Dr Janet Chamberlain

BSc PhD SFHEA

School of Medicine and Population Health

Senior University Teacher

J.Chamberlain@sheffield.ac.uk
+44 114 215 9566
+44 114 271 1863 (Fax)
The Medical School

Full contact details

Dr Janet Chamberlain
School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk

After completing an MRC-funded PhD studentship at the University of Manchester, I spent a year working as an immunohistochemist at Zeneca Pharmaceuticals, Alderley Park. I joined the University of Sheffield in 1995, and spent 3 years as a Postdoctoral Research Associate in the Department of Cardiovascular Research (with Professor David Crossman as PI).

Following this, I wrote my own funding applications, although remained as a Postdoctoral Research Associate, then an Experimental Officer; holding several Project Grants as Principal Investigator, working closely with Professors Sheila Francis and Julian Gunn. In 2016, I became a University Teacher and now concentrate mainly on teaching, although still have an interest in research.

Current PhD Opportunities

Research interests

My research career has focused on the understanding and prevention of restenosis and atherosclerosis, using several different experimental models, including research to develop a miniature stenting device for use in small calibre vessels.

My current areas of research relate to the mechanisms by which IL-1 is released from endothelial and smooth muscle cells, the role of IL-1 in the development of atherosclerosis, and the use of IL-1 antagonists to inhibit disease progression.

In addition, I am currently involved in investigating the role of carbon monoxide as a possible therapeutic for restenosis and myocardial infarction.

Current Projects

  • Release of IL-1 from endothelial and smooth muscle cells (with Professor Francis). 
  • The use of carbon-monoxide releasing molecules in Restenosis/atherosclerosis (BHF, with Francis/Gunn/Mann). 
  • The use of carbon-monoxide releasing molecules in MI (BHF with Gunn/Iqbal/Francis/Mann). 
  • Cholesterol crystal formation in atherosclerosis (with Francis).
Publications

Show: Featured publications All publications

Journal articles

  • Alfaidi MA, Chamberlain J, Rothman A, Crossman D, Villa-Uriol M-C, Hadoke P, Wu J, Schenkel T, Evans PC & Francis SE (2018) . Journal of the American Heart Association, 7(13).
  • Renshall L, Arnold N, West L, Braithwaite A, Pickworth J, Walker R, Alfaidi M, Chamberlain J, Casbolt H, Thompson AAR , Holt C et al (2017) . Pulmonary Circulation, 8(1).
  • Iqbal J, Chamberlain J, Francis SE & Gunn J (2016) . Annals of Biomedical Engineering, 44(2), 453-465.
  • Dénes Á, Pradillo JM, Drake C, Sharp A, Warn P, Murray KN, Rohit B, Dockrell DH, Chamberlain J, Casbolt H , Francis S et al (2014) . Ann Neurol, 75(5), 670-683.
  • Hameed AG, Arnold ND, Chamberlain J, Pickworth JA, Paiva C, Dawson S, Cross S, Long L, Zhao L, Morrell NW , Crossman DC et al (2012) . J Exp Med, 209(11), 1919-1935.
  • Denes A, Drake C, Stordy J, Chamberlain J, McColl BW, Gram H, Crossman D, Francis S, Allan SM & Rothwell NJ (2012) . JOURNAL OF THE AMERICAN HEART ASSOCIATION, 1(3).
  • Lawrie A, Hameed AG, Chamberlain J, Arnold N, Kennerley A, Hopkinson K, Pickworth J, Kiely DG, Crossman DC & Francis SE (2011) . Am J Pathol, 179(4), 1693-1705.
  • Ellam T, Wilkie M, Chamberlain J, Crossman D, Eastell R, Francis S & Chico TJA (2011) . Arterioscler Thromb Vasc Biol, 31(9), 1988-1990.
  • Watt V, Chamberlain J, Steiner T, Francis S & Crossman D (2011) . Atherosclerosis, 215(2), 348-354.
  • Chamberlain J, Wheatcroft M, Arnold N, Lupton H, Crossman DC, Gunn J & Francis S (2010) . Cardiovasc Res, 85(1), 38-44.
  • Chamberlain J, Francis S, Brookes Z, Shaw G, Graham D, Alp NJ, Dower S & Crossman DC (2009) . PLoS One, 4(4), e5073.
  • Evans DJW, Jackman LE, Chamberlain J, Crosdale DJ, Judge HM, Jetha K, Norman KE, Francis SE & Storey RF (2009) . Circulation, 119(1), 116-122.
  • Chamberlain J, Evans D, King A, Dewberry R, Dower S, Crossman D & Francis S (2006) . Am J Pathol, 168(4), 1396-1403.
  • Alfaidi M, Wilson H, Daigneault M, Burnett A, Ridger V, Chamberlain J & Francis SE () . Journal of Biological Chemistry.

