Professor Janet Brown
BMedSci, MBBS, MSc, MD, FRCP
School of Medicine and Population Health
Professor of Translational Medical Oncology
Professor of Translational Medical Oncology
Chair in Medical Oncology
+44 114 226 5007
Full contact details
School of Medicine and Population Health
Weston Park Hospital
Whitham Road
Sheffield
S10 2SJ
- Profile
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For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
After graduating in Medicine from the University of Newcastle upon Tyne and appointment as a Clinical Lecturer in Oncology in Sheffield, followed by a first consultant appointment in Leeds, Janet was appointed to a Chair in Translational Medical Oncology in the University of Sheffield and as Honorary Consultant in Medical Oncology at the Sheffield NHS Foundation Trust in 2012. Her specialist areas of clinical practice are prostate, renal and breast cancers. Her patient-orientated, practice-changing research focuses on optimising skeletal health in cancer patients and innovative treatment pathways for urological cancers, including novel approaches to immunotherapy.
As a Clinician Scientist, Janet is passionate about the need for research-led improvements for the benefit of patients and is especially concerned to support and develop clinical academic training to nurture and support the clinical academics of the future. Through her appointment as the Director of Clinical Academic Training for South Yorkshire, she leads the organisation of clinical academic training for Academic Clinical Fellows and Clinical Lecturers across all medical specialties in the region. She has brought in a number of innovations, including the organisation of workshops and training for which the trainees themselves play a major role in developing the agenda under senior guidance, as well as championing closer working between medical, dental and allied health professions, nursing and midwifery early career academics.
Amongst a range of personal awards, she gained the American Society for Clinical Oncology Pain Merit Award in 2003 and the UK McElwain Research Prize for Medical Oncology in 2005. In 2008, she won a Cancer Research UK Clinician Scientist Fellowship for studies in bone oncology, which she held until 2014.
She has acquired a global reputation in the effects of cancer on bone and has been appointed as President of the International Cancer and Bone Society from July 2025. She is also currently Deputy Director (and Oncology Lead) of the Sheffield Mellanby Centre for Musculoskeletal Research.
- Research interests
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With more than 170 published, peer-reviewed research papers, Janet has had more than 50 successful grant applications in recent years and has recent and current research funding totalling over £15 million, with more than £10 million as Principal Investigator, from Cancer Research UK, National Institute for Health Research (NIHR), Yorkshire Cancer Research, Breast Cancer Campaign, Prostate Cancer UK, Weston Park Hospital Cancer Charity and other bodies.
As an academic leader and clinician scientist, Janet engages in both clinical and laboratory research, which is internationally recognised, with publications in Lancet, Journal of Clinical Oncology, Journal of the National Cancer Institute, Nature Clinical Oncology, Clinical Cancer Research, Annals of Oncology Breast Cancer Research and Treatment and other journals. Her patient-orientated, practice-changing research focuses on optimising skeletal health in cancer patients and innovative treatment pathways for urological cancers. She leads clinical bone oncology research in the University of Sheffield, which is recognised as a global leader in this field.
As National Chief Investigator (CI) on a large Phase III kidney cancer trial in 60 UK sites (£2.4M from NIHR), Janet and colleagues demonstrated that treatment breaks from tyrosine kinase inhibitor systemic cancer therapy improved patient quality of life and saved NHS costs without reducing survival (Lancet Oncology, 2023)- As a result of this published study, NHS England recommended a national practice change to allow such treatment breaks.
Janet has also recently embarked as lead on a £2.8 million digital health programme (E-IMMUNE), funded by the Yorkshire Cancer Research Pioneer scheme, to reduce the effects of immunotherapy toxicity by empowering patients and clinicians in the management of immunotherapy toxicity through a new digital care pathway.
In the most recent UK Research Excellence Framework (REF), Janet contributed five 4* papers and led a 4* Impact Case on Sheffield’s practice-changing adjuvant bisphosphonate (BP) trials, which now save 1,000 UK breast cancer lives and £50M annually.
Janet also leads the Clinical Bone Oncology and Biomarkers Group in the University of Sheffield, which has a particular focus on the impact of cancer on the skeleton in patients with breast, prostate and renal cancer. Recent research includes the use of biomarkers in established bone metastasis to aid patient management and studies of the negative impact of cancer treatments on bone health. One of the main objectives of their current clinical and laboratory work is to develop novel prognostic and predictive biomarkers for clinical use in patients with early cancer to help in prevention or delay of cancer metastasis to bone, after which disease is incurable.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . The Lancet Oncology, 24(3), 213-227.
- . Journal of Bone Oncology, 29.
- . Journal of Bone Oncology, 28.
- . Bone, 147, 115907-115907.
- . Trials, 21(1).
- . Journal of Urology, 202(6), 1101-1101.
- . JAMA Oncology, 5(11), 1556-1564.
- . Health Technology Assessment, 23(30).
- . Clinical Cancer Research, 25(9), 2769-2782.
- . Oncogene, 38(10), 1751-1763.
- . The Journal of Pathology, 247(3), 381-391.
- . JNCI: Journal of the National Cancer Institute, 110(8), 871-879.
