Dr Irina-Alexandra Bacila

PhD, PGDip, MRCPCH

School of Medicine and Population Health

NIHR Academic Clinical Lecturer in Paediatrics

Dr Irina Bacila
Dr Irina Bacila
Profile picture of Dr Irina Bacila
i.bacila@sheffield.ac.uk
+44 114 215 9022
EU10, E Floor, The Medical School

Full contact details

Dr Irina-Alexandra Bacila
School of Medicine and Population Health
EU10, E Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk

I joined the University of Sheffield in 2018 when I started a four-year post as Clinical Research Fellow in Paediatrics. This marked the beginning of my research activity within the Department of Oncology and Metabolism at The University of Sheffield and the Endocrine Team at Sheffield Children’s Hospital. During this time, I also completed a PhD in Endocrinology studying metabolic complications in congenital adrenal hyperplasia (CAH). I am dedicated to developing a career as a Clinical Academic, and I am currently working as a Clinical Lecturer in Paediatrics, dividing my time between academic work in the School of Medicine and Population Health, and clinical training in Paediatric Endocrinology at The Sheffield Children’s Hospital.

Qualifications
  • PhD in Endocrinology, The University of Sheffield, Sheffield (2023)
  • Postgraduate Diploma in Child Health, Leeds University, Leeds (2018)
  • Membership of the Royal College of Paediatrics and Child Health (MRCPCH) (2015)
  • Specialty Exam in Paediatrics, Cluj, Romania, Qualification: Specialty Doctor in Paediatrics (2012)
  • University of Medicine and Pharmacy, Cluj, Romania (2007)
Research interests

My research interests are adrenal disease, disorders of steroid synthesis and disorders of sexual development. I have explored these areas in clinical research involving patients with congenital adrenal hyperplasia (CAH) and also in Basic Science research, using zebrafish models of abnormal steroid synthesis. I am also interested in using bioinformatics in combination with metabolomics and transcriptomics to explore molecular mechanisms involved in the pathophysiology of endocrine and metabolic disease.

Publications

Show: Featured publications All publications

Journal articles

  • Balagamage C, Lawrence NR, Krone R, Bacila IA & Krone NP (2024) . Hormone Research in Paediatrics, 97(4), 315-325.
  • Bacila I, Lawrence NR, Badrinath SG, Balagamage C & Krone NP (2024) . Clinical Endocrinology, 101(4), 300-310.
  • Eachus H, Oberski L, Paveley J, Bacila I, Ashton J-P, Esposito U, Seifuddin F, Pirooznia M, Elhaik E, Placzek M , Krone N et al (2023) . Disease Models & Mechanisms, 16(9).
  • Lawrence NR, Bacila I, Dawson J, Mahdi S, Alvi S, Cheetham TD, Crowne E, Das U, Dattani MT, Davies JH , Gevers E et al (2023) . The Journal of Clinical Endocrinology & Metabolism, 109(1), e336-e346.
  • Bacila I, Lawrence NR, Mahdi S, Alvi S, Cheetham TD, Crowne E, Das U, Dattani MT, Davies JH, Gevers E , Krone RE et al (2022) . European Journal of Endocrinology, 187(4), 543-553.
  • Lawrence N, Bacila I, Dawson J, Bryce J, Ali SR, van den Akker ELT, Bachega TASS, Baronio F, Birkebæk NH, Bonfig W , Claahsen van der Grinten H et al (2022) . Clinical Endocrinology, 97(5), 551-561.
  • Bacila I, Cunliffe VT & Krone NP (2021) . Molecular and Cellular Endocrinology, 535, 111372-111372.
  • Bacila I, Freeman N, Daniel E, Sandrk M, Bryce J, Ali SR, Yavas Abalı Z, Atapattu N, Bachega TA, Balsamo A , Birkebæk N et al (2021) . European Journal of Endocrinology, 184(4), 553-563.
  • Bacila I, Adaway J, Hawley J, Mahdi S, Krone R, Patel L, Alvi S, Randell T, Gevers E, Dattani M , Cheetham T et al (2019) . The Journal of Clinical Endocrinology & Metabolism, 104(12), 6417-6429.
  • Bacila I-A, Elder C & Krone N (2019) . Archives of Disease in Childhood, 104(12), 1223-1228.

