Dr Steven Reynolds

School of Medicine and Population Health

Preclinical MRI Facility Manager

Dr Steven Reynolds
Profile picture of Dr Steven Reynolds
Steven.Reynolds@sheffield.ac.uk
+44 114 215 9596
+44 114 271 1714 (Fax)
Polaris

Full contact details

Dr Steven Reynolds
School of Medicine and Population Health
Polaris
18 Claremont Crescent
Sheffield
S10 2TA
Profile

For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk

In 2009, I joined the University of Sheffield as a Senior Research fellow on a CRUK funded programme grant. Here I set up the lab to study cancer metabolism by Hyperpolarised Magnetic Resonance Imaging and Spectroscopy (MRI/S). Previously, I held positions in industry both as part of GE Healthcare (2001-2006), developing scientific instruments, and Oxford Instruments (2006 – 2009), where I led the MRS facility and was responsible for project delivery using the HyperSense hyperpolarisation instrument. It was from these roles that I developed an interest in hyperpolarised magnetic resonance experiments and metabolism.

I have a degree in chemistry from Aston University, where I also received my PhD. I have held research positions at the University of Surrey and the University of Cambridge. 

Research interests

My main research interest is in the use of (MRS) to study cellular metabolism and metabolomics. This is augmented by the use of hyperpolarisation technology that allows in vivo and in vitro cellular metabolism to be studied in real time.

The studies the metabolism of these unique cells to learn more about male factor infertility.  Sperm undergo a lot of changes before fertilising an egg. These changes require energy and our research examines how sperm metabolise at different stages of their journey through the female reproductive tract. We use MRS to track the conversion of substrates by different metabolic pathways to understand how sperm produce this energy. Alongside this, I have a longstanding collaboration with in studying the metabolic triggers of preterm birth. We examine how the bacteria present in the vagina can influence pregnancy outcomes. These bacteria produce metabolites that can be quantified by MRS and could be used to predict the likelihood of preterm birth.

I also manage the at the . Here I have a number of collaborations to develop the use of high resolution MRI, including live zebrafish imaging.

Publications

Show: Featured publications All publications

Journal articles

  • Amabebe E, Reynolds S, He X, Wood R, Stern V & Anumba DOC (2019) . PLOS ONE, 14(9).
  • Calvert SJ, Reynolds S, Paley MN, Walters SJ & Pacey AA (2019) . Molecular Human Reproduction, 25(1), 30-41.
  • Reynolds S, Metcalf S, Cochrane EJ, Collins RC, Jones S, Paley MNJ & Tozer GM (2017) . Magnetic Resonance in Medicine.
  • Reynolds S, Calvert SJ, Paley MN & Pacey AA (2017) . Molecular Human Reproduction, 23(7), 441-451.
  • Reynolds S, Ismail N, Calvert S, Pacey A & Paley M (2017) . Scientific Reports, 7(1).
  • Paley M, Reynolds S, Ismail N, Herigstad M, Jarvis D & Griffiths P (2017) . Technologies, 5(1).
  • Amabebe E, Reynolds S, Stern V, Stafford G, Paley M & Anumba DOC (2016) . Frontiers in Medicine, 3.
  • Amabebe E, Reynolds S, Stern VL, Parker JL, Stafford GP, Paley MN & Anumba DOC (2016) . Metabolomics, 12(4).
  • Bluff JE, Reynolds S, Metcalf S, Alizadeh T, Kazan SM, Bucur A, Wholey EG, Bibby BAS, Williams L, Paley MN & Tozer GM (2015) . Radiotherapy and Oncology, 116(3), 392-399.
  • Kailavasan M, Rehman I, Reynolds S, Bucur A, Tozer G & Paley M (2014) . NMR Biomed, 27(5), 610-616.
  • Reynolds S, Bucur A, Port M, Alizadeh T, Kazan SM, Tozer GM & Paley MNJ (2014) . J Magn Reson, 239(100), 1-8.
  • Kazan SM, Reynolds S, Kennerley A, Wholey E, Bluff JE, Berwick J, Cunningham VJ, Paley MN & Tozer GM (2013) . Magn Reson Med, 70(4), 943-953.
  • Jamin Y, Gabellieri C, Smyth L, Reynolds S, Robinson SP, Springer CJ, Leach MO, Payne GS & Eykyn TR (2009) . Magnetic Resonance in Medicine, 62(5), 1300-1304.
  • Reynolds S & Patel H (2008) . Applied Magnetic Resonance, 34(3-4), 495-508.
  • Gabellieri C, Reynolds S, Lavie A, Payne GS, Leach MO & Eykyn TR (2008) . Journal of the American Chemical Society, 130(14), 4598-4599.