- . European Journal of Cancer, 94, 70-78.
- . Clinical Cancer Research, 22(23), 5713-5721.
- . Health Technology Assessment, 20.
- . JAMA Oncology, 2(4), 493-493.
- . Journal of the National Cancer Institute, 108(4).
- . European Urology, 68(1), 42-50.
- . Endocrine-Related Cancer, 21(2), 327-341.
- Denosumab in patients with cancer-a surgical strike against the osteoclast. Nature Reviews Clinical Oncology.
- . Journal of Clinical Oncology, 28(18_suppl), LBA4507-LBA4507.
- . Journal of Clinical Oncology, 27(15_suppl), e16016-e16016.
- . J Natl Cancer Inst, 97(1), 59-69.
- . Cancers, 12(8), 2109-2109.
- . Annals of Oncology, 1-12.
Book chapters
- , Abeloff's Clinical Oncology (pp. 809-830.e3). Elsevier
Reports
- Expert panel : evaluation of the Government’s commitments in the area of cancer services in England
All publications
Journal articles
- . JBMR Plus, 9(10).
- . Journal of Geriatric Oncology, 16(7).
- . Annals of Oncology.
- . Journal of Bone Oncology, 53, 100694-100694.
- . Annals of Oncology.
- . Journal of Clinical Oncology, 43(16_suppl), 4531-4531.
- . Current Medical Research and Opinion, 41(3), 495-511.
- . Bone, 195.
- . Scientific Reports, 15(1).
- . Current Opinion in Supportive & Palliative Care, 19(2), 117-129.
- . eClinicalMedicine, 79.
- . Journal of Cancer Survivorship.
- . Health Technology Assessment, 28(45).
- . Journal for ImmunoTherapy of Cancer, 12(7).
- . Nature Communications, 15.
- . JBMR Plus, 8(9).
- . Cancer Treatment Reviews, 129, 102792-102792.
- . British Journal of General Practice, 74(suppl 1), bjgp24X737637-bjgp24X737637.
- . Journal of Bone Oncology, 47.
- . Trials, 25(1).
- . Journal of Bone Oncology, 45, 100568-100568.
- . Journal of Bone Oncology, 45, 100570-100570.
- . Journal of Bone Oncology, 45, 100566-100566.
- . Journal of Bone Oncology, 45, 100529-100529.
- . European Urology Oncology, 7(5), 993-1004.
- . Drugs - Real World Outcomes, 11(2), 195-207.
- . Journal of Bone and Mineral Research, 39(1), 8-16.
- . Frontiers in Immunology, 14.
- . Journal of Clinical Oncology, JCO2300236.
- . Annals of Oncology, 34, S956-S957.
- . BJU International, 132(5), 541-553.
- . British Journal of General Practice, 73(suppl 1).
- . British Journal of General Practice, 73(732), 326-329.
- . Cancers, 15(8).
- . The Lancet Oncology, 24(3), 213-227.
- . Future Pharmacology, 2(4), 444-459.
- . JAMA Oncology, 8(10), 1418-1418.
- . Annals of Oncology, 33, S1215-S1215.
- . JOURNAL OF BONE ONCOLOGY, 35.
- . European Urology, 82(3), 293-294.
- . Bone Reports, 16, 101362-101362.
- . Bone Reports, 16, 101363-101363.
- . British Journal of Cancer, 126(3), 419-429.
- . Journal of Bone Oncology, 31, 100402-100402.
- . Journal of Clinical Medicine, 10(17).
- . Annals of Oncology, 32, S1303-S1304.
- . Annals of Oncology, 32, S701-S701.
- . Annals of Oncology, 32, S1304-S1305.
- . Journal of Bone Oncology, 29.
- . Diagnostics, 11(7).
- . Scientific Reports, 11(1).
- . Journal of Bone Oncology, 28.
- . Bone Reports, 14, 100840-100840.
- . BMC Health Services Research, 21.
- . BMC Health Services Research, 21(1).
- . Bone, 147, 115907-115907.
- . Cancer Research, 81(4_Supplement).
- . Supportive Care in Cancer, 29(2), 1145-1145.
- . Addiction, 116(5), 1196-1211.
- . Mol Cancer Ther.
- . Trials, 21(1).
- . Journal of Clinical Oncology, 38(34), 4064-4075.
- . Journal of Bone Oncology, 25.
- . Annals of Oncology, 31, S26-S26.
- Abstract P2-18-08: Inclusion of adjuvant bone-modifying agents for early breast cancer into standard clinical practice: Challenges and lessons learnt from an international collaboration. Abstracts: 2019 San Antonio Breast Cancer Symposium.
- . European Urology Focus, 6(5), 991-998.
- . European Urology Focus, 6(5), 999-1005.
- . Current Osteoporosis Reports, 17(6), 527-537.
- . Journal of Urology, 202(6), 1101-1101.
- . JAMA Oncology, 5(11), 1556-1564.
- . Cancer Informatics, 18, 1-3.
- . Health Technology Assessment, 23(30).
- . European Urology, 75(6), 891-893.
