Professor Julian Gunn
MA, MB, BChir, MD, MRCP
School of Medicine and Population Health
Professor of Interventional Cardiology
Honorary Consultant Cardiologist
Insigneo Fellow
+44 114 215 9531
Full contact details
School of Medicine and Population Health
K103, K Floor Medical School
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
-
For enquiries, please contact – SMPH-West-Operational@sheffield.ac.uk
I was trained in Medicine at Cambridge, and took junior hospital posts around England before being appointed Clinical Lecturer in Cardiology at the University of Sheffield in 1994. I was trained in Cardiology in Sheffield, and in coronary intervention by Professor David Cumberland.
I won the BCS Young Investigator of the Year in 1995. I was appointed Senior Lecturer in 2000 and became Reader in Interventional Cardiology in 2014 and Professor in 2016. I lead the Mathematical Modelling in Medicine group within the School of Medicine & Population Health, and Chair the Cardio-Respiratory Workgroup of the Insigneo Institute for in silico medicine.
- Research interests
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My higher degree was in the field of local coronary artery injury and healing, and my interests since then have exclusively centred on coronary artery disease (CAD), its endovascular treatment with percutaneous coronary intervention (PCI; angioplasty), the injury and healing resulting from that, and how we can improve upon the results of PCI.
This research has spanned basic research, in vivo experimentation, translation into clinical studies and clinical decision making. Increasingly I am focusing on the application of computer models of coronary artery disease to develop ‘virtual’ coronary physiology based upon the coronary angiogram.
I supervise Academic Clinical Fellows and students at BMedSci, MD and PhD level and welcome applications from students interested in undertaking projects in the field of computational modelling of coronary artery blood flow.
Current project
- Computer modelling of coronary artery disease and blood flow
- Clinical decision making in coronary artery disease
- Complex percutaneous coronary interventions
- Translational clinical trials in these areas
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . Heart, 110(16), 1048-1055.
- . European Heart Journal - Digital Health, 3(3), 481-488.
- . Circulation, 146(9), 687-698.
- . Nature Cardiovascular Research, 1(7), 611-616.
- . Fluids, 7(6).
- . Frontiers in Materials, 13.
- . Scientific Reports, 11.
- . Frontiers in Cardiovascular Medicine, 8.
- . European Heart Journal - Digital Health, 2(4), 616-625.
- . Canadian Journal of Cardiology, 37(10), 1530-1538.
- . Cardiovascular Research, 117(6), 1567-1577.
- . European Heart Journal - Digital Health, 2(2), 263-270.
- . Heart, 107, 783-789.
- . Journal of Biomechanics, 103.
- . JACC: Cardiovascular Imaging, 12(5), 865-872.
- . EuroIntervention, 15(8), 707-713.
- . EuroIntervention, 14(8), 935-941.
- . JACC: Basic to Translational Science, 2(4), 434-446.
- . Frontiers in Physiology, 9.
Preprints
- , Research Square Platform LLC.
All publications
Journal articles
- . American Journal of Physiology-Heart and Circulatory Physiology.
- . European Heart Journal Open, 5(3).
- . Journal of Clinical Medicine, 14(6).
- . Angiology.
- . Mathematics, 13(3).
- . Heart, 111(6), 246-252.
- . European Heart Journal, 45(Supplement_1).
- . Nature Reviews Cardiology, 21(10), 667-681.
- . Expert Review of Cardiovascular Therapy, 22(7), 339-345.
- . American Journal of Physiology-Heart and Circulatory Physiology, 327(1), H182-H190.
- . Heart, 110(16), 1048-1055.
- . Computers in Biology and Medicine, 173.
- . Frontiers in Cardiovascular Medicine, 10.
- . The Lancet Digital Health, 5(7), E467-E476.
- . Fluids, 8(5).
- . European Heart Journal - Digital Health, 4(4), 283-290.
- . Cardiology Research and Practice, 2023.
- . European Heart Journal - Digital Health, 4(2), 81-89.
- . Heart, 109(2).
- . Cardiovascular Research, 118(Supplement_2).
- . European Heart Journal - Digital Health, 3(3), 481-488.
- . Circulation, 146(9), 687-698.
- . PLoS ONE, 17(7).
- . Nature Cardiovascular Research, 1(7), 611-616.
- . Heart, 108(22), 1754-1755.
- . Fluids, 7(6).
