Professor Nigel Hoggard
MD, MRCP, FRCR
School of Medicine and Population Health
Professor of Neuroradiology
+44 114 215 9607
Full contact details
School of Medicine and Population Health
Floor C
Royal Hallamshire Hospital
Glossop Road
Sheffield
S10 2JF
- Profile
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For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
I joined the University of Sheffield in 2006 with interests in adult diagnostic neuroradiology and novel MR imaging agents. Prior to that I had been an NHS Consultant Neuroradiologist at the Manchester Neurosciences Centre, Hope Hospital Salford from 2003. I have been Professor of Neuroradiology since 2018.
I have published over 90 peer reviewed articles.
- Research interests
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My research interests remain primarily centred on the diagnostic applications of MR imaging in radiology with a particular emphasis on neuroscience and the cerebellum in particular. I work closely with Prof Marios Hadjivassiliou, we are part of the SIGReD group founded by Marios, a multi-disciplinary research group focussed on gluten related diseases. We have published numerous articles on gluten ataxia and brain imaging in gluten sensitivity.
The cerebellum is a small part of the brain that never the less contains over half of the neurons. It represents a highly compact system for combining and analysing information subconsciously for the rest of the brain, it can be thought of as the brain’s own supercomputer. It is designed to compare feedback information such as where is my hand in space to pre-existing models held in the cerebellum and then feed-forward into motor commands to ensure movements coordinated in real time such as would be required for catching a ball.The cerebellum not only helps the brain to control balance and coordination of movement but is now having its role in control of emotion, language and cognition gradually revealed. When it is damaged patients may be affected by falls and feel clumsy. They may lose the ability to walk, speak normally, use utensils or dress themselves and quite frequently may have to use a wheel chair as it becomes more severe.
The cerebellum is affected by a wide range of diseases including genetic conditions, degenerative conditions, alcohol and auto-immunity related diseases. There are new treatments being developed for diseases affecting the cerebellum but trials are hampered by the lack of suitable ways to measure their effectiveness. In dementia and MS many trial outcomes are based on MR imaging techniques as a well as clinical changes in the patients. But because the cerebellum’s activity is subconscious and represents feedback control beneath the surface it is difficult to measure clinically. Our group’s research is focussed on assessment of the cerebellum with advanced MR imaging based techniques. In particular, there is a need for measurements in the autoimmune cerebellar diseases and aggressive degenerative cerebellar disease such as MSA-C.
Gluten sensitivity, as well as causing ataxia, can be associated with accelerated white matter small vessel disease and imaging to assess this and the evaluation the blood brain barrier is an area of great interest to us in SIGReD. We recently published a paper demonstrating cognitive and structural brain changes in patients with coeliac ideas from the UK BioBank study in Gastroenterology. We have been recently funded by the Peter Sowerby Foundation to investigate the potential consequences of gluten possessing antibodies gliadins in the blood, which affects about 10% of the UK population, on brain structure and neuro-cognitive performance.
I have been heavily involved in the UK and European response to the evidence of the accumulation of gadolinium in the brain in patients after routine administration of gadolinium based contrast agents for MR scans.I co-chaired the PRAC which recommended to the Human Medicines agency to restrict the use of linear structure gadolinium based contrast agents in the European Union.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . Gastroenterology, 158(8), 2112-2122.
- . Journal of Neurology, Neurosurgery, and Psychiatry, 88, 301-309.
- . British Journal of Radiology, 90(1069).
- . The Lancet Neurology, 15(3), 259-269.
- . Cerebellum, 12(2), 205-211.
- . Clin Gastroenterol Hepatol, 8(5), 433-438.
- . J Med Ethics, 35(3), 194-199.
All publications
Journal articles
- . Journal of Neurology, 272(10).
- . Journal of Neurology, 272(10).
- . Frontiers in Nuclear Medicine, 5.
- . Annals of Neurology.
- . American Journal of Gastroenterology, 120(3), 657-662.
- . Nutrients, 16(8).
- . Brain Communications, 6(2).
- . Gastroenterology, 166(3), 547-547.
- . The Cerebellum, 23, 1231-1234.
- . Journal of Neurology, Neurosurgery & Psychiatry, 95(2), 171-174.
- . BMJ Open, 13.
- . Quantitative Imaging in Medicine and Surgery, 13(10), 7304-7337.
- . Practical Neurology, 23(5), 411-413.