- . Clinical Cancer Research, 25(9), 2769-2782.
- . Journal of Bone Oncology, 15.
- . Oncogene, 38(10), 1751-1763.
- . The Journal of Pathology, 247(3), 381-391.
- . Supportive Care in Cancer, 27(5), 1755-1763.
- . Annals of Translational Medicine, 6(S1), S71-S71.
- . JOURNAL OF BONE ONCOLOGY, 13, 123-135.
- . Cancer Research , 78(18).
- . JNCI: Journal of the National Cancer Institute, 110(8), 871-879.
- . PLoS One, 13(7).
- . BMC Cancer, 18(1).
- . European Journal of Cancer, 94, 70-78.
- . Calcified Tissue International, 102(2), 251-264.
- . Journal of Bone Oncology, 9, 1-9.
- . Journal of Bone Oncology, 8, 13-17.
- . Annals of Oncology, 28, v315-v315.
- . European Journal of Cancer Care.
- . Clinical Cancer Research, 22(23), 5713-5721.
- . The Lancet, 388(10053), 1459-1544.
- . Health Technology Assessment, 20.
- . British Journal of Surgery, 103(8), 971-988.
- . BJU International.
- . Scientific Data, 3, 160030-160030.
- . JOURNAL OF CLINICAL ONCOLOGY, 34(14), 1660-U204.
- . Annals of Oncology, 27(5), 880-886.
- . Journal of Instrumentation, 11(04), P04008-P04008.
- . JAMA Oncology, 2(4), 493-493.
- . Journal of the National Cancer Institute, 108(4).
- . Supportive Care in Cancer, 24(3), 1327-1337.
- . Supportive Care in Cancer, 24(1), 447-455.
- . European Journal of Cancer, 53, 75-83.
- . Annals of Oncology, 27(1), 159-165.
- . Supportive Care in Cancer, 24(1), 457-458.
- . European Urology, 68(1), 42-50.
- . Journal of Urology, 193(4S).
- . PROTEOMICS – Clinical Applications, 9(3-4), 295-300.
- . European Urology, 66(3), 510-511.
- . Supportive Care in Cancer, 22(8), 2309-2310.
- . Endocrine-Related Cancer, 21(2), 327-341.
- Omic-profiling in breast cancer metastasis to bone: implications for mechanisms, biomarkers and treatment..
- , 95-124.
- . Clinical Cancer Research, 19(24), 6863-6872.
- . Patient Preference and Adherence, 7, 855-865.
- . Supportive Care in Cancer, 21(12), 3497-3507.
- . Cancer Treatment Reviews.
- . J Clin Oncol, 31(21), 2685-2691.
- . Journal of Clinical Oncology, 31(18_suppl), LBA5000-LBA5000.
- . Journal of Bone Oncology, 2(2), 70-76.
- . Journal of Clinical Oncology, 31(15_suppl), LBA5000-LBA5000.
- . Nat Rev Rheumatol, 9(6), 365-374.
- Efficacy of bisphosphonates and other bone-targeted agents in metastatic bone disease from solid tumors other than breast and prostate cancers. Clinical Advances in Hematology and Oncology, 11(5), 281-287.
- Denosumab and zoledronic acid (ZA) treatment in patients with genitourinary (GU) cancers and bone metastases. BJU INTERNATIONAL, 112, 11-11.
- . Cancer Research, 72(24_Supplement).
- . BMC CANCER, 12.
- . Clinical Oncology.
- . Clin Cancer Res, 18(22), 6348-6355.
- . EUROPEAN JOURNAL OF CANCER, 48(16), 3082-3092.
- . Journal of Bone Oncology, 1(2), 57-62.
- . Annals of Oncology, 23, ix309-ix309.
- . Journal of Clinical Oncology, 30(15_suppl), e16528-e16528.
- . Clinical Investigation, 2(5), 519-526.
- HEALTH RESOURCE UTILISATION (HRU) AND PATIENT BURDEN ASSOCIATED WITH SKELETAL-RELATED EVENTS (SRES) IN A RANDOMISED CONTROLLED TRIAL SETTING. ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 8, 354-354.
- Denosumab in patients with cancer-a surgical strike against the osteoclast. Nature Reviews Clinical Oncology.
- Denosumab in patients with cancer-a surgical strike against the osteoclast. Nature Reviews Clinical Oncology, 9(2), 110-118.
- . Annals of Oncology, 23(5), 1341-1347.
- . Cancer Treatment Reviews, 38(4), 284-291.
- . Cancer Research, 71(24_Supplement).
- . Trials, 12(S1).
- . VALUE IN HEALTH, 14(3), A158-A158.
- . VALUE IN HEALTH, 14(3), A158-A158.
- . Crit Rev Oncol Hematol, 80(3), 411-432.
- . Breast Cancer Res Treat, 127(2), 429-438.
- . EUROPEAN UROLOGY SUPPLEMENTS, 10(2), 336-336.
- . LANCET, 377(9768), 813-822.
- . Medical Oncology, 28(SUPPL. 1), S699-S701.
- . Expert Opin Drug Saf, 10(1), 133-145.
