Professor Steven Sourbron
School of Medicine and Population Health
Professor in Medical Imaging Physics
  
  +44 114 215 9155
Full contact details
School of Medicine and Population Health
Polaris
18 Claremont Crescent
Sheffield
S10 2TA
- Profile
 - 
    
For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
I am a medical physicist with expertise in quantitative Magnetic Resonance Imaging (MRI). Since November 2019, I am Professor in Medical Imaging in the University of Sheffield. Prior to that I was Lecturer in Magnetic Resonance Imaging in the University of Leeds (2010-2019) and post-doctoral researcher in the Radiology department of the Ludwig-Maximilian University Munich (2005-2010). I obtained a PhD in the radiology department of the Vrije Universiteit Brussel in 2005, and Bachelor and Master degree also at the Vrije Universiteit Brussel in 1999.
 
- Research interests
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My main research interest is in the development of quantitative imaging biomarkers (QIBs) and applications thereof in clinical studies, drug development and basic research. QIBs are measurements extracted from medical images that can be used as indicators of normal biological processes, disease progression or treatment response. Unlike other sources of biomarkers such as biological fluids (blood, urine, …), QIBs can track these processes in-vivo and in-situ, which can significantly impact on future clinical practice.
QIB development in MRI is a highly interdisciplinary area and sits on the interface between (bio)physics, engineering, computation, biology and medicine. An example of current work is the development and validation of QIBs that measure liver function, and using these to identify patients that are likely to suffer from toxic side effects of drugs . Another application is in predicting which patients can tolerate surgery for liver cancer, which may in future allow us to offer this life-saving treatment to more patients (HEPARIM project).
We are also very active in Chronic Kidney Disease, where we are looking at larger panels of QIBs to identify patients that are at risk of progression and therefore are in need of more aggressive management . Beyond liver and kidney, we are working on other application areas such as predicting outcomes of mechanical thrombectomy in acute stroke, studying mechanisms neurodegenerative disease progression in the spinal cord, or evaluating the effect of cancer treatment on the heart. QIBs promise to become essential tools in future medical practice just as blood- and urine tests today.
Realising this potential however is an enormous undertaking that requires a highly interdisciplinary and coordinated approach to research. I am therefore increasingly active in national and international networks aiming to improve reproducibility of research and societal impact. An example is the EU-wide networking project , the open-source project , and the UK-wide partnership project of the UK Renal Imaging Network (UKRIN-MAPS).
Sheffield medical imaging research strands:
- Abdominal imaging (lead)
 - Imaging biomarkers (lead)
 - Cardiovascular imaging (member)
 
Current projects:
- 10/2020 - 10/2024. . NIHR - Efficacy and Mechanism Evaluation Programme. Role: CoI and lead of the central image processing facility.
 - 09/2020-09/2027. PET-MRI of the spinal cord for translational neuroscience applications. Medical Research Council – General Electric iCASE studentship. DiMeN Doctoral Training Programme. Role: Lead supervisor.
 - 09/2019 – 09/2022. . EPSRC-CASE PhD studentship co-funded by Bayer AG. Role: supervisor.
 - 09/2018 – 09/2021. , Medical Research Council, Partnership Grant. Role: CoI and lead of the work package on image processing and quality assurance.
 - 01/2018 - 01/2021. (HEPARIM study), Medical Research Council. Role: PI
 - 04/2017 – 04/2021. .COST – European Cooperation in Science and Technology. Role: Primary proposer and chair.
 - 01/2017 - 01/2022. . Innovative Medicines Initiative. Role: lead of clinical MRI development.
 - 09/2016 – 09/2021. . Medicines Initiative. Role: work package lead.
 - 01/2019 – 01/2022. Targeting β-cell failure in lean patients with type 2 diabetes; Diabetes UK, CoI (Eylem Levelt, Sven Plein, Steven Sourbron, Ramzi Ajjan, Mark Kearney, Richard Cubbon). Role: CoI.
 - 06/2017 – 06/2020. ; EPSRC. Role: CoI.
 - 01/2017 – 01/2021. ,FRINATEK – Norwegian Research Council. Role: CoI.
 