All publications

Journal articles

  • Bacila IA, Welch R, Adam S, Faisal Ahmed S, Alimussina M, Chinnasamy E, Crowne EC, Davies JH, Davis A, Davis J , Debono M et al (2025) . Journal of the Endocrine Society, 9(Supplement_1).
  • Bacila I, Oberski L, Li N, Storbeck K-H, Cunliffe VT & Krone N (2025) . Biology Open, 14(9).
  • Bacila IA, Lawrence NR, Alvi S, Cheetham TD, Crowne E, Das U, Dattani MT, Davies JH, Gevers E, Keevil B , Krone RE et al (2025) . European Journal of Endocrinology, 193(3), 329-339.
  • Lawrence NR, Bacila I, Tonge J, Dawson J, Collins GS, Lang Z-Q, Bryce J, Alimussina M, Chen M, Ali SR , Adam S et al (2025) . European Journal of Endocrinology, 192(5), 529-539.
  • Balagamage C, Lawrence NR, Krone R, Bacila IA & Krone NP (2024) . Hormone Research in Paediatrics, 97(4), 315-325.
  • Bacila I, Lawrence NR, Badrinath SG, Balagamage C & Krone NP (2024) . Clinical Endocrinology, 101(4), 300-310.
  • Eachus H, Oberski L, Paveley J, Bacila I, Ashton J-P, Esposito U, Seifuddin F, Pirooznia M, Elhaik E, Placzek M , Krone N et al (2023) . Disease Models & Mechanisms, 16(9).
  • Lawrence NR, Bacila I, Dawson J, Mahdi S, Alvi S, Cheetham TD, Crowne E, Das U, Dattani MT, Davies JH , Gevers E et al (2023) . The Journal of Clinical Endocrinology & Metabolism, 109(1), e336-e346.
  • Bacila I, Lawrence NR, Mahdi S, Alvi S, Cheetham TD, Crowne E, Das U, Dattani MT, Davies JH, Gevers E , Krone RE et al (2022) . European Journal of Endocrinology, 187(4), 543-553.
  • Lawrence N, Bacila I, Dawson J, Bryce J, Ali SR, van den Akker ELT, Bachega TASS, Baronio F, Birkebæk NH, Bonfig W , Claahsen van der Grinten H et al (2022) . Clinical Endocrinology, 97(5), 551-561.
  • Bacila I, Cunliffe VT & Krone NP (2021) . Molecular and Cellular Endocrinology, 535, 111372-111372.
  • Bacila I-A, Lawrence N, Mahdi S, Alvi S, Cheetham T, Crowne E, Das U, Dattani M, Davies JH, Gevers EF , Krone R et al (2021) . Journal of the Endocrine Society, 5(Supplement_1), A717-A717.
  • Bacila I, Freeman N, Daniel E, Sandrk M, Bryce J, Ali SR, Yavas Abalı Z, Atapattu N, Bachega TA, Balsamo A , Birkebæk N et al (2021) . European Journal of Endocrinology, 184(4), 553-563.
  • Bacila I, Adaway J, Hawley J, Mahdi S, Krone R, Patel L, Alvi S, Randell T, Gevers E, Dattani M , Cheetham T et al (2019) . The Journal of Clinical Endocrinology & Metabolism, 104(12), 6417-6429.
  • Bacila I-A, Elder C & Krone N (2019) . Archives of Disease in Childhood, 104(12), 1223-1228.
  • Ferguson GR, Bacila IA & Swamy M (2016) . BMJ Open, 6(4), e010054-e010054.
  • Tonge JJ, Bacila I & Krone NP () . Drugs.
  • Bacila IA, Lawrence N, Balagamage C, Bryce J, Ali SR, Alimussina M, Chen M, Albanese A, Amin N, Davies J , Gazdagh G et al () . Endocrine Abstracts.
  • Balagamage C, Bacila I, Idkowiak J, Lawrence NR, Bryce J, Ahmed F, Alimussina M, Amr N, Arya VB, Atapattu N , Bachega T et al () . Endocrine Abstracts.
  • Bacila IA, Oberski L, Cunliffe V & Krone N () . Endocrine Abstracts.
  • Bacila IA, Li N, Cunliffe V & Krone NP () . Endocrine Abstracts.
  • Lawrence NR, Bacila IA, Collins GS, Dawson J, Lang Z-Q, Ji X, Ahmed SF, Alvi S, Bath LE, Blair J , Cheetham T et al () . Hormone Research in Paediatrics, 98(3), 296-306.

