Professor Penelope D Ottewell

School of Medicine and Population Health

Professor of Cancer Biology

Penny Ottewell
Profile picture of Penny Ottewell
p.d.ottewell@sheffield.ac.uk
+44 114 215 9058

Full contact details

Professor Penelope D Ottewell
School of Medicine and Population Health
Office: GU21
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk

I am a senior lecturer in the Academic Unit of Clinical Oncology, University of Sheffield UK. I was awarded a PhD from the Department of Gastroenterology at The University of Liverpool in 2005 before taking up my first position in Sheffield a post-doctoral scientist working on breast cancer and bone metastasis.

During my time in Sheffield I have carried out international collaborative work spending time at INSERM (University of Lyon), France and at TUFTS University in Boston, USA.

I have been awarded a total of 10 prizes for my research including the prestigious Breast Cancer Campaign Research Team of the year award in 2008 and the International Bone and Mineral Society Gregory Mundy Research Fellowship in 2011.

Current PhD opportunities:

Research interests

My research is focused on advanced breast cancer with particular emphasis on bone metastasis. Primarily, this involves using a complement of in vitro and in vivo model systems to investigate the molecular alterations that are acquired by breast cancer cells causing them to metastases to bone.

I hypothesise that metastases are a result of a stepwise accumulation of genetic mutations and that distinct molecular alterations are required at the different stages in the metastatic process; molecules involved in intravasation are not those involved in tissue homing and colonisation.

The aims of my research are to identify specific molecular determinants involved in tumour cell intravasation, homing to bone and colonisation of the metastatic site and to use this information to develop and apply new therapies for the treatment of breast cancer bone metastasis.

Publications

Show: Featured publications All publications

Journal articles

  • Eyre R, Alférez DG, Santiago-Gómez A, Spence K, McConnell JC, Hart C, Simões BM, Lefley D, Tulotta C, Storer J , Gurney A et al (2019) . Nature Communications, 10(1), ---.

