Professor John Newell-Price
MA, PhD, FRCP
School of Medicine and Population Health
Professor of Endocrinology
Honorary Consultant Physician
+44 114 215 9018
Full contact details
School of Medicine and Population Health
EU07, E Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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For enquiries, please contact - SMPH-West-Operational@sheffield.ac.uk
John Newell-Price trained in medicine at the University of Cambridge and then the Royal London Hospital. He did his specialist training in endocrinology at St. Bartholomew's Hospital, London, where he was an MRC Training Fellow from 1995-1998. He was appointed Senior Lecturer and Honorary Consultant Physician at the University of Sheffield in 2000.
The focus of both his clinical and basic research is glucocorticoids. His group has identified important aspects of epigenetic regulation of proopiomelanocortin, the key regulator of the hypothalamic-pituitary-adrenal axis, and now is using this information to design strategies to modify over-expression in conditions of excess hormone secretion, such as Cushing's disease.
The clinical research programme has been investigating means of inhibiting excess ACTH in man and improving cortisol replacement in adrenally insufficient patients. This has led to the testing of Chronocort, a new and modified-release form of hydrocortisone, in Phase I studies, which has proven to replicate the normal circadian rhythm of cortisol.
Other work focuses on the diagnostic and management strategies for patients with Cushing's syndrome, and those also for patients with neuroendocrine tumours.
In the Healthcare Trust, John chairs the Pituitary and Neuroendocrine Tumour Multidisciplinary Teams.Current PhD Opportunities
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . The Lancet Diabetes & Endocrinology, 8(9), 748-761.
- . European Journal of Endocrinology, 183(1), G1-G7.
- . European Journal of Endocrinology, 182(2), 207-217.
- . Clinical Endocrinology, 90(1), 114-121.
- . The Lancet Diabetes & Endocrinology, 7(4), 300-312.
- . Pituitary, 21, 247-255.
- . The Lancet Diabetes and Endocrinology, 6(1), 17-26.
- . Journal of Clinical Endocrinology and Metabolism, 102(9), 3461-3469.
- . European Journal of Endocrinology , 175, 561-570.
- . European Journal of Endocrinology, 175(2), G1-G34.
- . The Journal of Clinical Endocrinology & Metabolism, 100(11), 4146-4154.
- . The Journal of Clinical Endocrinology & Metabolism, 100(8), 2807-2831.
- . The Journal of Clinical Endocrinology & Metabolism, 99(12), 4462-4470.
- . J Clin Endocrinol Metab, 98(6), 2383-2391.
- . PLoS One, 8(4), e60984.
- . N Engl J Med, 366(10), 914-924.
All publications
Journal articles
- . Journal of the Endocrine Society, 9(Supplement_1).
- . Journal of the Endocrine Society, 9(Supplement_1).
- . European Journal of Endocrinology, 193(5), 606-617.
- . European Journal of Endocrinology, 193(1), 76-84.
- . European Journal of Endocrinology, 192(5), 680-690.
- . Journal of the Endocrine Society, 9(4).
- . Pituitary, 28.
- . The Journal of Clinical Endocrinology & Metabolism, 110(2), e506-e514.
- . Journal of the Endocrine Society, 9(1).
- The cost-effectiveness of using waking salivary cortisol in the diagnosis of adrenal sufficiency. HEDS Discussion Paper Series(24.04).
- . Journal of the Endocrine Society, 8(Supplement_1).
- . Journal of the Endocrine Society, 8(Supplement_1).
- . Journal of the Endocrine Society, 8(Supplement_1).
- . Journal of the Endocrine Society, 8(Supplement_1).
- . Journal of the Endocrine Society, 8(Supplement_1).
- . Journal of the Endocrine Society, 8(Supplement_1).
- . Endocrine Connections, 13(8).
- . Journal of the Endocrine Society, 8(7).
- . Journal of Endocrinological Investigation, 47(10), 2437-2448.
- . The Journal of Clinical Endocrinology & Metabolism, 109(11), e2031-e2037.
- . Clinical Endocrinology, 101(5), 443-445.
