Emeritus Professor Graham Russell
PhD, DM(Oxon), MD, FRCP, FRCPath. FMedSci, FRS
School of Medicine and Population Health
Emeritus Professor of Musculoskeletal Pharmacology
+44 7768 502842
Full contact details
School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
Graham Russell (R G G Russell) graduated with First Class Honours in Biochemistry from the University of Cambridge in 1962 and subsequently gained his PhD on pyrophosphate metabolism from the MRC Mineral Metabolism Unit at the University of Leeds. In 1965, he joined Dr Herbert Fleisch’s Medical Research Institute in Davos, Switzerland, and their collaborative work led to the discovery of the biological effects of bisphosphonates. He then moved to Oxford University, where he continued research based at the Nuffield Department of Orthopaedic Surgery. Working with Roger Smith, this led to the first and successful clinical applications of bisphosphonates in Paget’s disease of bone. Concurrently, he completed his medical degree with distinction in 1971. He held the Medical Research Fellowship at St Peter’s College from 1972-76. He was awarded his DM at Oxford in 1976, and also gained Membership and then the Fellowship of the Royal Colleges of Physicians and of Pathology.
During the 1970s, he held appointments in the University of Berne with Herbert Fleisch, and at Harvard University with John Potts and Stephen Krane as the Chiefs of the Endocrine and Arthritis Units respectively at the Massachusetts General Hospital, before moving in 1976 to the Department of Chemical Pathology in the University of Sheffield Medical School, under the leadership of Jack Martin. He became Professor and Head of Department of Human Metabolism and Clinical Biochemistry in 1977. Over the following years he helped to establish Sheffield as a major international centre for the study of basic and clinical aspects of bone diseases, and his group have nurtured many clinicians and PhDs who now hold senior positions in the field.
He has worked on topics related to calcium metabolism and bone diseases throughout his career and is author of more than 500 publications. He has played a central role in studying the biological effects of bisphosphonates, and in their clinical development and evaluation for the treatment of bone disorders, which includes Paget’s disease, myeloma, cancer metastases in bone, and osteoporosis. The use of bisphosphonates has now grown to a multi-billion dollar activity by the pharmaceutical industry. During the 1990s, Michael Rogers and others within his group in Sheffield elucidated the molecular mechanisms of action of the bisphosphonates, and showed that nitrogen-containing bisphosphonates act as inhibitors of mevalonate metabolism resulting in inhibition of protein prenylation. His research interests have included bone cell biology, pathogenic mechanisms in bone and joint diseases such as arthritis, myeloma, bone metastases, and osteoporosis, the evaluation of new therapeutic agents and their mode of action, and the pharmacology of bone and cartilage.
He has held several national and international appointments in scientific and charitable activities related to bone disease and arthritis. For the Nuffield Foundation (UK), he was Chairman of the Oliver Bird Committee from 1996-2003. He has been Chairman of the Scientific Advisory Committee of the National Association for Pagets Disease (UK), and of several Research Committees including the MRC, Research into Ageing, and the Arthritis Research UK (formerly ARC). In April 1997 he was Chairman of the 25th European Symposium for Calcified Tissues held in Harrogate, UK. From 1998-2001 he was the President of the International Bone and Mineral Society (IBMS), the longest established international academic society in this field. In 1986 he was one of the founding members of the National Osteoporosis Society (NOS, UK), which has grown to become one of the largest national charities devoted to osteoporosis, and from 2000-2002 he was Chairman of its Council of Management.
Among awards, he was Heberden Orator of the BSR in 1993, and was recipient of the John B. Johnson award of the Paget’s Foundation (USA) in 1997, and the Kohn award of the NOS in 2000. He received the W F Neuman award of the American Society of Bone and Mineral Metabolism in 2000. This is the most senior award of the ASBMR and he was the first British scientist to receive it. In 2007 he received the Pieter Gaillard Founders award of the IBMS, and in 2008 was elected a Fellow of the Royal Society of London.