- . Bone, 48(1), 160-166.
- . Clinical Cancer Research, 16(21), 5312-5319.
- . Current Opinion in Supportive and Palliative Care, 4(3), 189-194.
- . BJU INTERNATIONAL, 106(5), 726-727.
- . BJU International, 106(5), 727.
- . Breast Cancer Research and Treatment, 123(3), 805-814.
- A randomized phase III trial of denosumab versus zoledronic acid in patients with bone metastases from castration-resistant prostate cancer.. J Clin Oncol, 28(18_suppl), LBA4507.
- . Journal of Clinical Oncology, 28(18_suppl), LBA4507-LBA4507.
- . BJU International, 105(8), 1042-1043.
- . Expert Opinion on Medical Diagnostics, 4(2), 125-138.
- . BMJ (Online), 340(7738), 118.
- . Neoplasia, 12(9), 685-696.
- Prognostic factors for skeletal complications from metastatic bone disease in breast cancer. Breast Cancer Research and Treatment, 1-13.
- . Bone, 46(3), 801-805.
- . Journal of Clinical Oncology, 27(15_suppl), e16016-e16016.
- . Clin Cancer Res, 14(19), 6336-6342.
- . Cancer Treat Rev, 34(7), 629-639.
- . CANCER, 113(1), 193-201.
- Survival benefits of zoledronic acid in patients with bone metastases from non-small cell lung cancer and high NTX levels: The role of BALP.. J Clin Oncol, 26(15_suppl), 19003.
- Use of monthly oral ibandronate to prevent anastrozole-induced bone loss during adjuvant treatment for breast cancer: Two-year results from the ARIBON study.. J Clin Oncol, 26(15_suppl), 554.
- . CLINICAL ONCOLOGY, 20(4), 318-319.
- . Clinical Cancer Research, 14(6), 1775-1781.
- Zoledronic acid and survival in patients with metastatic bone disease from lung cancer and elevated markers of osteoclast activity. J THORAC ONCOL, 3(3), 228-236.
- . Cancer Treatment Reviews, 34, 51-52.
- . Calcif Tissue Int, 81(5), 341-351.
- . Clin Cancer Res, 13(18 Pt 1), 5406-5410.
- . Journal of Clinical Oncology, 25(18_suppl), 9013-9013.
- . Journal of Clinical Oncology, 25(18_suppl), 10601-10601.
- . Journal of Clinical Oncology, 25(18_suppl), 553-553.
- . UROLOGY, 70(2), 315-319.
- . Clin Cancer Res, 12(21), 6480-6486.
- . Journal of Clinical Oncology, 24(18_suppl), 4555-4555.
- . CLIN CANCER RES, 12(11), 3361-3367.
- Changes in bone resorption and vascular endothelial growth factor after a single zoledronic acid infusion in cancer patients with bone metastases from solid tumours. ONCOL REP, 15(5), 1351-1357.
- . Br J Cancer, 94(4), 469-472.
- . APPL PHYS LETT, 87(23).
- . J Clin Oncol, 23(22), 4925-4935.
- . Journal of Clinical Oncology, 23(16_suppl), 8023-8023.
- . J Natl Cancer Inst, 97(1), 59-69.
- . American Journal of Cancer, 3(4), 265-265.
- . American Journal of Cancer, 3(4), 265-265.
- . Journal of Clinical Oncology, 22(14_suppl), 8056-8056.
- . Journal of Clinical Oncology, 22(14_suppl), 8056-8056.
- . Endocr Relat Cancer, 11(2), 207-224.
- . American Journal of Cancer, 2(4), 269-281.
- . Br J Cancer, 89(11), 2031-2037.
- . Clin Oncol (R Coll Radiol), 15(7), 371-377.
- . Breast Cancer Res, 4(1), 24-29.
- . Breast, 11(5), 375-385.
- . British Journal of Haematology, 110(4), 1010-1012.
- Career focus on medical oncology. BMJ, 11, 2-3.
- Cancer Genetics: Friend or foe of the junior doctor. Morecambe Bay Medical Journal, 8, 272-272.
- Photodynamic therapy, its impact in clinical practice. Photodynamics, 3(2), 2-5.
- . Expert Opinion on Investigational Drugs, 8(12), 1967-1979.
- Photodynamic therapy - new light on cancer treatment. JOURNAL OF THE SOCIETY OF DYERS AND COLOURISTS, 115(9), 249-253.
- . Cancers, 12(8), 2109-2109.
- . Annals of Oncology, 1-12.