All publications

Journal articles

  • Lefley DV, Jones CG, Zhou J, Bryant HE, Collis SJ, Down JM, Brown JE & Ottewell PD (2025) . JBMR Plus, 9(10).
  • Puppo M, Croset M, Ceresa D, Valluru MK, Canuas Landero VG, Hernandez Guadarrama M, Iuliani M, Pantano F, Dawn Ottewell P & Clézardin P (2024) . Breast Cancer Research, 26.
  • Morita M, Arshad F, Quayle LA, George CN, Lefley DV, Kalajzic I, Balsubramanian M, Cebe T, Reilly G, Bishop NJ & Ottewell PD (2024) . Bone Reports, 22.
  • Zhou J & Ottewell PD (2024) . Journal of Bone Oncology, 46, 100608-100608.
  • Kwan A, Stark K, Allen R, Ottewell P & Muthana M (2024) . Medical Research Archives, 12(6).
  • Puppo M, Valluru MK, Croset M, Ceresa D, Iuliani M, Khan A, Wicinski J, Charafe-Jauffret E, Ginestier C, Pantano F , Ottewell PD et al (2023) . British Journal of Cancer, 129(5), 754-771.
  • Saleh L, Ottewell PD, Brown JE, Wood SL, Brown NJ, Wilson C, Park C, Ali S & Holen I (2023) . Cancers, 15(8).
  • Kwan A, Howard F, Winder N, Atkinson E, Jailani A, Patel PB, Allen R, Ottewell PD, Shaw GC, Conner J , Wilson C et al (2022) . Future Pharmacology, 2(4), 444-459.
  • Zhou J, Down JM, George CN, Murphy J, Lefley DV, Tulotta C, Alsharif MA, Leach M & Ottewell PD (2022) . Cancers, 14(19).
  • Zhou J, Tulotta C & Ottewell PD (2022) . Expert Reviews in Molecular Medicine, 24.
  • Canuas-Landero VG, George CN, Lefley DV, Corness H, Muthana M, Wilson C & Ottewell PD (2021) . Frontiers in Endocrinology, 12.
  • Quayle LA, Spicer A, Ottewell PD & Holen I (2021) . Cancers, 13(16).
  • Tulotta C, Lefley DV, Moore CK, Amariutei AE, Spicer-Hadlington AR, Quayle LA, Hughes RO, Ahmed K, Cookson V, Evans CA , Vadakekolathu J et al (2021) . npj Breast Cancer, 7(1).
  • Clezardin P, Coleman R, Puppo M, Ottewell P, Bonnelye E, Paycha F, Confavreux CB & Holen I (2021) . Physiological Reviews, 101(3), 797-855.
  • Canuas-Landero V, George C, Lefley D, Wilson C & Ottewell P (2021) . Bone Reports, 14.
  • George C, Lefley D, Canuas-Landero V, Tulotta C, Corness H, Wilson C, Muthana M & Ottewell P (2021) . Bone Reports, 14, 101024-101024.
  • Hughes R, Chen X, Cowley N, Ottewell PD, Hawkins RJ, Hunter KD, Hobbs JK, Brown NJ & Holen I (2021) . Cancers, 13(6).
  • Ottewell PD & Lawson MA (2021) . Journal of Cancer Metastasis and Treatment, 7.
  • Al-Sahaf S, Hendawi NB, Ollington B, Bolt R, Ottewell PD, Hunter KD & Murdoch C (2021) . Frontiers in Oral Health, 2.
  • Kwan A, Winder NJ, Atkinson E, Al-Janabi HH, Allen RJ, Hughes R, Moamin MR, Louie R, Evans D, Hutchinson M , Capper DT et al (2020) . Mol Cancer Ther.
  • George CN, Canuas-Landero V, Theodoulou E, Muthana M, Wilson C & Ottewell P (2020) . Journal of Bone Oncology, 25.
  • Bishop RT, Marino S, Carrasco G, Li B, Allen RJ, Sparatore A, Ottewell PD, Mollat P, Sims AH, Capulli M , Wang N et al (2020) . Cancer Letters, 488, 27-39.