- . Frontiers in Materials, 13.
- . Journal of the American College of Cardiology, 79(9), 2022.
- . Scientific Reports, 11.
- . Frontiers in Cardiovascular Medicine, 8.
- . European Heart Journal - Digital Health, 2(4), 616-625.
- . JACC: Cardiovascular Interventions, 14(15), 1731-1733.
- . Physics of Fluids, 33(7).
- . Canadian Journal of Cardiology, 37(10), 1530-1538.
- . BMJ Case Reports, 14(6), e238224-e238224.
- . Cardiovascular Research, 117(6), 1567-1577.
- . Wellcome Open Research, 6.
- . European Heart Journal. Acute Cardiovascular Care, 10(Supplement_1).
- . Platelets, 32(4), 555-559.
- . Quantitative imaging in medicine and surgery, 11(4), 1470-1482.
- . Clinical Medicine, 21(2), e242-e242.
- . European Heart Journal - Digital Health, 2(2), 263-270.
- . Heart, 107, 783-789.
- .
- . Journal of the American College of Cardiology, 76(17), B77-B77.
- . Interventional Cardiology Review, 15.
- . Canadian Journal of Cardiology, 36(6), 852-859.
- . Journal of Biomechanics, 103.
- . Journal of the American Heart Association, 9(6).
- . Cardiovascular Engineering and Technology, 10(4), 568-582.
- . Cardiovascular Revascularization Medicine, 20(11), 980-984.
- . Platelets, 31(2), 174-178.
- . Heart, 105(Suppl 6), a51-a51.
- . Heart, 105(Suppl 6), a15-a15.
- . Heart, 105(Suppl 6), a14-a14.
- . Expert Review of Cardiovascular Therapy, 17(5), 361-368.
- . JACC: Cardiovascular Imaging, 12(5), 865-872.
- . Heart, 105(Suppl 2), s44-s49.
- . BMJ Case Reports, 12(3).
- . EuroIntervention, 15(8), 707-713.
- . Catheterization and Cardiovascular Interventions, 92(6), E381-E392.
- . EuroIntervention, 14(8), 935-941.
- . Circulation, 138(13), 1290-1300.
- . European Heart Journal, 39(suppl_1).
- . Circulation: Cardiovascular Interventions, 10(9).
- . European Heart Journal, 38(suppl_1).
- . JACC: Basic to Translational Science, 2(4), 434-446.
- . Openheart, 4.
- . Platelets, 28(8).
- . Journal of the American College of Cardiology, 69(11), 1065-1065.
- . European Heart Journal: Acute Cardiovascular Care, 6(3), 272-279.
- . Cardiovascular Research .
- . International Journal of Cardiology, 223, 262-264.
- . Eurointervention, 11(13), 1454-1455.
- . Catheterization and Cardiovascular Interventions, 87(4), E104-E112.
- . Heart, 102(1), 18-28.
- . Annals of Biomedical Engineering, 44(2), 453-465.
- . Circulation, 132(suppl_3).
- . CIRCULATION-CARDIOVASCULAR INTERVENTIONS, 8.
- . Open Heart, 2(1).
- . Cardiovascular Revascularization Medicine, 16(8), 447-449.
- . JACC: Cardiovascular Interventions, 8(8), 1009-1017.
- . Circulation, 131(14), 1269-1277.
- . European Heart Journal, 36(13), 777-783.
- . Catheter Cardiovasc Interv, 85(3), 401-405.
- . JACC: Cardiovascular Interventions, 7(12), 1374-1385.
- . Circulation, 130(suppl_2).
- . EuroIntervention, 10(6), 709-716.
- . Cardiovasc Res, 103 Suppl 1, S53.
- . Cardiovascular Engineering and Technology, 5(2), 164-175.
- . Heart, 100 Suppl 3, A120.
- . Heart, 100 Suppl 3, A45.
- . Heart, 100 Suppl 3, A88-A89.
- . Heart, 100 Suppl 3, A41.
- . J R Soc Interface, 11(94), 20140022.
- . Arteriosclerosis, Thrombosis, and Vascular Biology, 34(suppl_1).
- . The International Journal of Artificial Organs, 37(10), 786-800.
- . Eur J Heart Fail, 16(6), 685-691.
- . Open Heart, 1(1).
