Professor Philippe Clézardin
BSc, MSc, PhD, DSc
School of Medicine and Population Health
Honorary Professor of Bone Oncology
Full contact details
School of Medicine and Population Health
EU28, E Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
-
For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
I was awarded my PhD from the University of Lyon, France, in 1984 after which I joined the Medical Research Council / Scottish National Blood Transfusion Centre in Edinburgh as a post-doctoral research associate for 2 years. I was appointed in 1987 as Research Scientist (Lecturer) at INSERM (National Institute for Health and Medical Research), Lyon, France. In 1990 I undertook a one-year sabbatical as visiting scientist at the Ottawa General Hospital (Ottawa, Canada). In 1991 I was appointed Senior Research Scientist (Senior Lecturer) and in 1993 Research Director 2nd class (Reader) at INSERM. In 2005 I was appointed Research Director 1st Class (Professor) and became head of the INSERM Research Unit UMR_S664 entitled: “Mechanisms and Treatments of Bone Metastases” (2005-2010) and then Director of the Federative Research Institute “IFR62” entitled: “Cancer, Nutrition and Metabolism” (14 laboratories, circa: 500 people; 2007-2010). From 2011, I am head of the INSERM Research Unit UMR_S1033 entitled: “Pathophysiology, Diagnosis and Treatments of Bone Diseases” (). I have recently become an Honorary Professor of Bone Oncology.
- Research interests
-
My main research interest is the understanding of molecular mechanisms that govern breast cancer cell colonisation of the bone marrow, with the goal of developing novel biomarkers to identify patients at high risk for developing bone metastasis.
Current projects:
ROBO. Role of axon guidance, roundabout (ROBO) transmembrane receptors in breast cancer bone metastasis formation.
LOXs. Role of lysyl oxidases in early onset of breast cancer bone metastasis formation.
AMG161. Anti-tumour effect of a human anti-RANKL monoclonal antibody on early-stage bone colonisation of human RANK-expressing breast cancer cells
MicroRNAs. Role of breast cancer stem cell-derived microRNAs, and their mRNA/protein targets in controlling bone metastasis formation.
- Publications
-
Show: Featured publications All publications
Featured publications
Journal articles
- . Oncogene.
- . Physiological Reviews.
- . British Journal of Pharmacology.
- . Oncogene, 38(7), 950-964.
- . Cancer Research, 78(18), 5259-5273.
- . Calcified Tissue International, 102(2), 227-250.
- . Cancer Research, 77(2), 268-278.
- . Annals of Oncology, 27(3), 379-390.
- . Oncotarget, 6(24), 20604-20620.
- . Journal of Bone and Mineral Research, 29(8), 1886-1899.
- . Clinical Cancer Research, 18(22), 6249-6259.
- . JNCI Journal of the National Cancer Institute, 104(14), 1059-1067.
- . Cancer Research, 71(17), 5728-5738.
- . Cancer Research, 71(13), 4562-4572.
- . Cancer Research, 67(20), 9894-9902.
- . Cancer Research, 67(12), 5821-5830.
All publications
Journal articles
- . Journal of Bone Oncology, 29, 100364-100364.
- . Current Osteoporosis Reports.
- . Oncogene.
- . Physiological Reviews.
- . Computer Methods in Biomechanics and Biomedical Engineering, 23(sup1), S115-S116.
- . Cancer Research.
- . Frontiers in Oncology, 10(1).
- . The Quarterly Journal of Nuclear Medicine and Molecular Imaging, 63(2), 98-111.
- . British Journal of Pharmacology.
- . Clinical and Translational Oncology, 21(8), 977-991.
- . Oncogene, 38(7), 950-964.
- . Cancer Letters, 438, 32-43.
- . Clinical Breast Cancer, 18(6), e1311-e1321.
- . Calcified Tissue International, 103(5), 567-580.
- . Cancer Research, 78(18), 5259-5273.
- . Annals of Oncology, 29, vi31-vi31.
- . Bone, 108, 202-209.
- . Calcified Tissue International, 102(2), 227-250.
- . Joint Bone Spine, 84(6), 677-684.
- . Computer Methods in Biomechanics and Biomedical Engineering, 20(sup1), S57-S58.
- . Oncotarget, 8(34).
- . Journal of Therapeutic Ultrasound, 5(S1).
- . Revue du Rhumatisme Monographies, 84(2), 107-114.
- . Cancer Research, 77(2), 268-278.
- . Oncotarget, 7(47), 77071-77086.
- . International Journal of Molecular Sciences, 17(10).
- . Journal of Bone Oncology, 5(3), 93-95.
- . Annals of Oncology, 27, iv60-iv60.
- . Ultrasound in Medicine & Biology, 42(1), 220-231.
- . Annals of Oncology, 27(3), 379-390.
- . Ultrasound in Medicine & Biology, 41(10), 2740-2754.
- . Current Opinion in Pharmacology, 22, 79-86.
- . Oncotarget, 6(24), 20604-20620.