  • Ran R, Harrison H, Syamimi Ariffin N, Ayub R, Pegg HJ, Deng W, Mastro A, Ottewell PD, Mason SM, Blyth K , Holen I et al (2020) . Oncogene, 39(12), 2624-2637.
  • Lefley D, Howard F, Arshad F, Bradbury S, Brown H, Tulotta C, Eyre R, Alférez D, Wilkinson JM, Holen I , Clarke RB et al (2019) . Breast Cancer Research, 21(1), ---.
  • Eyre R, Alférez DG, Santiago-Gómez A, Spence K, McConnell JC, Hart C, Simões BM, Lefley D, Tulotta C, Storer J , Gurney A et al (2019) . Nature Communications, 10(1), ---.
  • Ottewell P & Wilson C (2019) . Breast Cancer: Basic and Clinical Research, 13.
  • Allocca G, Hughes R, Wang N, Brown HK, Ottewell PD, Brown NJ & Holen I (2019) . Journal of Bone Oncology, 17.
  • Bishop RT, Marino S, de Ridder D, Allen RJ, Lefley DV, Sims AH, Wang N, Ottewell PD & Idris AI (2019) . Cancer Letters, 450, 76-87.
  • Tulotta C, Lefley DV, Freeman K, Gregory WM, Hanby AM, Heath PR, Nutter-Howard F, Wilkinson JM, Spicer-Hadlington AR, Liu X , Bradbury S et al (2019) . Clinical Cancer Research, 25(9), 2769-2782.
  • Ran R, Harrison H, Ariffin NS, Ayub R, Pegg HJ, Deng W, Mastro A, Ottewell PD, Fowles AM, Blyth SMMK , Holen I et al (2019) .
  • Al-Sahaf S, Hunter KD, Bolt R, Ottewell PD & Murdoch C (2019) . International Journal of Cancer, 144(2), 334-344.
  • Quayle LA, Ottewell PD & Holen I (2018) . Clinical & Experimental Metastasis, 35(8), 831-846.
  • Brown HK, Allocca G, Ottewell PD, Wang N, Brown NJ, Croucher PI, Eaton CL & Holen I (2018) . International Journal of Molecular Sciences, 19(10).
  • Tulotta C & Ottewell PD (2018) . Endocrine-Related Cancer, 25(7), R421-R434.
  • Holen I, Whitworth J, Nutter F, Evans A, Brown HK, Lefley DV, Barbaric I, Jones M & Ottewell PD (2017) . Breast Cancer Research, 19.
  • Holen I, Lefley DV, Francis SE, Rennicks S, Bradbury S, Coleman RE & Ottewell P (2016) . Oncotarget, 7, 75571-75584.
  • Ottewell PD (2016) . Journal of Bone Oncology, 5(3), 124-127.
  • Ottewell P, Brown H, Allocca G, Haider MT, Brown N & Holen I (2016) . European Journal of Cancer, 61, S74-S75.
  • Wright LE, Ottewell PD, Rucci N, Peyruchaud O, Pagnotti GM, Chiechi A, Buijs JT & Sterling JA (2016) . BoneKEy Reports, 5(804).
  • Westbrook JA, Cairns DA, Peng J, Speirs V, Hanby AM, Holen I, Wood SL, Ottewell PD, Marshall H, Banks RE , Selby PJ et al (2016) . Journal of the National Cancer Institute, 108(4).
  • Holen I, Walker M, Nutter F, Fowles A, Evans CA, Eaton CL & Ottewell PD (2016) . Clinical & Experimental Metastasis, 33(3), 211-224.
  • Wang N, Reeves KJ, Brown HK, Fowles ACM, Docherty FE, Ottewell PD, Croucher PI, Holen I & Eaton CL (2015) . JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 34.