- The Effect of Interleukin-1 Receptor Antagonist Therapy on Markers of Inflammation in Non-ST Elevation Acute Coronary Syndromes: The MRC-ILA Heart Study. CIRCULATION, 128(22).
- . European Heart Journal, 34(suppl 1), P3083-P3083.
- ST elevation in ECG lead aVR signals severe acute left main coronary artery disease.. Acute Med, 12(4), 220-223.
- . Heart.
- . International Journal for Numerical Methods in Biomedical Engineering, 29(12), 1373-1387.
- . EuroIntervention, 9(1), 62-69.
- . Cardiovasc Res, 99(2), 269-275.
- . BRITISH MEDICAL BULLETIN, 106(1), 193-211.
- . Catheter Cardiovasc Interv, 81, 939-946.
- . Journal of Cardiovascular Magnetic Resonance, 15, P172-P172.
- . LANCET, 381(9882), 1985-1986.
- . EuroIntervention, 8, 1286-1295.
- . JACC Cardiovasc Interv, 6(2), 149-157.
- . Hosp Pract (1995), 40(1), 224-231.
- . Catheter Cardiovasc Interv.
- . European Heart Journal: Acute Cardiovascular Care, 1(1_suppl), 18-55.
- . EuroIntervention, 8, 691-700.
- . Journal of Biomechanics, 45, S145-S145.
- . International Journal of Cardiology, 155, S167-S167.
- . Catheter Cardiovasc Interv, 80(1), 59-64.
- . Heart, 98, 329.
- . Ann Biomed Eng, 39(10), 2615-2626.
- . INTERFACE FOCUS, 1(3), 365-373.
- A Complex Automata approach for in-stent restenosis: Two-dimensional multiscale modelling and simulations. Journal of Computational Science.
- . Clin Cardiol, 34(2), 87-89.
- - Activation of Hypoxia-Inducible Factor by Di-Methyl Oxalyl Glycine (DMOG) Increases Neovascularization within Ischaemic Myocardium in a Porcine Coronary Artery Occlusion Model, - 0, -.
- Novel use of a pericardium-covered stent graft to treat bulky coronary artery thrombus. Catheterization and Cardiovascular Interventions, 45(4).
- Hemodynamics and In-stent Restenosis: Micro-CT Images, Histology, and Computer Simulations. Annals of Biomedical Engineering, 1-12.
- . Heart, 96, 408.
- . Journal of the American College of Cardiology, 55(10), A216.E2047-A216.E2047.
- . Cardiovasc Res, 85(1), 38-44.
- . J Am Coll Cardiol, 54(13), 1131-1136.
- . Heart, 95(17), 1448.
- . Heart, 95, 1308.
- . Heart, 95(16), 1354-1354.
- . Heart, 95, 987.
- . BMJ Case Reports, 2009, bcr2006102392-bcr2006102392.
- . Philos Trans A Math Phys Eng Sci, 366(1879), 3343-3360.
- . Journal of Biomechanics, 41, S482-S482.
- . Trials, 9, 8.
- A novel porcine endovascular model of chronic coronary occlusion. EUROPEAN HEART JOURNAL, 29, 688-688.
- . American Heart Journal, 155(2), 274-283.
- . Annual International Conference of the IEEE Engineering in Medicine and Biology Proceedings, 3069-3073.
- . Annu Int Conf IEEE Eng Med Biol Soc, 2007, 3069-3073.
- . Biochemical Society Transactions, 35(5), 900-904.
- . Heart, 93, 1262.
- . Arteriosclerosis Thrombosis and Vascular Biology, 27(4), 833-840.
- . International Journal of Clinical Practice, 61, 1580-1582.
- . Biomaterials, 28, 1218-1224.
- . Heart, 93, 251-252.
- . Arteriosclerosis Thrombosis and Vascular Biology, 27(4), 833-840.
- . Catheter Cardiovasc Interv, 69(2), 209-215.
- . Heart, 92, 1727.
- . Heart, 92, 1539-1540.
- . Heart, 92(3), 404.
- . Heart, 92, 310.
- . Heart, 91(12), 1603-1604.
- . Cardiovasc Res, 68(3), 493-501.
- . Gene Ther, 12(14), 1154-1157.
- . Comput Methods Biomech Biomed Engin, 7(5), 257-264.
- . Cardiovascular Pathology, 13(3), 93-93.
- . Heart, 90(3), 324-327.