- . Oncologie, 17(3), 69-74.
- . Cancer Letters, 357(1), 279-285.
- . World Journal of Nano Science and Engineering, 05(04), 219-228.
- . BoneKEy Reports, 4.
- . Scientific Reports, 5(1).
- . BoneKEy Reports, 4.
- . Future Oncology, 11(21), 2853-2856.
- . European Journal of Cancer, 50, 182-182.
- . Blood, 124(20), 3141-3150.
- . Proceedings of the National Academy of Sciences, 111(37), E3870-E3879.
- . International Journal of Cancer, 135(6), 1319-1329.
- . Journal of Bone and Mineral Research, 29(8), 1886-1899.
- . Journal of Biological Chemistry, 289(10), 6551-6564.
- . Revue des Maladies Respiratoires, 31, A131-A131.
- . BoneKEy Reports, 3.
- . Oncologie, 15(12), 673-686.
- . The Prostate, 73(16), 1738-1746.
- . Bulletin du Cancer, 100(11), 1083-1091.
- . Molecular & Cellular Proteomics, 12(8), 2111-2125.
- . Oncogene, 32(6), 804-804.
- . Oncogene, 32(6), 724-735.
- . BoneKEy Reports, 2.
- . Bone, 51(6), S28-S29.
- Overexpression of CD9 in human breast cancer cells promotes the development of bone metastases. Anticancer Research, 32(12), 5211-5220.
- . Journal of Bone Oncology, 1(3), 67-68.
- . Clinical Cancer Research, 18(22), 6249-6259.
- . Clinical Cancer Research, 18(21), 6077-6077.
- . 䲹Գ/鲹徱dzٳé辱, 16(5-6), 330-338.
- . Cancer Treatment Reviews, 38(5), 407-415.
- . JNCI Journal of the National Cancer Institute, 104(14), 1059-1067.
- . British Journal of Cancer, 107(1), 63-70.
- . Journal of Proteome Research, 11(4), 2247-2260.
- . International Journal of Oncology, 40(4), 1133-1141.
- . Anti-Cancer Agents in Medicinal Chemistry, 12(2), 102-113.
- . Oncologie, 14(1), 31-36.
- . The Prostate, 72(7), 713-720.
- . IBMS BoneKEy, 8(11), 305-312.
- . IBMS BoneKEy, 8(10), 428-432.
- . European Journal of Cancer, 47, S117-S117.
- . European Journal of Cancer, 47, S332-S332.
- . IBMS BoneKEy, 8(9), 390-396.
- . Cancer Research, 71(17), 5728-5738.
- . IBMS BoneKEy, 8(8), 352-361.
- . IBMS BoneKEy, 8(7), 305-312.
- . Cancer Research, 71(13), 4562-4572.
- . Bulletin du Cancer, 98(7), 837-846.
- . IBMS BoneKEy, 8(6), 257-263.
- . IBMS BoneKEy, 8(5), 211-220.
- . Breast Cancer Research, 13(2).
- . IBMS BoneKEy, 8(4), 171-177.
- . European Urology Supplements, 10(2), 265-265.
- . IBMS BoneKEy, 8(3), 159-164.
- . IBMS BoneKEy, 8(3), 128-134.
- . Bone, 48(3), 672-672.
- . Cancer Research, 71(5), 1647-1657.
- . IBMS BoneKEy, 8(2), 65-73.
- . Bone, 48(2), 259-266.
- . Bone, 48(1), S46-S46.
- . Bone, 48(1), S39-S40.
- . Bone, 48(1), S47-S48.
- . International Journal of Cancer, 128(2), 352-360.
- . Bone, 48(1), 71-79.
- . Bone, 49(1), 66-70.
- . Calcified Tissue International, 87(4), 341-350.
- . Bulletin du Cancer, 97(8), 937-949.
- . Neoplasia, 12(7), 571-578.
- . IBMS BoneKEy, 7(6), 208-217.
- . European Journal of Cancer Supplements, 8(5), 135-136.
- . Seminars in Oncology, 37, S3-S11.
- . Cancer Treatment Reviews, 36(8), 615-620.
- . Bone, 46, S43-S43.
- . Bone, 46, S37-S37.
- . Bone, 46, S40-S41.
- . Bone, 46, S41-S41.
- . Bone, 46, S43-S43.
- . Current Pharmaceutical Design, 16(27), 3007-3014.
- . Current Pharmaceutical Design, 16(11), 1260-1261.
- . Biomaterials, 30(31), 6367-6373.
- . Bone, 44, S270-S270.
- . IBMS BoneKEy, 6(6), 210-217.
- . Bone, 44, S135-S135.
- . British Journal of Haematology, 145(2), 264-266.
- Bioactive Lipids Lysophosphatidic Acid and Sphingosine 1-Phosphate Mediate Breast Cancer Cell Biological Functions Through Distinct Mechanisms (vol 18, pg 173, 2009). ONCOLOGY RESEARCH, 18(7), 357-357.