  • Ottewell PD, Wang N, Brown HK, Fowles CA, Croucher PI, Eaton CL & Holen I (2015) . International Journal of Cancer, 137(4), 968-977.
  • Quayle L, Ottewell PD & Holen I (2015) . CURRENT CANCER DRUG TARGETS, 15(6), 469-480.
  • Holen I, Nutter F, Wilkinson JM, Evans CA, Avgoustou P & Ottewell PD (2015) . Clinical & Experimental Metastasis, 32(7), 689-702.
  • Wang N, Docherty F, Brown HK, Reeves K, Fowles A, Lawson M, Ottewell PD, Holen I, Croucher PI & Eaton CL (2015) . FASEB Journal, 29(8), 3141-3150.
  • Ottewell PD, O'Donnell L & Holen I (2015) . Bonekey Reports, 4, 643.
  • Wilson C, Ottewell P, Coleman RE & Holen I (2015) . BMC Cancer, 15.
  • Wang N, Docherty FE, Brown HK, Reeves KJ, Fowles ACM, Ottewell PD, Dear TN, Holen I, Croucher PI & Eaton CL (2014) . J Bone Miner Res, 29(12), 2688-2696.
  • Ottewell PD, Wang N, Meek J, Fowles CA, Croucher PI, Eaton CL & Holen I (2014) . Endocrine Related Cancer, 21(5), 769-781.
  • Ottewell PD, Wang N, Brown HK, Reeves KJ, Fowles CA, Croucher PI, Eaton CL & Holen I (2014) . Clin Cancer Res, 20(11), 2922-2932.
  • David M, Machuca-Gayet I, Kikuta A, Ottewell PD, Mima F, Leblanc R, Bonnelye E, Ribeiro J, Holen I, Vales RJ , Jurdic P et al (2014) Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity.. Journal of Biological Chemistry, 10(289), 6551-6564.
  • Nutter F, Holen I, Brown HK, Cross SS, Evans CA, Walker M, Coleman RE, Westbrook JA, Selby PJ, Brown JE & Ottewell PD (2014) . Endocr Relat Cancer, 21(2), 327-341.
  • David M, Machuca-Gayet I, Kikuta J, Ottewell P, Mima F, Leblanc R, Bonnelye E, Ribeiro J, Holen I, Vales RL , Jurdic P et al (2014) . Journal of Biological Chemistry, 289(10), 6551-6564.
  • Rogers TL, Wind N, Hughes R, Nutter F, Brown HK, Vasiliadou I, Ottewell PD & Holen I (2013) . Cell Oncol (Dordr), 36(6), 505-514.
  • Holen I, Wang N, Reeves KJ, Fowles AM, Croucher PI, Eaton CL & Ottewell PD (2012) . Cancer Research, 72(24_Supplement).
  • Brown HK, Ottewell PD, Evans CA, Coleman RE & Holen I (2012) A single administration of combination therapy inhibits breast tumour progress bone and modifies both osteoblasts and osteoclasts. Journal of Bone Oncology, 1(2), 47-56.
  • Holen I, Whitworth J, Nutter F, Evans A, Brown HK, Lefley DV, Barbaric I, Jones M & Ottewell PD (2012) . Breast Cancer Res, 14(3), R86.
  • Brown HK, Ottewell PD, Evans CA & Holen I (2012) . Clin Exp Metastasis, 29(8), 927-938.
  • Ottewell PD, Brown HK, Jones M, Rogers TL, Cross SS, Brown NJ, Coleman RE & Holen I (2012) . Breast Cancer Res Treat, 133(2), 523-536.
  • Ottewell PD, Whitworth J, Cross SS, Nutter FH & Holen I (2011) . Cancer Research, 71(24_Supplement).
  • Ottewell PD (2011) . IBMS BoneKEy, 8(1), 41-45.
  • Brown HK, Ottewell PD, Coleman RE & Holen I (2011) . J Cell Mol Med, 15(3), 501-513.
  • Syddall SP, Ottewell PD & Holen I (2010) . Curr Pharm Des, 16(27), 2988-2997.