All publications

Journal articles

  • Kontogiannis A, Hodgkinson R, Reynolds S & Manchester EL (2025) . Journal of Fluid Mechanics, 1011.
  • Hernández-Quiles M, Martinez Campesino L, Morris I, Ilyas Z, Reynolds S, Soon Tan N, Sobrevals Alcaraz P, Stigter ECA, Varga Á, Varga J , van Es R et al (2023) . Molecular Metabolism, 78.
  • Hamilton N, Allen C & Reynolds S (2023) . NMR in Biomedicine, 36(7).
  • Amabebe E, Bhatnagar N, Kamble N, Reynolds S & Anumba DO (2022) . Reproduction and Fertility, 3(3), L6-L8.
  • Reynolds S, Calvert SJ, Walters SJ, Paley MN & Pacey A (2022) . Reproduction and Fertility, 3(2), 77-89.
  • Marrone L, Marchi PM, Webster CP, Marroccella R, Coldicott I, Reynolds S, Alves-Cruzeiro J, Yang Z-L, Higginbottom A, Khundadze M , Shaw PJ et al (2022) . Human Molecular Genetics, 31(16), 2693-2710.
  • Reynolds S, Kazan SM, Anton A, Alizadeh T, Gunn RN, Paley MN, Tozer GM & Cunningham VJ (2022) . NMR in Biomedicine, 35(5).
  • Amabebe E, Reynolds S & Anumba DOC (2021) . Reproduction and Fertility, 2(4), L4-L6.
  • Amabebe E, Anumba DO & Reynolds S (2020) .
  • Amabebe E, Reynolds S, He X, Wood R, Stern V & Anumba DOC (2019) . PLOS ONE, 14(9).
  • Calvert SJ, Reynolds S, Paley MN, Walters SJ & Pacey AA (2019) . Molecular Human Reproduction, 25(1), 30-41.
  • Reynolds S, Metcalf S, Cochrane EJ, Collins RC, Jones S, Paley MNJ & Tozer GM (2017) . Magnetic Resonance in Medicine.
  • Stafford GP, Parker JL, Amabebe E, Kistler J, Reynolds S, Stern V, Paley M & Anumba DOC (2017) . Frontiers in Physiology, 8.
  • Reynolds S, Calvert SJ, Paley MN & Pacey AA (2017) . Molecular Human Reproduction, 23(7), 441-451.
  • Reynolds S, Ismail N, Calvert S, Pacey A & Paley M (2017) . Scientific Reports, 7(1).
  • Herigstad M, Granados-Aparici S, Pacey A, Paley M & Reynolds S (2017) .
  • Paley M, Reynolds S, Ismail N, Herigstad M, Jarvis D & Griffiths P (2017) . Technologies, 5(1).
  • Amabebe E, Reynolds S, Stern V, Stafford G, Paley M & Anumba DOC (2016) . Frontiers in Medicine, 3.
  • Amabebe E, Reynolds S, Stern VL, Parker JL, Stafford GP, Paley MN & Anumba DOC (2016) . Metabolomics, 12(4).
  • Bluff JE, Reynolds S, Metcalf S, Alizadeh T, Kazan SM, Bucur A, Wholey EG, Bibby BAS, Williams L, Paley MN & Tozer GM (2015) . Radiotherapy and Oncology, 116(3), 392-399.
  • Kailavasan M, Rehman I, Reynolds S, Bucur A, Tozer G & Paley M (2014) . NMR Biomed, 27(5), 610-616.
  • Reynolds S, Bucur A, Port M, Alizadeh T, Kazan SM, Tozer GM & Paley MNJ (2014) . J Magn Reson, 239(100), 1-8.
  • Kazan SM, Reynolds S, Kennerley A, Wholey E, Bluff JE, Berwick J, Cunningham VJ, Paley MN & Tozer GM (2013) . Magn Reson Med, 70(4), 943-953.
  • Reynolds S, Kazan SM, Bluff JE, Port M, Wholey E, Tozer GM & Paley M (2012) Fully MR-Compatible Syringe Pump for the Controllable Injection of Hyperpolarized Substrate in Animals. Applied Magnetic Resonance, 1-11.
  • Jamin Y, Gabellieri C, Smyth L, Reynolds S, Robinson SP, Springer CJ, Leach MO, Payne GS & Eykyn TR (2009) . Magnetic Resonance in Medicine, 62(5), 1300-1304.
  • Reynolds S & Patel H (2008) . Applied Magnetic Resonance, 34(3-4), 495-508.
  • Gabellieri C, Reynolds S, Lavie A, Payne GS, Leach MO & Eykyn TR (2008) . Journal of the American Chemical Society, 130(14), 4598-4599.
  • Fries M, Stott KM, Reynolds S & Perham RN (2007) . Journal of Molecular Biology, 366(1), 132-139.