Conference proceedings

  • Lawrence NR, Bacila I, Tonge J, Dawson J, Collins GS, Lang Z-Q, Bryce J, Alimussina M, Chen M, Ali SR , Adam S et al (2024) Variation in Blood Pressure in Young Adults with 21a-Hydroxylase Deficiency: Longitudinal Multilevel Modelling of Data from the I-CAH Registry. HORMONE RESEARCH IN PAEDIATRICS, Vol. 97 (pp 154-155)
  • Panchigar K, Tonge J, Bacila I, Bryce J, Alimussina M, Koley S, Ahmed SF, Lawrence NR & Krone N (2024) An exploration of a data visualisation web application for rare disease registries. HORMONE RESEARCH IN PAEDIATRICS, Vol. 97 (pp 514-514)
  • Tonge JJ, Bacila I, Lawrence NR, Alvi S, Cheetham TD, Crowne E, Das U, Dattani MT, Davies JH, Gevers E , Keevil B et al (2024) Non-invasive biochemical monitoring for Congenital Adrenal Hyperplasia: use of urinary steroid metabolites and salivary 17α-Hydroxyprogesterone. HORMONE RESEARCH IN PAEDIATRICS, Vol. 97 (pp 209-210)
  • Lawrence NR, Bacila I, Tonge J, Dawson J, Collins GS, Lang Z-Q, Bryce J, Alimussina M, Chen M, Ali SR , Adam S et al (2024) Impact of Fludrocortisone on Blood Pressure in Young Children Under 5 with CAH in the I-CAH Registry: Autoregressive Causal Inference Analysis. HORMONE RESEARCH IN PAEDIATRICS, Vol. 97 (pp 153-154)
  • Bacila IA, Lawrence NR, Balagamage C, Bryce J, Ali SR, Alimussina M, Chen M, Arya VB, Atapattu N, Bachega TA , Barat P et al (2024) Real world data analysis of contemporary therapy and its association to anthropometric outcomes in 1500 patients with congenital adrenal hyperplasia (CAH). HORMONE RESEARCH IN PAEDIATRICS, Vol. 97 (pp 43-44)
  • Bacila IA, Lawrence NR, Alvi S, Cheetham TD, Crowne E, Das U, Dattani MT, Davies JH, Gevers E, Keevil B , Krone RE et al (2024) Leptin and adiponectin are associated with the glucocorticoid dose and androgen concentrations in children and young persons with congenital adrenal hyperplasia: data from the CAH-UK cohort. HORMONE RESEARCH IN PAEDIATRICS, Vol. 97 (pp 155-156)
  • Oberski L, Bacila I, Cunliffe V & Krone N (2023) The pathophysiologic response of central nervous system due to differently impaired steroidogenesis. HORMONE RESEARCH IN PAEDIATRICS, Vol. 96 (pp 27-28)
  • Bacila I, Lawrence NR, Ji X, Ahmed SF, Alvi S, Bath L, Blair J, Cheetham T, Crowne L, Davies JH , Dattani M et al (2023) National service evaluation project analysing the quality of care for children and young people with congenital adrenal hyperplasia in the United Kingdom: Data from patients and clinicians. HORMONE RESEARCH IN PAEDIATRICS, Vol. 96 (pp 418-419)
  • Bacila I, Oberski L, Cunliffe V & Krone N (2023) Metabolic effects of cortisol insufficiency are sex-depended in a zebrafish model of 21-hydroxylase deficiency. HORMONE RESEARCH IN PAEDIATRICS, Vol. 96 (pp 135-135)
  • Baker EL, Ellis J, Jayes S, Kingsley R, Lee A, Mitchell D, Peakman E, Smith DP, Watts W & Bacila IA (2023) York Paediatric Diabetes Team: A rewarding quality improvement project in children with type 1 diabetes. DIABETIC MEDICINE, Vol. 40
  • Bacila I, Li N, Eachus H, Storbeck K-H, Cunliffe VT & Krone NP (2022) Towards understanding the metabolic phenotype of glucocorticoid deficiency in 21-hydroxylase deficiency. HORMONE RESEARCH IN PAEDIATRICS, Vol. 95(SUPPL 2) (pp 79-79)
  • Lawrence NR, Bacila I, Dawson J, Ali SR, van den Akker ELT, Sartori Sanchez Bachega TA, Baronio F, Birkebaek NH, Bonfig W, van der Grinten C , Cools M et al (2022) Blood pressure (BP) status in Congenital Adrenal Hyperplasia (CAH) - longitudinal analysis of real world data from the I-CAH registry. HORMONE RESEARCH IN PAEDIATRICS, Vol. 95(SUPPL 2) (pp 112-113)
  • Lawrence NR, Bacila I-A, Mahdi S, Albi S, Cheetham TD, Crowne EC, Das U, Dawson J, Dattani MT, Davies J , Gevers E et al (2021) . Journal of the Endocrine Society, Vol. 5(Supplement_1) (pp A720-A720). Virtual meeting, 20 March 2021 - 20 March 2021.
  • Bacila I, Lawrence N, Alvi S, Cheetham T, Crowne E, Das U, Dattani M, Davies JH, Gevers E, Krone R , Kyriakou A et al (2021) Re-appraising the use of urinary steroid profiles for assessing therapy control in children with 21-hydroxylase deficiency - results from the CAH-UK cohort study. HORMONE RESEARCH IN PAEDIATRICS, Vol. 94(SUPPL 1) (pp 27-27)
  • Lawrence N, Bacila I, Dawson J, Bryce J, van den Akker EL, Sartori Sanchez Bachega TA, Baronio F, Birkebaek NH, Bonfig W, Claahsen H , Costa EC et al (2021) Variation of glucocorticoid dose and biomarkers in children with congenital adrenal hyperplasia longitudinal analysis of real world data from the I-CAH registry. HORMONE RESEARCH IN PAEDIATRICS, Vol. 94(SUPPL 1) (pp 26-26)
  • Lawrence N, Bacila I, Dawson J, Bryce J, van den Akker E, Sartori Sanchez Bachega TA, Baronio F, Birkebaek NH, Bonfig W, Claahsen H , Costa EC et al (2021) International practice of therapy monitoring in congenital adrenal hyperplasia - Real World data from the I-CAH registry. HORMONE RESEARCH IN PAEDIATRICS, Vol. 94(SUPPL 1) (pp 67-68)

Datasets

  • Bacila I-A .