- . Frontiers in Nutrition, 10.
- . Journal of Neurology, 270(3), 1682-1690.
- . The British Journal of Radiology, 96(1141).
- . Rheumatology, 61(Supplement_1).
- . Journal of Magnetic Resonance Imaging, 55(2), 435-442.
- . Nutrition Reviews, 80(3), 367-380.
- . Cerebellum & Ataxias, 8(1).
- . Journal of the Neurological Sciences, 429, 119412.
- . Practical Neurology, 21(4), 351-353.
- . Clinical Radiology, 76(9), 712.e9-712.e13.
- . The Lancet Rheumatology, 3(6), e406-e407.
- . Nutrients, 13(6).
- . Nutrients, 13(4).
- . The Cerebellum, 20(2), 179-185.
- . Nutrients, 13(2).
- . Cerebellum & Ataxias, 8.
- . The Lancet Rheumatology, 3(3), e195-e203.
- . The Cerebellum, 20(3), 454-461.
- . Brain, 143(12), 3603-3618.
- . The Cerebellum, 19, 680-684.
- . Journal of Neurology, 267(10), 3096-3099.
- . PLoS ONE, 15(8).
- . BMJ Open, 10(8).
- . The Cerebellum, 19(4), 605-610.
- . Nutrients, 12(7).
- . Biochemical Pharmacology, 178, 114109-114109.
- . Gastroenterology, 158(8), 2112-2122.
- . Clinical Radiology, 75(5), 348-350.
- . Radiology, 295(1), 171-180.
- . Journal of Neurology, 267(1), 244-256.
- . Journal of Functional Foods, 64, 103597-103597.
- . The Journal of Nutritional Biochemistry, 78, 108325-108325.
- . JOURNAL OF NEUROLOGY.
- . Cerebellum & Ataxias, 6(5).
- . Clinical Gastroenterology and Hepatology, 17(13), 2678-2686.
- . Gastroenterology, 157(3), 881-883.
- . Journal of Magnetic Resonance Imaging, 50(3), 1002-1004.
- . Cerebellum & Ataxias, 6(1).
- . Nutrients, 11(6).
- . NeuroImage, 191, 537-548.
- . Neurology, 92(15_supplement).
- . Clinical Radiology, 74(3), 242-246.
- . Neurology Genetics, 4(6).
- . Neurology Genetics, 4(6).
- . Genes & Nutrition, 13(1).
- . Lupus, 27(11), 1864-1866.
- . The Journal of Laryngology & Otology, 132(06), 550-553.
- . Neuroscience Letters, 678, 124-130.
- . Clinical Neurophysiology, 129(7), 1372-1373.
- . British Journal of Nutrition, 119(5), 496-506.
- . Journal of Neuromuscular Diseases, 5(1), 107-107.
- . Journal of Neurology, Neurosurgery and Psychiatry, 89, 248-255.
- . Seizure, 56, 26-30.
- . Pract Neurol, 18(1), 27-34.
- . Cerebellum Ataxias, 4(1).
- . J Neurol.
- . Neuroimage, 159, 32-45.
- . Pract Neurol.
- . Neurology, 89(7), 705-709.
- . Neurology Genetics, 3(5).
- . British Journal of Radiology, 90(1074).
- . Cerebellum Ataxias, 4.
- . Journal of Neurology, Neurosurgery, and Psychiatry, 88, 301-309.
- . British Journal of Radiology.
- . European Journal of Gastroenterology & Hepatology, 28(12), 1383-1387.
- . British Journal of Radiology, 90(1069).
- . Cerebellum Ataxias, 3, 17-17.
- . Neuroscience, 324, 377-389.
- . The American Journal of Gastroenterology, 111(4), 561-567.
- . The Lancet Neurology, 15(3), 259-269.
- . Pediatric Radiology, 46(1), 73-81.
- . Brain Stimulation, 8(6), 1230-1233.
- . Cerebellum, 14(2), 175-196.
- . Cerebellum Ataxias, 2.
- . Cerebellum & Ataxias(1).
- . AJNR Am J Neuroradiol, 35(9), 1753-1758.
- . Autoimmune Dis, 2014, 237107.
- . Neuropathol Appl Neurobiol, 40(3), 258-269.
- . British Journal of Radiology, 87(1033).
- . Pract Neurol, 14(4), 258-260.
- . Plos One, 8(10).