Book chapters

  • Paley M, Kaka S, Hilliard H, Zaytsev A, Bucur A, Reynolds S, Liu W, Milne E & Cook G (2015) In Hassanien A & Azar A (Ed.), Brain-Computer Interfaces (pp. 185-213).

Conference proceedings

  • Amabebe E, Chaudhuri R, Reynolds S & Anumba DOC (2023) Metabolic Characteristics of Vaginal Dysbiosis Associated Bacteria: Mobiluncus curtisii and Lactobacillus iners. REPRODUCTIVE SCIENCES, Vol. 30 (pp 192A-192A)
  • May GR, Amabebe E, Anumba DO & Reynolds S (2021) Metabolic Profiling of Gardenerella vaginalis: A Vaginal Dysbiosis and Preterm Birth-Associated Bacteria.. REPRODUCTIVE SCIENCES, Vol. 28(SUPPL 1) (pp 215A-216A)
  • Amabebe E, Anumba D & Reynolds S (2021) Differential Vaginal Lactobacillus Species Metabolism of Glucose, L- and D-lactate by13C-Nuclear Magnetic Resonance Spectroscopy.. REPRODUCTIVE SCIENCES, Vol. 28(SUPPL 1) (pp 216A-216A)
  • Amabebe E, Anumba D & Reynolds S (2020) Differential Metabolic Profiles of Lactobacillus Species and Preterm Birth-associated Bacteria.. REPRODUCTIVE SCIENCES, Vol. 27(SUPPL 1) (pp 122A-122A)
  • Amabebe E, Reynolds S & Anumba DO (2019) Discriminative Capacity of 1H-MRS Spectrum Binning for Preterm Delivery-Associated Lactobacilli-Dominated Vaginal Microbiota.. REPRODUCTIVE SCIENCES, Vol. 26 (pp 212A-212A)
  • Amabebe E, Reynolds S, Stern V, Stafford G, Paley M & Anumba D (2017) Decreased cervicovaginal fluid glutamate improves the predictive value of acetate for risk of preterm delivery within two weeks of presentation with threatened preterm labour. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol. 124 (pp 127-127)
  • Parker J, Stafford GP, Stern V, Amabebe E, Reynolds S, Paley M & Anumba DOC (2016) Prognostic Microbiomial and Metabolite Markers of Preterm Birth in Second Trimester Cervicovaginal Fluid from Women at Risk.. REPRODUCTIVE SCIENCES, Vol. 23 (pp 128A-128A)
  • Stern V, Amabebe E, Reynolds S, Stafford G, Paley M & Anumba D (2016) The Association of Cervicovaginal Fluid Metabolites at 20-22 Weeks Gestation with Quantitative Fetal Fibronectin, Ultrasound Cervical Length and Gestational Age at Delivery in Asymptomatic Pregnant Women.. REPRODUCTIVE SCIENCES, Vol. 23 (pp 190A-191A)
  • Amabebe E, Stern V, Parker J, Reynolds S, Stafford G, Paley M & Anumba D (2015) Elucidating Potential Metabolite Markers of Preterm Birth in Cervicovaginal Secretions By Nuclear Magnetic Resonance Spectroscopy. REPRODUCTIVE SCIENCES, Vol. 22 (pp 130A-130A)

Preprints

  • Hamilton N, Allen C & Reynolds S (2022) , Cold Spring Harbor Laboratory.
Research group

PhD students

  • Evie Gruszyk
Teaching interests

I deliver the MRI component of the FRCR (Radiology) programme to the Medical school Undergraduate course. I also contribute to the Student Selected Components on Phase 1b (Research Methods). I supervise Master students on the Reproductive and Developmental medicine course. Outside of the Medical school I provide research experiences for the University’s scheme and .

Reproductive and Developmental Medicine MSc

Postgraduate taught
  • September 2026 start
  • 1 year Full-time

Explore the science behind reproductive and developmental processes and their clinical applications. Develop specialist knowledge as a scientist or clinician, or prepare for further training in IVF or embryology.

Professional activities and memberships
  • Member of the Royal Society of Chemistry.
  • Member of the Institute for Physics.

Links