Dr Jovana Serbanovic-Canic

School of Medicine and Population Health

BHF Intermediate Basic Science Research Fellow

Dr Jovana Serbanovic-Canic
Dr Jovana Serbanovic-Canic
Profile picture of Dr Jovana Serbanovic-Canic
j.serbanovic-canic@sheffield.ac.uk
+44 114 215 9502
The Medical School

Full contact details

Dr Jovana Serbanovic-Canic
School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk

In 2013 I received my PhD from the University of Cambridge where, as a Marie Curie Fellow in the lab of Professor Willem Ouwehand, I used the zebrafish model for studying regulators of haematopoiesis.

Following my PhD, I took up the position of John Stokes Postdoctoral Fellow in the lab of Professor Paul Evans at the University of Sheffield. Here I developed a platform for functional screening of flow-responsive apoptotic regulators in zebrafish.

I subsequently used this model to identify mechanoreceptors regulating endothelial apoptosis in response to flow, which was the basis for my British Heart Foundation Intermediate Basic Science Research Fellowship, awarded in February 2018.

Research interests

I am interested in mechanoreceptors on endothelial cells which convert mechanical signals associated with blood flow into physiological changes. Disturbed blood flow conditions lead to endothelial cell injury which contributes to the development of cardiovascular disease, one of the leading causes of death globally.

My work is aimed at identifying mechanoreceptors which regulate endothelial cell death in response to mechanical forces and to study this I use a range of different models and approaches, including zebrafish, murine models and human cells.

Understanding the function and downstream pathways of these mechanoreceptors may provide useful targets for the prevention and treatment of cardiovascular disease.

Current projects

Role of the mechanoreceptor Pkd1 in endothelial dysfunction and atherosclerosis (British Heart Foundation funding, 2018-2023).

Publications

Show: Featured publications All publications

Journal articles

  • Souilhol C, Gauci I, Feng S, Tardajos Ayllon B, Mahmoud M, Canham L, Fragiadaki M, Serbanovic-Canic J, Ridger V & Evans PC (2019) . Cardiovascular Research.
  • Mahmoud M, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis S , Van der Heiden K et al (2017) . Scientific Reports, 7.
  • Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M, Feng S, Souilhol C , Bowden N et al (2016) . Arteriosclerosis, Thrombosis, and Vascular Biology.
  • Bryan MT, Duckles H, Feng S, Hsiao ST, Kim HR, Serbanovic-Canic J & Evans PC (2014) . Arterioscler Thromb Vasc Biol, 34(10), 2199-2205.
  • Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, Serbanovic-Canic J, Elling U, Goodall AH, Labrune Y , Lopez LM et al (2011) New gene functions in megakaryopoiesis and platelet formation. Nature.
  • Serbanovic-Canic J, Cvejic A, Soranzo N, Stemple DL, Ouwehand WH & Freson K (2011) . Blood, 118(18), 4967-4976.