- . J Neurol Neurosurg Psychiatry, 84(11), e2.
- . J Neurol Neurosurg Psychiatry, 84(11), e2.
- . Journal of Nutritional Science, 2.
- . PLoS One, 8(6), e66186.
- . Amyotroph Lateral Scler Frontotemporal Degener, 14(5-6), 414-423.
- . Pract Neurol, 13(4), 263-267.
- . Pract Neurol, 13(2), 114-119.
- . Neuroradiology, 1-5.
- . J Vasc Interv Radiol, 24(4), 528-533.
- . J Neuroradiol, 40(4), 310-312.
- . Postgrad Med J, 89(1050), 209-223.
- . Postgrad Med J, 89(1048), 94-106.
- . Cerebellum, 12(2), 205-211.
- . Clin Radiol, 68(3), 245-250.
- . British Journal of Nutrition, 109(6), 1040-1051.
- . Cerebellum, 12(2), 245-266.
- . Radiographics, 32(7), 2101-2112.
- . Seizure, 21(10), 820-822.
- . Obesity, 20(6), 1158-1167.
- . J Neurol Neurosurg Psychiatry, 83(12), 1216-1221.
- . Br J Radiol, 85(1017), 1236-1242.
- . Br J Neurosurg, 26(3), 361-366.
- . Acta Neurol Scand, 126(2), 138-143.
- . J NEUROL NEUROSUR PS, 82(9).
- . Journal of Cellular Physiology, 226(8), 2123-2130.
- . Br J Radiol, 84(1000), e79-e82.
- Magnetic resonance imaging of epilepsy at 3 Tesla. Clinical Radiology.
- USE OF MR SPECTROSCOPY AND DIFFUSION TO DIFFERENTIATE GBM FROM SOLITARY CEREBRAL METASTASES. NEURO-ONCOLOGY, 13, 141-141.
- CHO/CR RATIO APPEARS TO BE AN INDEPENDENT IMAGING BIOMARKER OF SURVIVAL FOR PATIENTS NOT SUITABLE FOR OPEN RESECTION OF GLIOBLASTOMA. NEURO-ONCOLOGY, 13, 141-142.
- . Digestive Diseases and Sciences, 56(4), 1028-1036.
- . Neurosurgery, 67(6), 1799-1815.
- . Postgrad Med J, 86(1019), 552-559.
- . Postgrad Med J, 86(1017), 409-418.
- . British Journal of Oral and Maxillofacial Surgery, 48, S28-S28.
- . AM J NEURORADIOL, 31(5), 856-861.
- . Clin Gastroenterol Hepatol, 8(5), 433-438.
- . Br J Radiol, 83(986), 113-117.
- . Epilepsia, 50(12), 2605-2610.
- . J Magn Reson Imaging, 30(5), 981-988.
- . J Cereb Blood Flow Metab, 29(12), 1975-1982.
- . Journal of Molecular Endocrinology, 43(4), 171-177.
- . J Med Ethics, 35(3), 194-199.
- . EUR RADIOL, 19(4), 1025-1025.
- . Phys Med Biol, 53(21), 6055-6063.
- . Neuroradiology Journal, 21(SUPPL. 1), 20-26.
- . Neuroradiology Journal, 21(SUPPL. 1), 47-66.
- . Neurosurgery, 62(2), 336-344.
- . Mechanisms of Ageing and Development, 129(3), 129-137.
- . Journal of Neuroendocrinology, 20(1), 79-84.
- . Journal of Molecular Endocrinology, 39(3), 199-210.
- . Neurosurgery, 61(1 Suppl), 187-196.
- . Endocrinology, 148(8), 3750-3757.
- . Int J Radiat Oncol Biol Phys, 68(3), 952-957.
- . Acta Radiol, 47(10), 1079-1084.
- . Journal of Molecular Endocrinology, 33(3), 693-703.
- . Neurology, 63(7), 1340-1341.
- . Clinical Endocrinology, 61(1), 31-39.
- . Journal of Molecular Endocrinology, 32(1), 145-153.
- . Clin Radiol, 59(4), 356-357.
- Short-term changes in cerebral microhemodynamics after carotid stenting.. AJNR Am J Neuroradiol, 24(8), 1501-1507.
- . DEV MED CHILD NEUROL, 45(2), 139-139.
- . Biochemical and Biophysical Research Communications, 299(3), 432-437.
- . Clin Radiol, 57(11), 957-968.
