Dr Graham Norquay
School of Medicine and Population Health
Lecturer in Magnetic Resonance Physics
+44 114 215 9148
Full contact details
School of Medicine and Population Health
Office 19F
Polaris
18 Claremont Crescent
Sheffield
S10 2TA
- Profile
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For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
After graduating in Physics from the University of Glasgow (2004-2007), I completed an MSc in Medical Physics at the University of Surrey (2008-2009) and a PhD in Magnetic Resonance Physics at the University of Sheffield (2010-2014).
During my postdoctoral posts – Postdoctoral Research Associate (2014-2016) and Senior Research Fellow (2016-2018) – at the University of Sheffield, I set up a lab within the dedicated to the hyperpolarisation of 129Xe gas for human magnetic resonance imaging (MRI) applications.
I was appointed Lecturer in Magnetic Resonance Physics in 2018.
- Research interests
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My research interests are the physics of spin-exchange optical pumping (SEOP) – a technique which can be used to dramatically (105-fold) enhance the nuclear magnetisation of the noble gases 3He and 129Xe – and nuclear magnetic resonance (NMR) applications of hyperpolarised 129Xe in biological systems.
My recent work on has made significant clinical impact by helping enable the first clinical studies in the UK with hyperpolarised 129Xe gas MRI, which has so far been utilised in the clinical evaluation of lung diseases such as Cystic Fibrosis, COPD, Asthma, Interstitial Lung Disease and Pulmonary Hypertension.
Current projects:
- Hyperpolarised 129Xe MRI as a probe for tissue oxygenation in humans.
- NMR dynamics of xenon gas in the cardiopulmonary system.
- Large-scale physics of 129Xe-rubidium spin-exchange optical pumping for clinical applications.
- Portable 129Xe polariser for multicentre dissemination of hyperpolarised 129Xe technology.
- 129Xe gas recycling collaboration with Linde gases.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . Journal of Magnetic Resonance Imaging, 50(3), 1002-1004.
- . Physical Review Letters, 121(15).
- . Radiology, 286(2).
- . Magnetic Resonance in Medicine, 77(4), 1399-1408.
- . Magnetic Resonance in Medicine , 74(2), 346-352.
- . Magnetic Resonance in Medicine, 74(2), 303-311.
- . Magnetic Resonance in Medicine, 73(1), 21-30.
- . Journal of Applied Physics, 113(4).
All publications
Journal articles
- . Journal of Magnetic Resonance, 377, 107889-107889.
- . Thorax.
- . NMR in Biomedicine, 38(6).
- . Magnetic Resonance in Medicine, 93(2), 584-596.
- . Magnetic Resonance in Medicine, 93(2), 741-750.
- . Journal of Applied Physics, 136(24).
- . Journal of Magnetic Resonance Open, 21, 100166-100166.
- . Journal of Magnetic Resonance Open, 21, 100175-100175.
- . Magnetic Resonance in Medicine, 92(6), 2546-2559.
- . Magnetic Resonance in Medicine, 92(4), 1471-1483.
- . Zeitschrift für Pneumologie, 21(1), 38-48.
- . ERJ Open Research, 9(4).
- . Scientific Reports, 13.
- . Chest, 164(3), 700-716.
- . Magnetic Resonance in Medicine, 89(6), 2217-2226.
- . Molecules, 28(1).
- . American Journal of Respiratory and Critical Care Medicine, 207(1), 89-100.
- . Zeitschrift für Pneumologie, 19(5), 264-276.
- . Die Radiologie, 62(6), 475-485.
- . The British Journal of Radiology, 95(1132).
- . Magnetic Resonance in Medicine, 85(3), 1561-1570.
- . Scientific Reports, 11.
- . Progress in Nuclear Magnetic Resonance Spectroscopy, 122, 42-62.
- . Magnetic Resonance in Medicine, 85(5), 2622-2633.
- . Magnetic Resonance in Medicine, 85(6), 2939-2949.
- . European Respiratory Journal, 56(6).
- . Journal of Magnetic Resonance Imaging, 50(3), 1002-1004.
- . Magnetic Resonance in Medicine, 83(1), 262-270.
- . Magnetic Resonance in Medicine, 82(1), 342-347.
- . Thorax, 74(5), 500-502.
- . Journal of Applied Physiology, 126(1), 183-192.
- . Journal of Magnetic Resonance Imaging, 49(4), 1195-1197.
- . International Journal of Radiation Oncology*Biology*Physics, 102(4), 1276-1286.
- . Physical Review Letters, 121(15).
- . Journal of Magnetic Resonance Imaging, 48(3), 632-642.
- . Annals of the American Thoracic Society, 15(12), 1487-1490.
- . Magnetic Resonance in Medicine, 79(6), 2986-2995.
- . Radiology, 286(2).
- . Magnetic Resonance in Medicine, 77(4), 1399-1408.
- . Thorax, 72, 760-762.
- . Magnetic Resonance in Medicine, 77(6), 2107-2113.
- . Magnetic Resonance in Medicine, 75(6), 2227-2234.
- . Magnetic Resonance in Medicine , 74(2), 346-352.
- . Magnetic Resonance in Medicine, 74(2), 303-311.
- . MAGNETIC RESONANCE IN MEDICINE, 74(1), 196-207.
- . Magnetic Resonance in Medicine, 73(1), 21-30.
- . NMR in Biomedicine, 27(12), 1461-1467.
- . Journal of Applied Physics, 113(4).
- . Radiology, 267(1), 251-255.
- . Magnetic Resonance in Medicine, 68(6), 1900-1904.