Book chapters
- , Reference Module in Biomedical Sciences Elsevier
- , 50 Landmark Papers every Breast Surgeon Should Know (pp. 243-248). CRC Press
- , 50 Landmark Papers every Breast Surgeon Should Know (pp. 165-170). CRC Press
- , 50 Landmark Papers every Breast Surgeon Should Know (pp. 237-242). CRC Press
- , 50 Landmark Papers every Breast Surgeon Should Know (pp. 159-164). CRC Press
- , Bone Cancer (pp. 783-803). Elsevier
- In Heymann D (Ed.), Bone Sarcomas and Bone Metastases - From Bench to Bedside (pp. 987-1002). Academic Press (Elsevier)
- In Heymann D (Ed.), Bone Sarcomas and Bone Metastases - From Bench to Bedside (pp. 783-803). Academic Press (Elsevier)
- , Abeloff's Clinical Oncology (pp. 809-830.e3). Elsevier
- Metabolic complications In Young A, Board RE, Leonard P, Cooksley T, Stewart A & Michie C (Ed.), Problem Solving in Acute Oncology (pp. 84-88). ebn Health
- , Oncogenomics (pp. xv-xx). Elsevier
- , Oncogenomics (pp. 551-563). Elsevier
- In Huhtaniemi I & Martini L (Ed.), Encyclopedia of Endocrine Diseases (pp. 310-319). Elsevier
- , Encyclopedia of Endocrine Diseases (pp. 310-319). Elsevier
- Medical Prevention and Treatment of Bone Metastases In Bilezikian JP (Ed.), Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, , 9th Edition (pp. 799-808). Wiley-Blackwell
- In Dammacco F & Silvestris F (Ed.), Oncogenomics: From Basic Research to Precision Medicine (pp. 551-563). Academic Press
- , Breast Cancer Management for Surgeons (pp. 673-679). Springer International Publishing
- , Management of Prostate Cancer (pp. 343-356). Springer International Publishing
- In Vassiliou V, Chow E & Kardamakis D (Ed.), Bone Metastases A translational and Clinical Approach (pp. 95-124). Springer Netherlands
- In Vassiliou V, Chow E & Kardamakis D (Ed.), Bone Metastases (pp. 125-153). Springer Netherlands
- Metabolic Complications In Marshall E, Clark P, Selby P & Young A (Ed.), Problem Solving in Acute Oncology Clinical Publishing
- Expert Commentary for Breast Disease. In - (Ed.), A Year Book Quarterly 21 (pp. 1-1).
- , Cancer Metastasis – Biology and Treatment (pp. 93-116). Springer Netherlands
- (pp. 105-121). Wiley
- The role of photodynamic therapy in cancer treatment opportunities and limitations In Griffiths J (Ed.), Colour science Volume (pp. 200-210).
- Springer Science and Business Media LLC
Conference proceedings
- Enhancement and Size-based Response Criteria for Evaluating Tyrosine Kinase Inhibitor Dosing Strategy in Metastatic Renal Cancer: Prospective Imaging Study from the UK STAR Trial. CLINICAL ONCOLOGY, Vol. 36(1) (pp E78-E79)
- Fracture-related hospitalisations in de novo advanced or metastatic hormonesensitive prostate cancer: Secondary analysis of the STAMPEDE abiraterone acetate plus prednisone plus /- enzalutamide and M1|RT phase 3 trials using health systems data. EUROPEAN UROLOGY, Vol. 85 (pp S1583-S1583)
- THE IMPACT OF ANDROGEN DEPRIVATION THERAPY ON BONE HEALTH IN PATIENTS WITH PROSTATE CANCER. AGING CLINICAL AND EXPERIMENTAL RESEARCH, Vol. 36 (pp S77-S77)
- CLINICAL FRACTURE INCIDENCE IN METASTATIC HORMONE-SENSITIVE PROSTATE CANCER (MHSPC) AND RISK-REDUCTION FOLLOWING ADDITION OF ZOLEDRONIC ACID TO ANDROGEN DEPRIVATION THERAPY (ADT) WITH OR WITHOUT DOCETAXEL (DOC): LONG-TERM RESULTS FROM 2 PHASE 3 TRIALS FROM THE STAMPEDE PLATFORM PROTOCOL. JOURNAL OF UROLOGY, Vol. 209 (pp E129-E129)
- Fracture and fall risk in men with advanced or metastatic prostate cancer treated with novel androgen receptor signalling inhibitors: A systematic review and meta-analysis of randomised controlled trials. EUROPEAN UROLOGY, Vol. 83
- Clinical fracture incidence in metastatic hormone-sensitive prostate cancer and risk-reduction following addition of zoledronic acid to androgen deprivation therapy with or without docetaxel: Long-term results from the STAMPEDE trial. EUROPEAN UROLOGY, Vol. 83
- Addition of ATM Inhibitors to Radium223 Reduces Prostate Cancer Bone Metastases In Vivo. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 38 (pp 214-215)
- . Annals of Oncology, Vol. 33 (pp S1220-S1220)
- . Cancer Research, Vol. 81(13_Supplement) (pp 2904-2904)
- . Cancer Research, Vol. 81(13_Supplement) (pp 2797-2797)
- Mechanical loading induced osteogenic response does not interfere with the colonization of breast cancer in bone.. CANCER RESEARCH, Vol. 81(13)
- Changes in the phenotype of macrophages and CD8+T Cells in the perivascular niche of prostate tumours following androgen deprivation.. CANCER RESEARCH, Vol. 81(13)
- A randomised phase IB/IIA study of CApecitabine plus Radium-223 in breast cancer patients with BONe metastases (CARBON) - Safety and preliminary efficacy findings. CANCER RESEARCH, Vol. 81(4)
- . Cancer Research, Vol. 80(4_Supplement)
- Preventing the progression of breast cancer bone metastasis by CDK inhibition. BREAST CANCER RESEARCH AND TREATMENT, Vol. 180(2) (pp 537-538)
- . Annals of Oncology, Vol. 30(Suppl 5) (pp v334-v335). Barcelona, Spain, 27 September 2019 - 27 September 2019.