All publications

Journal articles

  • Tardajos Ayllon B, Bowden N, Souilhol C, Darwish H, Tian S, Duckworth C, Pritchard DM, Xu S, Sayers J, Francis S , Serbanovic-Canic J et al (2025) . Cardiovascular Research, 121(5), 748-759.
  • Bowley G, Irving S, Hoefer I, Wilkinson R, Pasterkamp G, Darwish HMS, White S, Francis SE, Chico T, Noel E , Serbanovic-Canic J et al (2024) . Scientific Reports, 14(1).
  • Pirri D, Tian S, Tardajos-Ayllon B, Irving SE, Donati F, Allen SP, Mammoto T, Vilahur G, Kabir L, Bennett J , Rasool Y et al (2024) . Circulation Research, 135(8), 822-837.
  • X S, Aitken C, Mehta V, Tardajos-Ayllon B, Serbanovic-Canic J, Zhu J, Miao B, Tzima E, Evans P, Fang Y & Schwartz MA (2024) . Journal of Cell Science, 137(17).
  • Li X, Souilhol C, Canham L, Jia X, Diagbouga M, Ayllon BT, Serbanovic-Canic J & Evans PC (2023) . Vascular Pharmacology, 150, 107178-107178.
  • Canham L, Sendac S, Diagbouga MR, Wolodimeroff E, Pirri D, Tardajos Ayllon B, Feng S, Souilhol C, Chico TJA, Evans PC & Serbanovic-Canic J (2023) . Arteriosclerosis, Thrombosis, and Vascular Biology, 43(4), 547-561.
  • Souilhol C, Tardajos Ayllon B, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D, Chambers EV, Dunning MJ , Ariaans M et al (2022) . Science Advances, 8(35).
  • Bowley G, Kugler E, Wilkinson R, Lawrie A, Eeden F, Chico TJA, Evans PC, Noël ES & Serbanovic‐Canic J (2022) . British Journal of Pharmacology, 179(5), 900-917.
  • Bowley G, Chico TJA, Serbanovic-Canic J & Evans PC (2021) . F1000Research, 10.
  • Kugler E, Snodgrass R, Bowley G, Plant K, Serbanovic-Canic J, Hamilton N, Evans PC, Chico T & Armitage P (2021) . Vascular Biology, 3(1), 1-16.
  • Evans PC, Fragiadaki M, Morris PD & Serbanovic-Canic J (2021) . Cardiovascular Research, 117(8), 1811-1813.
  • Mahmoud MM, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis SE , Van der Heiden K et al (2020) . SCIENTIFIC REPORTS, 10(1).
  • Souilhol C, Serbanovic-Canic J, Fragiadaki M, Chico TJ, Ridger V, Roddie H & Evans PC (2020) . Nature Reviews Cardiology, 17(1), 52-63.
  • Souilhol C, Gauci I, Feng S, Tardajos Ayllon B, Mahmoud M, Canham L, Fragiadaki M, Serbanovic-Canic J, Ridger V & Evans PC (2019) . Cardiovascular Research.
  • Serbanovic-Canic J, Souilhol C & Evans PC (2019) . Cardiovascular Research, 115(10), 1449-1451.
  • Xanthis I, Souilhol C, Serbanovic-Canic J, Roddie H, Kalli AC, Fragiadaki M, Wong R, Shah DR, Askari JA, Canham L , Akhtar N et al (2019) . Journal of Cell Science, 132(11).
  • Mahmoud M, Souilhol C, Serbanovic-Canic J & Evans P (2019) . Cardiovascular Drugs and Therapy, 33(2), 231-237.
  • Mahmoud M, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis S , Van der Heiden K et al (2017) . Scientific Reports, 7.
  • Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M, Feng S, Souilhol C , Bowden N et al (2016) . Arteriosclerosis, Thrombosis, and Vascular Biology.
  • Bowden N, Bryan MT, Duckles H, Feng S, Hsiao S, Kim HR, Mahmoud M, Moers B, Serbanovic-Canic J, Xanthis I , Ridger VC et al (2016) . Antioxidants & Redox Signaling, 25(7), 389-400.
  • Mahmoud M, Kim HR, Xing R, Hsiao S, Mammmoto A, Chen J, Serbanovic-Canic J, Feng S, Bowden NP, Maguire R , Ariaans M et al (2016) . Circulation Research, 119, 450-462.
  • Bielczyk-Maczyńska E, Serbanovic-Canic J, Ferreira L, Soranzo N, Stemple DL, Ouwehand WH & Cvejic A (2014) . PLoS Genet, 10(7), e1004450.
  • Bryan MT, Duckles H, Feng S, Hsiao ST, Kim HR, Serbanovic-Canic J & Evans PC (2014) . Arterioscler Thromb Vasc Biol, 34(10), 2199-2205.
  • Gray C, Bratt D, Lees J, daCosta M, Plant K, Watson OJ, Solaymani-Kohal S, Tazzyman S, Serbanovic-Canic J, Crossman DC , Keavney BD et al (2013) . Arterioscler Thromb Vasc Biol, 33(6), 1257-1263.
  • Brieu N, Navab N, Serbanovic-Canic J, Ouwehand WH, Stemple DL, Cvejic A & Groher M (2012) . Med Image Anal, 16(4), 915-931.
  • Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, Serbanovic-Canic J, Elling U, Goodall AH, Labrune Y , Lopez LM et al (2011) New gene functions in megakaryopoiesis and platelet formation. Nature.
  • Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, Serbanovic-Canic J, Elling U, Goodall AH, Labrune Y , Lopez LM et al (2011) . Nature, 480(7376), 201-208.
  • Brieu N, Groher M, Serbanovic-Canic J, Cvejic A, Ouwehand W & Navab N (2011) . Med Image Comput Comput Assist Interv, 14(Pt 3), 579-586.
  • Serbanovic-Canic J, Cvejic A, Soranzo N, Stemple DL, Ouwehand WH & Freson K (2011) . Blood, 118(18), 4967-4976.
  • Cvejic A, Serbanovic-Canic J, Stemple DL & Ouwehand WH (2011) . Haematologica, 96(2), 190-198.
  • Soranzo N, Spector TD, Mangino M, Kühnel B, Rendon A, Teumer A, Willenborg C, Wright B, Chen L, Li M , Salo P et al (2009) . Nat Genet, 41(11), 1182-1190.

