), e656-e665.
  • Weissman D, Alameh M-G, de Silva T, Collini P, Hornsby H, Brown R, LaBranche CC, Edwards RJ, Sutherland L, Santra S , Mansouri K et al (2021) . Cell Host & Microbe, 29(1), 23-31.e4.
  • Korber B, Fischer WM, Gnanakaran S, Yoon H, Theiler J, Abfalterer W, Hengartner N, Giorgi EE, Bhattacharya T, Foley B , Hastie KM et al (2020) . Cell, 182(4), 812-827.e19.
  • Armitage EP, Senghore E, Darboe S, Barry M, Camara J, Bah S, Marks M, Cerami C, Roca A, Antonio M , Turner CE et al (2019) . PLOS Neglected Tropical Diseases, 13(10).
  • de Lima DS, Cardozo LE, Maracaja-Coutinho V, Suhrbier A, Mane K, Jeffries D, Silveira ELV, Amaral PP, Rappuoli R, de Silva TI & Nakaya HI (2019) . Proceedings of the National Academy of Sciences, 116(34), 17121-17126.
  • Lindsey BB, Jagne YJ, Armitage EP, Singanayagam A, Sallah HJ, Drammeh S, Senghore E, Mohammed NI, Jeffries D, Höschler K , Tregoning JS et al (2019) . The Lancet Respiratory Medicine, 7(8), 665-676.
  • Lindsey BB, Armitage EP, Kampmann B & de Silva TI (2019) . Lancet Infectious Diseases, 19(4), e110-e119.
  • de Silva TI, Gould V, Mohammed NI, Cope A, Meijer A, Zutt I, Reimerink J, Kampmann B, Hoschler K, Zambon M & Tregoning JS (2017) . Journal of Immunological Methods, 449, 1-6.
  • de Silva TI, Peng Y, Leligdowicz A, Zaidi I, Li L, Griffin H, Blais M-E, Vincent T, Saraiva M, Yindom L-M , van Tienen C et al (2013) . Blood, 121(21), 4330-4339.
  • de Silva TI, Aasa-Chapman M, Cotten M, Hué S, Robinson J, Bibollet-Ruche F, Sarge-Njie R, Berry N, Jaye A, Aaby P , Whittle H et al (2012) . Journal of Virology, 86(2), 930-946.