All publications

Journal articles

  • Patel P, Chamberlain J & Francis S (2025) . Atherosclerosis, 407, 119765-119765.
  • Bazaz R, Marriott HM, Wright C, Chamberlain J, West LE, Gelsthorpe C, Heath PR, Maleki-Dizaji A, Francis SE & Dockrell DH (2023) . Frontiers in Cellular and Infection Microbiology, 13.
  • Al Mansouri M, Patel PA, Chamberlain J & Francis S (2022) . Vascular Biology, 4(1), 11-18.
  • Alfaidi MA, Chamberlain J, Rothman A, Crossman D, Villa-Uriol M-C, Hadoke P, Wu J, Schenkel T, Evans PC & Francis SE (2018) . Journal of the American Heart Association, 7(13).
  • Renshall L, Arnold N, West L, Braithwaite A, Pickworth J, Walker R, Alfaidi M, Chamberlain J, Casbolt H, Thompson AAR , Holt C et al (2017) . Pulmonary Circulation, 8(1).
  • Iqbal J, Chamberlain J, Francis SE & Gunn J (2016) . Annals of Biomedical Engineering, 44(2), 453-465.
  • Alfaidi M, Chamberlain J & Francis S (2014) . Heart, 100 Suppl 3, A116-A117.
  • Dénes Á, Pradillo JM, Drake C, Sharp A, Warn P, Murray KN, Rohit B, Dockrell DH, Chamberlain J, Casbolt H , Francis S et al (2014) . Ann Neurol, 75(5), 670-683.
  • Alfaidi M, Wilson HL, Burnett A, Abdul-Aema BH, Ridger V, Chamberlain J & Francis SE (2014) . Heart, 100 Suppl 1, A2.
  • Alfaidi M, Wilson H, Ridger V, Chamberlain J & Francis S (2014) Neutrophil elastase enhances IL-1β secretion from coronary endothelium via an endolysosomal mediated mechanism, without caspase-1 activation. ANGIOGENESIS, 17(4), 941-941.
  • Hameed AG, Arnold ND, Chamberlain J, Pickworth JA, Paiva C, Dawson S, Cross S, Long L, Zhao L, Morrell NW , Crossman DC et al (2012) . J Exp Med, 209(11), 1919-1935.
  • Denes A, Drake C, Stordy J, Chamberlain J, McColl BW, Gram H, Crossman D, Francis S, Allan SM & Rothwell NJ (2012) . JOURNAL OF THE AMERICAN HEART ASSOCIATION, 1(3).
  • Lawrie A, Hameed AG, Chamberlain J, Arnold N, Kennerley A, Hopkinson K, Pickworth J, Kiely DG, Crossman DC & Francis SE (2011) . Am J Pathol, 179(4), 1693-1705.
  • Ellam T, Wilkie M, Chamberlain J, Crossman D, Eastell R, Francis S & Chico TJA (2011) . Arterioscler Thromb Vasc Biol, 31(9), 1988-1990.