- . Tumor Biology
- . Cancer Research, Vol. 79(13_Supplement)
- . Cancer Research, Vol. 79(4_Supplement)
- . Molecular Cancer Research, Vol. 16(8_Supplement) (pp B13-B13)
- . Cancer Research, Vol. 78(4_Supplement)
- Plasma G-CSF levels are predictive of lack of response to zoledronic acid treatment in reducing breast cancer recurrence.. MOLECULAR CANCER RESEARCH, Vol. 16(8) (pp 68-69)
- . Journal of Clinical Oncology, Vol. 35(15_suppl) (pp e16061-e16061)
- . Clinical Oncology, Vol. 29(3) (pp e89-e89)
- Prospective comparison of RECIST and alternative response assessment criteria in the evaluation of metastatic renal cell cancer patients from phase II of the multi-centre randomised STAR trial. ANNALS OF ONCOLOGY, Vol. 28
- . Journal of Clinical Oncology, Vol. 33(7_suppl) (pp 267-267)
- . Journal of Clinical Oncology, Vol. 32(15_suppl) (pp 4525-4525)
- . Cancer Research, Vol. 73(24_Supplement)
- Effect of skeletal-related events on pain interference in patients with solid tumors and bone metastases. EUROPEAN JOURNAL OF CANCER, Vol. 49 (pp S269-S269)
- Impact of skeletal-related events on pain and analgesic use in patients with solid tumors and bone metastases.. JOURNAL OF CLINICAL ONCOLOGY, Vol. 31(15)
- Skeletal-related events in patients with solid tumors receiving denosumab or zoledronic acid by baseline pain status: Results from three phase 3 trials. EUROPEAN JOURNAL OF CANCER, Vol. 49 (pp S268-S268)
- Clinical outcomes in patients with castrate-refractory prostate cancer (CRPC) metastatic to bone randomized in the factorial trapeze trial to docetaxel (D) with strontium-89 (Sr89), zoledronic acid (ZA), neither, or both (ISRCTN 12808747).. JOURNAL OF CLINICAL ONCOLOGY, Vol. 31(15)
- Risk factors for developing osteonecrosis of the jaw (ONJ) in patients receiving denosumab or zoledronic acid for bone metastases: Results from three phase 3 trials. EUROPEAN JOURNAL OF CANCER, Vol. 49 (pp S268-S269)
- Incidence of osteonecrosis of the jaw in patients receiving denosumab or zoledronic acid for bone metastases from solid tumors or multiple myeloma: Results from three phase III trials.. JOURNAL OF CLINICAL ONCOLOGY, Vol. 31(15)
- Clinical outcomes in patients with castrate-refractory prostate cancer (CRPC) metastatic to bone randomized in the factorial TRAPEZE trial to docetaxel (D) with strontium-89 (Sr89), zoledronic acid (ZA), neither, or both (ISRCTN 12808747).. JOURNAL OF CLINICAL ONCOLOGY, Vol. 31(18)
- Denosumab and zoledronic acid treatment in patients with genitourinary cancers and bone metastases. JOURNAL OF CLINICAL ONCOLOGY, Vol. 31(15)
- 2-year open-label extension phase results from the pivotal phase 3 study of denosumab in patients with metastatic castration-resistant prostate cancer (CRPC) previously treated with denosumab or zoledronic acid. BJU INTERNATIONAL, Vol. 111 (pp 91-92)
- . EUROPEAN JOURNAL OF CANCER, Vol. 48 (pp S8-S8)
- Health state preferences associated with subcutaneous injections and intravenous infusions for treatment of bone metastases. JOURNAL OF CLINICAL ONCOLOGY, Vol. 30(15)
- Baseline covariates impacting overall survival (OS) in a phase III study of men with bone metastases from castration-resistant prostate cancer.. JOURNAL OF CLINICAL ONCOLOGY, Vol. 30(15)
- Health resource utilization and patient burden associated with SREs in a randomized controlled trial setting. JOURNAL OF CLINICAL ONCOLOGY, Vol. 30(15)
- DENOSUMAB IN PATIENTS WITH METASTATIC PROSTATE CANCER PREVIOUSLY TREATED WITH DENOSUMAB OR ZOLEDRONIC ACID: 2-YEAR OPEN-LABEL EXTENSION PHASE RESULTS FROM THE PIVOTAL PHASE 3 STUDY. ANNALS OF ONCOLOGY, Vol. 23 (pp 309-309)
- . EUROPEAN JOURNAL OF CANCER, Vol. 47 (pp S240-S240)
- UK INNOVATORS IN BREAST CANCER: AN INITIATIVE TO SUPPORT THE NEXT GENERATION OF BREAST CANCER RESEARCHERS (ON BEHALF OF PAST AND PRESENT 'UK INNOVATORS'). ANNALS OF ONCOLOGY, Vol. 22 (pp 58-58)
- UK INNOVATORS IN BREAST CANCER: AN INITIATIVE TO SUPPORT THE NEXT GENERATION OF BREAST CANCER RESEARCHERS (ON BEHALF OF PAST AND PRESENT 'UK INNOVATORS'). ANNALS OF ONCOLOGY, Vol. 22
- . BONE, Vol. 48(1) (pp S50-S51)
- . BONE, Vol. 48(1) (pp S16-S16)
- . BONE, Vol. 48(1) (pp S18-S19)
