Dr Helen Marshall
PhD
School of Medicine and Population Health
Research Staff Scientist
+44 114 215 9145
Full contact details
School of Medicine and Population Health
Polaris
18 Claremont Crescent
Sheffield
S10 2TA
- Profile
-
For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
I have worked on the development and application of hyperpolarised gas and proton lung MRI at the University of Sheffield since 2009. Previously I was a post-doctoral fellow at the University of Toronto working on dynamic contrast-enhanced breast imaging. I have a PhD in MRI Physics and a BSc in Physics from Imperial College London.
- Research interests
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My research interests are focused on the application of MR imaging techniques in patients with lung disease. Projects that I have worked on include:
- early detection of lung disease in children with cystic fibrosis
- visualisation of collateral and delayed ventilation in patients with advanced chronic obstructive pulmonary disease (COPD)
- imaging of ventilation response to therapies in patients with asthma and COPD
- visualisation of ventilation and perfusion matching in patients with chronic thromboembolic pulmonary hypertension, asthma and COPD
- imaging ventilation and microstructural changes in young adults with congenital diaphragmatic hernia
I am involved in clinical research study design and delivery, devising MR acquisition protocols and image computing workflows, and performing data analysis and interpretation. I helped to establish and am active in maintaining our clinical hyperpolarised gas lung imaging service.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . The British Journal of Radiology, 95(1132).
- . European Respiratory Journal, 7(3).
- . Journal of Allergy and Clinical Immunology, 147(6), 2154-2161.e6.
- . Progress in Nuclear Magnetic Resonance Spectroscopy, 122, 42-62.
- . Journal of Magnetic Resonance Imaging, 49(4), 1195-1197.
- . American Journal of Respiratory and Critical Care Medicine, 197(3).
- . Thorax, 72, 760-762.
- . Pediatric Pulmonology, 51(5), 517-524.
- . American Journal of Respiratory and Critical Care Medicine, 190(5), e18-e19.
- . Magn Reson Med, 71(3), 1172-1178.
- . Thorax, 67(7), 613-617.
All publications
Journal articles
- . American Journal of Respiratory and Critical Care Medicine.
- . Thorax.
- . Journal of Magnetic Resonance Imaging.
- . ERJ Open Research, 11(1).
- . Magnetic Resonance in Medicine, 92(6), 2546-2559.
- . Magnetic Resonance in Medicine, 92(4), 1471-1483.
- . Radiotherapy and Oncology, 194(Supplement 1), S5062-S5066.
- . European Respiratory Journal, 63(5), 2301010-2301010.
- . Journal of Magnetic Resonance Imaging, 59(6), 1953-1964.
- . Scientific Reports, 13.
- . Chest, 164(3), 700-716.
- . Journal of Magnetic Resonance Imaging.
- . ERJ Open Research, 9(1).
- . Journal of Magnetic Resonance Imaging, 57(6), 1878-1890.
- . American Journal of Respiratory and Critical Care Medicine, 207(1), 89-100.
- . Journal of Magnetic Resonance Imaging.
- . Scientific Reports, 12(1).
- . Pulmonary Circulation, 12(2).
- . Respiratory Research, 23(1).
- . Journal of Magnetic Resonance Imaging, 55(3), 633-652.
- . The British Journal of Radiology, 95(1132).
- . European Respiratory Journal, 7(3).
- . Journal of Cystic Fibrosis, 20(4), 625-631.
- . Journal of Allergy and Clinical Immunology, 147(6), 2154-2161.e6.
- . Progress in Nuclear Magnetic Resonance Spectroscopy, 122, 42-62.
- . Thorax, 76(2), 144-151.
- . European Respiratory Journal, 56(6).
- . Thorax, 74(5), 500-502.
- . Physics in Medicine and Biology, 64(5).
- . Journal of Applied Physiology, 126(1), 183-192.
- . Journal of Magnetic Resonance Imaging, 49(4), 1195-1197.
- . International Journal of Radiation Oncology*Biology*Physics, 102(4), 1276-1286.
- . Journal of Magnetic Resonance Imaging, 48(3), 632-642.
- . Annals of the American Thoracic Society, 15(12), 1487-1490.
- . American Journal of Respiratory and Critical Care Medicine, 197(3).
- . Journal of Magnetic Resonance Imaging, 47(3), 640-646.
- . Thorax, 72, 760-762.
- . Cancer Research, 77(4_Supplement).
- . Magnetic Resonance in Medicine, 77(6), 2107-2113.
- . Pediatric Pulmonology, 51(5), 517-524.
- . Radiology, 278(2), 585-592.
- . Journal of Applied Physiology, 119(9), 1007-1014.