  • Ottewell PD (2010) Effects of gastrin and its precursor peptides upon intestinal epithelia..
  • Ottewell PD, Lefley DV, Cross SS, Evans CA, Coleman RE & Holen I (2010) . Int J Cancer, 126(2), 522-532.
  • Ottewell PD, Woodward JK, Lefley DV, Evans CA, Coleman RE & Holen I (2009) . Mol Cancer Ther, 8(10), 2821-2832.
  • Ottewell PD, Lefley DV, Coleman RE & Holen I (2009) . Cancer Research, 69(2_Supplement), 2151-2151.
  • Ottewell PD, Mönkkönen H, Jones M, Lefley DV, Coleman RE & Holen I (2008) . J Natl Cancer Inst, 100(16), 1167-1178.
  • Ottewell PD, Deux B, Mönkkönen H, Cross S, Coleman RE, Clezardin P & Holen I (2008) . Clin Cancer Res, 14(14), 4658-4666.
  • Mönkkönen H, Ottewell PD, Kuokkanen J, Mönkkönen J, Auriola S & Holen I (2007) . Life Sci, 81(13), 1066-1070.
  • Ottewell PD, Duckworth CA, Varro A, Dimaline R, Wang TC, Watson AJM, Dockray GJ & Pritchard DM (2006) . Gastroenterology, 130(4), 1169-1180.
  • Ottewell PD, Coleman RE & Holen I (2006) . Breast Cancer Res Treat, 96(2), 101-113.
  • Keen H, Dekker B, Lyons S, Disley L, Hastings D, Reader A, Ottewell PD, Watson A & Zweit J (2005) . Nucl Med Biol, 4(32), 395-402.
  • Dekker B, Keen H, Lyons S, Disley L, Hastings D, Reader A, Ottewell PD, Watson A & Zweit M (2005) . Nucl Med Biol, 3(32), 241-252.
  • Ottewell PD, Varro A, Dockray GJ, Kirton CM, Watson AJM, Wang TC, Dimaline R & Pritchard DM (2005) . Am J Physiol Gastrointest Liver Physiol, 288(3), G541-G549.
  • Ottewell PD, Watson AJM, Wang TC, Varro A, Dockray GJ & Pritchard DM (2003) . Gastroenterology, 124(5), 1348-1357.
  • Pritchard DM, Ottewell PD, Watson AJM, Wang TC & Dockray GJ (2002) . Clinical Science, 103(s47), 43P-43P.
  • Ottewell PD, Watson AJM, Wang TC, Dockray GJ & Pritchard DM (2002) Progastrin stimulates murine colonic epithelial mitosis after DNA damage. GUT, 50, A93-A93.
  • Pritchard D, Ottewell PD, Watson AJM, Wang TC & Dockray GJ (2002) Progastrin stimulates murine colonic epithelial mitosis after DNA damage. GASTROENTEROLOGY, 122(4), A684-A684.
  • Marshman E, Ottewell PD, Potten CS & Watson AJ (2001) . J Pathol, 195(3), 285-292.
  • MCMICHAEL D, DAVIES A, MARSHMAN E, OTTEWELL P, JENKINS J & WATSON A (2001) . Gastroenterology, 120(5), A660-A660.
  • McMichael DP, Davies A, Marshman E, Ottewell PD, Jenkins JR & Watson AJM (2001) Gene array and knockout mouse analysis of VP-16 induced apoptosis in the murine small intestine. GASTROENTEROLOGY, 120(5), A660-A660.
  • Eksteen JA, Smith JL, Tselepis C, Perry I & Harrison RF (2001) . Gut, 48(suppl 1), A60.2-A64.
  • Haider M-T, Ottewell PD, Brown NJ, Lefley DV & Holen I () . Bone Abstracts.
  • Bradbury S, Rennicks S, Evans A, del CBM, Holen I & Ottewell P () . Bone Abstracts.
  • Ottewell PD () . IBMS BoneKEy, 9.