- . New England Journal of Medicine, 389(20), 1920-1921.
- . Journal of the Endocrine Society, 7(12).
- . European Journal of Endocrinology, 189(4), S88-S101.
- . Journal of the Endocrine Society, 7(Supplement_1).
- . European Journal of Endocrinology, 189(1), 87-95.
- . Endocrine, 82, 1-14.
- . European Journal of Endocrinology, 189(1), G1-G42.
- . Endocrine Abstracts, 90.
- . European Journal of Endocrinology, 188(1), 109-117.
- . NEJM Evidence, 2(2).
- . Hormone Research in Paediatrics, 96(4), 423-425.
- . Pituitary, 25(6), 777-779.
- . Journal of the Endocrine Society, 6(Supplement_1), A474-A475.
- . Endocrine Journal, 69(11), 1281-1284.
- . Endocrine Connections, 11(11).
- . Archives of Endocrinology and Metabolism.
- . World Journal of Surgery, 46(12), 3025-3033.
- . European Journal of Endocrinology, 187(4), 531-541.
- . Lancet Diabetes and Endocrinology, 10(10), 700-709.
- . Journal of Hypertension, 40(11), 2085-2101.
- . The Lancet Diabetes & Endocrinology, 10(6), 385-387.
- . The Journal of Clinical Endocrinology & Metabolism, 107(10), e4232-e4233.
- . The Lancet Diabetes & Endocrinology, 10(7), 499-508.
- . Clinical Endocrinology.
- . Endocrinology, 163(2).
- . Journal of the Endocrine Society, 6(2), 1-5.
- . Brain and Spine, 2, 101289-101289.
- . Clinical Endocrinology, 96(4), 499-512.
- . The Lancet Diabetes & Endocrinology, 9(12), 847-875.
- . European Journal of Endocrinology, 185(5), 607-615.
- . Medicine, 49(8), 483-487.
- . The Journal of Clinical Endocrinology & Metabolism, 106(7), 2114-2123.
- . Pituitary, 24(5), 724-736.
- . The Journal of Clinical Endocrinology & Metabolism, 106(5), e2063-e2077.
- . European Journal of Endocrinology, 184(3), P1-P16.
- . European Journal of Endocrinology, 184(2), R51-R59.
- . The Lancet Diabetes & Endocrinology, 8(9), 748-761.
- . The Lancet Diabetes & Endocrinology, 8(9), e4-e4.
- . European Journal of Endocrinology, 183(1), G1-G7.
- . Journal of the Endocrine Society, 4(Supplement_1).
- . Journal of the Endocrine Society, 4(Supplement_1).
- . Journal of the Endocrine Society, 4(Supplement_1).
- . European Journal of Endocrinology, 182(2), 207-217.
- . Gland Surgery, 9(1), 94-104.
- . The Journal of Clinical Endocrinology & Metabolism, 105(5), 1527-1537.
- . Clinical Endocrinology, 91(6), 776-785.
- . European Journal of Endocrinology, 181(5), 461-472.
- . The Lancet Diabetes & Endocrinology, 7(12), 959-964.
- . Clinical Endocrinology, 91(6), 708-715.
- . Current Opinion in Endocrine and Metabolic Research, 8, 183-188.
- . Journal of the Endocrine Society, 3(Supplement_1).
- . Journal of Neurology, Neurosurgery & Psychiatry, 90(3), e36.2-e36.
- . BMC Cancer, 19(1).
- . Clinical Endocrinology, 90(1), 114-121.
- Cushing's disease-from Minnie G to key issues in the early 21st century (vol 7, pg 959, 2019). LANCET DIABETES & ENDOCRINOLOGY, 7(12), E23-E23.
- . Journal of Clinical Endocrinology and Metabolism, 104(3), 765-772.
- . The Lancet Diabetes & Endocrinology, 7(4), 300-312.
- . Endocrine, 62(3), 517-518.
- . Endocrine, 62(3), 506-516.
- . European Journal of Endocrinology, 179(2), 97-108.