 
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . BMC Nephrol, 21(1), 242.
 - . Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 131-140.
 - . Alzheimer's & Dementia, 15(6), 840-858.
 - . Nephrology Dialysis Transplantation, 33(Suppl 2), ii4-ii14.
 
Book chapters
- , Methods in Pharmacology and Toxicology (pp. 627-651). Springer New York
 
All publications
Journal articles
- . Frontiers in Nuclear Medicine, 5.
 - . Journal of Hepatology, 82, S97-S97.
 - . Heart.
 - . Magnetic Resonance Materials in Physics, Biology and Medicine, 38(5), 791-802.
 - . Journal of the American Society of Nephrology, 35(10S).
 - . Magnetic Resonance Materials in Physics, Biology and Medicine, 37(4), 697-708.
 - . Annals of Biomedical Engineering, 52(11), 3098-3112.
 - . Physics in Medicine & Biology, 69(11).
 - . Nephrology Dialysis Transplantation, 39(Supplement_1).
 - . Journal of Magnetic Resonance Imaging, 60(5), 2144-2155.
 - . Magnetic Resonance Materials in Physics, Biology and Medicine, 37(4), 565-582.
 - . Magnetic Resonance in Medicine, 91(5), 1761-1773.
 - . Magnetic Resonance in Medicine, 91(5), 1774-1786.
 - . Magnetic Resonance in Medicine, 91(5), 1740-1742.
 - . Magnetic Resonance in Medicine.
 - . Journal of the American Society of Nephrology, 34(11S), 852-852.
 - . Nephrology Dialysis Transplantation, 38(Supplement_1).
 - . iScience, 26(5), 106686-106686.
 - . Pharmaceutics, 15(3).
 - . Circulation, 146(4), 364-367.
 - . Journal of Magnetic Resonance Imaging, 56(4), 1042-1052.
 - . Journal of Magnetic Resonance Imaging, 55(4), 1241-1250.
 - . European Radiology, 32(1), 34-45.
 - . Journal of Magnetic Resonance Imaging, 55(2), 323-335.
 - . Magnetic Resonance Materials in Physics, Biology and Medicine, 34, 805-822.
 - . BMC Cancer, 21(1).
 - . Journal of the American Society of Nephrology, 32(10S), B12-B12.
 - . EJNMMI Physics, 8.
 - . Molecular Pharmaceutics, 18(8), 2997-3009.
 - . Methods Mol Biol(2216), 3-23.
 - . NMR in Biomedicine, 34(1).
 - . Circulation, 143(6), 516-525.
 - . Journal of Nuclear Cardiology, 28(5), 1875-1886.
 - . European Journal of Heart Failure, 22(7), 1276-1277.
 - . BMC Nephrol, 21(1), 242.
 - . Insights into Imaging, 11(1).
 - . Nephrology Dialysis Transplantation, 35(6), 915-919.
 - . Quantitative Imaging in Medicine and Surgery, 10(6), 1298-1306.
 - . RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 192(S 01), S91-S91.
 - . IEEE Transactions on Radiation and Plasma Medical Sciences, 4(4), 422-432.
 - . Journal of the American College of Cardiology, 75(11), 1672-1672.
 - . Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 1-2.
 - . Insights into Imaging, 10(1).
 - . Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 197-198.
 - .
 - . Drug Metabolism and Pharmacokinetics, 35(1), S96-S96.
 - . Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 141-161.
 - . Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 199-215.
 - . MAGMA, 33(1), 163-176.
 - . Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 177-195.
 - . Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 131-140.
 - . Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 11, 191-204.
 - . Alzheimer's & Dementia, 15(6), 840-858.
 - . Magnetic Resonance Imaging, 59, 121-129.
 - . Magnetic Resonance Imaging, 59, 53-60.
 - . European Journal of Radiology, 117, 209-215.
 - . Nephrology Dialysis Transplantation, 33(Suppl 2), ii4-ii14.
 - . Journal of the Belgian Society of Radiology, 102(1).
 - . Investigative Radiology, 52(3), 135-141.
 - . Acta Radiologica, 58(6), 748-757.
 - . Magnetic Resonance in Medicine, 77(6), 2414-2423.
 - . Journal of Magnetic Resonance Imaging, 45(4), 1177-1185.
 - . Journal of Cardiovascular Magnetic Resonance, 18(1), 37-37.
 - . HPB, 18, e697-e697.
 - . BMC Medical Imaging, 16(1).
 - . Magnetic Resonance in Medicine, 76(3), 998-1006.
 - . Journal of Magnetic Resonance Imaging, 43(3), 566-573.
 - . Investigative Radiology, 50(9), 584-593.