Book chapters

  • Zhou J, Lefley D & Ottewell P (2025) , Methods in Molecular Biology (pp. 399-421). Springer US
  • Holen I, Saleh L, Ottewell PD & Lawson MA (2022) , Bone Cancer (pp. 35-53). Elsevier
  • George C, Michael N & Ottewell PD (2022) , Bone Cancer (pp. 121-128). Elsevier
  • Ottewell PD & Quayle LA (2019) , Reference Module in Biomedical Sciences Elsevier
  • Tulotta C, Groenewoud A, Snaar-Jagalska BE & Ottewell P (2019) , Methods in Molecular Biology (pp. 309-330). Springer New York

Conference proceedings

  • Lefley D, Jones C, Danson S, Bryant H, Collis S, Brown J & Ottewell P (2023) Addition of ATM Inhibitors to Radium223 Reduces Prostate Cancer Bone Metastases In Vivo. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 38 (pp 214-215)
  • Saleh L, Ottewell PD, Brown JE, Wood SL, Brown NJ, Wilson C, Park C & Holen I (2020) Preventing the progression of breast cancer bone metastasis by CDK inhibition. BREAST CANCER RESEARCH AND TREATMENT, Vol. 180(2) (pp 537-538)
  • Tulotta C, Moore CK, Lefley DV, Amariutei AE, Ahmed K, Spicer-Hadlington AR & Ottewell PD (2020) Inhibition of breast cancer bone metastasis through Interleukin-1B regulated tumour-associated innate immune response. BREAST CANCER RESEARCH AND TREATMENT, Vol. 180(2) (pp 538-539)
  • Bishop N, Kalajzic I, Arshad F, Lefley D, Gossiel F & Ottewell P (2019) . Bone Abstracts, Vol. 7. Salzburg, Austria, 22 June 2019 - 22 June 2019.
  • Moamin MR, Monk P, Cox A, Ottewell P, Saint-Pol J, Rubinstein E & Muthana M (2019) . Cancer Research, Vol. 79(13_Supplement)
  • Moamin MR, Monk P, Cox A, Ottewell P, Saint-Pol J, Rubinstein E & Muthana M (2019) . Tumor Biology
  • Ottewell PD, Lefley DV, Freeman K, Gregory WM, Hanby AM, Spicer-Hadlington AR, Liu X, Bradbury SM, Hambley L, Allocca G , Cookson V et al (2019) . Cancer Research, Vol. 79(4_Supplement)
  • Hughes R, Ottewell P, Hobbs J, Holen I & Brown NJ (2019) Breast Cancer Metastasis to Bone: The Role of the Perivascular Niche in Regulating Tumour Cell Dormancy. JOURNAL OF VASCULAR RESEARCH, Vol. 56 (pp 17-18)
  • (2018) . Breast Cancer Research and Treatment, Vol. 167(1) (pp 309-405)
  • Lefley D, Nutter F, Brown H, Tulotta C, Eyre R, Clarke R, Alferez D, Wilkinson M, Holen I & Ottewell P (2017) . Clinical and Experimental Metastasis , Vol. 34(8) (pp 516-516). Berlin, Germany , 27 November 2017 - 27 November 2017.
  • Quayle L, Park S, McDonnell DP, Ottewell PD & Holen I (2017) . Cancer Research, Vol. 77(4_Supplement)
  • Eyre R, Alferez D, Santiago-Gomez A, Spence K, McConnell J, Simoes B, Hart C, Lefley D, Tulotta C, Gurney A , Howell S et al (2017) Targeting IL-1β-Wnt signalling to prevent breast cancer colonisation in the bone microenvironment. CLINICAL & EXPERIMENTAL METASTASIS, Vol. 34(8) (pp 493-493)
  • Tulotta C, Lefley D, Liu X, Spicer-Hadlington A, Hamley L, Cookson V, Allocca G & Ottewell P (2017) IL-1B signalling regulates breast cancer bone metastasis. CLINICAL & EXPERIMENTAL METASTASIS, Vol. 34(8) (pp 516-516)
  • Ottewell P, Brown H, Allocca G, Haider MT, Brown N & Holen I (2016) . EUROPEAN JOURNAL OF CANCER, Vol. 61 (pp S74-S75)
  • Byrne M, Ottewell PD, Holen I, Sanderson T & Cross SS (2012) The Use of p63 in Distinguishing In Situ and Invasive Tumour in the PyMT Mouse Model of Breast Cancer. JOURNAL OF PATHOLOGY, Vol. 228 (pp S38-S38)
  • Brown HK, Ottewell PD, Evans CA, Coleman RE & Holen I (2011) . BONE, Vol. 48 (pp S255-S255)
  • Ottewell PD, Whitworth J & Holen I (2011) THE ROLE OF PLAKOGLOBIN IN THE INITIATION OF BREAST CANCER METASTASES. ANNALS OF ONCOLOGY, Vol. 22 (pp 32-32)
  • Ottewell PD, Brown H, Rogers TL, Lefley DV, Evans AC, Wind N, Cross SS, Brown N, Coleman R & Holen I (2011) PREVENTION OF SPONTANEOUS MAMMARY TUMOUR GROWTH BY SEQUENTIAL ADMINISTRATION OF DOXORUBICIN AND ZOLEDRONIC ACID IN AN IMMUNOCOMPETENT MOUSE MODEL. ANNALS OF ONCOLOGY, Vol. 22 (pp 29-29)