- . Oncologie, 11(1), 10-15.
- . Current Cancer Drug Targets, 9(7), 801-806.
- . Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 18(4), 173-184.
- . Cancer Research, 68(21), 8945-8953.
- . Neoplasia, 10(9), 1014-IN11.
- . Current Opinion in Supportive and Palliative Care, 2(3), 218-222.
- . Clinical Cancer Research, 14(14), 4658-4666.
- . Revue du Rhumatisme, 75(4), 327-331.
- . Clinical & Experimental Metastasis, 25(1), 33-42.
- . Cancer Letters, 257(1), 16-35.
- . Bone, 41(5), 901-902.
- . British Journal of Cancer, 97(7), 964-970.
- . Cancer Research, 67(20), 9894-9902.
- . Cancer Research, 67(18), 8742-8751.
- . Cancer Research, 67(12), 5821-5830.
- . European Journal of Cancer, 43(5), 852-858.
- Increased invasive potential and up-regulation of MMP-2 in MDA-MB-231 breast cancer cells expressing the β3 integrin subunit. International Journal of Oncology, 30(2), 325-332.
- . JNCI Journal of the National Cancer Institute, 99(4), 322-330.
- . Clinical & Experimental Metastasis, 24(8), 699-705.
- . Clinical & Experimental Metastasis, 24(8), 599-608.
- . Breast Cancer Research and Treatment, 101(2), 135-148.
- . Proceedings of the National Academy of Sciences, 103(25), 9643-9648.
- . European Journal of Cancer Supplements, 4(2), 163-163.
- . Cell and Tissue Research, 323(3), 457-463.
- . International Journal of Cancer, 116(5), 686-691.
- . Cancer Research, 65(12), 4971-4974.
- . éԱ/Գ, 21(4), 353-355.
- Androgens repress the expression of the angiogenesis inhibitor thrombospondin-1 in normal and neoplastic prostate.. Cancer Res, 65(1), 300-308.
- . Cancer Treatment Reviews, 31, 1-8.
- . Journal of Clinical Investigation, 114(12), 1714-1725.
- [Does tumor angiogenesis play a role in bone metastatic process?].. Rev Med Suisse Romande, 124(2), 83-84.
- . Journal of Biological Chemistry, 278(46), 45826-45832.
- SiRNA-mediated inhibition of vascular endothelial growth factor severely limits tumor resistance to antiangiogenic thrombospondin-1 and slows tumor vascularization and growth.. Cancer Res, 63(14), 3919-3922.
- . European Urology Supplements, 2(1), 82-82.
- . Current Medicinal Chemistry, 10(2), 173-180.
- Biphosphonates and bone metastases of solid tumors: Therapeutic significance beyond osteolytic activity. Progres en Urologie, 13(2 SUPPL. 1), 28-35.
- . American Journal of Clinical Oncology, 25, S3-S9.
- . Seminars in Oncology, 29(6 Suppl 21), 33-42.
- Bisphosphonates inhibit angiogenesis in Vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats. Cancer Research, 62(22), 6538-6544.
- . Revue du Rhumatisme, 69(10-11), 997-1001.
- . The FASEB Journal, 16(10), 1266-1268.
- . European Urology Supplements, 1(1), 52-52.
- . Genes & Development, 15(11), 1373-1382.
- Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases.. Cancer Res, 60(11), 2949-2954.
- [Bone hyperresorption in bone metastases].. Presse Med, 29(9), 487-491.
- . Revue du Rhumatisme, 67(1), 28-36.
- Mechanisms of action of bisphosphonates on tumor cells and prospects for use in the treatment of malignant osteolysis.. Joint Bone Spine, 67(1), 22-29.
- . Journal of Cellular Biochemistry, 75(3), 538-546.
- Modulation of prostatic angiogenesis. Oncologie, 1(7), 428-432.
- . International Journal of Cancer, 83(2), 263-269.
- [Thrombospondins, tumor angiogenesis and breast cancer].. Pathol Biol (Paris), 47(4), 368-374.
- . Cell Biochem Funct, 16(3), 211-221.
- . Cellular and Molecular Life Sciences (CMLS), 54(6), 541-548.
- . Journal of Cellular Biochemistry, 67(1), 75-83.
- Bisphosphonates inhibit prostate and breast carcinoma cell adhesion to unmineralized and mineralized bone extracellular matrices.. Cancer Res, 57(18), 3890-3894.
- . Biochemical Journal, 321(3), 819-827.
- Thrombospondin-1 and -2 messenger RNA expression in normal, benign, and neoplastic human breast tissues: correlation with prognostic factors, tumor angiogenesis, and fibroblastic desmoplasia.. Cancer Res, 57(3), 396-399.
- . Bone, 17(6), 599-599.
- . Virchows Archiv, 427(4).
- . Differentiation, 57(2), 133-141.
- . Differentiation, 57(2), 133-133.
- . FEBS Letters, 335(2), 161-166.