- . Endocrinology and Metabolism Clinics of North America, 47(2), 367-373.
- . Pituitary, 21, 247-255.
- . Clinical Endocrinology, 88(6), 787-798.
- . Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 55(6), 665-672.
- . European Journal of Endocrinology, 178(4), 399-409.
- . European Journal of Endocrinology, 178(3), 265-276.
- . The Lancet Diabetes and Endocrinology, 6(1), 17-26.
- . BJA Education, 17(11), 377-382.
- . Medicine (United Kingdom), 45(8), 475-479.
- . Endocrinology, Diabetes and Metabolism Case Reports, 2017(1).
- . Journal of Clinical Endocrinology and Metabolism, 102(9), 3461-3469.
- . Clinical Medicine, 17(3), 278-279.
- . F1000Research, 6, 613-613.
- . Endocrine Abstracts.
- . European Journal of Endocrinology , 175, 561-570.
- . Endocrinology, Diabetes and Metabolism Case Reports, 2016.
- . European Journal of Endocrinology, 175(2), G1-G34.
- . Nature Reviews Endocrinology, 12(9), 502-503.
- . The Lancet Diabetes & Endocrinology, 4(7), 611-629.
- . Frontiers of Hormone Research, 46, 15-27.
- . Clinical Endocrinology, 85(1), 17-20.
- . The Journal of Clinical Endocrinology & Metabolism, 100(11), 4146-4154.
- . Drug Design, Development and Therapy, 9, 5075-5086.
- . The Journal of Clinical Endocrinology & Metabolism, 100(8), 2807-2831.
- . Current Opinion in Endocrinology, Diabetes & Obesity, 22(3), 185-192.
- . Clinical Endocrinology, 82(5), 623-623.
- . Pituitary, 18(2), 206-210.
- . European Journal of Endocrinology, 172(6), R263-R280.
- . The Journal of Clinical Endocrinology & Metabolism, 99(12), 4462-4470.
- . J Clin Endocrinol Metab, 99(5), 1586-1588.
- . Clin Endocrinol (Oxf), 81(3), 408-417.
- . Clin Endocrinol (Oxf), 80(2), 261-269.
- Effectiveness of Stereotactic Gamma Knife Radiosurgery for the Treatment of Acromegaly. ENDOCRINE REVIEWS, 35(3).
- Rapid-Sequence MRI for Long-Term Monitoring of Succinate Dehydrogenase (SDHx) Mutation Carriers. ENDOCRINE REVIEWS, 35(3).
- Biological Variability of Plasma 5-Hiaa. ENDOCRINE REVIEWS, 35(3).
- Clinical Effectiveness of Metyrapone Monotherapy in 195 Patients with Cushing's Syndrome. ENDOCRINE REVIEWS, 35(3).
- . Eur J Heart Fail, 16(2), 143-150.
- . Journal of Clinical Oncology, 31(15_suppl), 4031-4031.
- . J Clin Endocrinol Metab, 98(6), 2383-2391.
- . J Clin Endocrinol Metab, 98(7), 2902-2907.
- . PLoS One, 8(4), e60984.
- . Medicine United Kingdom, 41(9), 508-511.
- . Obstetrical and Gynecological Survey, 67(8), 475-477.
- . Reprod Biomed Online, 25(2), 180-189.
- . N Engl J Med, 366(10), 914-924.
- . J Clin Endocrinol Metab, 97(4), 1187-1193.
- . Gut, 61(1), 6-32.
- . J Clin Endocrinol Metab, 96(4), 939-941.
- . Eur J Endocrinol, 164(3), 413-419.
- . Neuroendocrinology, 92 Suppl 1, 82-85.
- . Curr Opin Endocrinol Diabetes Obes, 17(4), 350-355.
- . Best Pract Res Clin Endocrinol Metab, 23 Suppl 1, S5-14.
- . Nat Rev Endocrinol, 5(11), 591-592.
- . J Chromatogr B Analyt Technol Biomed Life Sci, 877(29), 3771-3775.
- . Medicine, 37(8), 403-406.
- . J Clin Endocrinol Metab, 94(5), 1548-1554.