  • Ottewell PD, Whitworth J & Holen I (2011) THE ROLE OF PLAKOGLOBIN IN THE INITIATION OF BREAST CANCER METASTASES. ANNALS OF ONCOLOGY, Vol. 22 (pp 32-32)
  • Ottewell PD, Brown H, Rogers TL, Lefley DV, Evans AC, Wind N, Cross SS, Brown N, Coleman R & Holen I (2011) PREVENTION OF SPONTANEOUS MAMMARY TUMOUR GROWTH BY SEQUENTIAL ADMINISTRATION OF DOXORUBICIN AND ZOLEDRONIC ACID IN AN IMMUNOCOMPETENT MOUSE MODEL. ANNALS OF ONCOLOGY, Vol. 22 (pp 29-29)
  • Wind NS, Brown H, Ottewell PD, Sadej R, Romanska H, Berditchevski F & Holen I (2011) . BONE, Vol. 48(1) (pp S45-S45)
  • Brown HK, Ottewell PD, Evans CA, Coleman RE & Nolen I (2011) . BONE, Vol. 48(1) (pp S41-S41)
  • Ottewell PD, Brown H, Evans CA, Wind NS, Brown NJ, Coleman RE & Holen I (2011) . BONE, Vol. 48(1) (pp S42-S42)
  • Westbrook JA, Peng J, Cairns DA, Ottewell PD, Holen I, Coleman RE, Selby PJ, Banks RE & Brown JE (2011) . BONE, Vol. 48(1) (pp S33-S33)
  • Brown HK, Ottewell PD, Evans CA & Holen I (2011) . BONE, Vol. 48(1) (pp S40-S41)
  • Holen I, Ottewell PD & Coleman RE (2010) . Cancer Research, Vol. 70(24_Supplement)
  • Ottewell PD, Lefely DV, Cross SS, Coleman RE & Holen I (2010) . BONE, Vol. 47 (pp S317-S317)
  • Brown HK, Ottewell PD, Lefely DV, Coleman RE & Holen I (2010) . BONE, Vol. 47 (pp S318-S319)
  • Woodward J, Holen I, Lefley D, Ottewell P & Buttle D (2010) Breast cancer-bone marrow stromal cell interactions modify expression of proteolytic enzymes and regulators of bone turnover. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 91(2) (pp A45-A46)
  • Ottewell PD, Leftey DV, Coleman RE & Holen I (2009) Evaluation of the molecular mechanisms for the sequence-dependent, synergistic anti-tumour effects of doxorubicin and zoledronic acid in breast cancer.. CANCER RESEARCH, Vol. 69(2) (pp 200S-201S)
  • Ottewell P, Coleman RE & Holen I (2008) . European Journal of Cancer Supplements, Vol. 6(9) (pp 18-18)
  • Ottewell PD, Lefley DV, Coleman RE & Holen I (2008) . BREAST CANCER RESEARCH, Vol. 10 (pp S40-S41)
  • Lefley DV, Holen I, Coleman RE & Ottewell PD (2008) . BREAST CANCER RESEARCH, Vol. 10 (pp S40-S40)
  • Ottewell P, Croucher P & Holen I (2008) . Cancer Treatment Reviews, Vol. 34 (pp 12-12)
  • Ottewell P, Coleman R & Holen I (2008) . Cancer Treatment Reviews, Vol. 34 (pp 19-19)
  • Woodward J, Lefley D, Cross N, Ottewell PD, Buttle DJ, Coleman RE & Holen I (2007) Tumour cell-bone marrow stromal cell interactions modify expression of cathepsin K, ADAMTS-15, TIMP-3 and osteoprotegerin (OPG). INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 88(6) (pp A97-A97)
  • Ottewell PD, Deux B, Monkkonen H, Cross SS, Coleman RE, Clezardin P & Holen I (2007) Differential effects of doxorubicin and zoledronic acid on intra-osseous vs extra-osseous breast tumour growth in vivo.. BREAST CANCER RESEARCH AND TREATMENT, Vol. 106 (pp S39-S39)
  • Ottewell PD, Deux B, Monkkonen H, Coleman RE, Clezardin P & Holen I (2007) Differential effect of doxorubicin and zoledronic acid on intra-osseous vs extra osseous breast tumour growth in vivo. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 22(7) (pp 1111-1111)
  • Woodward JKL, Lefley DV, Cross NA, Ottewell PD, Battle DJ, Coleman RE & Holen I (2007) Tumour cell-bone marrow stromal cell interactions modify expression of cathepsin K, ADAMTS-15, TIMP-3 and osteoprotegerin (OPG). JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 22(7) (pp 1142-1143)
  • Van Pozanki C, Otterwell P, Cross S, Hudis C, Coleman RE & Holen I (2007) Osteoprotegerin (OPG) expression in breast tumors and bone metastases. INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS, Vol. 22(1) (pp 83-84)
  • Ottewell PD, Jones M, Coleman RE & Holen I (2006) . BREAST CANCER RESEARCH, Vol. 8 (pp S17-S17)
  • Cross SS, Ottewell P, Swinscoe M, Majeed AW & Holen I (2006) Osteoprotegerin is strongly expressed in the intratumoural endothelial cells of gastrointestinal carcinomas. JOURNAL OF PATHOLOGY, Vol. 208 (pp 9A-9A)