In 2001 he moved back to the University of Oxford as the holder of the newly established Norman Collisson Chair of Musculoskeletal Sciences, and became a Professorial Fellow at St Peter’s College. From 2003-6 he was Head of the Nuffield Department of Orthopaedic Surgery (now NDORMS). He was the first Director of the Oxford University Institute of Musculoskeletal Sciences (the ), from 2002-7. He is now Professor of Musculoskeletal Pharmacology and continues his research within the Botnar Research Centre, and also in the Mellanby Centre for Bone Research at Sheffield University.
- Research interests
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Graham’s research interests include bone cell biology, cytokines, pathogenic mechanisms in bone and joint diseases such as arthritis, myeloma, bone metastases, and osteoporosis, and the evaluation of new therapeutic agents and their modes of action.
Throughout he has played a central role in studying the biological effects of bisphosphonates, and in their clinical development and evaluation for the treatment of skeletal diseases. During the 1990s, Michael Rogers and others within his group in Sheffield elucidated the molecular mechanisms of action of the bisphosphonates, and showed that nitrogen-containing bisphosphonates act as inhibitors of mevalonate metabolism resulting in inhibition of protein prenylation. His current research focuses on understanding their structure activity relationships, the design of novel compounds, and the detailed mechanisms of their actions on the skeleton and other systems.
- Publications
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Books
- . Elsevier.
Journal articles
- . Bioactive Materials, 45, 257-273.
- . Aging, 15(9), 3331-3355.
- . Bone, 172, 116754-116754.
- . International Journal of Molecular Sciences, 24(3).
- . Archives of Osteoporosis, 17(1).
- . Bone, 156.
- . British Journal of Pharmacology, 178(9), 2008-2025.
- . British Journal of Pharmacology, 178(9), 1889-1890.
- . Bone, 147, 115933-115933.
- . Bone, 137, 115411-115411.
- . Scientific Reports, 10.
- . Bone, 137, 115390-115390.
- . Journal of Bone and Mineral Research, 34(12), 2327-2329.
- . BMJ Open, 9(9).
- . British Journal of Clinical Pharmacology, 85(6), 1049-1051.
- . British Journal of Clinical Pharmacology, 85(6), 1052-1062.
- . Journal of Bone and Mineral Research, 34(4), 579-604.
- . JBMR Plus, 2(S2).
- . Journal of Bone and Mineral Research, 33(12), 2091-2098.
- . Journal of Bone and Mineral Research, 32(9), 1860-1869.
- . New England Journal of Medicine, 376(18), 1794-1795.
- . Journal of Medicinal Chemistry, 60(6), 2326-2343.
- . Journal of Bone and Mineral Research, 31(10), 1785-1786.
- . Phosphorus, Sulfur, and Silicon and the Related Elements, 191(11-12), 1504-1508.
- . Current Opinion in Pharmacology, 28, 57-68.
- . Bioconjugate Chemistry, 27(2), 329-340.
- . Stem Cells.
- . Bone, 81, 478-486.
- . Current Opinion in Pharmacology, 22, 115-130.
- . Current Opinion in Pharmacology, 22, v-viii.
- . Journal of Bone and Mineral Research, 30(5), 751-752.
- . Urolithiasis, 43(1), 1-2.
- . BMJ, 346(mar12 3), f1514-f1514.
- . Osteoporosis International, 24(3), 1141-1142.
- . Osteoporosis International, 23(12), 2873-2884.
- . Osteoporosis International, 23(11), 2693-2701.
- . Calcified Tissue International, 90(3), 202-210.
- . Journal of Bone and Mineral Research, 27(3), 679-686.
- . Osteoporosis International, 23(1), 285-294.
- . Journal of Bone and Mineral Research, 27(4), 835-847.
- . Annals of the New York Academy of Sciences, 1240(1).
- . Bone, 49(1), 1-1.
- . Bone, 49(1), 2-19.
- . Bone, 49(1), 133-139.
- . Bone, 49(1), 20-33.
- Risedronate does not reduce mechanical loading-related increases in cortical and trabecular bone mass in mice. Bone.
- . Therapeutics and Clinical Risk Management, 7, 131-144.
- . Bone, 49(6), 1121-1124.
- . Bone, 48(4), 677-692.
- . Journal of Biological Chemistry, 286(5), 3315-3322.