  • Watt V, Chamberlain J, Steiner T, Francis S & Crossman D (2011) . Atherosclerosis, 215(2), 348-354.
  • Watt V, Chamberlain J, Steiner T, Francis S & Crossman D (2011) . Atherosclerosis, 215(2), 348-354.
  • Chamberlain J, Wheatcroft M, Arnold N, Lupton H, Crossman DC, Gunn J & Francis S (2010) . Cardiovasc Res, 85(1), 38-44.
  • Francis S, Chamberlain J, Brookes Z, Shaw G, Alp N, Rogus J, Kornman K & Crossman D (2009) . Atherosclerosis Supplements, 10(2), e463-e463.
  • Chamberlain J, Francis S, Brookes Z, Shaw G, Graham D, Alp NJ, Dower S & Crossman DC (2009) . PLoS One, 4(4), e5073.
  • Evans DJW, Jackman LE, Chamberlain J, Crosdale DJ, Judge HM, Jetha K, Norman KE, Francis SE & Storey RF (2009) . Circulation, 119(1), 116-122.
  • Chamberlain J, Evans D, King A, Dewberry R, Dower S, Crossman D & Francis S (2006) . Am J Pathol, 168(4), 1396-1403.
  • Chamberlain J, Dower S, Crossman D & Francis S (2004) . Cardiovascular Pathology, 13(3), 116-117.
  • Evans D, Crossman D, Francis S & Chamberlain J (2004) . Cardiovascular Pathology, 13(3), 117-117.
  • Chamberlain J (2001) . Cardiovasc Drug Rev, 19(4), 329-344.
  • Chico TJ, Chamberlain J, Gunn J, Arnold N, Bullens SL, Gadek TR, Francis SE, Bunting S, Horton M, Shepherd L , Lipari MT et al (2001) . Circulation, 103(8), 1135-1141.
  • Lawrie A, Brisken AF, Francis SE, Tayler DI, Chamberlain J, Crossman DC, Cumberland DC & Newman CM (1999) . Circulation, 99(20), 2617-2620.
  • Malik N, Francis SE, Holt CM, Gunn J, Thomas GL, Shepherd L, Chamberlain J, Newman CM, Cumberland DC & Crossman DC (1998) . Circulation, 98(16), 1657-1665.
  • Lawrie A, Brisken AF, Chamberlain JC, Francis SE, Tayler DI, Crossman DC, Cumberland DC & Newman CM (1998) 1MHz ultrasound enhances transfection of porcine aortic endothelial cells in vitro and oligonucleotide uptake in an organ culture model.. AMERICAN JOURNAL OF CARDIOLOGY, 82(7A), 29S-29S.
  • Iqbal J, Chamberlain J, Alfaidi M, Hughes M, Alizadeh T, Casbolt H, Evans P, Mann B, Motterlini R, Francis S & Gunn J () . Journal of Cardiovascular Pharmacology, 78(5), e656-e661.
  • Alfaidi M, Wilson H, Daigneault M, Burnett A, Ridger V, Chamberlain J & Francis SE () . Journal of Biological Chemistry.