 - . Journal of Computer Assisted Tomography, 39(5), 643-648.
 - . Clinical, A78-A79.
 - . Heart, 101(Suppl 4), A48.2-A49.
 - . Radiology, 275(2), 393-402.
 - . BMC Cancer, 15.
 - . Journal of Cardiovascular Magnetic Resonance, 17(1).
 - . Magnetic Resonance in Medicine, 73(1), 244-253.
 - . Magnetic Resonance in Medicine, 72(3), 902-902.
 - . Heart, 100(Suppl 3), A60.3-A61.
 - . Journal of Cardiovascular Magnetic Resonance, 16, 19.
 - . IEEE Transactions on Medical Imaging, 33(4), 935-946.
 - . Journal of Cardiovascular Magnetic Resonance, 16, O34-O34.
 - . Journal of Cardiovascular Magnetic Resonance, 16, P178-P178.
 - . Journal of Cardiovascular Magnetic Resonance, 16, P335-P335.
 - . Journal of Cardiovascular Magnetic Resonance, 16, P12-P12.
 - . Journal of Cardiovascular Magnetic Resonance, 16, P209-P209.
 - . Investigative Radiology, 49(1), 7-14.
 - . Journal of Magnetic Resonance Imaging, 40(2), 457-466.
 - . European Radiology, 24(1), 112-119.
 - . Journal of Magnetic Resonance Imaging, 38(6), 1554-1563.
 - . American Journal of Physiology-Renal Physiology, 305(5), F672-F678.
 - . The International Journal of Cardiovascular Imaging, 29(7), 1527-1536.
 - . American Journal of Roentgenology, 200(6), W635-W643.
 - . Academic Radiology, 20(6), 685-693.
 - . Heart, 99(suppl 2), A55-A56.
 - . Heart, 99(suppl 2), A56.2-A57.
 - . NMR in Biomedicine, 26(8), 1004-1027.
 - . Clinical Radiology, 68(9), 887-894.
 - . Journal of Pharmacokinetics and Pharmacodynamics, 40(3), 281-300.
 - . Magnetic Resonance in Medicine, 70(6), 1591-1597.
 - . Journal of Cardiovascular Magnetic Resonance, 15, P205-P205.
 - . Journal of Cardiovascular Magnetic Resonance, 15, P206-P206.
 - . Journal of Cardiovascular Magnetic Resonance, 15, P195-P195.
 - . Journal of Cardiovascular Magnetic Resonance, 15, P214-P214.
 - Regional variation in myocardial blood flow in patients with left bundle branch block evaluated with quantitative perfusion CMR. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 15(Suppl 1), P205-P205.
 - Associated factors for a false negative cardiovascular magnetic resonance perfusion study: a CE-MARC substudy. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 15(Suppl 1), P214-P214.
 - Quantitative whole-heart three-dimensional magnetic resonance myocardial perfusion imaging in systole and diastole at 3.0T. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 15(Suppl 1), P206-P206.
 - . Investigative Radiology, 48(2), 92-97.
 - . Journal of Magnetic Resonance Imaging, 37(5), 1109-1114.
 - . Journal of Digital Imaging, 26(2), 344-352.
 - . Magnetic Resonance in Medicine, 69(5), 1430-1437.
 - . Radiology, 263(3), 874-883.
 - . Physics in Medicine and Biology, 57(11), 3609-3628.
 - . RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 184(S 01).
 - . RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 184(S 01).
 - . Journal of Cardiovascular Magnetic Resonance, 14(S1).
 - . American Journal of Roentgenology, 198(2), 384-391.
 - . Investigative Radiology, 47(6), 332-338.
 - . Investigative Radiology, 47(4), 252-258.
 - . Physics in Medicine and Biology, 57(2), R1-R33.
 - . European Radiology, 22(1), 73-82.
 - . Journal of Neuroradiology, 39(4), 227-235.
 - . Abdominal Imaging, 37(2), 164-179.
 - . RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 183(12).
 - . Journal of Magnetic Resonance Imaging, 34(3), 595-607.
 - . RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 183(S 01).
 - . RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 183(S 01).
 - . RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 183(S 01).
 - . RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 183(S 01).
 - . RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 183(S 01).
 - . Magnetic Resonance in Medicine, 66(3), 735-745.
 - . European Journal of Radiology, 77(3), 528-528.
 - . Journal of Magnetic Resonance Imaging, 33(3), 676-683.
