Professor Spencer Collis
School of Medicine and Population Health
Professor of Genome Stability
+44 114 215 9043
Full contact details
School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
1994 - 1997
BSc (Hons): Biochemistry, UMIST1997 - 2000
PhD: Oncology, CRUK Paterson Institute for Cancer Research2001 - 2004
Post-Doc: Prof. Theodore DeWeese laboratory, Johns Hopkins University2004 - 2009
Post-Doc: Dr Simon Boulton laboratory, Clare Hall Laboratories, CRUK London Research Institute2009 - 2013
Group leader: Institute for Cancer Studies, University of Sheffield2013 - 2015
Senior Lecturer: Academic unit of Molecular Oncology, Department of Oncology, University of Sheffield2016 - 2024
Reader: Academic unit of Molecular Oncology, Department of Oncology, University of Sheffield2024 - present
Professor: Division of Clinical Medicine, University of SheffieldCurrent PhD Opportunities:
- Research interests
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The overarching research goals of the Collis laboratory is to identify and functionally characterise novel factors that are important for the maintenance of genome integrity in human cells. This research also aims to establish if such factors are novel drug targets and/or biomarkers that can be exploited to improve the treatment of diseases such as cancer, either alone, or in combination with existing chemo- and/or radio-therapeutic regimes. To achieve this, the Collis group collaborate with a range of national and international scientists and clinicians to maximise the potential therapeutic impact of their basic biological discoveries.
Funding Sources
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . JBMR Plus, 9(10).
- . Cell Reports, 44(3), 115361-115361.
- . Cell Death & Disease, 15(12).
- . F1000Research, 13.
- . Cancers, 16(5).
- . F1000research, 12.
- . British Journal of Cancer, 129(11), 1829-1840.
- . Expert Reviews in Molecular Medicine, 24.
- . Molecular Oncology, 16(1), 11-41.
- . Cancers, 13(5).
- . Br J Cancer, 124(4), 697-709.
- . Sci Adv, 6(28), eaba5974.
- . Cancers (Basel), 11(3).
- . Oncotarget, 9(50), 29508-29524.
- . Sci Rep, 6, 35548.
- . Nucleic Acids Res, 44(18), 8772-8785.
- . Cell Rep, 16(10), 2565-2575.
- . Cilia, 5, 19.
- . Cell Cycle, 13(21), 3450-3459.
- . Oncotarget, 5(15), 6414-6424.
- . J Cell Sci, 127(Pt 13), 2910-2919.
- . J Cell Sci, 125(Pt 20), 4770-4779.
All publications
Journal articles
- . Neuro-Oncology, 27(Supplement_3), iii130-iii130.
- . Neuro-Oncology, 27(Supplement_2), ii29-ii29.
- . JBMR Plus, 9(10).
- . Cell Reports, 44(3), 115361-115361.
- . Neuro-Oncology Practice, 12(4), 585-599.
- . Cell Death & Disease, 15(12).
- . Neuro-Oncology, 26(Supplement_8), viii118-viii118.
- . Neuro-Oncology, 26(Supplement_8), viii117-viii118.
- . F1000Research, 13.
- . Cancers, 16(5).
- . Neuro-Oncology, 26(4), 625-639.
- . F1000research, 12.
- . British Journal of Cancer, 129(11), 1829-1840.
- . Neuro-Oncology, 25(Supplement_3), iii14-iii14.
- . Nanotheranostics, 7(1), 102-116.
- . Neuro-Oncology, 24(Supplement_7), vii31-vii31.
- . Neuro-Oncology, 24(Supplement_7), vii93-vii93.
- . Expert Reviews in Molecular Medicine, 24.
- . Molecular Oncology, 16(1), 11-41.
- . BRITISH JOURNAL OF CANCER, 125(4), 623-623.
- . British Journal of Surgery, 108(Supplement_1).
- . Cancers, 13(5).
- . Br J Cancer, 124(4), 697-709.
- . Sci Adv, 6(28), eaba5974.
- . J Cell Sci, 133(9).
- . Neuro-Oncology, 21(Supplement_6), vi209-vi209.
- . Neuro-Oncology, 21(Supplement_6), vi271-vi271.
- . Cancers (Basel), 11(3).
- NOVEL DRUG TARGETS TO AUGMENT TEMOZOLOMIDE SENSITIVITY IN HIGH-GRADE BRAIN TUMOURS. NEURO-ONCOLOGY, 20, 346-346.
- . Neuro-Oncology, 20(suppl_3), iii297-iii297.
- . Oncotarget, 9(50), 29508-29524.
- . Sci Rep, 6, 35548.
- . Nucleic Acids Res, 44(18), 8772-8785.
- . Cell Rep, 16(10), 2565-2575.
- . Cilia, 5, 19.
- . Neuro-Oncology, 17(suppl 8), viii20.1-viii20.
- . Cell Cycle, 13(21), 3450-3459.
- . Oncotarget, 5(15), 6414-6424.
- . J Cell Sci, 127(Pt 13), 2910-2919.
- . Development, 140(2), e207-e207.
- . J Cell Sci, 125(Pt 20), 4770-4779.
- . Mol Cell, 39(6), 839-850.
- . Mol Cell, 39(1), 25-35.
- . PLoS One, 5(6), e11208.
- . EMBO J, 29(4), 703-705.
- . Cell Cycle, 8(8), 1133-1137.
- . Mol Cell Biol, 28(5), 1470-1479.
- . Mol Cell, 32(3), 313-324.
- . Cell, 135(2), 261-271.