All publications

Journal articles

  • Townsley H, Locke T, Laundy N, Keil C, Keeley AJ, Hamilton J, Pandor A, Darton T & de Silva TI (2025) . Journal of Infection.
  • Hodgson D, Hay J, Jarju S, Jobe D, Wenlock R, de Silva TI & Kucharski AJ (2025) . PLoS Computational Biology, 21(9).
  • Sanyang B, Dabrowska MB, Amenyogbe N, Camara B, Beloum N, Jammeh M, Bojang D, Goodall J, Mohammed N, Sesay AK , Roca A et al (2025) . Nature Communications, 16.
  • Keeley AJ, Camara FE, Armitage EP, de Crombrugghe G, Sillah J, Fofana ML, Rollinson V, Senghore E, Jammeh M, Whitcombe AL , Bittaye A et al (2025) . Nature Medicine, 31(10), 3360-3371.
  • McLornan DP, Hazenberg MD, Ciceri F, Alexander T, Angelucci E, Averbuch D, Bazarbachi A, Chakraverty R, Booth C, Heemskerk MHM , Holler E et al (2025) . Bone Marrow Transplantation.
  • Symes R, Keddie SH, Walker J, McKeever T, Ahmad S, Arnold D, Evans CM, Pelosi E, Rahman NM, Sapey E , Zambon M et al (2025) . Journal of Infection, 91(3), 106570-106570.
  • Hao S, Tomic I, Lindsey BB, Jagne YJ, Hoschler K, Meijer A, Carreño Quiroz JM, Meade P, Sano K, Peno C , Costa-Martins AG et al (2025) . Journal of Clinical Investigation, 135(18).
  • Armitage EP, Senghore E, Camara FE, Jarju S, Jagne S, Ceesay E, Darboe FF, de Crombrugghe G, Keeley AJ, Hall JN , Angyal A et al (2025) . Journal of Infection, 91(2), 106546-106546.
  • Carreño JM, Meade P, Sogodogo NF, Sano K, Tcheou J, Raskin A, Singh G, Fried M, Loganathan M, Francis B , Bielak D et al (2025) . iScience, 28(7), 112893-112893.
  • Jagne YJ, Jobe D, Darboe A, Danso M, Barratt N, Gomez M, Wenlock R, Jarju S, Sylva EL, Touray AF , Toure F et al (2025) . Communications Medicine, 5(1).
  • de Crombrugghe G, Armitage EP, Keeley AJ, Senghore E, Camara F, Jammeh M, Bittaye A, Ceesay H, Ceesay I, Samateh B , Manneh M et al (2025) . The Journal of Infectious Diseases, 232(3), 550-559.
  • Chen J-L, Wang B, Lu Y, Antoun E, Bird O, Drennan PG, Yin Z, Liu G, Yao X, Pidoux M , Bates A et al (2025) . Nature Communications, 16.
  • Pagano L, Maschmeyer G, Lamoth F, Blennow O, Xhaard A, Spadea M, Busca A, Cordonnier C, Maertens J, Guisado MA , Akova M et al (2025) . Leukemia, 39, 1547-1557.
  • Saso A, Kanteh E, Jeffries D, Okoye M, Mohammed N, Kumado M, Roetynck S, Jobe H, Faal A, Roberts E , Gageldonk P et al (2025) . The Lancet Infectious Diseases, 25(8), 909-924.
  • Mellors J, Dhaliwal R, Longet S, Tipton T, McInnes I, Siebert S, Kearns P, Rea D, Cook G, Willicombe M , Thomas D et al (2025) . Nature Communications, 16(1).
  • Locke TE, Keeley AJ, Laundy N, Keil C, Hamilton J, Pandor A, I de Silva T & Darton TC (2025) . Journal of Infection, 90(4).
  • Peno C, Jagne YJ, Clerc M, Balcazar Lopez C, Armitage EP, Sallah H, Drammeh S, Senghore E, Goderski G, van Tol S , Meijer A et al (2025) . The Lancet Microbe, 6(3), 100971-100971.
  • Massai L, Carducci M, Rovetini L, Paterson A, Whitcombe A, McGregor R, Lorenz N, Keeley AJ, de Silva TI, Bennett J , Berlanda Scorza F et al (2025) . Journal of Immunological Methods, 536, 113786-113786.
  • Hall JN, Armitage EP, Senghore E, Darboe S, Barry M, Camara J, Bah S, Keeley AJ, McCarthy JS, Smeesters P , Turner CE et al (2025) . The Journal of Infectious Diseases, 231(1), e28-e37.
  • Locke T, Siribaddana S, Jayaweera JAAS, Suligoy CM, de Silva TI, Corrigan RM & Darton TC (2024) . Microbial Genomics, 10(12).
  • Colton H, Barratt N, Temperton N, Hornsby H, Angyal A, Grouneva I, Lindsey BB, Kearns P, Barnes E, Goodyear CS , Richter A et al (2024) . British Journal of Haematology, 205(6), 2206-2218.
  • Saville TJ, Colton H, Jarju S, Armitage EP, Drammeh S, Tazzyman S, Jagne YJ, Sallah HJ, Senghore E, Evans CM , Darton TC et al (2024) . Scientific Reports, 14(1).
  • Wiseman JP, Scarrott JM, Alves-Cruzeiro J, Saffari A, Böger C, Karyka E, Dawes E, Davies AK, Marchi PM, Graves E , Fernandes F et al (2024) . EMBO Molecular Medicine, 16(11), 2882-2917.
  • Hall JN, Bah SY, Khalid H, Brailey A, Coleman S, Kirk T, Hussain N, Tovey M, Chaudhuri RR, Davies S , Tilley L et al (2024) . Microbial Genomics, 10(8).
  • Galgut O, Ashford F, Deeks A, Ghataure A, Islam M, Sambhi T, Ker YW, Duncan CJA, de Silva TI, Hopkins S , Hall V et al (2024) . Vaccine: X, 20, 100546-100546.
  • Sanyang B, de Silva TI, Camara B, Beloum N, Kanteh A, Manneh J, de Steenhuijsen Piters WAA, Bogaert D, Sesay AK & Roca A (2024) . iScience, 27(9), 110626-110626.