- . Clinical Science, 106(s50), 2P-2P.
- Methotrexate eluting stents: to modify or cure?. Heart, 90, 121-122.
- . Pathol Biol (Paris), 52, 196-205.
- . J Med Eng Technol, 27(2), 59-70.
- Revascularisation for acute coronary syndromes: PCI or CABG?. Heart, 89, 967-970.
- . BMJ, 327, 150-153.
- . Lancet, 361, 2123.
- Position and Mobilisation Post-Angiograph Study (PAMPAS): a comparison of 4.5 hours and 2.5 hours bed rest. HEART, 89(4), 447-448.
- In-stent restenosis and atherosclerosis in a human saphenous vein graft. Heart, 89, 132.
- . Heart, 89(2), 127-131.
- . Clinical Science, 104(s48), 4P-5P.
- . Evidence Based Cardiovascular Medicine, 7(4), 162-163.
- . Cardiovascular Research, 56(1), 164-172.
- . Heart, 88(4), 401-405.
- Stenting the stent.. J Invasive Cardiol, 14(8), 447-451.
- Angiopeptin-eluting stents: Observations in human vessels and pig coronary arteries. Journal of Invasive Cardiology, 14(5), 230-237.
- Ultrasound as treatment for coronary artery disease. Echocardiography, 18, 213-217.
- . Heart, 86(3), 336-340.
- . Cardiovasc Res, 50(1), 125-136.
- Phosphorylcholine-coated stents in porcine coronary arteries: in vivo assessment of biocompatibility.. J Invasive Cardiol, 13(3), 193-201.
- . Circulation, 103(8), 1135-1141.
- Increased intimal hyperplasia after experimental vein graft stenting compared to arterial stenting in a new rabbit model of stent injury. CIRCULATION, 104(17), 666-666.
- Local delivery of angiopeptin from PC-coated stents.. AMERICAN JOURNAL OF CARDIOLOGY, 88(5A), 54G-54G.
- A new injury scoring system appropriate to mild/moderate stent injuries. CIRCULATION, 104(17), 743-743.
- Increased intimal hyperplasia after experimental vein graft stenting compared to arterial stenting: comparisons in a new rabbit model of stent injury. EUROPEAN HEART JOURNAL, 22, 280-280.
- Importance of arterial deformation in the development of InStent neointima.. AMERICAN JOURNAL OF CARDIOLOGY, 88(5A), 52G-53G.
- . Arterioscler Thromb Vasc Biol, 21(11), 1727-1732.
- Interventional therapy on a coarctation of the aorta with a concomitant thoracic aneurysm using a stent graft. Z KARDIOL, 89(10), 962-964.
- Antisense delivery from phosphorylcholine (PC) coated stents. EUR HEART J, 21, 285-285.
- Anti-CD18 antibody blocks leucocyte trafficking in porcine coronary arteries following PTCA. EUR HEART J, 21, 284-284.
- Caspase-3 activity in porcine coronary arteries following PTCA. EUR HEART J, 21, 282-282.
- Possible different involvement of interleukin-1 receptor antagonist gene polymorphism in coronary single vessel disease and myocardial infarction - Response. CIRCULATION, 101(18), E193-E193.
- Antisense oligonucleotide to c-myb induces apoptosis in vascular smooth muscle cells in vitro and in vivo. Heart, 83(SUPPL. 1), P17.
- Small stent, small vessel is not equivalent to standard stent, standard vessel.. AMERICAN JOURNAL OF CARDIOLOGY, 86(8A), 42I-42I.
- Are we achieving intended dimensions in stenting very small coronary arteries?. AMERICAN JOURNAL OF CARDIOLOGY, 86(8A), 42I-42I.
- Effects of arterial taper upon in-stent restenosis in very small coronary vessels.. AMERICAN JOURNAL OF CARDIOLOGY, 86(8A), 117I-117I.
- New Developments in Therapeutic Ultrasound-Assisted Coronary Angioplasty. Curr Interv Cardiol Rep, 1, 281-290.
- . Eur Heart J, 20, 1693-1700.
- . Cardiovasc Res, 44(1), 156-165.
- . Heart, 82(3), 351-351.
- . Eur Heart J, 20, 1009-1013.
- Platelet glycoprotein IIb/IIIa inhibition by Lamifiban reduces the neointimal response to angioplasty in a porcine model. Heart, 81(SUPPL. 1), P17.