- . Current Cardiovascular Imaging Reports, 8(12).
- . MAGNETIC RESONANCE IN MEDICINE, 74(1), 196-207.
- . Physics in Medicine and Biology, 59(23), 7267-7277.
- . NMR in Biomedicine, 27(12), 1461-1467.
- . American Journal of Respiratory and Critical Care Medicine, 190(5), e18-e19.
- . Pulm Circ, 4(1), 61-70.
- . J Appl Physiol (1985), 116(2), 129-139.
- . Magn Reson Med, 71(3), 1172-1178.
- . Thorax, 68(7), 677-678.
- . Radiology, 267(1), 251-255.
- . Magn Reson Med, 67(2), 322-325.
- . Insights Imaging, 3(4), 345-353.
- . NMR in Biomedicine, 25(2), 389-399.
- . Magn Reson Med, 68(6), 1900-1904.
- . Thorax, 67(7), 613-617.
- . Eur Radiol, 22(3), 695-702.
- . NMR Biomed, 25(1), 44-51.
- . Magn Reson Med, 66(6), 1788-1797.
- . NMR Biomed, 24(2), 130-134.
- . Journal of Magnetic Resonance Imaging, 31(2), 328-338.
- . Magnetic Resonance Materials in Physics, Biology and Medicine, 22(3), 187-200.
- . American Journal of Roentgenology, 179(1), 187-192.
- . Medical Physics.
- . European Respiratory Journal, 52(5).
- . Radiology.
Book chapters
- , Hyperpolarized and Inert Gas MRI (pp. 47-59). Elsevier
Conference proceedings
- A pilot study to explore the potential for 129Xe and 1H lung magnetic resonance imaging as a tool to investigate the pathophysiology of obstructive lung disease in people living with HIV. HIV MEDICINE, Vol. 26 (pp 62-63)
- . ‘The Catcher in the MRI’ – Functional imaging in lung disease (pp A8-A8)
- . Imaging (pp PA5251-PA5251)
- . Paediatric respiratory physiology and sleep (pp OA4664-OA4664)
- . Respiratory function technologists/scientists (pp OA4590-OA4590)
- . Physiotherapists (pp PA1430-PA1430)
- . ‘Shake it off’ – Recovery from COVID-19 (pp A18-A19)
- . ‘You ain’t seen nothing yet’ – Imaging across COPD, nodules and lung cancer screening (pp A215-A215)
- . ‘You ain’t seen nothing yet’ – Imaging across COPD, nodules and lung cancer screening (pp A214-A214)
- . Imaging (pp OA4857-OA4857)
- . Physiotherapists (pp PA5039-PA5039)
- . Respiratory function technologists/scientists (pp PA4500-PA4500)
- . Respiratory function technologists/scientists (pp OA757-OA757)
- . Clinical respiratory physiology, exercise and functional imaging (pp OA4954-OA4954)
- . Clinical respiratory physiology, exercise and functional imaging (pp PA2260-PA2260)
- . 05.02 - Monitoring airway disease (pp 2865-2865)
- . 09.01 - Respiratory function technologists/scientists (pp 4486-4486)
- . European Respiratory Society (ERS) International Congress 2022, Vol. 60(Suppl 66) (pp 760). Barcelona, Spain, 4 September 2022 - 4 September 2022.
- . A99. LOOK AT THAT! NEW FINDINGS FROM LUNG IMAGING, Vol. 205 (pp a2175-a2175). San Francisco, CA, 13 May 2022 - 13 May 2022.
- . Imaging (pp PA1872-PA1872)
- Hyperpolarized Gas MRI Ventilation Synthesis From CT: Comparison of Conventional and Deep Learning Methods. MEDICAL PHYSICS, Vol. 48(6)
- Comparison of 3D Deep Convolutional Neural Networks and Training Strategies for Ventilated Lung Segmentation Using Multi-Nuclear Hyperpolarized Gas MRI. MEDICAL PHYSICS, Vol. 48(6)
- . Thoracic Image Analysis, Vol. 12502 (pp 24-35). Lima, Peru, 8 October 2020 - 8 October 2020.
- . Imaging (pp PA3171-PA3171)
- . Cystic fibrosis (pp OA2131-OA2131)
- . Respiratory function technologists/scient. (pp PA3907-PA3907)
- . Imaging (pp PA3163-PA3163)
- . Cystic fibrosis (pp PA334-PA334)
- . Journal of Cystic Fibrosis, Vol. 18(Suppl 1) (pp S116-S117). Liverpool, United Kingdom, 5 June 2019 - 5 June 2019.
- . Journal of Cystic Fibrosis, Vol. 18(Suppl 1) (pp S32-S32). Liverpool, United Kingdom, 5 June 2019 - 5 June 2019.