- Role of Platelet Membrane Glycoproteins Ib/IX and Ilb/IIIa, and of Platelet a-Granule Proteins in Platelet Aggregation Induced by Human Osteosarcoma Cells. Cancer Research, 53(19), 4695-4700.
- . FEBS Letters, 329(3), 341-346.
- Expression of Thrombospondin (TSP1) and Its Receptors (CD36 and CD51) in Normal, Hyperplastic, and Neoplastic Human Breast. Cancer Research, 53(6), 1421-1430.
- [Role of osteoclasts in the physiopathological mechanisms of malignant osteolysis].. Bull Cancer, 80(10 Suppl), 11-15.
- . Blood, 79(4), 936-941.
- . Blood, 79(4), 936-941.
- Thrombospondin binds to the surface of human osteosarcoma cells and mediates platelet-osteosarcoma cell interaction.. Cancer Res, 51(10), 2621-2627.
- . Biochemical Journal, 275(1), 263-266.
- . European Journal of Biochemistry, 181(3), 721-726.
- Rapid purification and partial characterization of human platelet glycoprotein IIIb. Interaction with thrombospondin and its role in platelet aggregation.. J Biol Chem, 264(1), 501-506.
- . European Journal of Biochemistry, 175(2), 275-284.
- . FEBS Letters, 228(2), 215-218.
- . äDzٲDZDz, 07(06), 172-182.
- . Seminars in Thrombosis and Hemostasis, 13(03), 261-275.
- . Seminars in Thrombosis and Hemostasis, 13(03), 378-384.
- . European Journal of Biochemistry, 159(3), 569-579.
- . Journal of Chromatography A, 358, 209-218.
- . Journal of Chromatography A, 354, 425-433.
- . FEBS Letters, 196(1), 49-53.
- . European Journal of Biochemistry, 154(1), 95-102.
- . British Journal of Haematology, 60(2), 331-344.
- . Journal of Chromatography A, 326, 179-190.
- . European Journal of Biochemistry, 148(1), 97-106.
- . Journal of Chromatography A, 319, 67-77.
- . Journal of Chromatography A, 296, 249-256.
- . Thrombosis Research, 29(6), 569-581.
- . Biochimica et Biophysica Acta (BBA) - Biomembranes, 689(3), 513-522.
- . Cancers, 15(1), 242-242.
- . Frontiers in Oncology, 11.
- . Frontiers in Oncology, 10.
- . Bone Abstracts.
- . Bone Abstracts.
- . Bone Abstracts.
- . Bone Abstracts.
- . PLoS ONE, 9(5), e97771-e97771.
- . PLoS ONE, 8(9), e75092-e75092.
- . PLoS ONE, 6(4), e19234-e19234.
- . PLoS ONE, 5(3), e9741-e9741.
- . Journal of Bone and Mineral Research, 21(12), 1913-1923.
- . Journal of Bone and Mineral Research, 16(11), 2027-2034.
- . Journal of Bone and Mineral Research, 15(2), 361-368.
- . Journal of Bone and Mineral Research, 6(10), 1059-1070.
- . Cells, 10(2), 430-430.
- . Cancers, 13(22), 5711-5711.
Book chapters
- , Bone Cancer (pp. 457-469). Elsevier
- , Advanced Structured Materials (pp. 17-34). Springer International Publishing
- Springer Science and Business Media LLC
- , Encyclopedia of Bone Biology (pp. 403-420). Elsevier
- , Encyclopedia of Endocrine Diseases (pp. 304-309). Elsevier
- , Bone Cancer (pp. 479-489). Elsevier
- , Bone Cancer (pp. 41-45). Elsevier
- , Bone Cancer (pp. xi-xv). Elsevier
- , Protides of the Biological Fluids (pp. 821-824). Elsevier
- , Protides of the Biological Fluids (pp. 815-820). Elsevier
- , Proceedings of the Second Symposium Lyon, France, June 27–30, 1983 (pp. 601-604). De Gruyter
- , Proceedings of the Second Symposium Lyon, France, June 27–30, 1983 (pp. 601-604). De Gruyter
- , Textbook of Bone Metastases (pp. 345-350). John Wiley & Sons, Ltd
Conference proceedings
- . Tumor Biology
- . Tumor Biology
- ERRa in primary breast tumours promotes tumour cell dissemination to bone by regulating RANK. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 33 (pp 72-72)
- . Molecular and Cellular Biology / Genetics
- . Tumor Biology
- . ANNALS OF ONCOLOGY, Vol. 27
- ELISA MEASUREMENT OF CIRCULATING PERIOSTIN IN ANIMAL MODELS OF BONE LOSS OR BONE FORMATION AND IDENTIFICATION OF CIRCULATING AND TISSUE-SPECIFIC ASSOCIATED FORMS OF PERIOSTIN. OSTEOPOROSIS INTERNATIONAL, Vol. 27 (pp S207-S207)
- . Poster Session Abstracts
- THE HIF-1 TARGET LYSYL OXIDASE PROMOTES SURVIVAL AND OUTGROWTH OF COLON CANCER CELLS IN THE BONE MARROW ENABLING BONE METASTASIS FORMATION. ANTICANCER RESEARCH, Vol. 34(10) (pp 6134-6134)
- . Molecular and Cellular Biology
- ERRalpha, a pro-Bone metastatic factor : Implication in metastatic Niche and prostate Cancer Stem Cells phenotype.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 29 (pp S13-S13)
- Roundabout receptors mediate breast cancer bone metastasis formation and progression.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 29 (pp S65-S66)