  • Brudenell EL, Pohare MB, Zafred D, Phipps J, Hornsby HR, Darby JF, Dai J, Liggett E, Cain KM, Barran PE , de Silva TI et al (2024) . Biochemical Journal, 481(11), 669-682.
  • Armitage EP, de Crombrugghe G, Keeley AJ, Senghore E, Camara FE, Jammeh M, Bittaye A, Ceesay H, Ceesay I, Samateh B , Manneh M et al (2024) . The Lancet Microbe, 5(7), 679-688.
  • Liu C, Zhou D, Dijokaite-Guraliuc A, Supasa P, Duyvesteyn HME, Ginn HM, Selvaraj M, Mentzer AJ, Das R, de Silva TI , Ritter TG et al (2024) . Cell Reports Medicine, 5(5), 101553-101553.
  • Goodyear CS, Patel A, Barnes E, Willicombe M, Siebert S, de Silva TI, Snowden JA, Lim SH, Bowden SJ, Billingham L , Richter A et al (2024) . The Lancet Rheumatology, 6(6), e339-e351.
  • Jarju S, Wenlock RD, Danso M, Jobe D, Jagne YJ, Darboe A, Kumado M, Jallow Y, Touray M, Ceesay EA , Gaye H et al (2024) . Nature Communications, 15(1).
  • Ali M, Longet S, Neale I, Rongkard P, Chowdhury FUH, Hill J, Brown A, Laidlaw S, Tipton T, Hoque A , Hassan N et al (2024) . Clinical and Experimental Immunology, 218(1), 78-92.
  • Liew F, Efstathiou C, Fontanella S, Richardson M, Saunders R, Swieboda D, Sidhu JK, Ascough S, Moore SC, Mohamed N , Nunag J et al (2024) . Nature Immunology, 25(4), 607-621.
  • Suau Sans M, Manneh M, Ceesay I, Bittaye A, de Crombrugghe G, Keeley AJ, de Silva TI, Palmer J, Armitage EP & Marks M (2024) . PLOS Global Public Health, 4(3).
  • Brittain G, Petrie J, Duffy KEM, Glover R, Hullock K, Papaioannou D, Roldan E, Beecher C, Bursnall M, Ciccarelli O , Coles AJ et al (2024) . BMJ Open, 14(2).
  • Carducci M, Whitcombe A, Rovetini L, Massai L, Keeley AJ, de Silva TI, Bennett J, Berlanda Scorza F, Iturriza M, Moreland NJ , Moriel DG et al (2024) . Journal of Immunological Methods, 526, 113618-113618.
  • Sidhu JK, Siggins MK, Liew F, Russell CD, Uruchurtu ASS, Davis C, Turtle L, Moore SC, Hardwick HE, Oosthuyzen W , Thomson EC et al (2024) . The Journal of Infectious Diseases, 230(1), e17-e29.
  • Gupta V, Kariotis S, Rajab MD, Errington N, Alhathli E, Jammeh E, Brook M, Meardon N, Collini P, Cole J , Wild JM et al (2023) . npj Digital Medicine, 6.
  • Hall J, Angyal A, Armitage E, Senghore E, Darboe S, Barry M, Camara J, Bah S, Keeley A, McCarthy J , Turner C et al (2023) . Clinical Infection in Practice, 20(Supplement 1).
  • Armitage EP, Keeley AJ, de Crombrugghe G, Senghore E, Camara FE, Jammeh M, Bittaye A, Ceesay H, Ceesay I, Samateh B , Manneh M et al (2023) . Wellcome Open Research, 8.
  • Neale I, Ali M, Kronsteiner B, Longet S, Abraham P, Deeks AS, Brown A, Moore SC, Stafford L, Dobson SL , Plowright M et al (2023) . mBio, 14(5).
  • Hornsby H, Nicols AR, Longet S, Liu C, Tomic A, Angyal A, Kronsteiner B, Tyerman JK, Tipton T, Zhang P , Gallis M et al (2023) . Nature Communications, 14(1).
  • Barnes E, Goodyear CS, Willicombe M, Gaskell C, Siebert S, I de Silva T, Murray SM, Rea D, Snowden JA, Carroll M , Pirrie S et al (2023) . Nature Medicine, 29(7), 1760-1774.
  • Asante IA, Hsu SN, Boatemaa L, Kwasah L, Adusei-Poku M, Odoom JK, Awuku-Larbi Y, Foulkes BH, Oliver-Commey J, Asiedu EK , Parker MD et al (2023) . The Lancet Global Health, 11(7), e1075-e1085.
  • Panca M, Blackstone J, Stirrup O, Cutino-Moguel M-T, Thomson E, Peters C, Snell LB, Nebbia G, Holmes A, Chawla A , Machin N et al (2023) . Journal of Hospital Infection, 139, 23-32.
  • Williams DM, Hornsby HR, Shehata OM, Brown R, Gallis M, Meardon N, Newman TAH, Plowright M, Zafred D, Shun-Shion ASM , Hodder AJ et al (2023) . iScience, 26(7).
  • Bah SY, Kujabi MA, Darboe S, Kebbeh N, Kebbeh BFK, Kanteh A, Bojang R, Lawn JE, Kampmann B, Sesay AK , de Silva TI et al (2023) . Communications Medicine, 3(1).
  • Keeley AJ, Groves D, Armitage EP, Senghore E, Jagne YJ, Sallah HJ, Drammeh S, Angyal A, Hornsby H, de Crombrugghe G , Smeesters PR et al (2023) . The Journal of Infectious Diseases, 228(7), 957-965.
  • Goldswain H, Dong X, Penrice-Randal R, Alruwaili M, Shawli GT, Prince T, Williamson MK, Raghwani J, Randle N, Jones B , Donovan-Banfield I et al (2023) . Genome Biology, 24(1).
  • Dijokaite-Guraliuc A, Das R, Zhou D, Ginn HM, Liu C, Duyvesteyn HME, Huo J, Nutalai R, Supasa P, Selvaraj M , de Silva TI et al (2023) . Cell Reports, 42(4).
