Dr Thomas Darton
DTM&H MRCP(UK)(Infectious Diseases) FRCPath
School of Medicine and Population Health
Florey Advanced Clinical Fellow
Honorary Consultant in Infectious Diseases
+44 114 215 9507
Full contact details
School of Medicine and Population Health
LU109
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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For enquiries, please contact – SMPH-West-Operational@sheffield.ac.uk
I graduated from Nottingham in 2002 and completed general medical training in Sheffield. During an Academic Clinical Fellowship in Sheffield I became interested in the host-pathogen interactions occurring during invasive bacterial infection with Streptococcus pneumoniae and Neisseria meningitidis.
Between 2010 and 2014 I worked on the development of human challenge models of enteric fever (Salmonella Typhi and S. Paratyphi A) at the Oxford Vaccine Group (Oxford) and explored how these models relate to natural infection and how they might accelerate vaccine and diagnostic development. This work led to further studies of diagnostics, disease burden and vaccine implementation in endemic regions.
Antimicrobial resistance (AMR) is a major threat to global health and, for human-restricted pathogens such as S. Typhi, prevention by vaccination is a vital control strategy. After completion of specialist training and a Clinical Lectureship placement at the Oxford Clinical Research Unit in Ho Chi Minh City, Vietnam, I joined the Florey Institute for Host-Pathogen Interactions and the School of Medicine & Population Health in 2018 as a Florey Advanced Fellow.
- Research interests
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Investigating the drivers of antimicrobial resistance in lower- and middle-income country settings.
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Understanding the role and developing vaccines and diagnostics for enteric fever and other causes of non-specific febrile illness in low-resource settings.
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The ethical use of human challenge studies to advance the discovery and translation of tools for patient benefit.
Current Projects
- Investigating the effects of environmental exposure to fluoroquinolone-resistant Enterobacteriaceae on the gastrointestinal microbiota of children in Vietnam (AMS CLSG 2016–2018).
- STRATAA: Understanding the burden of enteric fever in Africa and Asia: a study of transmission and antibiotic resistance to improve diagnostics and inform vaccine strategies (Wellcome Trust Strategic Award 2015–2019).
- Identification of serological diagnostic markers for typhoid fever by protein microarray (BMFG 2015–2017)
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- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . The Lancet, 397(10269), 99-111.
- . EMBO Molecular Medicine, 11(10), ---.
- . Clinical Infectious Diseases, 68(8), 1265-1273.
- . mBio, 9(3), ---.
- . Frontiers in Immunology, 8.
- . Frontiers in Microbiology, 8.
- . Clinical Infectious Diseases, 64(11), 1522-1531.
- . BMJ Open, 7(6).
- . PLoS Neglected Tropical Diseases, 10(8).
- . The Journal of Experimental Medicine, 213(6), 1061-1077.
- . PLoS Neglected Tropical Diseases, 9(9).
- . Lancet Infectious Diseases, 15(7), 840-851.
- . Clinical Infectious Diseases, 58(9), 1230-1240.
- . Clinical Infectious Diseases, 48(5), 587-594.
- Epidemiology and control of tuberculosis in Western European cities. International Journal of Tuberculosis and Lung Disease, 7(8), 751-757.
All publications
Journal articles
- . PLOS Neglected Tropical Diseases, 19(10).
- . Journal of Infection.
- . The Lancet Infectious Diseases.
- . Journal of Infection, 91(3).
- . Microbiome, 13.
- . Vaccine, 62.
- . The Lancet Infectious Diseases.
- . Genome Medicine, 17.
- . PLOS Global Public Health, 5(4).
- . Journal of Infection, 90(4).
- . eClinicalMedicine, 81.
- . The Journal of Infectious Diseases, 231(1), e28-e37.
- . Microbial Genomics, 10(12).
- . Scientific Reports, 14(1).
- . Frontiers in Immunology, 15.
- . Frontiers in Immunology, 15.
- . The Lancet Microbe, 5(11).
- . The Lancet Microbe, 5(8).
- . The Lancet Microbe, 5(3), e226-e234.
- . Nature Communications, 15.
- . Journal of Infection, 88(3).
- . The Lancet Child & Adolescent Health, 8(3), 190-200.
- . Clinical Infection in Practice, 20(Supplement 1).
- . Clinical Infection in Practice, 20(Supplement 1).
- . International Journal of Molecular Sciences, 24(22).
- . Immunotherapy Advances, 3(1).
- . The Lancet Diabetes & Endocrinology, 11(12), 905-914.
- . Frontiers in Cellular and Infection Microbiology, 13.
- . Wellcome Open Research, 8.
- . Infection and Immunity, 19(10).
- . The Lancet Global Health, 11(9), E1422-E1431.
- . Communications Biology, 6(1).
- . BMC Infectious Diseases, 23(1).
- . The Lancet Infectious Diseases, 23(9), 1007-1019.
- . The Lancet, 401(10387), 1499-1507.
- . Journal of Infection, 86(6), 574-583.
- . Wellcome Open Research, 8.
- . Nature Medicine, 29(1), 147-157.
- . Cochrane Database of Systematic Reviews, 2022(11).
- . PLoS ONE, 17(11).
- . The Lancet Infectious Diseases, 22(12), 1703-1715.
- . PLOS Global Public Health, 2(9).
- . The Lancet, 400(10349), 359-368.
- . Cellular Immunology, 378.
- . Wellcome Open Research, 6.
- . Journal of Hospital Infection, 126, 21-28.
- . Wellcome Open Research, 6.
- . Infection and Immunity, 90(4).
- . The Lancet, 399(10325), 665-676.
- . The Lancet, 399(10320), 143-151.
- . The Lancet, 399(10319), 36-49.
- . BMJ Open, 8.