- . BONE, Vol. 48(1) (pp S33-S33)
- . BONE, Vol. 48(1) (pp S29-S29)
- . BONE, Vol. 48(1) (pp S20-S21)
- . BONE, Vol. 48(1) (pp S29-S29)
- . BONE, Vol. 47 (pp S312-S312)
- . BONE, Vol. 47 (pp S302-S303)
- . BONE, Vol. 47 (pp S311-S312)
- . BONE, Vol. 47 (pp S311-S311)
- . BONE, Vol. 47 (pp S310-S311)
- ZOLEDRONIC ACID (ZOL) REDUCES THE INCIDENCE OF SKELETAL-RELATED EVENT (SRES) AND MAY IMPROVE SURVIVAL IN PATIENTS WITH BONE METASTASES (METS) FROM RENAL CELL CARCINOMA (RCC): A RETROSPECTIVE INTEGRATED ANALYSIS. ANNALS OF ONCOLOGY, Vol. 21 (pp 287-287)
- Correlation of N-telopeptide of type I collagen (NTX) with survival and fractures in patients (pts) with bone metastases from renal cell carcinoma (RCC). JOURNAL OF CLINICAL ONCOLOGY, Vol. 27(15)
- . JOURNAL OF CLINICAL ONCOLOGY, Vol. 26(15)
- . JOURNAL OF CLINICAL ONCOLOGY, Vol. 26(15)
- Serum lactate dehydrogenase (LDH) is a significant prognostic variable for survival in patients with metastatic breast cancer - a multivariate analysis. EJC SUPPLEMENTS, Vol. 6(7) (pp 189-189)
- . CANCER TREATMENT REVIEWS, Vol. 34 (pp S81-S82)
- . CANCER TREATMENT REVIEWS, Vol. 34 (pp S78-S78)
- RISK FACTORS FOR SKELETAL-RELATED EVENT (SRES) IN ZOLEDRONIC ACID-TREATED PATIENTS WITH BONE METASTASES (METS) FROM NON-SMALL CELL LUNG CANCER (NSCLC). ANNALS OF ONCOLOGY, Vol. 19 (pp 275-275)
- . CANCER TREATMENT REVIEWS, Vol. 34 (pp S79-S79)
- . CANCER TREATMENT REVIEWS, Vol. 34 (pp S51-S51)
- . CANCER TREATMENT REVIEWS, Vol. 34 (pp S78-S79)
- . CANCER TREATMENT REVIEWS, Vol. 34 (pp S85-S85)
- Preoperative sodium concentration as a possible predictor of survival in patients with renal cell carcinoma. JOURNAL OF CLINICAL ONCOLOGY, Vol. 25(18)
- Normalization of bone markers and improved survival during zoledronic acid therapy. JOURNAL OF CLINICAL ONCOLOGY, Vol. 25(18)
- Effect of monthly oral ibandronate on anastrozole-induced bone loss during adjuvant treatment for breast cancer: One-year results from the ARIBON study. JOURNAL OF CLINICAL ONCOLOGY, Vol. 25(18)
- . BONE, Vol. 38(3) (pp S79-S79)
- . BONE, Vol. 38(3) (pp S79-S80)
- . BONE, Vol. 38(3) (pp S70-S70)
- The ARIBON study: Reversal of anastrozole (Arimidex) induced bone loss with oral monthly ibandronate (Bondronat) treatment during adjuvant therapy for breast cancer.. CANCER TREATMENT REVIEWS, Vol. 32 (pp S48-S49)
- Infrequent zoledronic acid produces sustained increases in bone mineral density (BMD) in patients with cancer treatment induced bone loss (CTIBL). CANCER TREATMENT REVIEWS, Vol. 32 (pp S19-S19)
- Effects of clodronate on serum osteoprotogerin (OPG) in patients with metastatic bone disease. CANCER TREATMENT REVIEWS, Vol. 32 (pp S40-S40)
- Baseline N-telopeptide levels correlate with risk of skeletal morbidity in patients with multiple myeloma during zoledronic acid therapy.. BLOOD, Vol. 106(11) (pp 964A-965A)
- Prognostic significance of biochemical markers of bone metabolism in patients with bone lesions from multiple myeloma (MM).. BLOOD, Vol. 106(11) (pp 335B-335B)
- Can an annual infusion of zoledronic acid protect against cancer-treatment induced bone loss (CTIBL)?. JOURNAL OF CLINICAL ONCOLOGY, Vol. 23(16) (pp 734S-734S)
- Using bone turnover markers to direct bisphosphonate therapy: Is this a feasible approach?. CANCER TREATMENT REVIEWS, Vol. 31 (pp S30-S30)
- The use of point of care devices for the monitoring of urinary NTX levels in metastatic breast cancer. CANCER TREATMENT REVIEWS, Vol. 31 (pp S52-S53)
- Do long-term cancer survivors, treated for testicular cancer or lymphoma, suffer chemotherapy-induced bone loss?. CANCER TREATMENT REVIEWS, Vol. 31 (pp S46-S46)
- A study to determine whether the bisphosphonate zoledronic acid can be shown to exert a direct anti tumour effect in vivo. CANCER TREATMENT REVIEWS, Vol. 31 (pp S48-S49)
- An investigation of the long-term effects of chemotherapy on bone in male long-term cancer survivors. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19(9) (pp 1587-1587)
- The predictive value of bone resorption and formation markers in patients with prostate cancer metastatic to bone. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19(9) (pp 1596-1596)