  • Jarju S, Senghore E, Brotherton H, Saidykhan A, Jallow S, Krubally E, Sinjanka E, Ndene MN, Bajo F, Sanyang MM , Saidy B et al (2023) . Gates Open Research, 6.
  • Moore SC, Kronsteiner B, Longet S, Adele S, Deeks AS, Liu C, Dejnirattisai W, Reyes LS, Meardon N, Faustini S , Al-Taei S et al (2023) . Med, 4(3), 191-215.e9.
  • Kanteh A, Jallow HS, Manneh J, Sanyang B, Kujabi MA, Ndure SL, Jarju S, Sey AP, Damilare K D, Bah Y , Sambou S et al (2023) . The Lancet Global Health, 11(3), e414-e424.
  • Turtle L, Thorpe M, Drake TM, Swets M, Palmieri C, Russell CD, Ho A, Aston S, Wootton DG, Richter A , de Silva TI et al (2023) . PLoS Medicine, 20(1).
  • Armitage EP, Keeley AJ, de Crombrugghe G, Senghore E, Camara FE, Jammeh M, Bittaye A, Ceesay H, Ceesay I, Samateh B , Manneh M et al (2023) . Wellcome Open Research, 8.
  • Carabelli AM, Peacock TP, Thorne LG, Harvey WT, Hughes J, de Silva TI, Peacock SJ, Barclay WS, Towers GJ & Robertson DL (2023) . Nature Reviews Microbiology, 21(3), 162-177.
  • Liew F, Talwar S, Cross A, Willett BJ, Scott S, Logan N, Siggins MK, Swieboda D, Sidhu JK, Efstathiou C , Moore SC et al (2023) . eBioMedicine, 87.
  • Huo J, Dijokaite-Guraliuc A, Liu C, Zhou D, Ginn HM, Das R, Supasa P, Selvaraj M, Nutalai R, Tuekprakhon A , Duyvesteyn HME et al (2023) . Cell Reports, 42(1).
  • Bah S, Keeley A, Armitage E, Khalid H, Chaudhuri R, Senghore E, Manneh J, Tilley L, Marks M, Darboe S , Sesay A et al (2023) . mSphere, 8(1).
  • Miller PDE, Patel SR, Skinner R, Dignan F, Richter A, Jeffery K, Khan A, Heath PT, Clark A, Orchard K , Snowden JA et al (2023) . Journal of Infection, 86(1), 1-8.
  • Colton H, Parker MD, Stirrup O, Blackstone J, Loose M, McClure CP, Roy S, Williams C, McLeod J, Smith D , Taha Y et al (2023) . Journal of Hospital Infection, 131, 34-42.
  • Jarju S, Senghore E, Brotherton H, Saidykhan A, Jallow S, Krubally E, Sinjanka E, Ndene MN, Bajo F, Sanyang MM , Saidy B et al (2022) . Gates Open Research, 6.
  • Stirrup O, Blackstone J, Mapp F, MacNeil A, Panca M, Holmes A, Machin N, Shin GY, Mahungu T, Saeed K , Saluja T et al (2022) . eLife, 11.
  • Longet S, Hargreaves A, Healy S, Brown R, Hornsby HR, Meardon N, Tipton T, Barnes E, Dunachie S, Duncan CJA , Klenerman P et al (2022) . Frontiers in Immunology, 13.
  • Boswell MT, Nazziwa J, Kuroki K, Palm A, Karlson S, Månsson F, Biague A, da Silva ZJ, Onyango CO, de Silva TI , Jaye A et al (2022) . Virus Evolution, 8(2).
  • Sanyang B, de Silva TI, Kanteh A, Bojang A, Manneh J, de Steenhuijsen Piters WAA, Peno C, Bogaert D, Sesay AK & Roca A (2022) . eBioMedicine, 83.
  • Wilkinson SAJ, Richter A, Casey A, Osman H, Mirza JD, Stockton J, Quick J, Ratcliffe L, Sparks N, Cumley N , Poplawski R et al (2022) . Virus Evolution, 8(2).
  • Smallman-Raynor MR & Cliff AD (2022) . Epidemiology and Infection, 150.
  • Parker MD, Stewart H, Shehata OM, Lindsey BB, Shah DR, Hsu S, Keeley AJ, Partridge DG, Leary S, Cope A , State A et al (2022) . Communications Biology, 5.
  • Keeley AJ, Carducci M, Massai L, Pizza M, de Silva TI, G. Moriel D & Rossi O (2022) . Methods and Protocols, 5(4).
  • Colton H, Hodgson D, Hornsby H, Brown R, Mckenzie J, Bradley KL, James C, Lindsey BB, Birch S, Marsh L , Wood S et al (2022) . Wellcome Open Research, 6.
  • Relph KA, Russell CD, Fairfield CJ, Turtle L, de Silva TI, Siggins MK, Drake TM, Thwaites RS, Abrams S, Moore SC , Hardwick HE et al (2022) . Open Forum Infectious Diseases, 9(5).
  • Blackstone J, Stirrup O, Mapp F, Panca M, Copas A, Flowers P, Hockey L, Price J, Partridge D, Peters C , de Silva T et al (2022) . BMJ Open, 12(4).
  • Shankar S, Beckett J, Tipton T, Ogbe A, Kasanyinga M, Dold C, Lumley S, Dengu F, Rompianesi G, Elgilani F , Longet S et al (2022) . Journal of the American Society of Nephrology, 33(5), 883-887.
  • Locke T, Parsons H, Briffa N, Stott M, de Silva TI & Darton TC (2022) . Journal of Hospital Infection, 126, 21-28.
  • Wright DW, Harvey WT, Hughes J, Cox M, Peacock TP, Colquhoun R, Jackson B, Orton R, Nielsen M, Hsu NS , Harrison EM et al (2022) . Virus Evolution, 8(1), 1-14.
  • Tomic A, Skelly DT, Ogbe A, O’Connor D, Pace M, Adland E, Alexander F, Ali M, Allott K, Azim Ansari M , Belij-Rammerstorfer S et al (2022) . Nature Communications, 13(1).
  • Colton H, Hodgson D, Hornsby H, Brown R, Mckenzie J, Bradley KL, James C, Lindsey BB, Birch S, Marsh L , Wood S et al (2022) . Wellcome Open Research, 6.