  • Van Poznak C, Ottewell P, Cross S, Hudis C, Coleman RE & Holen I (2006) . Bone, Vol. 38(3) (pp 31-32)
  • Ottewell PD, Jones M, Coleman RE & Holen I (2006) Synergistic effects of cytotoxic drugs and anti-resorptive agents in vitro and in vivo.. BREAST CANCER RESEARCH AND TREATMENT, Vol. 100 (pp S290-S290)
  • Ottewell PD, Jones M, Coleman RE & Holen I (2006) Synergistic effects of zoledronic acid and doxorubicin in breast cancer models in vivo. CANCER TREATMENT REVIEWS, Vol. 32 (pp S30-S30)
  • Duckworth CA, Ottewell PD, Dimaline R, Varro A & Pritchard DM (2005) Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced mucositis in mice. GUT, Vol. 54 (pp A98-A98)
  • Duckworth CA, Ottewell PD, Varro A, Dimaline R & Pritchard DM (2005) Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced intestinal mucositis in mice.. GASTROENTEROLOGY, Vol. 128(4) (pp A203-A203)
  • Ottewell PD, Watson AJ, Varro A & Pritchard DM (2005) Radiation induces gastrin-CCKB receptor expression in IEC-6 and IEC-18 intestinal epithelial cells. GUT, Vol. 54 (pp A88-A88)
  • Przemeck SMC, Ottewell PD, Watson AJM & Pritchard DM (2005) Radiation induces p53 dependent apoptosis in the proliferative zone of mouse gastric epithelium. GUT, Vol. 54 (pp A88-A88)
  • Ottewell PD, Varro A, Watson AJM, Dimaline R, Dockray GJ & Pritchard DM (2004) Progastrin stimulates murine colonic epithelial mitosis after DNA damage in the absence of murine amidated gastrin. GASTROENTEROLOGY, Vol. 126(4) (pp A272-A272)
  • Davies A, Ottewell P, McNamara A, Jenkins JR & Watson AJM (2004) Etoposide induced p53-dependent gene expression in the GI tract: Analysis of BIRC3, a candidate gene. GASTROENTEROLOGY, Vol. 126(4) (pp A546-A546)
  • Ottewell PD, Watson A, Wang T, Dockray G & Pritchard M (2003) Progastrin stimulates murine colonic mitosis after DNA damage via the cyclin D1-cdk4 complex. GASTROENTEROLOGY, Vol. 124(4) (pp A100-A100)
  • Ottewell PD, Watson A, Wang T, Varro A, Dockray G & Pritchard M (2003) Elevated plasma concentrations of amidated gastrin cause increased crypt survival in murine intestinal epithelia after Gamma-radiation. GASTROENTEROLOGY, Vol. 124(4) (pp A610-A610)
  • Ottewell PD, Watson AJM, Wang TC, Varro A, Dockray GJ & Pritchard DM (2003) Elevated plasma concentrations of amidated gastrin cause increased crypt survival in murine intestinal epithelia after gamma radiation. GUT, Vol. 52 (pp A8-A8)
  • Davies A, Ottewell PD, McNamara A, Watson AJM & Jenkins JR (2003) P53 dependent differential expression analysis of etoposide induced stress in the murine small intestine. GUT, Vol. 52 (pp A36-A36)
  • Ottewell PD, Watson AJM, Wang TC, Dockray GJ & Pritchard DM (2003) Progastrin stimulates murine colonic mitosis after DNA damage via the cyclin D-cdk4 complex. GUT, Vol. 52 (pp A55-A55)
  • McMichael DP, Davies A, Marshman E, Ottewell PD, Jenkins JR & Watson AJM (2001) Knockout mouse and gene array analysis of etoposide induced apoptosis in the murine small intestine. GUT, Vol. 48 (pp A61-A62)
  • Arshad F, Lefley D, Madan S, Fernandes J, Bishop N & Ottewell P () . Bone Abstracts

Preprints

  • Cabral S, Parsons J, Harrison H, Kedward T, Fullwood P, Spence K, Lefley DV, Barden D, Ferguson J, Watson J , Tsafou K et al (2023) , Cold Spring Harbor Laboratory.
  • Shah KM, Tattersall L, Hussain A, Macfarlane SC, Williamson A, Acosta-Martin AE, Erler JT, Ottewell PD & Gartland A (2022) , Cold Spring Harbor Laboratory.
Research group
  • Diane Lefley - Research Technician
  • Claudia Tulotta - Post-doctoral Research Associate
Professional activities and memberships
  • British Association for Cancer Research, executive committee member
  • International Bone and Mineral Society, Young Investigators committee member.
  • Analytical and Cellular Pathology, editorial board
  • Open Journal of Oncology, editorial board