- , 253-261.
- . Eur J Endocrinol, 160(5), 719-729.
- . J CLIN ENDOCR METAB, 93(7), 2454-2462.
- . J Clin Endocrinol Metab, 93(5), 1526-1540.
- . J Clin Endocrinol Metab, 93(5), 1860-1864.
- . Nat Clin Pract Endocrinol Metab, 4(4), 192-193.
- . Clin Med (Lond), 8(2), 204-208.
- . Clin Endocrinol (Oxf), 68(1), 130-135.
- . Clin Endocrinol (Oxf), 68(6), 912-918.
- . Clin Endocrinol (Oxf), 68(3), 343-349.
- . Clinical Endocrinology, 68(1), 136-142.
- . Arq Bras Endocrinol Metabol, 51(8), 1199-1206.
- . Arq Bras Endocrinol Metabol, 51(8), 1392-1396.
- . Arq Bras Endocrinol Metabol, 51(8), 1182-1184.
- . J Clin Endocrinol Metab, 92(5), 1758-1763.
- . Clin Endocrinol (Oxf), 65(1), 45-50.
- . Lancet, 367(9522), 1605-1617.
- . J Clin Endocrinol Metab, 91(2), 371-377.
- . Eur J Endocrinol, 152(4), 569-574.
- Effectiveness of combined dopamine agonist and long-acting somatostatin analogues in the management of resistant acromegaly. EUR J ENDOCRINOL, 152.
- . Medicine, 33(11), 11-13.
- . Postgrad Med J, 80(947), 506-515.
- . Clin Endocrinol (Oxf), 61(3), 367-375.
- . J CLIN ENDOCR METAB, 88(12), 5593-5602.
- Managing adrenal disorders.. Practitioner, 247(1648), 588-592.
- . Lancet, 361(9376), 2203-2204.
- . J Endocrinol, 177(3), 365-372.
- . J Clin Endocrinol Metab, 87(4), 1640-1645.
- . Clinical Science, 103(s47), 24P-24P.
- Endocrine emergencies. CPD Journal Acute Medicine, 1(1), 4-8.
- . Clin Endocrinol (Oxf), 56(1), 19-21.
- Biochemical and imaging evaluation of Cushing's syndrome.. Minerva Endocrinol, 27(2), 95-118.
- . Mol Endocrinol, 15(2), 338-348.
- The differential diagnosis of Cushing's syndrome.. Ann Endocrinol (Paris), 62(2), 173-179.
- . Trends Endocrinol Metab, 11(4), 142-148.
- . J Clin Endocrinol Metab, 85(4), 1741.
- . Frontiers of Hormone Research, 24, 110-130.
- . Horm Res, 51 Suppl 3, 81-94.
- . Lancet, 353(9170), 2087-2088.
- . J Clin Endocrinol Metab, 84(2), 602-605.
- . J Clin Endocrinol Metab, 84(2), 487-492.
- . J Clin Endocrinol Metab, 84(6), 2238-2240.
- . AJR Am J Roentgenol, 172(4), 997-1002.
- . J Clin Endocrinol Metab, 83(9), 3083-3088.
- . Endocr Rev, 19(5), 647-672.
- . J Clin Endocrinol Metab, 82(1), 176-181.
- The desmopressin test and Cushing's syndrome: current state of play.. Clin Endocrinol (Oxf), 47(2), 173-174.
- . Postgrad Med J, 72(846), 207-210.
- . Hypertension, 28(6), 1123-1125.
- . Clin Endocrinol (Oxf), 43(5), 545-550.
- . Br Heart J, 74(3), 207-208.
- . J Clin Invest, 96(2), 687-692.
- . J Clin Endocrinol Metab, 80(2), 412-417.
- . Endocrine Abstracts.
- . Endocrine Abstracts.
- . Endocrine Abstracts.
- . Endocrine Abstracts.
- . Endocrine Abstracts.
- . Endocrine Abstracts.
- . Endocrine Abstracts.
- . BMJ, k277-k277.
- . Endocrine Abstracts.