  • Lindsey BB, Villabona-Arenas CJ, Campbell F, Keeley AJ, Parker MD, Shah DR, Parsons H, Zhang P, Kakkar N, Gallis M , Foulkes BH et al (2022) . Nat Commun, 13(1), 1013.
  • Costa-Martins AG, Mane K, Lindsey BB, Ogava RLT, Castro I, Jagne YJ, Sallah HJ, Armitage EP, Jarju S, Ahadzie B , Ellis-Watson R et al (2022) . CELL REPORTS MEDICINE, 3(2).
  • Lindsey BB, Villabona-Arenas CJ, Campbell F, Keeley AJ, Parker MD, Shah DR, Parsons H, Zhang P, Kakkar N, Gallis M , Foulkes BH et al (2022) . Nature Communications, 13(1).
  • Cencioni MT, Genchi A, Brittain G, de Silva TI, Sharrack B, Snowden JA, Alexander T, Greco R & Muraro PA (2022) . Frontiers in Immunology, 12.
  • Jagne I, Keeley AJ, Bojang A, Camara B, Jallow E, Senghore E, Oluwalana C, Bah SY, Turner CE, Sesay AK , D’Alessandro U et al (2022) . BMC Infectious Diseases, 22(1).
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  • de Lima DS, Cardozo LE, Maracaja-Coutinho V, Suhrbier A, Mane K, Jeffries D, Silveira ELV, Amaral PP, Rappuoli R, de Silva TI & Nakaya HI (2019) . Proceedings of the National Academy of Sciences, 116(34), 17121-17126.
  • Lindsey BB, Jagne YJ, Armitage EP, Singanayagam A, Sallah HJ, Drammeh S, Senghore E, Mohammed NI, Jeffries D, Höschler K , Tregoning JS et al (2019) . The Lancet Respiratory Medicine, 7(8), 665-676.
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  • Lindsey BB, Armitage EP, Kampmann B & de Silva TI (2019) . Lancet Infectious Diseases, 19(4), e110-e119.
  • Miller PDE, de Silva TI, Leonard H, Anthias C, Hoschler K, Goddard K, Peggs K, Madrigal A & Snowden JA (2019) . Vaccine, 37(3), 452-457.
  • James KL, de Silva TI, Brown K, Whittle H, Taylor S, McVean G, Esbjörnsson J & Rowland-Jones SL (2018) . Journal of Virology, 93.
  • Knight GM, Clarkson M & de Silva TI (2018) . Journal of Antimicrobial Chemotherapy, 73(8), 2197-2200.
  • de Silva T, Leligdowicz A, Carlson J, Garcia-Knight M, Onyango C, Miller N, Yindom LM, Hue S, Jaye A, Dong T , Cotten M et al (2018) . AIDS, 32(6), 709-714.
  • Armitage EP, Camara J, Bah S, Forster AS, Clarke E, Kampmann B & de Silva TI (2018) . Vaccine, 36(13), 1772-1780.
  • de Silva TI, Gould V, Mohammed NI, Cope A, Meijer A, Zutt I, Reimerink J, Kampmann B, Hoschler K, Zambon M & Tregoning JS (2017) . Journal of Immunological Methods, 449, 1-6.
  • de Silva TI & Kampmann B (2017) . Lancet Global Health, 5(3).
  • Miller PD, de Silva TI, Skinner R, Gilleece M, Peniket A, Hamblin A, Greenfield D, Anthias C, Peggs K, Madrigal A & Snowden JA (2017) . Bone Marrow Transplant.
  • Parkash V, Mudhar HS, Wagner BE, Raoult D, Batty R, Lepidi H, Burke J, Collini P & de Silva T (2016) . Ocular Oncology and Pathology, 3, 17-21.
  • Garcia-Knight MA, Slyker J, Payne BL, Pond SLK, de Silva TI, Chohan B, Khasimwa B, Mbori-Ngacha D, John-Stewart G, Rowland-Jones SL & Esbjörnsson J (2016) . Scientific Reports, 6.
  • Fryer HR, Van Tienen C, Van Der Loeff MS, Aaby P, Da Silva ZJ, Whittle H, Rowland-Jones SL & de Silva TI (2015) . AIDS, 29(18), 2479-2486.
  • Yindom L, James K, de Silva TI & Rowland‐Jones SL (2015) . Tissue Antigens, 86(3), 220-221.
  • Yindom L, de Silva TI & Rowland‐Jones SL (2015) . Tissue Antigens, 86(4), 312-313.
  • Yindom L, de Silva TI & Rowland‐Jones SL (2015) . Tissue Antigens, 86(2), 150-151.
  • Yindom L, James K, de Silva TI & Rowland‐Jones SL (2015) . Tissue Antigens, 86(1), 70-71.
  • Yindom L, de Silva TI & Rowland‐Jones SL (2015) . Tissue Antigens, 85(2), 153-154.
  • Yindom L, de Silva TI & Rowland‐Jones SL (2015) . Tissue Antigens, 85(2), 151-152.
  • de Silva TI, Debroy Kidambi A, Green ST, Mahadeva U, Mcgregor AC, Levy M & Hardcastle N (2015) . Journal of Infection, 70(3), 314-316.
  • Yindom L, Wong G, de Silva TI & Rowland‐Jones SL (2014) . Tissue Antigens, 84(6), 595-596.
  • Yindom L, de Silva TI & Rowland‐Jones SL (2014) . Tissue Antigens, 84(6), 596-597.
  • Yindom L, James K, de Silva TI & Rowland‐Jones SL (2014) . Tissue Antigens, 84(6), 594-595.
  • Yindom L, Wong G, de Silva TI & Rowland‐Jones SL (2014) . Tissue Antigens, 84(5), 521-522.
  • Yindom L, James K, de Silva TI & Rowland‐Jones SL (2014) . Tissue Antigens, 84(5), 520-521.
  • Yindom L, James K, de Silva TI & Rowland‐Jones SL (2014) . Tissue Antigens, 84(4), 427-429.