- . Endocrinology, 143(4), 1166-1173.
- . American Journal of Reproductive Immunology, 47(3), 151-158.
- Brain MR perfusion imaging in humans - Advantages of high-molarity gadolinium chelates. ACTA RADIOL, 42(6), 555-559.
- Brain MR perfusion imaging in humans.. Acta Radiol, 42(6), 555-559.
- . Imaging Decisions MRI, 5(1), 2-10.
- Multimodality MR imaging depiction of hemodynamic changes and cerebral ischemia in subarachnoid hemorrhage.. AJNR Am J Neuroradiol, 22(9), 1690-1697.
- Comparison of the aging of neonatal and adult blood samples in an in vitro subdural hemorrhage model. RADIOLOGY, 221, 487-487.
- Research outcomes in British gastroenterology: an audit of the subsequent full publication of abstracts presented at the British Society of Gastroenterology. GUT, 49(1), 154-155.
- Erratum: Brain iron deposition in Parkinson's disease imaged using the PRIME magnetic resonance sequence (Brain (December 2000) 123:12 (2423-2431)). Brain, 124(6), 1258.
- . Journal of Endocrinology, 169(3), 465-476.
- . Neurosurgery, 48(5), 973-983.
- Cerebral arteriovenous malformations: comparison of novel magnetic resonance angiographic techniques and conventional catheter angiography.. Neurosurgery, 48(5), 973-982.
- . Clin Radiol, 56(3), 171-183.
- In vivo measurement of cerebral blood flow: a review of methods and applications.. Vasc Med, 6(1), 51-60.
- . J Neurol Neurosurg Psychiatry, 70(2), 205-211.
- . Placenta, 22(4), 347-352.
- . Endocrinology, 142(7), 2888-2897.
- . CNS Drugs, 14(6), 413-424.
- . British Journal of Nutrition, 83(3), 317-326.
- . Journal of Neuroendocrinology, 12(7), 649-655.
- . Brain, 123 Pt 12, 2423-2431.
- Brain arteriovenous malformations: assessment with dynamic MR digital subtraction angiography.. AJNR Am J Neuroradiol, 21(10), 1892-1899.
- . Stroke, 31(9), 2266-2278.
- . Stroke, 31(9), 2266-2278.
- Leptomeningeal enhancement and extravasation of contrast medium into the CSF space? Response. STROKE, 31(9), 2276-2277.
- . Molecular Human Reproduction, 6(8), 763-769.
- Full publication of abstracts presented at the British Society of Gastroenterology.. GASTROENTEROLOGY, 118(4), A217-A217.
- Full publication of abstracts presented at the British Society of Gastroenterology. GUT, 46, A18-A18.
- . Stroke, 31(4), 848-851.
- . Reviews of Reproduction, 5(1), 18-24.
- . American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 278(1), R271-R281.
- . Journal of Neuroendocrinology, 11(3), 165-169.
- . International Journal of Obesity, 23(S1), S22-S28.
- . Archiv für Tierernaehrung, 51(2-3), 177-185.
- . Proceedings of the Nutrition Society, 57(3), 421-427.
- . Proceedings of the Nutrition Society, 57(3), 413-419.
- . Regulatory Peptides, 75-76, 271-278.
- . Biochemical and Biophysical Research Communications, 247(3), 654-658.
- . Endocrinology, 139(1), 29-34.
- . Physiology & Behavior, 64(2), 191-195.
- . FEBS Letters, 415(2), 134-138.
- . FEBS Letters, 402(2-3), 185-188.
- . American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 273(1), R446-R450.
- . Biochemical and Biophysical Research Communications, 232(2), 383-387.
- . Biochemical and Biophysical Research Communications, 230(2), 360-364.
- . Journal of Neuroendocrinology, 8(10), 733-735.
- . FEBS Letters, 387(2-3), 113-116.
- . Multiple Sclerosis Journal.
- . Nutrients, 13(5), 1692-1692.
- . Nutrients, 10(10), 1444-1444.
- . Neuroradiologie Scan, 03(04), 285-298.
- . Frontiers in Genetics, 3.
- . Br J Radiol.
- . International Journal of General Medicine, 403-403.
Conference proceedings
- . 2023 IEEE Nuclear Science Symposium, Medical Imaging Conference and International Symposium on Room-Temperature Semiconductor Detectors (NSS MIC RTSD) (pp 1-1), 4 November 2023 - 11 November 2023.