- . Journal of Clinical Densitometry, 13(1), 1-9.
- . Journal of Biomedical Materials Research Part B: Applied Biomaterials, 92B(1), 149-155.
- . Journal of Biomedical Materials Research Part A, 92A(4), 1256-1264.
- . Journal of Nuclear Medicine, 50(1), 6-7.
- . Journal of Bone and Mineral Research, 23(5), 610-620.
- . Chemistry & Biology, 15(12), 1296-1306.
- . Bioconjugate Chemistry, 19(12), 2308-2310.
- . Journal of Medicinal Chemistry, 51(7), 2187-2195.
- . Osteoporosis International, 19(6), 733-759.
- . Journal of Cellular Physiology, 215(2), 488-496.
- . Journal of Biomedical Materials Research Part A, 85A(4), 993-1000.
- . Journal of Bone and Mineral Research, 22(11), 1651-1653.
- . Molecular Cancer Therapeutics, 6(12), 3219-3228.
- . Journal of Medicinal Chemistry, 50(24), 5967-5975.
- . Osteoporosis International, 18(8), 1019-1021.
- . Bone, 40(5), S21-S25.
- . The Journal of Pharmacology and Experimental Therapeutics, 322(1), 228-235.
- . Calcified Tissue International, 80(4), 233-243.
- . Leukemia, 21(4), 805-812.
- . International Journal of Cancer, 120(8), 1657-1663.
- . Tissue Engineering, 13(1), 133-145.
- . Proceedings of the National Academy of Sciences, 103(20), 7829-7834.
- . Journal of Biological Chemistry, 281(31), 22004-22012.
- . International Journal of Cancer, 119(6), 1254-1261.
- . Bone, 38(4), S7-S12.
- . Bone, 38(5), 617-627.
- . Journal of Bone and Mineral Research, 20(7), 1265-1274.
- . Arthritis & Rheumatism, 52(4), 1110-1117.
- . Osteoporosis International, 15(6).
- . International Journal of Clinical Practice, 57(8), 710-718.
- . Rheumatology, 41(7), 725-729.
- , 251-271.
- . QJM, 94(11), 575-597.
- . Calcified Tissue International, 69(2), 63-66.
- . Bone, 28(1), 108-112.
- . Biochemical and Biophysical Research Communications, 280(2), 574-580.
- . Blood, 98(13), 3534-3540.
- . Acta Oncologica, 39(7), 829-835.
- . British Journal of Haematology, 111(1), 283-286.
- . British Journal of Haematology, 108(2), 383-390.
- . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1502(2), 297-306.
- . Osteoporosis International, 11(4), 331-337.
- . The Lancet, 355(9200), 265-269.
- . Journal of Bone and Mineral Research, 14(S2), 53-65.
- . Phosphorus, Sulfur, and Silicon and the Related Elements, 144(1), 793-820.
- . British Journal of Haematology, 104(2), 350-357.
- . Journal of Cellular Biochemistry, 72(3), 387-395.
- Pharmacokinetics of alendronate: An overview. International Journal of Clinical Practice, 18-26.
- . Calcified Tissue International, 65(2), 173-180.
- . Osteoporosis International, 9(S2), S66-S80.
- . General and Comparative Endocrinology, 114(1), 80-87.
- . Proceedings of the National Academy of Sciences, 96(1), 133-138.
- Pharmacokinetics of alendronate: An overview. International Journal of Clinical Practice Supplement(101), 18-26.
- . Bone, 25(1), 97-106.
- . Bone, 24(5), 73S-79S.
- . Journal of Bone and Mineral Research, 13(3), 432-442.
- . Journal of Bone and Mineral Research, 13(4), 581-589.
- . Journal of Bone and Mineral Research, 13(11), 1668-1678.
- . Leukemia & Lymphoma, 32(1-2), 129-138.
- . Journal of Internal Medicine, 244(4), 271-292.
- . British Journal of Haematology, 101(4), 694-702.
- . British Journal of Haematology, 101(2), 287-295.
- The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. Cancer Research, 58(23), 5294-5297.
- Mechanisms of action of etidronate and other bisphosphonates. Reviews in Contemporary Pharmacotherapy, 9(4), 233-243.