  • Uchtenhagen H, Schiffner T, Bowles E, Heyndrickx L, LaBranche C, Applequist SE, Jansson M, De Silva T, Back JW, Achour A , Scarlatti G et al (2014) . The Journal of Immunology, 192(12), 5802-5812.
  • de Silva TI, Green ST, Cole J, Stone BJ, Dockrell DH & Vedio AB (2014) . Journal of Infection, 68(4), 397-399.
  • Yindom L, de Silva TI & Rowland‐Jones SL (2014) . Tissue Antigens, 83(4), 305-306.
  • Yindom L, de Silva TI & Rowland‐Jones SL (2014) . Tissue Antigens, 83(2), 126-127.
  • de Silva T, Peng Y, Leligdowicz A, Zaidi I, Li L, Griffin H, Blais M-E, Vincent T, Saraiva M, Yindom L-M , van Tienen C et al (2013) . Journal of Infection, 67(4), 344-344.
  • de Silva TI, Peng Y, Leligdowicz A, Zaidi I, Li L, Griffin H, Blais M-E, Vincent T, Saraiva M, Yindom L-M , van Tienen C et al (2013) . Blood, 121(21), 4330-4339.
  • de Silva TI, van Tienen C, Onyango C, Jabang A, Vincent T, Loeff MFSVD, Coutinho RA, Jaye A, Rowland-Jones S, Whittle H , Cotten M et al (2013) . AIDS, 27(1), 125-134.
  • Vannberg FO, McDermid JM, Jaye A, MRC Gambia HIV Clinical Cohort Study & Wellcome Trust Case Control Consortium 3 (2012) . N Engl J Med, 367(20), 1962.
  • (2012) . New England Journal of Medicine, 367(20), 1961-1963.
  • Daigneault M, De Silva TI, Bewley MA, Preston JA, Marriott HM, Mitchell AM, Mitchell TJ, Read RC, Whyte MKB & Dockrell DH (2012) . PLoS Pathogens, 8(7).
  • Zaidi I, Peterson K, Jeffries D, Whittle H, de Silva T, Rowland-Jones S, Jaye A & de Jong BC (2012) . PLoS ONE, 7(6).
  • van Tienen C, de Silva TI, Junior Alcantara LC, Onyango CO, Jarju S, Goncalves N, Vincent T, Aaby P, Whittle H, van der Loeff MS & Cotten M (2012) . PLoS Neglected Tropical Diseases, 6(6).
  • van Tienen C, McConkey SJ, de Silva TI, Cotten M, Kaye S, Sarge-Njie R, da Costa C, Gonçalves N, Parker J, Vincent T , Jaye A et al (2012) . AIDS Research and Human Retroviruses, 28(6), 584-590.
  • Sabbah S, Jagne YJ, Zuo J, de Silva T, Ahasan MM, Brander C, Rowland-Jones S, Flanagan KL & Hislop AD (2012) . Blood, 119(9), 2083-2092.
  • de Silva TI, Aasa-Chapman M, Cotten M, Hué S, Robinson J, Bibollet-Ruche F, Sarge-Njie R, Berry N, Jaye A, Aaby P , Whittle H et al (2012) . Journal of Virology, 86(2), 930-946.
  • Stewart B, Jobarteh ML, Sarge-Njie R, Alabi A, de Silva T, Peterson K, Peterson I, Whittle H, Rowland-Jones S, Jaye A , Cotten M et al (2011) . BMC Research Notes, 4.
  • van Tienen C, van der Loeff MS, Peterson I, Cotten M, Andersson S, Holmgren B, Vincent T, de Silva T, Rowland-Jones S, Aaby P & Whittle H (2011) . PLoS ONE , 6(12).
  • Peterson I, Togun O, de Silva T, Oko F, Rowland-Jones S, Jaye A & Peterson K (2011) . AIDS, 25(17), 2167-2175.
  • van Tienen C, de Silva TI, Alcantara LC, van der Loeff MS, Vincent T, Gonçalves N, Coutinho RA, Aaby P, Whittle H & Cotten M (2011) . Retrovirology, 8(S1).
  • van Tienen C, McConkey SJ, de Silva TI, Cotten M, Kaye S, Sarge-Njie R, da Costa C, Gonçalves N, Parker J, Vincent T , Jaye A et al (2011) . Retrovirology, 8(S1).
  • Peterson K, Jallow S, Rowland-Jones SL & de Silva TI (2011) . AIDS Research and Treatment, 2011.
  • de Silva T & Weiss RA (2010) HIV-2 goes global: An unaddressed issue in Indian anti-retroviral programmes. Indian Journal of Medical Research, 132(12), 660-662.
  • de Silva TI, Turner R, Hue S, Trikha R, van Tienen C, Onyango C, Jaye A, Foley B, Whittle H, Rowland-Jones SL & Cotten M (2010) . Retrovirology, 7.
  • Onyango CO, Leligdowicz A, Yokoyama M, Sato H, Song H, Nakayama EE, Shioda T, de Silva T, Townend J, Jaye A , Whittle H et al (2010) . Vaccine, 28, B60-B67.
  • de Silva TI, van Tienen C, Rowland-Jones SL & Cotten M (2010) . HIV Therapy, 4(3), 305-323.
  • Jallow S, Vincent T, Leligdowicz A, De Silva T, Van Tienen C, Alabi A, Sarge‐Njie R, Aaby P, Corrah T, Whittle H , Jaye A et al (2009) . Clinical Infectious Diseases, 48(12), 1790-1793.
  • Stone B, Patel TG, De Silva TI, Green ST & Chapman ALN (2008) . Journal of Infection, 57(5), 426-427.
  • de Silva TI, Cotten M & Rowland-Jones SL (2008) . Trends in Microbiology, 16(12), 588-595.
  • Rowland-Jones S & de Silva T (2008) . PLOS MEDICINE, 5(5), 721-724.
  • de Silva T, Kudesia G, Joall A, Whittaker D, Ryan C & Davies S (2007) . Journal of Infection, 55(3), e67-e68.
  • de Silva T, Thickett K & Winstanley T (2007) . Journal of Infection, 55(3), e58-e58.