- Integrin Alpha5beta1 is a Potential Therapeutic Target to Treat Experimental Breast Cancer Bone Metastasis.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 29 (pp S65-S65)
- . Poster Session Abstracts
- MUTATIONAL PROFILING OF SYNCHRONOUS BONE METASTASES FROM LUNG ADENOCARCINOMA: FEASIBILITY AND RESULTS IN A PROSPECTIVE COHORT OF 46 PATIENTS (POUMOS STUDY). JOURNAL OF THORACIC ONCOLOGY, Vol. 8 (pp S796-S796)
- Ectopic expression of twist-1 in breast cancer cells promotes bone metastasis formation. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 28
- Function of ERRa in Mediating Mixed Metastatic Bone Lesion from Prostate Cancer Cells: Implication of Endothelin 1 and Wnt/periostin pathway. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 28
- Role of axon guidance receptor Robo-1 in training and development of bone metastases of breast cancer. BULLETIN DU CANCER, Vol. 98 (pp S27-S28)
- The HIF-1-inducible Lysyl Oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell. BULLETIN DU CANCER, Vol. 98 (pp S9-S10)
- PATHOPHYSIOLOGY OF TUMORAL BONE DISEASE. OSTEOPOROSIS INTERNATIONAL, Vol. 22 (pp 6-7)
- Targeting breast cancer osteomimetic genes by microRNAs-30 decreases the formation of metastatic osteolytic lesions in mice. BULLETIN DU CANCER, Vol. 98 (pp S29-S30)
- . BONE, Vol. 47 (pp S266-S267)
- . BONE, Vol. 47 (pp S322-S323)
- . BONE, Vol. 47 (pp S289-S289)
- . BONE, Vol. 47 (pp S273-S273)
- . BONE, Vol. 47 (pp S328-S329)
- . BONE, Vol. 47 (pp S322-S322)
- . Tumor Biology
- . European Urology Supplements, Vol. 9(2) (pp 221-221)
- Platelets Contribute to Circulating Levels of Dickkopf-1 (Dkk-1): Clinical Implications in Multiple Myeloma.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 23 (pp S297-S297)
- Lysophospholipids LPA and S1P cooperate to mediate the growth and osteolytic bone metastasis formation of breast cancer. CANCER RESEARCH, Vol. 68(9)
- Autotaxin controls the metastatic progression of breast cancer cells. BULLETIN DU CANCER, Vol. 95 (pp S91-S92)
- . Bone, Vol. 42 (pp S102-S103)
- . Cancer Treatment Reviews, Vol. 34 (pp 41-41)
- . Cancer Treatment Reviews, Vol. 34 (pp 37-37)
- New physiopathological pathways of bone metastases. CALCIFIED TISSUE INTERNATIONAL, Vol. 82 (pp S24-S24)
- . Cancer Treatment Reviews, Vol. 34 (pp 42-42)
- . Cancer Treatment Reviews, Vol. 34 (pp 20-21)
- Cathepsin K inhibitors for treating cancer-induced bone disease. CLINICAL & EXPERIMENTAL METASTASIS, Vol. 25 (pp 15-15)
- Differential effects of doxorubicin and zoledronic acid on intra-osseous vs extra-osseous breast tumour growth in vivo.. BREAST CANCER RESEARCH AND TREATMENT, Vol. 106 (pp S39-S39)
- . European Journal of Cancer Supplements, Vol. 5(4) (pp 174-174)
- Differential effect of doxorubicin and zoledronic acid on intra-osseous vs extra osseous breast tumour growth in vivo. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 22(7) (pp 1111-1111)
- Role of lysophosphatidic acid (LPA) and LPA1 receptor in the treatment of bone metastases in breast cancer. BULLETIN DU CANCER, Vol. 94(6) (pp 560-561)
- Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer. BONE, Vol. 40(6) (pp S145-S145)
- Transmigration, a new property of mature osteoclasts.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 21 (pp S161-S161)
- The type 1 lysophosphatidic acid receptor (LPA1): identification of a new therapeutic target for patients with bone metastases. CANCER RESEARCH, Vol. 66(8)
- . Bone, Vol. 38(3) (pp 45-45)
- . Bone, Vol. 38(3) (pp 55-56)
- . Bone, Vol. 38(3) (pp 44-45)
- Transcriptome analysis reveals an osteomimetic phenotype for human bone metastatic breast cancer cells. CALCIFIED TISSUE INTERNATIONAL, Vol. 78 (pp S85-S86)
- Dickkopf-1 (Dkk-1) is involved in the development of breast cancer osteolytic lesions. CALCIFIED TISSUE INTERNATIONAL, Vol. 78 (pp S27-S27)
- Prevention of breast cancer bone metastasis by an integrin alpha V beta 3 antagonist. CANCER TREATMENT REVIEWS, Vol. 32 (pp S18-S18)
- A cathepsin K inhibitor inhibits the progression of breast cancer bone metastases. CANCER TREATMENT REVIEWS, Vol. 32 (pp S16-S16)
- Integrin alpha V beta 3 confers tumor cells a higher sensitivity to the pro-apoptotic effect of the aminobisphosphonate zoledronate in vitro. CANCER TREATMENT REVIEWS, Vol. 32 (pp S45-S46)