- . QJM, 91(2), 71-92.
- . Bone, 22(1), 7-16.
- . Molecular Pharmacology, 54(4), 631-638.
- . Journal of Bone and Mineral Research, 12(9), 1358-1367.
- . British Journal of Haematology, 98(3), 665-672.
- . FEBS LETTERS, 411(1), 145-148.
- . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1362(2-3), 208-220.
- . Biochemical and Biophysical Research Communications, 241(3), 714-719.
- . Rheumatology, 36(7), 729-734.
- . Pharmaceutical Research, 14(5), 625-630.
- . Biochemical and Biophysical Research Communications, 230(2), 335-339.
- Introduction to bisphosphonates and the clinical pharmacology of alendronate. British Journal of Rheumatology, 36(SUPPL. 1), 10-14.
- . Developmental Dynamics, 205(3), 332-347.
- . Biochemical Society Transactions, 24(4), 562S-562S.
- . Journal of Bone and Mineral Research, 11(10), 1482-1491.
- . Biochemical Journal, 318(2), 459-462.
- . Biochemical and Biophysical Research Communications, 224(3), 863-869.
- . Biochimica et Biophysica Acta (BBA) - General Subjects, 1290(1), 29-36.
- . Phosphorus, Sulfur, and Silicon and the Related Elements, 111(1), 64-64.
- . Research in Veterinary Science, 61(2), 160-164.
- . Endocrinology, 137(8), 3557-3565.
- Molecular studies of apoptosis induced by antiresorfitve bisphosphonate drugs. Michael T. Rogers. Biochemical Society Transactions, 24(4), 568.
- . Equine Veterinary Journal, 27(3), 201-207.
- . Bone, 17(3), 221-227.
- . Molecular Pharmacology, 47(2), 398-402.
- . Biochimica et Biophysica Acta (BBA) - General Subjects, 1201(2), 298-304.
- . Biochemical Journal, 303(1), 303-311.
- . Journal of Bone and Mineral Research, 9(8), 1259-1266.
- . Agents and Actions, 41(S2), C198-C200.
- . Journal of Bone and Mineral Research, 9(7), 1029-1039.
- . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1226(2), 193-200.
- . Seminars in Arthritis and Rheumatism, 23(4), 240-241.
- . The American Journal of Medicine, 96(4), 349-353.
- . Clinical Chemistry, 40(1), 167-168.
- . Osteoarthritis and Cartilage, 2(4), 235-245.
- . Journal of Endocrinology, 143(2), R9-R16.
- . Journal of Bone and Mineral Research, 9(1), 99-109.
- . European Journal of Clinical Investigation, 23(6), 341-349.
- . Cell Biochemistry and Function, 11(1), 13-23.
- . Cell Biochemistry and Function, 11(1), 25-34.
- . Clinical Science, 85(5), 569-575.
- . Osteoporosis International, 3(5), 255-260.
- . Rheumatology, 32(suppl 2), 6-10.
- . Osteoporosis International, 3(S1), 100-101.
- . Bone and Mineral, 22(1), 1-8.
- GLUCOCORTICOIDS AND BONE - PROCEEDINGS OF A SYMPOSIUM HELD IN VIENNA, AUSTRIA, 12 MARCH 1991. BRITISH JOURNAL OF RHEUMATOLOGY, 32, 1-2.
- . Equine Veterinary Journal, 24(2), 78-80.
- . Scandinavian Journal of Rheumatology, 21(sup95), 9-18.
- . Clinical Endocrinology, 37(1), 45-50.
- . Journal of Bone and Mineral Research, 7(12), 1363-1371.
- . Biochemical and Biophysical Research Communications, 189(1), 414-423.
- . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1137(1), 52-58.
- . Clinical Science, 83(4), 503-507.
- . Clinical Science, 83(3), 375-382.
- . Biochemical Society Transactions, 20(3), 278S-278S.
- . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1135(1), 97-102.
- . Journal of Clinical Endocrinology & Metabolism, 74(3), 487-494.
- . Osteoporosis International, 2(2), 94-102.