- Local drug delivery from coronary stents in the porcine coronary artery. Heart, 81(SUPPL. 1), P23.
- . Circulation, 99(7), 861-866.
- Transforming growth factor-beta gene polymorphisms and coronary artery disease. CLIN SCI, 95(6), 659-667.
- . Heart, 80(5), 509-516.
- Overlapping stents: No alteration in neointima formation.. CIRCULATION, 98(17), 189-189.
- . Circulation, 98(16), 1657-1665.
- Aorto-ostial stent: Procedural, angiographic and histological evaluation in porcine coronary arteries.. AM J CARDIOL, 82(7A), 68S-68S.
- Assessment of the safety and efficacy of supersaturated oxygen solution: A novel method of reducing myocardial ischaemia in PTCA.. AM J CARDIOL, 82(7A), 100S-100S.
- Has stenting killed local drug delivery?. Eur Heart J, 19, 689-692.
- Interleukin-1 (IL-1) gene polymorphisms: Risk of coronary arterial disease. Heart, 79(SUPPL. 1), P46.
- Phosphorylcholine coated stents: Angiographic and morphometric assessment in porcine coronary arteries. J AM COLL CARDIOL, 31(2), 414A-414A.
- Apoptosis and cell proliferation following porcine angioplasty. J AM COLL CARDIOL, 31(2), 22A-22A.
- Biomimicry 1: PC.. Semin Interv Cardiol, 3(3-4), 149-150.
- In-stent restenosis: More metal and more symmetry required?. Heart, 77(SUPPL. 1), P46.
- The BioDivYsio(R) stent: Morphometric superiority to the Palmaz-Schatz stent in the porcine coronary model. AMERICAN JOURNAL OF CARDIOLOGY, 80, TCT95-TCT95.
- . Circ Res, 80(4), 520-531.
- Restenosis after balloon angioplasty: Intimal hyperplasia or vessel remodelling?. HEART, 75(5), 88-88.
- Dual balloon catheter.. Semin Interv Cardiol, 1(1), 31-33.
- INTRA-CORONARY DRUG-DELIVERY VIA POROUS BALLOON - LOCAL OR REGIONAL. CIRCULATION, 92(8), 3220-3220.
- . Journal of the American College of Cardiology, 25(2), 376A-377A.
- . Journal of the American College of Cardiology, 25(2), 268A-268A.
- . LANCET, 344(8931), 1225-1225.
- . CORONARY ARTERY DISEASE, 5(3), 257-265.
- . CIRCULATION, 89(4), 1587-1592.
- POTENTIAL ROLE OF THERAPEUTIC ULTRASOUND IN CORONARY ANGIOPLASTY (TUSCA). JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, A186-A186.
- THERAPEUTIC ULTRASONIC CORONARY ANGIOPLASTY - IMMEDIATE AND 24-HOUR QUANTITATIVE ANGIOGRAPHIC ASSESSMENT. CIRCULATION, 88(4), 645-645.
- THERAPEUTIC ULTRASONIC CORONARY ANGIOPLASTY - 1ST 20 CASES. CIRCULATION, 88(4), 296-296.
- A case of meningococcal endocarditis. European Heart Journal, 13, 1004-1005.
- Lymphoma presenting with Addison's disease. Postgrad Med J, 68, 229.
- Malignant thymoma causing tricuspid valve obstruction. Eur Heart J, 11, 854-856.
- Hypertensive crisis and broad complex bradycardia after a single dose of monoamine oxidase inhibitor. BMJ, 298, 964.
- BUTANE SNIFFING CAUSING VENTRICULAR FIBRILLATION. The Lancet, 333, 617.
- . Cardiovascular Research.
- . PLOS ONE, 19(11), e0314392-e0314392.
- . Communications in Computational Physics, 33(1), 283-309.
- . Journal of Cardiovascular Pharmacology, 78(5), e656-e661.
- . Frontiers in Physiology, 9.
- . Thrombosis and Haemostasis , 118(7), 1250-1256.
- . International Journal of Cardiovascular Research, 06(03).
- . BMJ Case Reports, 2015, bcr2014204519-bcr2014204519.