- Effects of thrombospondin-1 overexpression and VEGF silencing on bone metastasis formation. CANCER TREATMENT REVIEWS, Vol. 32 (pp S41-S41)
- Serum levels of Dickkopf-1 (Dkk-1) are increased in women with breast cancer and bone metastases. CANCER TREATMENT REVIEWS, Vol. 32 (pp S38-S38)
- The type 1 lysophosphatidic acid receptor is a pivotal factor for early and late events for bone metastasis formation in breast cancer. CANCER TREATMENT REVIEWS, Vol. 32 (pp S30-S30)
- Use of bisphosphonate analogs of risedronate to elucidate antiangiogenic mechanisms of bisphosphonates in vivo. BONE, Vol. 36 (pp S219-S219)
- Use of bisphosphonate analogs of risedronate to elucidate antiangiogenic mechanisms of bisphosphonates in vivo. CANCER TREATMENT REVIEWS, Vol. 31 (pp S23-S24)
- A novel integrin antagonist: Evaluation in bone growth tumor models. CANCER TREATMENT REVIEWS, Vol. 31 (pp S16-S16)
- Use of analogs of risedronate to elucidate antitumor mechanisms of bisphosphonates in vivo. CANCER TREATMENT REVIEWS, Vol. 31 (pp S36-S37)
- Integrin alpha v beta 3 is critical for human breast cancer bone metastasis. CANCER TREATMENT REVIEWS, Vol. 31 (pp S26-S26)
- LPA: A new local factor acting on breast cancer bone metastasis. CANCER TREATMENT REVIEWS, Vol. 31 (pp S27-S27)
- Antibody to rank ligand - Overview of RANK ligand. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20 (pp P23-P24)
- Use of bisphosphonate analogs of risedronate to elucidate antiangiogenic mechanisms of bisphosphonates in vivo. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20 (pp P24-P24)
- Integrin alpha V beta 3 is critical for human breast cancer bone metastasis. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20 (pp P16-P17)
- Genome profiling aiming at identifying "bone metastasis signatures". JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20 (pp P36-P36)
- Transcriptome analysis reveals an osteomimetic phenotype for human breast cancer cells that selectively target the skeleton. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20 (pp P32-P32)
- Lysophosphatidic acid: A new link between breast cancer and bone metastasis.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19 (pp S25-S25)
- A nonpeptide integrin avb3 antagonist inhibits bone metastasis formation. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19 (pp S66-S66)
- Use of bisphosphonate analogs of risedronate to elucidate antitumor mechanisms of bisphosphonates in vivo.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19 (pp S25-S25)
- The bisphosphonate risedronate inhibits angiogenesis and tumor growth in vivo. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19(9) (pp 1599-1599)
- Cell adhesion and bone metastasis. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19(9) (pp 1561-1562)
- NE-10790, a phosphonocarboxylate analogue of the bisphosphonate risedronate, exhibits direct antitumor activity in vivo. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19(6) (pp 1033-1033)
- NE-10790, A PHOSPHONOCARBOXYLATE ANALOGUE OF THE BISPHOSPHONATE RISEDRONATE, EXHIBITS DIRECT ANTITUMOR ACTIVITY IN IN VIVO. CALCIFIED TISSUE INTERNATIONAL, Vol. 74 (pp S43-S44)
- NE-10790, a phosphonocarboxylate analogue of the bisphosphonate risedronate, exhibits direct antitumor activity in vivo. BONE, Vol. 34 (pp S56-S57)
- The bisphosphonate risedronate inhibits angiogenesis and tumor growth in vivo.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 18 (pp S113-S113)
- Androgens repress the expression of thrombospondin-1, an inhibitor of angiogenesis, in the rat prostate and in hormone-responsive human prostate cancer. JOURNAL OF UROLOGY, Vol. 169(4) (pp 84-84)
- Integrin alpha v beta 3 plays an essential role in the homing of tumor cells in bone.. BONE, Vol. 30(3) (pp 43S-43S)
- Effects of bisphosphonates zoledronic acid and risedronate on the growth of a human breast carcinoma cell line in vivo. BONE, Vol. 30(3) (pp 40S-40S)
- Zoledronic acid inhibits in vivo experimental angiogenesis. BONE, Vol. 30(3) (pp 38S-38S)
- Ectopic expression of integrin alpha v beta 3 confers tumor cells a high propensity to metastasize to bone.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 15 (pp S177-S177)
- Effects of bisphosphonates on different steps of the metastatic cascade leading to bone metastasis formation. Medecine et Hygiene, Vol. 58(2305 SUPPL.)