- . Int J Radiat Oncol Biol Phys, 70(5), 1310-1318.
- . Int J Radiat Oncol Biol Phys, 69(4), 1262-1271.
- . Chromosoma, 116(4), 331-339.
- . Nat Cell Biol, 9(4), 391-401.
- . CANCER RES, 66(17), 8814-8821.
- . DNA Repair (Amst), 5(11), 1398-1406.
- . Oncogene, 24(6), 949-961.
- . J Biol Chem, 279(48), 49624-49632.
- . Cancer Metastasis Rev, 23(3-4), 277-292.
- . Radiat Res, 162(1), 48-55.
- . Radiat Res, 161(3), 247-255.
- . World J Urol, 21(4), 275-289.
- Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factors.. Cancer Res, 63(7), 1550-1554.
- Expression of the DNA-PK binding protein E4-34K fails to confer radiation sensitivity to mammalian cells.. Int J Radiat Biol, 79(1), 53-60.
- . Nucleic Acids Res, 30(2), E1.
- . Nucleic Acids Res, 29(7), 1534-1538.
- . F1000Research, 12, 954-954.
Book chapters
- , Targeted Radionuclide Tumor Therapy Biological Aspects (pp. 329-347).
- Molecular targeting of DNA repair: A means to improve therapeutic index, New Research on DNA Repair (pp. 1-37).
Conference proceedings
- Addition of ATM Inhibitors to Radium223 Reduces Prostate Cancer Bone Metastases In Vivo. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 38 (pp 214-215)
- . Neuro-Oncology, Vol. 25(Supplement_3) (pp iii5-iii6)
- GENERATION AND CHARACTERISATION OF A LIVING BIOBANK OF POST-SURGICAL RESIDUAL GLIOBLASTOMA TO IDENTIFY NOVEL THERAPEUTIC TARGETS.. NEURO-ONCOLOGY, Vol. 24 (pp 31-31)
- COMBINING TUMOUR TREATING FIELDS WITH THERAPEUTIC DNA DAMAGE RESPONSE INHIBITORS TO INCREASE POTENCY IN HIGH-GRADE GLIOBLASTOMAS USING CLINICALLY RELEVANT EX-VIVO GLIOMA STEM CELL MODELS.. NEURO-ONCOLOGY, Vol. 24 (pp 93-93)
- . Brain Tumor Research and Treatment, Vol. 10(Suppl) (pp s240). Seoul, Korea, 24 March 2022 - 24 March 2022.
- . WFNOS 2022 Abstract Book (pp S251-S251), 24 March 2022 - 27 March 2022.
- . WFNOS 2022 Abstract Book (pp S65-S65), 24 March 2022 - 27 March 2022.
- . WFNOS 2022 Abstract Book (pp S219-S219), 24 March 2022 - 27 March 2022.
- . WFNOS 2022 Abstract Book (pp S253-S253), 24 March 2022 - 27 March 2022.
- . WFNOS 2022 Abstract Book (pp S227-1), 24 March 2022 - 27 March 2022.
- EX-VIVO 3-DIMENSIONAL MODELS OF POST-SURGICAL RESIDUAL DISEASE IN HUMAN GLIOBLASTOMA. NEURO-ONCOLOGY, Vol. 21 (pp 271-271)
- FA-BASED COMBINATIONS TO TARGET THE DNA DAMAGE RESPONSE IN GLIOBLASTOMA. NEURO-ONCOLOGY, Vol. 20 (pp 358-358)
- PRECLINICAL EVALUATION OF COMBINATIONS TARGETING THE DNA DAMAGE RESPONSE IN 2D AND 3D MODELS OF GLIOBLASTOMA STEM CELLS. NEURO-ONCOLOGY, Vol. 20 (pp 297-297)
- Improving the Efficacy of Pulsed Radiation Therapy Using DNA Repair Inhibitors: A Preclinical Study. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol. 96(2) (pp E566-E567). Boston, Massachusetts, USA
- . European Journal of Cancer, Vol. 61 (pp S35-S35)
- IDENTIFICATION OF NOVEL SMALL MOLECULE INHIBITORS OF THE FANCONI ANAEMIA DNA REPAIR PATHWAY AS A MEANS TO SENSITISES GLIOBLASTOMAS TO CHEMOTHERAPEUTIC AGENTS. NEURO-ONCOLOGY, Vol. 17 (pp 20-20)
- Optimization of siRNA-transgene expression in adenoviral vector systems for radiation sensitizing strategies. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol. 69(3) (pp S595-S596)
- . BREAST CANCER RESEARCH, Vol. 8 (pp S6-S6)
Preprints
- , Springer Science and Business Media LLC.
- , Springer Science and Business Media LLC.
- , Cold Spring Harbor Laboratory.
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- Research group
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Research Group
- Dr. Katie Myers (Research Assistant/Lab Manager)
- Dr. Callum Jones (Postdoctoral Research Associate)
- Dr. Nikita Lad (Postdoctoral Research Associate)
- Dr. Sophie Williams (Clinical PhD Fellow)
- Connor McGarrity-Cottrell (PhD student)
- Hannah Gagg (PhD student with Dr. Greg Wells and Mr. Ola Rominiyi)
- Kelsey Wosnitzka (PhD student with Mr. Ola Rominiyi)
- Rebecca Livesey (PhD student with Prof. Fred Claeyssens)
- Tegan Torpey (PhD student with Mr. Ola Rominiyi and Prof. Fred Claeyssens)
- Teaching interests
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M.Sc. Molecular Medicine
M.Sc. Translational Oncology
MSc Genomic Medicine