Book chapters
- , Practical Interventional Cardiology (pp. 109-123). CRC Press
- , Complications of Percutaneous Coronary Intervention (pp. 91-98). Springer London
- , Developments in Cardiovascular Medicine (pp. 263-269). Springer US
- , Vascular Disease (pp. 401-416). Humana Press
Conference proceedings
- . Young Investigator Award (pp A294-A299)
- . Acute coronary syndromes & interventional cardiology (pp A88.2-A89)
- . Imaging (pp A191-A193)
- . Basic science (pp A281.2-A282)
- . Stable IHD/Prevention/Hypertension/Lipids (pp A228.2-A229)
- . Acute coronary syndromes & Interventional Cardiology (pp A81.1-A81)
- . Acute coronary syndromes & Interventional Cardiology (pp A49-A50)
- . Acute coronary syndromes & Interventional Cardiology (pp A62-A63)
- . Acute coronary syndromes & Interventional Cardiology (pp A44-A46)
- . European Heart Journal, Vol. 42(Suppl 1) (pp 1074-1074). Digital Congress, 27 August 2021 - 27 August 2021.
- . Acute coronary syndromes & Interventional cardiology (pp A29-A30)
- . Heart Failure (pp A61-A62)
- . BMC Geriatrics, Vol. 20(1)
- Novel Pericardial Left Ventricular Assist Device (PALVAD) Assessment via Large Animal and Cadaveric Models. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 76(17) (pp B77-B77)
- . Heart, Vol. 105(Suppl 6) (pp a45-a45). Manchester, UK, 3 June 2019 - 3 June 2019.
- Feasibility of Coronary Angiogram-based Computational Modelling of Fractional Flow Reserve in Everyday Practice. CIRCULATION, Vol. 140
- Prolonged Enoxaparin Infusion in Patients Undergoing Primary Percutaneous Coronary Intervention Compared to Standard-of-care: A Single-centre Clinical Trial. CIRCULATION, Vol. 140
- . Cardiovascular Research, Vol. 114(suppl_2) (pp S9-S9)
- . International Journal of Surgery, Vol. 55 (pp S9-S9)
- . Heart, Vol. 103(Suppl 7) (pp a3)
- . European Heart Journal Supplements, Vol. 38(1). Barcelona, Spain, 26 August 2017 - 26 August 2017.
- . European Heart Journal , Vol. 38, S1 (pp 183-184). Barcelona, Spain, 26 August 2017 - 26 August 2017.
- . European Heart Journal, Vol. 38(Suppl 1) (pp 87-87). Barcelona, Spain, 26 August 2017 - 26 August 2017.
- . Journal of the American College of Cardiology, Vol. 69(11) (pp 1014-1014)
- . Heart View (pp A18-A18)
- . Heart, Vol. 102(Suppl 6) (pp A114.2-A114), 6 June 2016 - 8 August 2016.
- . Journal of the American College of Cardiology, Vol. 67(13) (pp 111-111)
- . Heart, Vol. 101(Suppl 4) (pp A115.1-A115)
- . Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, Vol. 2 (pp 619-626)
- Reconstruction of coronary trees from 3DRA using a 3D+t statistical cardiac prior. Medical Image Computing and Computer Assisted Intervention Miccai International Conference on Medical Image Computing and Computer Assisted Intervention, Vol. 17 (pp 619-626)
- Outcomes in patients with cardiogenic shock following percutaneous coronary intervention in the contemporary era: an analysis from the british cardiovascular intervention society (BCIS) database. EUROPEAN HEART JOURNAL, Vol. 35 (pp 1040-1040)
- Radio-Frequency Denervation Of The Pulmonary Artery Reduces Pulmonary Hypertension In An Acute Porcine Model. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- Lower Mortality and Stent Thrombosis Rates Associated With Introduction of Potent P2Y12 Inhibitors in Patients With Acute Coronary Syndromes. CIRCULATION, Vol. 130
- . HEART, Vol. 99
- Morphine Delays the Onset of Action of Prasugrel in Patients With Prior History of St Elevation Myocardial Infarction. CIRCULATION, Vol. 128(22)
- Frailty assessment as a prognostic tool in elderly acute coronary syndrome patients to identify those approaching end-of-life: results from prospective multicenter fate-acs study. EUROPEAN HEART JOURNAL, Vol. 34 (pp 559-560)
- . Proceedings International Symposium on Biomedical Imaging (pp 618-621)
- . HEART, Vol. 98 (pp A28-A28)
- . HEART, Vol. 98 (pp A14-A14)
- . HEART, Vol. 97 (pp A13-A13)
- SYNTAX Score Does Not Add to Clinical Risk Score in a Typical PCI Population. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 58(20) (pp B111-B111)