Conference proceedings

  • Serbanovic-Canic J, Evans PC & Chico T (2023) . Basic Science (pp A247.1-A247)
  • Bowley G, Evans P, Serbanovic-Canic J & Chico T (2021) . Basic science (pp A163.2-A164)
  • Souilhol C, Feng S, Gauci I, Serbanovic-Canic J, Canham L & Evans PC (2019) Mechanosensitive Hox Genes Control Vascular Dysfunction in Adult Arteries. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 33(2) (pp 272-272)
  • Serbanovic-Canic J, Feng S, Souilhol C & Evans PC (2019) The Role of FAM176A in Endothelial Cell Responses to Flow. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 33(2) (pp 273-273)
  • Serbanovic-Canic J, de Luca A, Warboys C, Chico T & Evans P (2013) . Heart, Vol. 99(suppl 2) (pp A6.1-A6)
  • Freson K, Serbanovic-Canic J, Cvejic A, Soranzo N, Stemple D & Ouwehand W (2011) Silencing of RhoA nucleotide exchange factor, ARHGEF3, reveals its role in thrombopoiesis and iron uptake. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol. 9 (pp 33-33)
  • Brieu N, Serbanovic-Canic J, Cvejic A, Stemple D, Ouwehand W, Navab N & Groher M (2010) . Progress in Biomedical Optics and Imaging Proceedings of SPIE, Vol. 7623(PART 1)
  • Cvejic A, Serbanovic-Canic J, Stemple D & Ouwehand W (2010) THE ROLE OF MEIS1 IN PRIMITIVE AND DEFINITIVE HAEMATOPOIESIS AND VASCULAR PATTERNING DURING ZEBRAFISH DEVELOPMENT. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, Vol. 95 (pp 247-247)

Preprints

  • Tardajos-Ayllon B, Diagbouga M, Edsfeldt A, Kalucka J, Serbanovic-Canic J, Chambers E, Sun J, Gialeli C, Dunning M, Li X , Xu S et al (2025) , Cold Spring Harbor Laboratory.
  • Pirri D, Tian S, Tardajos-Ayllon B, Irving S, Donati F, Allen SP, Mammoto T, Vilahur G, Miller C, Schenkel T , Chambers EV et al (2023) , Cold Spring Harbor Laboratory.
  • Kugler E, Snodgrass R, Bowley G, Plant K, Serbanovic-Canic J, Evans PC, Chico T & Armitage P (2020) , Cold Spring Harbor Laboratory.
  • Souilhol C, Li X, Canham L, Roddie H, Pirri D, Ayllon BT, Chambers EV, Dunning MJ, Ariaans M, Li J , Fang Y et al (2020) , Cold Spring Harbor Laboratory.
Research group
  • Mr George Bowley (NC3R PhD Studentship)
  • Mr Samuel Sendac (Research Technician)
Professional activities and memberships
  • Member of British Atherosclerosis Society (since 2013)
  • Committee member of the British Society for Cardiovascular Research (since January 2021)