 - . Journal of Cardiovascular Magnetic Resonance, 13(S1).
 - . Journal of Cardiovascular Magnetic Resonance, 13(S1).
 - . Journal of Biomedical Science and Engineering, 04(04), 315-319.
 - . Investigative Radiology, 46(9), 594-599.
 - . Magnetic Resonance in Medicine, 65(5), 1491-1497.
 - . Interface Focus, 1(1), 101-116.
 - . European Journal of Radiology, 77(2), 312-318.
 - . Acta Radiologica, 51(10), 1163-1171.
 - . Physics in Medicine and Biology, 55(21), 6431-6443.
 - . Investigative Radiology, 45(7), 387-392.
 - . European Journal of Radiology, 76(3), 298-303.
 - . European Journal of Radiology, 76(3), 337-347.
 - . Magnetic Resonance in Medicine, 64(1), 115-124.
 - . RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 182(S 01).
 - . RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 182(S 01).
 - . RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 182(S 01).
 - . European Journal of Radiology, 76(3), 323-328.
 - . European Journal of Radiology, 76(3), 304-313.
 - . Academic Radiology, 17(4), 441-449.
 - . Journal of Magnetic Resonance Imaging, 31(3), 556-561.
 - . Magnetic Resonance in Medicine, 63(3), 691-700.
 - . Journal of Magnetic Resonance Imaging, 31(2), 490-501.
 - . Investigative Radiology, 45(1), 7-14.
 - Determination of glomerular filtration rate using dynamic CT-angiography: simultaneous acquisition of morphological and functional information (vol 45, pg 387, 2010). INVESTIGATIVE RADIOLOGY, 45(8), 506-506.
 - . Journal of Magnetic Resonance Imaging, 31(1), 125-133.
 - . Zeitschrift für Medizinische Physik, 20(2), 101-114.
 - . European Journal of Cancer Supplements, 7(3), 18-18.
 - . Magnetic Resonance in Medicine, 62(3), 672-681.
 - . Magnetic Resonance in Medicine, 62(1), 205-217.
 - . RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 181(S 01).
 - . RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 181(S 01).
 - . Journal of Cardiovascular Magnetic Resonance, 11(S1).
 - . Journal of Cardiovascular Magnetic Resonance, 11(S1).
 - . Journal of Magnetic Resonance Imaging, 29(2), 398-403.
 - . RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 181(01).
 - Perfusion MRI for monitoring therapy effects in experimental chronic limb ischemia. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 11(Suppl 1).
 - Differences in MR perfusion of malignant and benign cardiac tumors. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 11(Suppl 1).
 - . European Journal of Radiology, 69(3), 542-549.
 - . Radiology, 249(2), 471-482.
 - . European Radiology, 18(6), 1260-1268.
 - . RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 180(S 1).
 - . RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 180(S 1).
 - . RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 180(S 1).
 - . RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 180(S 1).
 - . Investigative Radiology, 43(12), 877-892.
 - . Investigative Radiology, 43(2), 120-128.
 - . Investigative Radiology, 43(1), 40-48.
 - . European Journal of Radiology, 65(1), 59-65.
 - . Nieren- und Hochdruckkrankheiten, 36(12), 589-599.
 - . Physics in Medicine and Biology, 52(22), 6761-6778.
 - . Journal of Magnetic Resonance Imaging, 25(6), 1159-1167.
 - . Topics in Magnetic Resonance Imaging, 18(2), 117-125.
 - . Physics in Medicine and Biology, 52(2), 429-447.
 - . Abdominal Imaging, 32(6), 758-771.
 - . Magnetic Resonance in Medicine, 54(4), 841-849.
 - ABSTRACTS : Scientific posters. Cancer imaging : the official publication of the International Cancer Imaging Society, 5(Spec No A), S157-S172.
 - . Physics in Medicine and Biology, 49(14), 3307-3324.
 - . Magnetic Resonance in Medicine, 52(1), 209-213.
 - . Magnetic Resonance Imaging, 20(4), 327-336.
 - . European Journal of Radiology, 38(1), 19-27.
 - . Foundations of Physics Letters, 13(4), 357-367.
 - . Magnetic Resonance in Medicine.
 - . Diagnostics, 8(1), 3-3.
 - . Cancer Imaging, 13(4), 557-566.
 - . Cancer Imaging, 5(Spec No A), s157-s172.
 