- . The Journal of Clinical Endocrinology & Metabolism, 74(3), 487-494.
- . Regulatory Peptides, 37(2), 111-121.
- . Baillière's Clinical Rheumatology, 6(2), 351-372.
- . Bone and Mineral, 16(2), 121-129.
- . Bone and Mineral, 19(2), 117-125.
- . British Journal of Cancer, 66(6), 1159-1163.
- . Seminars in Arthritis and Rheumatism, 21(6), 16-22.
- . Critical Reviews in Clinical Laboratory Sciences, 28(3), 195-232.
- Phosphate-sensitive enzymes: A possible molecular basis for cellular disorders of phosphate metabolism. Clinical Chemistry and Enzymology Communications, 4(4), 235-257.
- . Biochemical and Biophysical Research Communications, 180(2), 602-608.
- . Biochimica et Biophysica Acta (BBA) - General Subjects, 1074(1), 151-158.
- . Rheumatology, 30(2), 84-85.
- . Journal of Bone and Mineral Research, 6(2), 141-148.
- . Journal of Bone and Mineral Research, 6(1), 3-8.
- . Endocrinology, 129(3), 1513-1520.
- The cellular mechanism of action of bisphosphonates. Drugs Under Experimental and Clinical Research, 17(2), 109-114.
- . Arthritis & Rheumatism, 33(11), 1733-1738.
- . Biochemical Society Transactions, 18(5), 1010-1011.
- . Journal of Bone and Mineral Research, 5(9), 983-988.
- . Biochemical Society Transactions, 18(4), 624-625.
- . Regulatory Peptides, 29(2-3), 109-116.
- . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1052(2), 323-326.
- . Journal of Clinical Investigation, 85(5), 1421-1426.
- . Biochemical and Biophysical Research Communications, 166(3), 1163-1170.
- . Biochemical and Biophysical Research Communications, 166(1), 208-216.
- . Endocrinology, 126(2), 1250-1255.
- . Cytokine, 2(2), 106-111.
- . Bone, 11(5), 380-380.
- . Bone, 11(6), 385-391.
- . Journal of Pediatric Endocrinology and Metabolism, 3(2).
- . Arthritis & Rheumatism, 32(6), 780-784.
- . Biochemical Journal, 264(3), 729-736.
- . Biochemical and Biophysical Research Communications, 164(3), 1076-1085.
- . Analytical Biochemistry, 181(1), 130-134.
- . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1012(2), 128-134.
- . Journal of Clinical Investigation, 83(6), 1930-1935.
- . Biochemical and Biophysical Research Communications, 160(2), 588-595.
- . Biochemical and Biophysical Research Communications, 159(3), 1242-1248.
- . Biochemical Society Transactions, 17(1), 124-125.
- . Clinical Chemistry, 35(2), 326-326.
- . Current Orthopaedics, 3(4), 262-269.
- Clinical disorders of phosphate metabolism: Does orthophosphate have an important regulatory role in mammalian cells?. Clinical Chemistry and Enzymology Communications, 1(5-6), 265-274.
- . Arthritis & Rheumatism, 31(12), 1500-1507.
- . Journal of Theoretical Biology, 134(3), 351-364.
- . Biochemical Society Transactions, 16(5), 781-782.
- . Biochimica et Biophysica Acta (BBA) - General Subjects, 966(3), 310-317.
- . Clinical Chemistry, 34(9), 1937-1941.
- . Clinical Science, 74(5), 455-460.
- . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 969(2), 139-147.
- . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 969(2), 148-157.
- . Clinical Science, 74(1), 101-106.
- Erythrocyte phosphate metabolism and pH in vitro: A model for clinical phosphate disorders in acidosis and alkalosis. Mineral and Electrolyte Metabolism, 14(5), 266-270.
- . Biochemical Society Transactions, 15(6), 1090-1091.
- . Biochemical Society Transactions, 15(6), 1141-1142.
- . Biochemical Society Transactions, 15(6), 1140-1141.
- . Biochemical Society Transactions, 15(5), 915-916.
- . Biochemical Society Transactions, 15(5), 914-915.
- . Biochimica et Biophysica Acta (BBA) - General Subjects, 924(3), 473-482.