- The prognostic significance of biochemical markers of bone metabolism in patients with bone metastases from solid tumors other than breast and prostate cancer. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19(9) (pp 1596-1596)
- Effect of an annual infusion of zoledronic acid on bone mineral density in cancer survivors following antineoplastic therapy. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19(9) (pp 1596-1596)
- A double blind, parallel, placebo controlled, dose ranging study on efficacy and safety of oral clodronate in cancer induced osteolysis measured by biochemical markers of bone resorption.. JOURNAL OF CLINICAL ONCOLOGY, Vol. 22(14) (pp 743S-743S)
- Prediction of skeletal complications in metastatic bone disease and strategies for management of treatment-induced bone loss. BRITISH JOURNAL OF CANCER, Vol. 91 (pp S20-S20)
- Bone loss in long term cancer survivors. A pilot study to evaluate the effect of annual intravenous zoledronic acid on bone mineral density (BMD) and bone turnover markers. BONE, Vol. 34 (pp S93-S93)
- Development of a touch screen questionnaire approach for measurement of pain assessment scales in cancer patients with bone metastasis. BRITISH JOURNAL OF CANCER, Vol. 88 (pp S67-S67)
- Bone marker directed bisphosphonate therapy in metastatic bone disease. BRIT J CANCER, Vol. 86 (pp S19-S19)
- Relationship between bone resorption and skeletal events in metastatic done disease. BONE, Vol. 30(3) (pp 47S-47S)
- Bone marker directed bisphosphonate treatment. A pilot study to determine feasibility. BONE, Vol. 30(3) (pp 47S-47S)
Reports
- Implementing frailty assessment and management in oncology services
- Expert panel : evaluation of the Government’s commitments in the area of cancer services in England
Other
- .
Preprints
- , Cold Spring Harbor Laboratory.
- , Springer Science and Business Media LLC.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Research Square Platform LLC.
- , Research Square Platform LLC.
- , Research Square Platform LLC.
- Research group
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Associated Staff
- Sarah Williams - YCR Support for E-IMMUNE
- Carly Fisher - PA
- Dr Steven Wood, Senior Research Associate
- Maria Oliva, Research Assistant
- Dr Margaret Paggiosi
- Dr Jo Bird
- Kate Fryer
- Dr Elisavet Theodoulou, Clinical Research Fellow
- Dr Rebecca Andrews, Clinical Research Fellow (Dr Andrew Chantry, main Clinical Supervisor)
- Dr Qizhi Huang
- Sophie Williams
- Teaching activities
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Janet has been engaged in many aspects of medical teaching including examining at undergraduate and postgraduate levels, and recently been personal tutor for many medical students, educational supervisor for 2 SpRs, supervisor for 5 Clinical PhD Fellows, 2 Clinical Lecturers, 4 ACFs, 4 SHOs, 2 BMedSci and 6 MSc students and 3 research nurses.
- Principal recent professional activities and memberships
- Appointed National Cancer Expert (2021-22) to the Expert Panel of the Parliamentary Health & Social Care Select Committee, to assess Government performance in meeting its cancer targets
- Since 2024, South Yorkshire Director of Clinical Academic Training across all medical specialties
- Since 2020, appointed to the MHRA National Oncology/Haematology Expert Advisory Group to advise on safety, efficacy and approval of medicines in UK, participating in licensing decisions on more than 50 drugs.
- Since 2020, Clinical Lead for NICE appraisals of specific cancer drugs, advising on clinical need and value:- 2020-21, Alpelisib, a breast cancer drug from which 3,500 UK NHS patients are now benefiting.- 2022 radioligand targeted therapy in advanced prostate cancer, with 177Lu PSMA.
- Since 2022, ED&I lead for MRC PhD studentships for 240 students at 5 northern Universities, embedding ED&I in the appointments process and providing support to appointees.
- Since 2020, as a Disability Champion, she led disability initiatives, including a leading role in establishing the University of Sheffield Disability Network (Co-chair 2020-22), linking with NHS disability services.
- Ongoing. Service on various UK and global Company Advisory Boards