Book chapters
- , Advances in Magnetic Resonance Technology and Applications (pp. liii-lxxxvi). Elsevier
 - , Methods in Pharmacology and Toxicology (pp. 627-651). Springer New York
 - , Deutsche Gesellschaft für Chirurgie (pp. 109-111). Springer Berlin Heidelberg
 - , Clinical MR Neuroimaging (pp. 113-128). Cambridge University Press
 
Conference proceedings
- Gadoxetate-enhanced MRI detects acute rifampicin-induced inhibition of hepatocellular transporter function in rats and normalization of function after chronic dosing. JOURNAL OF HEPATOLOGY, Vol. 82
 - Cardiac autonomic neuropathy: an independent risk factor for renal decline in diabetic kidney disease. DIABETOLOGIA, Vol. 67 (pp S425-S426)
 - Cardiac autonomic neuropathy: an independent risk factor for renal decline in diabetic kidney disease. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 39 (pp I1742-I1743)
 - . 2023 IEEE Nuclear Science Symposium, Medical Imaging Conference and International Symposium on Room-Temperature Semiconductor Detectors (NSS MIC RTSD) (pp 1-1), 4 November 2023 - 11 November 2023.
 - Cardiac autonomic neuropathy and progressive renal decline in patients with type 1 diabetes: A 15-year follow up study. DIABETIC MEDICINE, Vol. 40
 - PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODELLING OF TRANSPORTER-MEDIATED HEPATIC DISPOSITION USING THE IMAGING BIOMARKER GADOXETATE. DRUG METABOLISM AND PHARMACOKINETICS, Vol. 35(1) (pp S96-S96)
 - . Heart, Vol. 101(Suppl 2) (pp A12.1-A12)
 - . Abstracts (pp A12.2-A13)
 - . Heart, Vol. 99(suppl 2) (pp A60.2-A61)
 - . Heart, Vol. 99(suppl 2) (pp A59-A60)
 - (pp 356-358)
 - . SPIE Proceedings, Vol. 6914 (pp 691432-691432)
 - . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
 - . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
 - . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
 - . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
 - . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
 - . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
 - . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
 - . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
 - . ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
 - . ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
 - . ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
 - . ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
 - . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
 - . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
 - . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
 - . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
 
Preprints
- , Cold Spring Harbor Laboratory.
 
 
- Research group
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Post-doctoral fellows
- Kanishka Sharma (BEAt-DKD)
 - Susmita Basak (HEPARIM)
 
Software engineers
- Joao de Souza (UKRIN-MAPS)
 - Steve Shillitoe (TRISTAN)
 
PhD/MD students
- Eve Shalom (CFD in liver)
 - Eve Lennie (spinal cord PET/MRI)
 - Bashair al-Hummiany (CKD biomarkers)
 - Fotis Tagkalakis (Motion correction)
 - Mohamed El-Sharif (HEPARIM)
 - Meaad Almusined (mechanical thrombectomy)
 
 
- Professional activities and memberships
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- Chair of the Open Source Initiative on Perfusion Imaging
 - Chair of the COST Action CA16103 (PARENCHIMA) on Renal MRI Biomarkers
 - Chair of the ISMRM perfusion study group
 - Chair designate of the ISMRM annual meeting program committee
 
 
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