- . Endocrine Abstracts.
- . Endocrine Abstracts.
- . Endocrine Abstracts.
- . Endocrine, 54(2), 516-523.
- . Blood, 127(21), 2641-2644.
- . Endocrine Abstracts.
- . Endocrine Abstracts.
- . Endocrine Abstracts.
- . Endocrine Abstracts.
- . Endocrine Abstracts.
Book chapters
- , Reference Module in Biomedical Sciences Elsevier
- , Pituitary Tumors (pp. 231-244). Elsevier
- , The Pituitary (pp. ix-ix). Elsevier
- , Pituitary Fourth Edition (pp. 515-571).
- , The Pituitary (pp. 515-571). Elsevier
- , Williams Textbook of Endocrinology (pp. 489-555). Elsevier
- , Cushing's Syndrome (pp. 21-29). Humana Press
Conference proceedings
- . Journal of the Endocrine Society, Vol. 8(Supplement_1). Boston, USA, 1 June 2024 - 1 June 2024.
- Blood pressure (BP) status in Congenital Adrenal Hyperplasia (CAH) - longitudinal analysis of real world data from the I-CAH registry. HORMONE RESEARCH IN PAEDIATRICS, Vol. 95(SUPPL 2) (pp 112-113)
- . Journal of the Endocrine Society, Vol. 4(Supplement_1)
- SERUM CORTISOL AND SALIVARY CORTISONE AND FREQUENCY OF SAMPLING TO ESTIMATE CORTISOL EXPOSURE. HORMONE RESEARCH IN PAEDIATRICS, Vol. 88 (pp 53-54)
- . Journal of the American College of Surgeons, Vol. 219(4) (pp e24-e24)
- A multicenter, randomized, blinded, phase III study of pasireotide LAR versus octreotide LAR in patients with metastatic neuroendocrine tumors (NET) with disease-related symptoms inadequately controlled by somatostatin analogs. JOURNAL OF CLINICAL ONCOLOGY, Vol. 31(15)
- . BONE, Vol. 50 (pp S53-S53)
- HIGH CIRCULATING SEROTONIN IN CARCINOID SYNDROME IS NOT ASSOCIATED WITH ALTERATIONS IN BONE TURNOVER OR BONE DENSITY. OSTEOPOROSIS INTERNATIONAL, Vol. 23 (pp S536-S537)
- Baseline Characteristics and Urine Free Cortisol (UFC) Variability of 162 Patients Enrolled in a Randomized, Double-Blind Phase III Study Assessing the Efficacy and Safety of Pasireotide (SOM230) in Patients with Cushing's Disease.. ENDOCRINE REVIEWS, Vol. 31(3)
- . Endocrine Abstracts
- . British Journal of Surgery, Vol. 109(Supplement_2) (pp znac055.001)
- Grants
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- Society for Endocrinology, £120,000, 2005-2008. RNA interference as therapy for models of Cushing's disease and acromegaly.
- Sheffield Hospitals' Charitable Trust, £24,995, 2006-2008. RNA interference as therapy for models of Cushing's disease and acromegaly.
- European Union, 450,000 Euros (Joint partner). European Register on Cushing's Syndrome, in Framework of Public Health Programme. 2007-2010.
- Professional activities and memberships
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National Committee Membership
- Society for Endocrinology Clinical Subcommittee, 1997-2000.
- Chair of the UK Medical Committee, Pituitary Foundation, UK, 2007.
- UK and Ireland Neuroendocrine Tumour Society, Executive Officer, 2007.
- UK Acromegaly Database Steering Committee, 2005-to date.
Editorship
- Associate Editor of Clinical Endocrinology 2001-to date.
- Editorial Board, Clinical Endocrinology, 2001-to date.
- Editorial Board, Journal of Clinical Endocrinology and Metabolism, 2008-2010.
Advisory Boards
- NICE Appraisal of Pituitary Disease, 2004-2005.
National and International Guidelines
- Task Force Member (one of six) for the American Endocrine Society's Guidelines on the Diagnosis of Cushing's Syndrome.