- CEREBELLAR ATAXIA IN PRIMARY SJOGREN'S SYNDROME: IS GLUTEN SENSITIVITY THE ANSWER?. RHEUMATOLOGY, Vol. 61
- Cerebellar Ataxia in Primary Sjogren's Syndrome, Is Gluten Sensitivity the Answer?. ARTHRITIS & RHEUMATOLOGY, Vol. 73 (pp 624-625)
- Balo's concentric sclerosis successfully treated with alemtuzumab. MULTIPLE SCLEROSIS JOURNAL, Vol. 26(3_SUPPL) (pp 264-264)
- . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 90(12) (pp e55.4-e56)
- Investigating Directionality of Neurodegeneration in vivo in ALS using Multimodal MRI. NEUROLOGY, Vol. 92(15)
- . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 89(10) (pp A29.1-A29)
- Imaging denervation in amyotrophic lateral sclerosis for future clinical trials: 12-month follow-up from a longitudinal cohort study. EUROPEAN JOURNAL OF NEUROLOGY, Vol. 25 (pp 302-302)
- . Journal of the Neurological Sciences , Vol. 381s (pp 102-102). Kyoto, Japan, 16 September 2017 - 16 September 2017.
- . Journal of the Neurological Sciences, Vol. 381 (pp 304-305). Kyoto, Japan, 16 September 2017 - 16 September 2017.
- . Gut, Vol. 65(Suppl 1) (pp A165.2-A166)
- . Heart, Vol. 102(Suppl 6) (pp A123.2-A124), 6 June 2016 - 8 June 2016.
- . Neurology, Vol. 86(16_supplement)
- Prognostic Factors Associated with Axonal Loss after Optic Neuritis. NEUROLOGY, Vol. 86
- . Gut, Vol. 64(Suppl 1) (pp A144.1-A144)
- Alcoholic Cerebellar Degeneration: Not All Due to Alcohol. ANNALS OF NEUROLOGY, Vol. 72 (pp S96-S96)
- TRANSFORMATION OF LOW-GRADE GLIOMA ASSESSED BY VOLUMETRIC 3T MRI. NEURO-ONCOLOGY, Vol. 14 (pp 4-4)
- SEMI-AUTOMATED VOLUMETRIC ANALYSIS OF LOW-GRADE GLIOMAS. NEURO-ONCOLOGY, Vol. 13 (pp 140-140)
- Can hyperpolarized He-3 MRI detect radiation induced lung damage?. LUNG CANCER, Vol. 60 (pp S28-S28)
- Dexamethasone and enhancing gliomas: Alterations in perfusion and blood-tumor barrier kinetics shown by magnetic resonace imaging. NEURO-ONCOLOGY, Vol. 9(4) (pp 578-578)
- Improved image registration of hyperpolarized helium-3 MRI and CT for NSCLC planning. RADIOTHERAPY AND ONCOLOGY, Vol. 84 (pp S173-S173)
- . Clinical Oncology, Vol. 19(3) (pp S5-S5)
- . Biochemical Society Transactions, Vol. 29(2) (pp 57-63)
- . Biochemical Society Transactions, Vol. 26(2) (pp S98-S98)
Preprints
- , Springer Science and Business Media LLC.
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- Teaching interests
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I am the lead for the Sheffield academic clinical radiology training scheme and Deputy Lead for the Sheffield academic training programme. The Sheffield radiology training scheme continues to show strong success developing academic radiologists all the way from thesis to tenured full time academic posts. I teach on the Neurology MSc course, the Sheffield Fundamentals of Neuroradiology course and the National ENT radiology Masterclass.
- Professional activities and memberships
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- Editor-in-Chief British Journal of Radiology 2013-2016.
- Expert Advisory Panel member, Commission for Human Medicines/MHRA 2009-present.
- Expert Advisory Panel member, European Medicines Agency 2016.
- Cancer Peer reviewer 2012-2013.
- Member of the Royal College of Radiologists FRCR part I examination committee 2011-2014.
- NIHR doctoral research fellowship selection panel member 2011 and 2013-present.
- NIHR IAT panel for competitive bids for ACF and ACL posts 2015-present.
- Sheffield Teaching Hospitals NHS Foundation Trust, Research Lead for the Directorate of Radiology 2008-present.
- Member of the Sheffield Regional Ethics committee 2006-2012.