- Identification of specific sequences within thrombospondin-1 involved in the formation of irreversible platelet macroaggregates. THROMBOSIS AND HAEMOSTASIS (pp P1385-P1385)
- Decorin inhibits cell adhesion by binding to a specific cell adhesive site of thrombospondin.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 11 (pp M460-M460)
- Bisphosphonates inhibit tumor cell attachment to unmineralized and mineralized bone extracellular matrices.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 11 (pp P229-P229)
- MOLECULAR MECHANISMS OF ATTACHMENT OF CD36-TRANSFECTED CELLS TO THROMBOSPONDIN-1. MOLECULAR BIOLOGY OF THE CELL, Vol. 6 (pp 267-267)
- MECHANISMS OF PLATELET-OSTEOSARCOMA CELL-INTERACTIONS. THROMBOSIS AND HAEMOSTASIS, Vol. 69(6) (pp 573-573)
- EXPRESSION OF THROMBOSPONDIN (TSP1) AND ITS RECEPTORS (CD36, CD51) IN NORMAL, HYPERPLASTIC AND NEOPLASTIC HUMAN BREAST. JOURNAL OF CELLULAR BIOCHEMISTRY (pp 159-159)
- ORIGIN AND ROLE OF THROMBOSPONDIN IN THE EARLY DEVELOPMENT OF THE HUMAN MAMMARY-GLAND. JOURNAL OF CELLULAR BIOCHEMISTRY (pp 160-160)
- THROMBOSPONDIN INDUCES THE PROLIFERATION OF RAT CALVARIA OSTEOBLASTIC CELLS. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 7 (pp S213-S213)
- THROMBOSPONDIN MEDIATES PROLIFERATION OF HUMAN OSTEOBLASTIC CELLS INDUCED BY THROMBIN. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 7 (pp S223-S223)
- THROMBOSPONDIN BINDS TO THE SURFACE OF HUMAN OSTEOSARCOMA CELLS AND MEDIATES PLATELET-OSTEOSARCOMA CELL-INTERACTION. THROMBOSIS AND HAEMOSTASIS, Vol. 65(6) (pp 1055-1055)
- PSEUDO-GRAY PLATELET SYNDROME - MULTIPLE PLATELET ABNORMALITIES AND NORMAL HEMOSTASIS. THROMBOSIS AND HAEMOSTASIS, Vol. 65(6) (pp 1105-1105)
- THROMBOSPONDIN BINDING BY HUMAN OSTEOSARCOMA CELLS - RELATIONSHIP TO PLATELET-AGGREGATING ACTIVITY OF OSTEOSARCOMA CELLS. PLATELET IMMUNOLOGY : FUNDAMENTAL AND CLINICAL ASPECTS, Vol. 206 (pp 195-207)
- THROMBOSPONDIN AND CELL-ADHESION. THROMBOSIS AND HAEMOSTASIS, Vol. 62(1) (pp 592-592)
- OSTEONECTIN DEFICIENCY IN PLATELETS ISOLATED FROM A PATIENT WITH THE GRAY PLATELET SYNDROME. THROMBOSIS AND HAEMOSTASIS, Vol. 62(1) (pp 420-420)
- A POLYCLONAL ANTIBODY TO OSTEONECTIN INHIBITS COLLAGEN-INDUCED PLATELET-AGGREGATION AND CELL-SURFACE EXPRESSION OF ENDOGENOUS THROMBOSPONDIN. THROMBOSIS AND HAEMOSTASIS, Vol. 62(1) (pp 195-195)
- RAPID PURIFICATION AND PARTIAL CHARACTERIZATION OF HUMAN-PLATELET GLYCOPROTEIN IIIB. CLINICAL RESEARCH, Vol. 36(3) (pp A567-A567)
- STRUCTURAL AND FUNCTIONAL COMPARISON OF THROMBOSPONDIN FROM PLATELETS, ENDOTHELIAL-CELLS AND FIBROBLASTS. THROMBOSIS AND HAEMOSTASIS, Vol. 58(1) (pp 278-278)
- . XIth International Congress on Thrombosis and Haemostasis, 6 July 1987 - 10 July 1987.