- . Biochimica et Biophysica Acta (BBA) - General Subjects, 924(2), 276-283.
- . Cell Biochemistry and Function, 4(1), 47-54.
- . Clinical Science, 71(6), 729-735.
- . Biochemical Society Transactions, 14(6), 1193-1194.
- Vitamin D metabolites in patients with established non-union of fracture. Bone and Mineral, 1(3), 205-209.
- . Biochemical and Biophysical Research Communications, 139(3), 1150-1157.
- . Clinica Chimica Acta, 158(1), 43-47.
- . BMJ, 292(6513), 79-80.
- , 469-478.
- , 131-152.
- . Endocrinology, 119(4), 1776-1785.
- . Bone, 7(4), 255-259.
- . General and Comparative Endocrinology, 64(1), 143-150.
- . The Journal of Clinical Endocrinology & Metabolism, 63(5), 1237-1241.
- . Endocrinology, 118(6), 2445-2449.
- . British Medical Bulletin, 42(4), 435-446.
- . Clinical Endocrinology, 22(4), 559-566.
- . FEBS Letters, 179(2), 247-251.
- . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 847(1), 40-47.
- . Clinical Science, 69(4), 429-434.
- . Clinical Science, 69(4), 435-440.
- . The Lancet, 325(8444), 1474-1477.
- . Clinical Science, 68(4), 449-454.
- . Journal of Clinical Investigation, 75(4), 1223-1229.
- . Biochimica et Biophysica Acta (BBA) - General Subjects, 838(1), 161-169.
- . Bone, 6(2), 69-72.
- . Rheumatology, XXIV(suppl 1), 55-58.
- Studies on the actions of interleukin-1 on bone metabolism: IL-1 stimulation of bone cell proliferation, and inhibition of IL-1-induced bone resorption by interferon-γ. British Journal of Rheumatology, 24(SUPPL. 1), 147-149.
- . Rheumatology, XXIV(suppl 1), 118-121.
- . Cellular Immunology, 90(1), 41-51.
- . Rheumatology, XXIV(suppl 1), 147-149.
- . Rheumatology, XXIV(suppl 1), 158-161.
- . British Journal of Cancer, 51(5), 665-669.
- . Journal of Endocrinology, 105(3), 391-396.
- . Arthritis & Rheumatism, 27(6), 654-662.
- . FEBS Letters, 169(1), 49-52.
- . Rheumatology International, 4(4), 143-149.
- . Biochimica et Biophysica Acta (BBA) - General Subjects, 801(1), 58-65.
- . Bioscience Reports, 4(5), 415-419.
- . Biochimica et Biophysica Acta (BBA) - General Subjects, 797(2), 186-193.
- Deflazacort and skeletal, phosphate and glucose metabolism in monkeys.. Advances in Experimental Medicine and Biology, 171, 101-110.
- . Metabolic Bone Disease and Related Research, 5(5), 229-234.
- Effects of papain on rat duodenal brush border membranes: enzyme release and membrane morphology.. Cellular and Molecular Biology, 30(2), 97-103.
- . British Journal of Haematology, 54(1), 121-132.
- . British Journal of Haematology, 53(4), 688-690.
- . Nature, 306(5941), 378-380.
- . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 763(2), 129-139.
- . BMJ, 287(6394), 727-727.
- . World Journal of Urology, 1(3), 150-154.
- . The Lancet, 321(8337), 1328-1328.
- . Clinical Science, 64(4), 395-398.
- . Clinical Science, 64(4), 387-394.
- . BMJ, 286(6365), 587-590.
- . Clinical Science, 64(2), 73P-73P.
- . Metabolic Bone Disease and Related Research, 5(1), 23-31.
- . Annals of the Rheumatic Diseases, 42, 27-37.
- Interactions in connective tissues involving monocyte/macrophages and control of production of proteinases and proteinase inhibitors.. Agents and Actions Supplements, 11, 131-138.
- Stimulation of prostacyclin production from vascular endothelial cells by plasma, serum and platelets under normal and pathological conditions.. Agents and Actions Supplements, 11, 83-92.