Conference proceedings

  • Almansouri M, Francis S & Chamberlain J (2018) . Heart, Vol. 104(Suppl 6) (pp A102-A103). Manchester, UK, 4 June 2018 - 4 June 2018.
  • Alfaidi M, Hughes M, Alizadeh T, Casbolt H, Chamberlain J, Mann BE, Francis SE, Iqbal J & Gunn J (2016) . Heart, Vol. 102(Suppl 6) (pp A114.2-A114), 6 June 2016 - 8 August 2016.
  • Alfaidi M, Schenkel T, Evans P, Chamberlain J & Francis S (2015) . Basic Science (pp A107.2-A107)
  • Alfaidi M, Wilson H, Burnett A, Chamberlain J & Francis S (2013) . HEART, Vol. 99 (pp A99-A99)
  • Hameed AG, Arnold ND, Chamberlain J, Pickworth JA, Paiva C, Dawson S, Cross S, Long L, Zhao L, Morrell NW , Crossman DC et al (2013) . The Lancet, Vol. 381, Supplement 1 (pp S47 --S47 -)
  • Hameed AG, Arnold ND, Chamberlain J, Pickworth J, Newman CMH, Crossman DC, Francis SE & Lawrie A (2012) . HEART, Vol. 98 (pp A1-A1)
  • Lawrie A, Hameed AG, Arnold N, Chamberlain J, Pickworth J, Dawson S, Newman CMH & Francis SE (2012) . D97. PULMONARY HYPERTENSION: NEW INSIGHTS INTO CAUSES AND TREATMENTS? (pp A6515-A6515)
  • Hameed AG, Arnold ND, Pickworth J, Chamberlain JC, Newman CMH, Crossman DC, Francis SE & Lawrie A (2011) . THORAX, Vol. 66 (pp A3-A3)
  • Lawrie A, Hameed AG, Chamberlain J, Arnold N, Crossman DC & Francis SE (2011) . HEART, Vol. 97(20) (pp 10-10)
  • Hameed AG, Chamberlain J, Arnold N, Newman C, Francis S, Crossman D & Lawrie A (2011) . B61. PULMONARY HYPERTENSION: EXPERIMENTAL MODELS I (pp A3407-A3407)
  • Hameed AG, Chamberlain J, Arnold ND, Francis SE, Newman CMH, Crossman DC & Lawrie A (2010) . THORAX, Vol. 65 (pp A68-A68)
  • Francis S, Chamberlain J, Brookes Z, Shaw G, Alp N, Rogus J, Kornman K & Crossman D (2009) IL-1 MODULATES BLOOD PRESSURE IN MICE AND MAN. ATHEROSCLEROSIS SUPP, Vol. 10(2)
  • Francis S, Chamberlain J, Brookes Z, Shaw G, Alp N, Rogus J, Kornman K & Crossman D (2009) IL-1 MODULATES BLOOD PRESSURE IN MICE AND MAN. ATHEROSCLEROSIS SUPPLEMENTS, Vol. 10(2). Boston, MA, 14 June 2009 - 18 June 2009.
  • Chamberlain J, Wheatcroft M, Arnold N, Francis S, Lupton H & Gunn J (2009) A NOVEL MURINE MODEL OF STENTING. HEART, Vol. 95 (pp A37-A38)
  • Evans DJW, Crosdale DJ, Judge HM, Chamberlain J, Jetha K, Norman KE, Francis SE & Storey RF (2008) The platelet P2Y12 receptor influences the vessel wall response to arterial injury and thrombosis. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 51(10) (pp A291-A291)
  • Townsend CF, Francis SE, Chamberlain J, Gunn J, Crossman DC & Newman CMH (2001) Modulation of MSS1, a component of the 26S proteasome, in vascular smooth muscle cells in vitro and following experimental PTCA. EUR HEART J, Vol. 22 (pp 3-3)
  • Chamberlain J, Gunn J, Francis SE, Holt CM, Cumberland DC & Crossman DC (1998) IL-1 beta synthesis and neovascularisation following porcine coronary arterial injury. J VASC RES, Vol. 35(5) (pp 389-389)
  • Gunn J, Francis S, Holt C, Chamberlain J, Lambert D, Newman C, Crossman D & Cumberland D (1997) Is local drug delivery truly a low efficiency procedure?. AM J CARDIOL, Vol. 80 (pp TC240-TC240)
  • Alfaidi MAA, Wilson H, Ridger, V, Chamberlain J & Francis S () Neutrophil elastase enhances IL-1 beta secretion from coronary endothelium via an endolysosomal mediated mechanism, without caspase-1 activation. ANGIOGENESIS, Vol. 17(4) (pp 941-941). California, USA, 18 October 2014 - 23 October 2014.

Preprints

  • Bazaz R, Marriott H, Wright C, Chamberlain J, West L, Gelsthorpe C, Heath P, Maleki-Dizaji A, Francis S & Dockrell D (2022) , Research Square Platform LLC.
Teaching interests

I teach on several undergraduate and postgraduate taught modules, including MBB334 Biochemical Basis of Human Disease, CDL301 Cardiovascular Pharmacology: Personalising Medicine, several modules within both the MSc in Molecular Medicine, and within the CDLT01 MRes Cardiovascular Medicine: From Molecules to Man.

I am the module co-ordinator for CDL301/6301, module lead CDL601 and CDL602 (Research Skills), deputy module lead for CDL601 (Literature Review) and CDL401 (Vascular Cell Biology), and occasionally deputise for the overall programme of CDLT01 MRes Cardiovacular Medicine:From Molecules to Man. In addition, I also am responsible for the Blackboard site, for CDL302 (Pharmacology of Respiratory Disease).

I am Deputy Director of Learning & Teaching for the Department. I am Chair of the Department’s Undergraduate Teaching Committee, and am a member of the MRes Committee. I have a particular interest in supporting students with an SpLD, and actively engage in delivering CPD to staff with respect to the use of new teaching technologies and ensuring their teaching is inclusive to all students.