  • de Silva TI, Post FA, Griffin MD & Dockrell DH (2007) . Mayo Clinic proceedings, 82(9), 1103-1116.
  • de Silva TI, Cope A, Goepel J & Greig JM (2007) . Journal of Infection, 54(4), e207-e210.
  • de Silva T, Evans C, Mudhar HS, Rennie I & Green ST (2006) . Journal of Clinical Pathology, 59(11), 1226.1-1226.
  • de Silva T, Kudesia G, Joall A, Whittaker D, Davies S & Ryan C (2006) . Journal of Clinical Microbiology, 44(12), 4628-4629.
  • Raychaudhuri M, de Silva T, Connor S & Poulton M (2006) . International Journal of STD & AIDS, 17(7), 495-497.
  • Chapman AL, Kudesia G, McKendrick MW & de Silva TI (2006) . Journal of Infection.
  • Evans CM, Mudhar H, Rennie I, Green ST & de Silva TI (2006) . Journal of Infection.
  • de Silva T, Chapman A, Kudesia G & McKendrick M (2006) . Journal of Infection, 52(4), e113-e116.
  • de Silva T (2005) . Journal of Neurology, Neurosurgery & Psychiatry, 76(8), 1074-1074.
  • de Silva T (2005) . Sexually Transmitted Infections, 81(3), 276-277.
  • Keeley AJ, Camara FE, Armitage EP, de Crombrugghe G, Sillah J, Fofana ML, Rollinson V, Senghore E, Jammeh M, Whitcombe AL , Bittaye A et al () . Nature Medicine.
  • Michael BD, Dunai C, Needham EJ, Tharmaratnam K, Williams R, Huang Y, Boardman SA, Clark JJ, Sharma P, Subramaniam K , Wood GK et al () . Nature Communications, 15(1).
  • Lindsey B, Jagne YJ, Armitage E, Singanayagam A, Sallah H, Drammeh S, Senghore E, Mohammed N, Jeffries D, Höschler K , Tregoning J et al () The impact of an updated pandemic H1N1 strain on shedding and immunogenicity to Russian-backbone live attenuated influenza vaccine among children in The Gambia: an open-label, observational, phase 4 study. The Lancet Respiratory Medicine.
  • Miller PDE, Forster AS, de Silva TI, Leonard H, Anthias C, Mayhew M, Klammer M, Paskar S, Hurst E, Peggs K , Madrigal A et al () . BMJ OPEN, 8(8).
  • Rowland-Jones S & de Silva T () . PLoS Medicine, 5(6), e134-e134.
  • Shankar S, Beckett J, Tipton T, Ogbe A, Kasanyinga M, Dold C, Lumley S, Dengu F, Rompianesi G, Elgilani F , Longet S et al () Poor Antibody Responses to SARS-CoV-2 Infection or Vaccination Are Associated With High Re-Infection Rates in Haemodialysis and Renal Transplant Patients.
  • Kearns P, Siebert S, willicombe M, Gaskell C, Kirkham A, Pirrie S, Bowden S, Magwaro S, Hughes A, Lim Z , Dimitriadis S et al () Examining the Immunological Effects of COVID-19 Vaccination in Patients with Conditions Potentially Leading to Diminished Immune Response Capacity – The OCTAVE Trial.
  • Russell CD, Fairfield CJ, Drake TM, Turtle L, Seaton RA, Wootton DG, Sigfrid L, Harrison EM, Docherty A, de Silva TI , Egan C et al () Co-Infections, Secondary Infections, and Antimicrobial Usage in Hospitalised Patients with COVID-19 from the ISARIC WHO CCP-UK Study: A Prospective, Multicentre Cohort Study.
  • Costa-Martins AG, Mane K, Lindsey BB, Ogava RLT, Castro Í, Jagne YJ, Sallah H, Armitage E, Ahadzie B, Ellis-Watson R , Tregoning JS et al () Pre-Existing Upregulation of Interferon Pathways in the Nasopharynx Impacts Viral Shedding Following Live Attenuated Influenza Vaccine Challenge in Children.
  • Williams DM, Hornsby H, Shehata OM, Brown R, Gallis M, Meardon N, Newman TAH, Plowright M, Zafred D, Shun-Shion ASM , Hodder AJ et al () Characterisation of SARS-CoV-2 Membrane Protein-Specific Antibodies as an Additional Serological Target Following COVID-19 Infections Identified Through a High Content Microscopy-Based Platform.
  • Armitage E, de Crombrugghe G, Keeley AJ, Senghore E, Camara FE, Jammeh M, Bittaye A, Ceesay H, Ceesay I, Samateh B , Manneh M et al () Streptococcus Pyogenes Carriage and Infection within Households in the Gambia: A Longitudinal Cohort Study.
  • Jarju S, Wenlock R, Danso M, Jobe D, Jagne YJ, Darboe A, Kumado M, Jallow Y, Touray M, Ceesay EA , Gaye H et al () SARS-CoV-2 Incidence and Re-Infection During Delta and Omicron Ba.1 Waves in the Gambia: Results from a Prospective Household Cohort Study in a Population with Low SARS-CoV-2 Vaccine Coverage.
  • Goodyear CS, Patel A, Barnes E, willicombe M, Siebert S, de Silva TI, Snowden JA, Lim S, Bowden S, Billingham LJ , Richter AG et al () Immunogenicity of SARSCoV2 Third Dose Vaccine Strategies in Immunocompromised Patients with Suboptimal Immunity Following Two Doses (OCTAVE-DUO): An Open-Label, Multi-Centre, Randomised, Controlled Phase III Trial.