- . Biochemical Journal, 208(1), 35-42.
- . Rheumatology International, 2(3), 113-120.
- . Clinical Science, 63(2), 145-152.
- . Journal of Clinical Pathology, 35(7), 771-779.
- . Thrombosis Research, 26(4), 241-247.
- . Clinical Science, 62(2), 56P-57P.
- . Clinical Science, 62(2), 24P-24P.
- . International Journal of Immunopharmacology, 4(2), 91-102.
- Effect of glucocorticoids on human synovial and cartilage cells and their interactions in vitro. Calcified Tissue International, 34(6), 589.
- , 147-155.
- . Acta Endocrinologica, 101(4), 636-640.
- , 137-146.
- . Thrombosis and Haemostasis.
- . Thrombosis and Haemostasis.
- . Scandinavian Journal of Rheumatology, 10(sup40), 75-87.
- . Nephron, 28(1), 17-25.
- . Current Medical Research and Opinion, 7(5), 294-315.
- . FEBS Letters, 134(1), 88-90.
- . Clinical Science, 61(6), 711-716.
- . Clinical Science, 61(6), 703-710.
- . Biochemical Journal, 198(2), 391-396.
- . Biochemical Society Transactions, 9(2), 225P-225P.
- . Biochemical Pharmacology, 30(6), 635-637.
- . Journal of Cell Science, 47(1), 227-236.
- . Metabolic Bone Disease and Related Research, 3(3), 155-158.
- . Metabolic Bone Disease and Related Research, 3(4-5), 327-335.
- . The Journal of Bone and Joint Surgery. British volume, 63-B(4), 495-503.
- Ultrastructural characteristics of sub-populations of isolated rat enterocytes. Scandinavian Journal of Gastroenterology Supplement, 16(Suppl. 70), 183-185.
- Vitamin D metabolism and homeostasis of bone tissue in man. Acta Rhumatologica, 4(4), 345-372.
- . Metabolic Bone Disease and Related Research, 3(4-5), 255-262.
- . Seminars in Arthritis and Rheumatism, 11(1), 138-139.
- . Metabolic Bone Disease and Related Research, 3(4-5), 217-217.
- . Thrombosis Research, 22(5-6), 525-533.
- . Metabolic Bone Disease and Related Research, 3(4-5), 219-230.
- Diphosphonates inhibit production of prostaglandin and collagenase by human cells in vitro. Annals of the Rheumatic Diseases, 40(5), 515.
- . Thrombosis and Haemostasis, 43(01), 038-040.
- . Arthritis & Rheumatism, 23(10), 1185-1192.
- . Nature, 286(5776), 891-892.
- Studies on the role of calcium in the control of thromboxane B2 production. Artery, 8(5), 487-493.
- . Biochemical Society Transactions, 8(5), 527-528.
- . Biochemical Society Transactions, 8(5), 530-531.
- . Biochemical Society Transactions, 8(5), 529-530.
- . Clinical Science, 59(2), 131-135.
- . The Lancet, 315(8166), 488-489.
- , 239-248.
- Thromboxane B2 production and lipid peroxidation in human blood platelets.. Advances in Prostaglandin and Thromboxane Research, 6, 297-299.
- Stimulation of prostaglandin biosynthesis induced by mononuclear cell factor added to cells from human gingiva, cartilage, synovium, and endometrium.. Advances in Prostaglandin and Thromboxane Research, 8, 1709-1711.
- . Agents and Actions, 10(6), 486-490.
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- Proceedings: Background to the use of diphosphonates as bone scanning agents.. British Journal of Radiology, 48(565), 73.
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Book chapters
- , Principles of Bone Biology (pp. 1671-1687). Elsevier
- , The Duration and Safety of Osteoporosis Treatment (pp. 17-36). Springer International Publishing
- , Osteogenesis Imperfecta (pp. 495-500). Elsevier
- , Osteogenesis Imperfecta A Translational Approach to Brittle Bone Disease (pp. 495-500).