- Left Main Bifurcation Stenting: Long Term Followup of Simultaneous Kissing Stents in 140 Consecutive, Unselected Patients. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 58(20) (pp B84-B84)
- Virtual Coronary Physiology and Anatomy Derived From Rotational Angiography: The First Step. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 58(20) (pp B189-B189)
- . HEART, Vol. 96 (pp A61-A62)
- . HEART, Vol. 96 (pp A59-A60)
- . Lecture Notes in Computer Science Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics, Vol. 5544 LNCS(PART 1) (pp 705-714)
- COAST: Modelling Restenosis and Stent Based Therapies. INTERNATIONAL CONFERENCE ON ADVANCEMENTS OF MEDICINE AND HEALTH CARE THROUGH TECHNOLOGY, Vol. 26 (pp 319-322)
- Complete Versus Incomplete Revascularisation In A 'Real World', Consecutive Population Of 241 Patients With Triple Vessel Coronary Artery Disease Undergoing Percutaneous Intervention. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 104(6A) (pp 203D-203D)
- Simultaneous Kissing Paclitaxel-eluting Stents to Treat Unprotected Left Main Stem Bifurcation Disease: Medium Term Outcome In 140 Consecutive Patients. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 104(6A) (pp 105D-105D)
- A NOVEL MURINE MODEL OF STENTING. HEART, Vol. 95 (pp A37-A38)
- A porcine endovascular model of a chronic total coronary artery occlusion. HEART, Vol. 94 (pp A46-A46)
- Evidence for a potential new method of therapeutic angiogenesis: Increased endothelial cell mobility and tubule formation in cell culture after stabilisation of hypoxia-inducible factor. HEART, Vol. 94 (pp A46-A47)
- In-vivo observations on angiogenesis: Dose-dependent effects of the prolyl-4-hydroxylase inhibitor, di-methyl oxalyl-glycine, on arterial development in embryonic zebrafish. HEART, Vol. 94 (pp A47-A48)
- Simultaneous kissing stents to treat left main bifurcation stenosis. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 51(10) (pp B47-B48)
- Left main stem percutaneous coronary intervention: The first 250 patients from the Sheffield unselected, consecutive registry. HEART, Vol. 94 (pp A132-A132)
- Is preprocedural rotational angiography superior to conventional, single-plane angiography for planning percutaneous coronary intervention?. HEART, Vol. 94 (pp A40-A40)
- Incidence And Outlook Of Recurrent Restenosis After Treatment Of Unprotected Left Main Disease With Drug-Eluting Stents: Cohort Study On 718 Patients And 70 Restenotic Cases. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 102(8A) (pp 117I-117I)
- Coronary artery bypass grafting and percutaneous coronary intervention for left main stem coronary artery disease: synergy in a real-world registry. HEART, Vol. 94 (pp A30-A31)
- Simultaneous kissing stents (shotgun stents) to treat left main bifurcation stenosis. HEART, Vol. 93 (pp A93-A93)
- The effect of Interleukin-1 receptor antagonist on restenosis - continued suppression of neointima at 90 days. EUROPEAN HEART JOURNAL, Vol. 27 (pp 230-231)
- Shotgun stenting of left main bifurcation stenosis. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 47(4) (pp 15B-15B)
- The impact of a policy of selective drug eluting stent implantation upon clinical resteosis: A 'real world' registry. HEART, Vol. 92 (pp A98-A98)
- Shotgun stenting of left main bifurcation stenosis. HEART, Vol. 92 (pp A99-A99)
- Left Main Stem Percutaneous Coronary Intervention an unselected registry of all comers 2000-2005. EUROPEAN HEART JOURNAL, Vol. 27 (pp 929-929)
- In-stent stenosis in apolipoprotein-E knockout mice: A novel mouse model of balloon angioplasty and stenting. HEART, Vol. 92 (pp A113-A113)
- A new murine model of arterial stenting. HEART, Vol. 91 (pp A51-A51)
- Ultrasound-mediated delivery of TIMP-3 plasmid DNA into saphenous vein leads to increased lumen size in a porcine interposition graft model. CIRCULATION, Vol. 110(17) (pp 161-161)
- Interleukin 1 receptor antagonist (IL 1ra) modulates the response to oversized balloon angioplasty and stenting in a porcine coronary artery model. HEART, Vol. 90 (pp A1-A2)
- Interleukin-1 receptor antagonist (IL-1ra) modulates the porcine coronary arterial response to stenting. ATHEROSCLEROSIS, Vol. 174(1) (pp S4-S4)