- . Journal of Cystic Fibrosis, Vol. 18(Suppl 1) (pp S117-S117). Liverpool, United Kingdom, 5 June 2019 - 5 June 2019.
- . Journal of Cystic Fibrosis, Vol. 18(Suppl 1) (pp S117-S117). Liverpool, United Kingdom, 5 June 2019 - 5 June 2019.
- . Radiotherapy and Oncology, Vol. 133(Suppl_1) (pp S274-S275). Milan, Italy, 26 April 2019 - 26 April 2019.
- . Thorax, Vol. 73(Suppl 4) (pp A44-A45). London, UK, 5 December 2018 - 5 December 2018.
- . Imaging (pp PA387-PA387)
- . Cystic fibrosis (pp OA4990-OA4990)
- . Radiotherapy and Oncology, Vol. 127(Supplement 1) (pp S96-S97). Barcelona, Spain, 20 April 2018 - 20 April 2018.
- Hyperpolarised Gas MRI Shows Reversibility of Lung Ventilation Defects at Increased Inspiratory Lung Volumes in Cystic Fibrosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 197
- Dynamic Contrast-Enhanced Magnetic Resonance Imaging for the Evaluation of Perfusion Heterogeneity in Idiopathic Pulmonary Fibrosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 197
- Assessment of Suitable Patients and Targets for Lung Volume Reduction with Endobronchial Valves in COPD. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 197
- . Paediatric Respiratory Physiology and Sleep (pp PA3342-PA3342)
- . Imaging (pp OA4645-OA4645)
- . European Respiratory Journal, Vol. 50(Suppl 61). Milan, Italy, 9 September 2017 - 9 September 2017.
- . European Respiratory Journal, Vol. 50(Suppl 61). Milan, Italy, 9 September 2017 - 9 September 2017.
- . Journal of Thoracic Oncology, Vol. 12(1) (pp S1050-S1050). Virtual conference, 4 December 2016 - 4 December 2016.
- . 9.1 Respiratory Function Technologists/Scientists (pp PA4410-PA4410)
- . European Respiratory Journal, Vol. 48(Suppl 60). London, UK, 3 September 2016 - 3 September 2016.
- . Pediatric Pulmonology, Vol. 51(Supplement S45) (pp 348-348). Orlando, Florida, 27 October 2016 - 27 October 2016.
- . European Respiratory Journal, Vol. 48. London, UK, 3 September 2016 - 3 September 2016.
- . European Respiratory Journal, Vol. 48(Suppl 60). Estoril, Portugal, 10 March 2016 - 10 March 2016.
- . Medical Physics, Vol. 43(6) (pp 3795-3796). Washington, DC, 31 July 2016 - 31 July 2016.
- . Journal of Cystic Fibrosis, Vol. 15(Suppl 1) (pp S24-S25). Basel, Switzerland, 8 June 2016 - June 2016.
- . Thorax, Vol. 70(Suppl 3) (pp A220.3-A221)
- . Thorax, Vol. 70(Suppl 3) (pp A222-A223)
- . Thorax, Vol. 70(Suppl 3) (pp A223.1-A223)
- . 1.3 Imaging (pp PA3752-PA3752)
- . 4.1 Clinical respiratory physiology, exercise and functional imaging (pp PA517-PA517)
- . 4.1 Clinical respiratory physiology, exercise and functional imaging (pp OA2946-OA2946)
- . 1.3 Imaging (pp OA4992-OA4992)
- . 9.1 Respiratory Function Technologists/Scientists (pp OA307-OA307)
- . 4.1 Clinical respiratory physiology, exercise and functional imaging (pp OA2945-OA2945)
- . Thorax, Vol. 69(Suppl 2) (pp A192-A193)
- Visualising regional ventilation heterogeneity by linking multiple breath washout to He-3 MRI imaging. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- Influence of the cardiac cycle on the airflow patterns during inhalation in healthy subjects investigated with He-3 MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- Quantitative lung T-1 mapping and oxygen enhanced MRI in IPF. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- Delayed gas filling imaged in asthma patients using hyperpolarised He-3 MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- . Journal of Cystic Fibrosis, Vol. 13 (pp S28-S28)
- Age-dependent changes in whole-lung septal thickness measured by Xe-129 MRI: A comparison of healthy volunteers and subjects with IPF. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- Detection of early-stage lung disease in cystic fibrosis; comparing the sensitivity of 3He and 1H MRI, CT and LCI. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- Feasibility of high quality lung MRI with naturally abundant hyperpolarised 129Xe. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- Age-dependent changes in whole-lung septal thickness measured by 129Xe MRI: A comparison of healthy volunteers and subjects with IPF. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- Linking Helium-3 Mri Washout Imaging To Multiple Breath Washout - First Steps To Understanding Regional Lung Ventilation Heterogeneity. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- Dissolved 129xe Mri - Delayed Gas Uptake Indicates Septal Thickening In Patients With Idiopathic Pulmonary Fibrosis And Systemic Sclerosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- Quantitative Mapping Of Treatment Response In The Lungs Of Asthmatics Using Hyperpolarized Ventilation Helium-3 Mri. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- Reproducibility Of Lung Ventilation Volume From Helium-3 And Proton Mri In Asthmatics. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- Comparison Of CT-Based Lobar Ventilation Models With Helium-3 Mri Ventilation Measurements In Asthmatics. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- Assessment Of Structural And Functional Changes In Early Stage Cf With Helium-3 Mri, CT And Multi-Breath Washout. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- Mutli-Nuclear Mr Imaging Of Vq Distribution Response To Bronchodilator In Asthma. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- Mapping The Microscopic Distribution Of Acinar Airway Length Scales Using Fractal Exponential Analysis Of Helium-3 Diffusion Mri. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- . THORAX, Vol. 68 (pp A7-A8)
- Imaging The Effect Of Airway Opening In Asthma Due To Inflation State With 3he Mri. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 187
- Bronchodilator treatment response mapping in COPD using hyperpolarised gas ventilation MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 42
- Quantifying peripheral and central lung response to bronchodilator in asthma with hyperpolarised gas MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 42
- Comparison of lung ventilation volume measurements made with single and separate breath-hold hyperpolarized 3-helium and proton MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 42
- Imaging of bronchodilator effects in COPD with hyperpolarised 3He and 1H MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 42
- 3HE MRI IN YOUNG ADULTS WITH CONGENITAL DIAPHRAGMATIC HERNIA: ALVEOLAR SIZE DIFFERENCES BETWEEN THE IPSI- AND CONTRALATERAL LUNG. INTENSIVE CARE MEDICINE, Vol. 39 (pp S107-S107)
- . D100. THE BIG ROLE OF SMALL AIRWAYS (pp A6544-A6544)
- . B98. NOVEL APPROACHES TO LUNG IMAGING (pp A3683-A3683)
- . C28. DIAGNOSIS AND TREATMENT OF PULMONARY HYPERTENSION (pp A4097-A4097)
- Modelling of hyperpolarized gas diffusion in lungs of COPD patients and healthy volunteers using a fractional dynamics approach. EUROPEAN RESPIRATORY JOURNAL, Vol. 40
- 3He MRI in young adults with congenital diaphragmatic hernia: Alveolar size differences between lungs. EUROPEAN RESPIRATORY JOURNAL, Vol. 40
- MRI of delayed-ventilation perfusion matching in COPD. EUROPEAN RESPIRATORY JOURNAL, Vol. 40
- Quantifying lung function in COPD with hyperpolarised 3He MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 40
- Simultaneous imaging of lung structure and function with triple nuclear MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 40
- Simultaneous imaging of lung structure and function with triple nuclear MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 40
- . THORAX, Vol. 66 (pp A54-A55)
- AUTOMATIC IMAGE REGISTRATION OF LUNG CT WITH SYNCHRONOUSLY ACQUIRED HYPERPOLARIZED HELIUM-3 MRI AND PROTON MRI FOR PATIENTS WITH NSCLC. J THORAC ONCOL, Vol. 6(6) (pp S1123-S1124)
- . RADIOTHERAPY AND ONCOLOGY
- . Radiotherapy and Oncology, Vol. 99 (pp S481-S482)
- . A62. PULMONARY HYPERTENSION: BIOMARKERS AND TRANSLATIONAL SCIENCE (pp A2006-A2006)
- . ISMRM Annual Meeting, 10 May 2025 - 15 May 2025.
- . ISMRM Annual Meeting, 10 May 2025 - 15 May 2025.
- . ISMRM Annual Meeting, 10 May 2025 - 15 May 2025.
- . ISMRM Annual Meeting, 10 May 2025 - 15 May 2025.
- . ISMRM Annual Meeting, 10 May 2025 - 15 May 2025.
- . ISMRM Annual Meeting, 10 May 2025 - 15 May 2025.
- . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- . ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- . ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- . ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- . ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- . ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- . ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
Other
- . Thorax.
Preprints
- , Cold Spring Harbor Laboratory.
- Current projects
- Imaging a large cohort of patients with asthma and/or COPD with 129Xe MRI as a sub-study of the .
- Comparison of hyperpolarised gas and free-breathing proton ventilation MRI in patients with cystic fibrosis.
- Imaging the effects of mepolizumab in patients with COPD.