- , Principles of Bone Biology (pp. 1737-1767). Elsevier
- , Osteoporosis and the Osteoporosis of Rheumatic Diseases (pp. 27-32). Elsevier
- , Dynamics of Bone and Cartilage Metabolism (pp. 99-113). Elsevier
- , Advances in Experimental Medicine and Biology (pp. 261-273). Springer US
- , Advances in Experimental Medicine and Biology (pp. 487-503). Springer US
Conference proceedings
- . Bone Reports, Vol. 13(Supplement) (pp 83-84). Online, 22 October 2020 - 22 October 2020.
- Pharmacokinetic Models for Bisphosphonate-Conjugated Drugs. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 33 (pp 178-178)
- Bone targeted bisphosphonate-antibiotic conjugates for the treatment of osteomyelitis biofilms.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 32 (pp S285-S285)
- "50 years of the Centre for Rheumatic Diseases in Glasgow'' (in conjunction with the Scottish Society for Rheumatology), 22 May 2015: Oral Presentations. SCOTTISH MEDICAL JOURNAL, Vol. 60(3) (pp 115-116)
- . Bone, Vol. 46 (pp S22-S22)
- . Bone, Vol. 42 (pp S36-S36)
- . Bone, Vol. 42 (pp S36-S37)
- . Bone, Vol. 42 (pp S90-S91)
- . Annals of the New York Academy of Sciences, Vol. 1117(1) (pp 209-257)
- . Bone, Vol. 41(5) (pp S29-S29)
- . Pediatrics, Vol. 119(Supplement_2) (pp S150-S162)
- Bisphosphonates and tissue restoration: Current and future opportunities. TISSUE ENGINEERING, Vol. 13(6) (pp 1371-1371)
- . Current Opinion in Rheumatology, Vol. 18(Suppl 1) (pp S3-S10)
- . Annals of the New York Academy of Sciences, Vol. 1068(1) (pp 367-401)
- . Journal of Organometallic Chemistry, Vol. 690(10) (pp 2679-2687)
- . Biochemical Society Transactions, Vol. 31(2) (pp 462-464)
- Health economic approach of treatment strategies inhibition of bone resorption: State of the art. OSTEOPOROSIS INTERNATIONAL, Vol. 11 (pp S10-S10)
- Future treatments for osteoporosis. KEY ADVANCES IN THE EFFECTIVE MANAGEMENT OF OSTEOPOROSIS (pp 39-46)
- . Hormone and Metabolic Research, Vol. 29(03) (pp 138-144)
- . Cancer, Vol. 80(S8) (pp 1652-1660)
- The synthesis and evaluation of quaternary pyridinium bisphosphonates as potent anti-resorptives. PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, Vol. 111(1-4) (pp 696-696)
- The assessment of bone metabolism in vivo using biochemical approaches. Nefrologia, Vol. 15(SUPPL. 1) (pp 36-43)
- The cell biology of bone growth. European Journal of Clinical Nutrition, Vol. 48(SUPPL. 1) (pp S131-S149)
- The effects of cyclosporin A on bone and cartilage. British Journal of Rheumatology, Vol. 32(SUPPL. 1) (pp 42-46)
- Ciclosporin A. Mode of action and effects on bone and joint tissues. Reumatismo, Vol. 44(SUPPL. 2) (pp 19-33)
- Immunomodulation in rheumatic and related diseases. Mount Sinai Journal of Medicine, Vol. 57(5) (pp 305-310)
- . Biochemical Society Transactions, Vol. 18(5) (pp 951-952)
- PRODUCTION OF IL-1 AND TNF BY HUMAN OSTEOBLAST-LIKE CELLS AND RESORBING MOUSE CALVARIAE. LYMPHOKINE RESEARCH, Vol. 7(3) (pp 268-268)
- STRONTIUM IONS STIMULATE THE METABOLISM OF PHOSPHOINOSITIDES IN HUMAN-BLOOD PLATELETS. THROMBOSIS AND HAEMOSTASIS, Vol. 46(1) (pp 295-295)
- RESPONSE OF THE BONE AND KIDNEY TO EHDP IN MAN. CALCIFIED TISSUE INTERNATIONAL, Vol. 27 (pp A41-A41)
Patents
- . Appl. 01 Dec 2006.
Preprints
- , Cold Spring Harbor Laboratory.
Links