- STRUCTURAL AND IMMUNOLOGICAL COMPARISON OF THROMBOSPONDIN FROM PLATELETS AND COLOSTRUM. THROMBOSIS RESEARCH (pp 55-55)
- CHARACTERIZATION OF AN ANTI-THROMBOSPONDIN MURINE MONOCLONAL-ANTIBODY (P8) THAT INHIBITS HUMAN-BLOOD PLATELET FUNCTIONS. THROMBOSIS AND HAEMOSTASIS, Vol. 54(1) (pp 218-218)
- STUDY ON THE RELEASE OF THROMBOSPONDINE DURING PLATELET CONSERVATION - DOSAGE BY MEANS OF THE ELISA METHOD, WITH A MONOCLONAL-ANTIBODY. NOUVELLE REVUE FRANCAISE D HEMATOLOGIE, Vol. 27(2) (pp 117-117)
- CHARACTERIZATION OF MONOCLONAL-ANTIBODIES WHICH AFFECT HUMAN-PLATELET THROMBOSPONDIN HEMAGGLUTINATION ACTIVITY. THROMBOSIS AND HAEMOSTASIS, Vol. 54(1) (pp 249-249)
- MEMBRANEOUS PROTEINS AND GLYCOPROTEINS OF ENDOTHELIAL-CELLS FROM UMBILICAL CORDS. NOUVELLE REVUE FRANCAISE D HEMATOLOGIE, Vol. 26(6) (pp 417-417)
- PLATELET MEMBRANE GLYCOPROTEIN ABNORMALITIES IN PATIENTS WITH MYELOPROLIFERATIVE DISORDERS, ACUTE-LEUKEMIA AND SECONDARY THROMBOCYTOSIS. THROMBOSIS AND HAEMOSTASIS, Vol. 50(1) (pp 218-218)
- PROTEINS AND GLYCOPROTEINS OF NEONATAL PLATELETS. THROMBOSIS AND HAEMOSTASIS, Vol. 50(1) (pp 213-213)
- PURIFICATION OF THROMBOSPONDIN, FIBRONECTIN AND FIBRINOGEN BY FAST PROTEIN LIQUID-CHROMATOGRAPHY. THROMBOSIS AND HAEMOSTASIS, Vol. 50(1) (pp 16-16)
- IDENTIFICATION AND CHARACTERIZATION OF FRAGMENTS OF MAJOR MEMBRANE-GLYCOPROTEINS REMAINING ON PLATELETS AFTER CHYMOTRYPSIN TREATMENT. THROMBOSIS AND HAEMOSTASIS, Vol. 50(1) (pp 187-187)
- . European Heart Journal, Vol. 4(suppl B) (pp 5-5)
- MEMBRANE-PROTEINS AND GLYCOPROTEINS OF ENDOTHELIAL-CELLS ISOLATED FROM HUMAN UMBILICAL CORDS. THROMBOSIS AND HAEMOSTASIS, Vol. 50(1) (pp 396-396)
- . Oral Presentations, 13 July 1981 - 17 July 1981.
- . Oral Presentations, 13 July 1981 - 17 July 1981.
- ADDITIONAL GLYCOPROTEIN DEFECTS IN GLANZMANN THROMBASTHENIA PLATELETS. THROMBOSIS AND HAEMOSTASIS, Vol. 46(1) (pp 22-22)
- FURTHER CHARACTERIZATION OF PLATELET MEMBRANE-GLYCOPROTEINS. THROMBOSIS AND HAEMOSTASIS, Vol. 46(1) (pp 108-108)
- TRYPTIC PEPTIDE MAPS OF THE MAJOR HUMAN-BLOOD PLATELET MEMBRANE-GLYCOPROTEINS, IIA, IIA, IIB, IIIA, IIIB AND IIIC. THROMBOSIS AND HAEMOSTASIS, Vol. 46(1) (pp 22-22)
Preprints
- , Cold Spring Harbor Laboratory.
- Teaching interests
-
I have supervised a total of 18 PhD students (16 as main supervisor and 2 as co-supervisor) and 9 postdocs.
I am currently module leader of the UE « Metastasis, Migration and EMT » for the Master in Oncology at the University Claude Bernard Lyon-1, Lyon, France.
- Professional activities and memberships
-
I am/was engaged, as academic partner or coordinator, in several research projects/programmes funded by the French National Agency for Cancer (INCa) and INSERM, as well as European projects within the framework of FP6 and FP7, and H2020 research programmes [MetaBre (partner; 2004-2007), PROMET (partner; 2006-2010), BONE-NET (coordinator; 2011-2014), miROMeS (coordinator; 2016-2017)]. In this respect, I received a European Star Award (Paris, France, 2015) as coordinator of the Marie Curie ITN project BONE-NET.
Board of Directors member of the Laboratory of Excellence « DEVweCAN » funded by the French National Research Agency (ANR) (2011-present).
President of the Cancer & Bone Society (CABS; 2009-2010).
Board of Directors member of national and international learned societies (2004-2018) [CABS, International Bone and Mineral Society (IBMS), ARTP (French Prostate Cancer Society), and GEMO ((French Study Group of Bone Metastasis)].
Member of American Association for Cancer Research (AACR), American Society for Bone and Mineral Research (ASBMR), Cancer & Bone Society (CABS), and GEMO.