Book chapters

  • Abrahamian FM, Aldape MJ, Aldasoro E, Allen UD, Al-Sum H, Anadkat MJ, Anders K, Angelakis E, Angus BJ, Antoniadou A , Arena F et al (2017) , Infectious Diseases (pp. xv-xxxvi). Elsevier
  • De Silva TI & Green ST (2017) , Infectious Diseases (pp. 133-135.e1). Elsevier
  • Moysi E, de Silva T & Rowland-Jones S (2012) , Models of Protection Against HIV/SIV (pp. 293-315). Elsevier
  • Ball TB, Barré-Sinoussi F, Biasin M, Blankson JN, Broliden K, Buckheit RW, Card CM, Clerici M, de Silva T, Fellay J , Fowke KR et al (2012) , Models of Protection Against HIV/SIV (pp. xi-xii). Elsevier

Conference proceedings

  • Miller PDE, de Silva T, Leonard H, Goddard K, Anthias C, Hoschler K, Peggs K, Madrigal A & Snowden JA (2017) . Bone Marrow Transplantation, Vol. 52(Suppl 1) (pp S269-S270). Marseille, France, 26 March 2017 - 26 March 2017.
  • Miller PDE, de Silva T, Skinner R, Gilleece M, Peniket A, Hamblin A, Greenfield D, Anthias C, Peggs K, Madrigal A & Snowden JA (2016) Routine Vaccination Programme (RVP) Practice after Adult and Paediatric Allogeneic Haematopoietic Stem Cell Transplant (HSCT): A British Society of Blood and Marrow Transplantation (BSBMT) Survey of UK NHS-Based Programmes. BONE MARROW TRANSPLANTATION, Vol. 51 (pp S400-S401)
  • Meiring J, De Silva T & Snowden J (2015) A study of adherence to a vaccination schedule following adult allogenic haematopoietic stem cell transplants in UK transplant centre. BONE MARROW TRANSPLANTATION, Vol. 50 (pp S203-S204)

Preprints

  • Hodgson D, Hay J, Jarju S, Jobe D, Wenlock R, de Silva TI & Kucharski AJ (2025) , Cold Spring Harbor Laboratory.
  • Keeley AJ, Camara FE, Armitage E, de Crombrugghe G, Sillah J, Fofana ML, Rollinson V, Senghore E, Jammeh M, Whitcombe AL , Bittaye A et al (2025) , Cold Spring Harbor Laboratory.
  • Hao S, Tomic I, Lindsey BB, Jagne YJ, Hoschler K, Meijer A, Quiroz JMC, Meade P, Sano K, Peno C , Costa-Martins AG et al (2025) , Cold Spring Harbor Laboratory.
  • JAGNE YJ, Jobe D, Darboe A, Danso M, Barratt N, Gomez M, Wenlock R, Jarju S, Sylva E, Touray AF , Toure F et al (2024) , Springer Science and Business Media LLC.
  • Hall JN, Bah SY, Khalid H, Brailey A, Coleman S, Kirk T, Hussain N, Tovey M, Chaudhuri RR, Davies S , Tilley L et al (2024) , Cold Spring Harbor Laboratory.
  • Hall JN, Armitage EP, Senghore E, Darboe S, Barry M, Camara J, Bah S, Keeley AJ, McCarthy JS, Smeesters P , Turner CE et al (2024) , Cold Spring Harbor Laboratory.
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Teaching interests

I am involved in delivering the undergraduate (MBChB) Infectious Diseases, Tropical Medicine and Microbiology curriculum at the University of Sheffield. I also lecture on the MSc in Antimicrobial Resistance (MED404), Molecular Medicine MSc (MED6006) and Pharmacology of Respiratory Disease (CDL302, Biomedical Science).

Professional activities and memberships

National and International

  • British Infection Association Scientific and Research Secretary (2023 - )
  • Wellcome Trust Early Career Award Interview Committee, Infection and Immunobiology (2022 - )
  • Africa Research Excellence Fund () College of Experts (2022 - )
  • Chair, Vaccines Subcommittee, British Society of Blood and Marrow Transplantation and cellular therapy (BSBMTCt), vaccination subcommittee (2023 - )
  • Associate Editor, Journal of Infection (2019 - )

Local

  • Co-Director, Florey Institute of Infection (2023 - )
  • Director of CL3 suite, Medical School, University of Sheffield (2022 - )
  • UREC Ethics reviewer for Medical School (2022 -)
  • University of Sheffield Biosafety Committee (2019 -)
Research themes and key projects

Mucosal and systemic immunity to respiratory viruses

  1. Hybrid immunity to SARS-CoV-2 in Zimbabwean adults with HIV and other chronic diseases (Bill and Melinda Gates Foundation, 2023 – 2026). Key collaborators: , , .
  2. Study of SARS-CoV-2 systemic and mucosal immunity within a household transmission study in The Gambia (UKRI). Key collaborators: , .
  3. Study of SARS-CoV-2 T-cell and antibody responses as part of the , and consortium (2024 – 2028).
  4. Part of a consortium to establish a (Chan Zuckerberg Initiative, 2021 – 2025).
  5. Supervisor for Dr. Ben Lindsey, Wellcome Trust 4ward North Clinical PhD fellowship on inflammatory memory in the upper respiratory tract following respiratory viral infections (2023 – 2026).

Epidemiology of respiratory viruses

  1. Surveillance for SARS-CoV-2 and other respiratory viruses by establishment of a sentinel surveillance platform for influenza-like illness in The Gambia, along with a household transmission cohort (TransVir) with , , Dr. Abdul Karim Sesay.
  2. University of Sheffield lead for the (COG-UK), using Oxford Nanopore Technology (ONT) to sequence SARS-CoV-2 isolates in South Yorkshire.  Building on our group’s sequencing expertise gained during this project, we are now focusing on optimising ONT-based assays with direct utility in NHS diagnostic microbiology and virology laboratories. This aligns work with key deliverables our group are leading within the Infection and Immunity Theme of .

The epidemiology and immune responses to Streptococcus pyogenes

Several clinical and molecular epidemiology studies forming part of the MRC Unit The Gambia Strep A research portfolio, with (School of Biosciences), (LSHTM) and (MRC Gambia).

  1. Co-supervisor for three Wellcome Trust Clinical PhD Training Fellows in Global Health (Dr. Edwin Armitage, Dr. Alex Keeley, Dr Ed Monk) who are using the platform of a household and school transmission studies to explore transmission and natural immunity to S. pyogenes.
  2. Co-lead at the MRC Gambia in a global network of scientists seeking to define correlates of immune protection in natural infection with Streptococcus pyogenes (iSpy Network, 2023 - 2027).
  3. Lead for immunology studies across UoS and MRC Gambia in a Wellcome Trust funded S. pyogenes human challenge study to establish correlates of protection (2025 – 2027).