- Interleukin-1 receptor antagonist (IL-1ra) modulates the porcine coronary arterial response to oversized balloon angioplasty and stenting. CIRCULATION, Vol. 108(17) (pp 195-195)
- Adjunctive ultrasound exposure enhances gene delivery to vascular smooth muscle cells in vitro and to ex vivo and in vivo porcine saphenous vein grafts. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 92(6A) (pp 100L-100L)
- Restitution of a tubular lumen after stent implantation in porcine coronary arteries. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 92(6A) (pp 208L-208L)
- Vascular delivery of antisense oligonucleotide to c-myc via coated stents: In vitro and in vivo findings. HEART, Vol. 89 (pp A52-A53)
- Same-session discharge after PCI. HEART, Vol. 89 (pp A18-A18)
- Endoluminal ultrasound enhances nonviral gene delivery from plasmid-coated stents.. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 90(6A) (pp 118H-119H)
- In vivo pharmacokinetics and bioactivity of stent-based delivery of antisense oiligonucleotides to c-myc. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 90(6A) (pp 123H-123H)
- A polymer-based copper coating can generate nitric oxide from S-nitrosoglutathione but does not induce significant neointimal formation. EUROPEAN HEART JOURNAL, Vol. 23 (pp 142-142)
- Stenting the stent. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 90(6A) (pp 91H-91H)
- Drug-eluting stents: Maximizing benefit and minimizing costs.. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 90(6A) (pp 71H-71H)
- A polymer-based copper coating generates nitric oxide from s-nitrosoglutathione but does not induce significant neointimal formation when used as a stent coating.. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 90(6A) (pp 77H-77H)
- Modulation of MSS1, a component of the 26S proteasome, in vascular smooth muscle cells in vitro and following experimental PTCA. EUR HEART J, Vol. 22 (pp 3-3)
- Integrin αIIbβ3 and ανβ3 inhibition reduces neointima after porcine coronary angioplasty. Heart, Vol. 83(SUPPL. 1) (pp P46)
- A selective integrin alpha V beta 3 antagonist reduces neointimal proliferation in a porcine coronary angioplasty model via a thrombus independent mechanism. CIRCULATION, Vol. 100(18) (pp 414-414)
- Antagonists of integrins alpha IIb beta 3 and alpha v beta 3 reduce the neointimal response to arterial injury in a porcine coronary angioplasty model.. AM J CARDIOL, Vol. 84(6A) (pp 29P-30P)
- IL-1 beta synthesis and neovascularisation following porcine coronary arterial injury. J VASC RES, Vol. 35(5) (pp 389-389)
- Is local drug delivery truly a low efficiency procedure?. AM J CARDIOL, Vol. 80 (pp TC240-TC240)
Digital content
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Preprints
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- Research group
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- Mr Marco Frison
- Dr Becky Gosling (Staff Candidate)
- Miss Martina Sciola
- Grants
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I currently hold NIHR, BHF and MRC-DPFS grants.
- Teaching activities
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I lecture to undergraduate medical students and enjoy bedside teaching. I also teach Cardiology trainees on a regional level. I am a trainer in PCI in Sheffield and lecture on advanced PCI techniques nationally and internationally.
I also teach on the Molecular Medicine MSc course. I have taught 21 BMedSci, 7 MD and 8 PhD students.
- Professional activities and memberships
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I am Honorary Consultant Cardiologist at the Sheffield Teaching Hospitals NHS Foundation Trust and Lead for Acute Coronary Syndrome Pathways, Sheffield Teaching Hospitals Foundation Trust.
I am Chairman of the Insigneo Cardiovascular Working Group. I am a member of the British Cardiovascular Society, and of the British Cardiovascular Intervention Society and its R&D committee.
I am a Supervisor for the Wellcome 4Ward North Clinical PhD Programme, and Member of the EPSRC Image-guided therapies UK Network. I am reviewer for six Cardiology journals and for the BHF, MRC and NIHR.