- . Journal of Infectious Diseases, 224((Supplement_7)), S759-S763.
- . The Lancet Global Health, 9(12), e1688-e1696.
- . Wellcome Open Research, 6.
- . Science Translational Medicine, 13(620).
- . Wellcome Open Research, 6.
- . The Lancet, 398(10304), 981-990.
- . Vaccine, 39(34), 4778-4783.
- . The Lancet, 397(10289), 2049-2059.
- . The American Journal of Bioethics, 21(5), W8-W11.
- . The Lancet, 397(10285), 1637-1645.
- . The Lancet, 397(10282), 1351-1362.
- . The American Journal of Tropical Medicine and Hygiene, 104(5), 1755-1757.
- . The Lancet, 397(10277), 881-891.
- . Clinical Infectious Diseases, 72(4), 710-715.
- . The American Journal of Bioethics, 21(3), 11-31.
- . Lancet, 397(10274), 605-612.
- . The Lancet, 397(10269), 99-111.
- . BMJ, 371.
- . The Lancet, 396(10267), 1979-1993.
- . PLOS Neglected Tropical Diseases, 14(10).
- . Wellcome Open Research, 5.
- . Bioethics, 34(8), 764-770.
- . Clinical & Translational Immunology, 9(9).
- . Wellcome Open Research, 5.
- . Clinical Infectious Diseases, 71(Supplement_2), S64-S70.
- . Science, 369(6500), 151-151.
- . Science, 368(6493), 832-834.
- . Frontiers in Cellular and Infection Microbiology, 9.
- . Wellcome Open Research, 4.
- . EMBO Molecular Medicine, 11(10), ---.
- . Clinical Infectious Diseases, 68(8), 1265-1273.
- . Frontiers in Medicine, 5.
- . mBio, 9(3), ---.
- . Antimicrobial Agents and Chemotherapy, 62(4).
- . Frontiers in Immunology, 8.
- . Transactions of The Royal Society of Tropical Medicine and Hygiene, 111(9), 418-424.
- . PLoS Neglected Tropical Diseases , 11(11).
- . Frontiers in Microbiology, 8.
- . Frontiers in Immunology, 8.
- . Frontiers in Microbiology, 8.
- . Vaccine, 35(38), 5081-5088.
- . Clinical Infectious Diseases, 64(11), 1522-1531.
- . BMJ Open, 7(6).
- . Journal of Infection, 75(2), 104-114.
- . Clinical Infectious Diseases, 64(8), 1066-1073.
- . BMC Infectious Diseases, 17.
- . Frontiers in Immunology, 8.
- . Frontiers in Immunology, 8.
- . Journal of Infection.
- . PLoS Neglected Tropical Diseases, 10(8).
- . PLoS Negl Trop Dis, 10(8), e0004888-e0004888.
- . PLOS Neglected Tropical Diseases, 10(6), e0004766-e0004766.
- . The Journal of Experimental Medicine, 213(6), 1061-1077.
- . PLoS ONE, 11(3).
- . Journal of Translational Medicine, 14(1).
- . Journal of Infection, 71(6), 689-689.
- . Clinical Infectious Diseases, 61(4), S266-S271.
- . PLoS Neglected Tropical Diseases, 9(9).
- . Lancet Infectious Diseases, 15(7), 840-851.
- . BMJ Open, 5.
- . PLoS Neglected Tropical Diseases, 9(6).
- . PLoS Pathogens, 11(5).
- . Clinical Microbiology and Infection, 20(12), 1337-1342.
- . Frontiers in Microbiology, 5.
- . Immunology, 143(3), 438-446.
- . Clinical Infectious Diseases, 59(8), 1198-1199.
- . Clinical Infectious Diseases, 58(9), 1230-1240.
- . Journal of Infection, 68(5), 405-418.
- . Current Opinion in Gastroenterology, 30(1), 7-17.
- . Journal of Infection, 68, S38-S50.
- . Clinical Epidemiology, 5, 465-473.
- . Vaccine, 31(25), 2744-2748.
- . Surgery (Oxford), 31(4), 187-192.
- . International Journal of Infectious Diseases, 16, e244-e244.
- . International Journal of Infectious Diseases, 16, e224-e224.
- . International Journal of Infectious Diseases, 16, e215-e215.
- . Journal of Infection, 63(6), 496-497.
- . Clinical Infectious Diseases, 53(5), 463-467.
- . Clinical Infectious Diseases, 52(9), 1133-1136.
- . European Journal of Clinical Microbiology & Infectious Diseases, 29(3), 347-349.
- . Surgery (Oxford), 28(2), 95-100.
- . Journal of Infection, 59(5), 371-372.
- . Clinical Infectious Diseases, 48(5), 587-594.
- . Journal of Infection, 58(2), 172-173.
- . Critical Care, 12(Suppl 5), P25-P25.
- . Critical Care, 12(Suppl 5), P24-P24.
- . European Journal of Internal Medicine, 14, S151-S152.
- Epidemiology and control of tuberculosis in Western European cities. International Journal of Tuberculosis and Lung Disease, 7(8), 751-757.
- . International Journal of Clinical Practice, 59(5), 605-611.
Book chapters
- , Salmonella - Distribution, Adaptation, Control Measures and Molecular Technologies InTech
Preprints
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Wellcome Open Res.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Center for Open Science.
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- Teaching interests
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I teach on the Diploma of Tropical Medicine and Hygiene (DTM&H) in Sheffield, the in Nepal and Masters courses in molecular medicine and vaccinology. I am also involved in undergraduate and postgraduate teaching, demonstrating and supervision at the Medical School.
- Professional activities and memberships
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- Member of the British HIV Association, British Infection Association, and the British Global and Travel Health Association.
- Member of the
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