Book chapters
- , New Developments in NMR (pp. 365-391). Royal Society of Chemistry
- 129Xe chemical shift and spin-lattice relaxation dependences on blood oxygenation (pp. 365-391).
- 129Xe Chemical Shift and Spin-Lattice Relaxation Dependences on Blood Oxygenation, HYPERPOLARIZED XENON-129 MAGNETIC RESONANCE: CONCEPTS, PRODUCTION, TECHNIQUES AND APPLICATIONS (pp. 365-391).
Conference proceedings
- . Respiratory function technologists/scientists (pp OA4590-OA4590)
- . Paediatric respiratory physiology and sleep (pp OA4664-OA4664)
- . Imaging (pp PA5251-PA5251)
- . ‘You ain’t seen nothing yet’ – Imaging across COPD, nodules and lung cancer screening (pp A215-A215)
- . ‘You ain’t seen nothing yet’ – Imaging across COPD, nodules and lung cancer screening (pp A214-A214)
- . Clinical respiratory physiology, exercise and functional imaging (pp PA2260-PA2260)
- . Respiratory function technologists/scientists (pp PA4500-PA4500)
- . Clinical respiratory physiology, exercise and functional imaging (pp OA4954-OA4954)
- . Imaging (pp OA4857-OA4857)
- . Respiratory function technologists/scientists (pp OA757-OA757)
- . Physiotherapists (pp PA5039-PA5039)
- . 09.01 - Respiratory function technologists/scientists (pp 4486-4486)
- . European Respiratory Society (ERS) International Congress 2022, Vol. 60(Suppl 66) (pp 760). Barcelona, Spain, 4 September 2022 - 4 September 2022.
- . 05.02 - Monitoring airway disease (pp 2865-2865)
- . A99. LOOK AT THAT! NEW FINDINGS FROM LUNG IMAGING, Vol. 205 (pp a2175-a2175). San Francisco, CA, 13 May 2022 - 13 May 2022.
- . Thorax, Vol. 76(Suppl 1) (pp a46-a47). Virtual conference, 17 February 2021 - 17 February 2021.
- . Imaging (pp 2091-2091)
- . Cystic fibrosis (pp OA2131-OA2131)
- . Imaging (pp PA3171-PA3171)
- . Imaging (pp PA3158-PA3158)
- . Cystic fibrosis (pp PA334-PA334)
- . Journal of Cystic Fibrosis, Vol. 18(Suppl 1) (pp S116-S117). Liverpool, United Kingdom, 5 June 2019 - 5 June 2019.
- . Journal of Cystic Fibrosis, Vol. 18(Suppl 1) (pp S32-S32). Liverpool, United Kingdom, 5 June 2019 - 5 June 2019.
- . Journal of Cystic Fibrosis, Vol. 18(Suppl 1) (pp S117-S117). Liverpool, United Kingdom, 5 June 2019 - 5 June 2019.
- . Journal of Cystic Fibrosis, Vol. 18(Suppl 1) (pp S117-S117). Liverpool, United Kingdom, 5 June 2019 - 5 June 2019.
- . Thorax, Vol. 73(Suppl 4) (pp A44-A45). London, UK, 5 December 2018 - 5 December 2018.
- . Imaging (pp OA5177-OA5177)
- . European Respiratory Journal, Vol. 50(Suppl 61). Milan, Italy, 9 September 2017 - 9 September 2017.
- . Paediatric Respiratory Physiology and Sleep (pp PA3342-PA3342)
- . Imaging (pp OA4645-OA4645)
- . European Respiratory Journal, Vol. 50(Suppl 61). Milan, Italy, 9 September 2017 - 9 September 2017.
- . European Respiratory Journal, Vol. 48(Suppl 60). London, UK, 3 September 2016 - 3 September 2016.
- . Pediatric Pulmonology, Vol. 51(Supplement S45) (pp 348-348). Orlando, Florida, 27 October 2016 - 27 October 2016.
- . European Respiratory Journal - ERS International Congress 2016 abstracts, Vol. 48(Suppl 60). London, UK, 3 September 2016 - 3 September 2016.
- . European Respiratory Journal, Vol. 48(Suppl 60). Estoril, Portugal, 10 March 2016 - 10 March 2016.
- . European Respiratory Journal, Vol. 48. London, UK, 3 September 2016 - 3 September 2016.
- . Medical Physics, Vol. 43(6) (pp 3795-3796). Washington, DC, 31 July 2016 - 31 July 2016.
- . Thorax, Vol. 70(Suppl 3) (pp A223.1-A223)
- . Thorax, Vol. 70(Suppl 3) (pp A220.3-A221)
- . 4.1 Clinical respiratory physiology, exercise and functional imaging (pp OA2945-OA2945)
- . 1.3 Imaging (pp OA4992-OA4992)
- . Thorax, Vol. 69(Suppl 2) (pp A192-A193)
- Feasibility of high quality lung MRI with naturally abundant hyperpolarised 129Xe. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- Age-dependent changes in whole-lung septal thickness measured by 129Xe MRI: A comparison of healthy volunteers and subjects with IPF. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- Age-dependent changes in whole-lung septal thickness measured by Xe-129 MRI: A comparison of healthy volunteers and subjects with IPF. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- Dissolved 129xe Mri - Delayed Gas Uptake Indicates Septal Thickening In Patients With Idiopathic Pulmonary Fibrosis And Systemic Sclerosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- A polariser for on demand production of hyperpolarised 129Xe for human lung MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 42
- Measuring red blood cell oxygenation in vivo using hyperpolarized 129Xe MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 40
- Simultaneous imaging of lung structure and function with triple nuclear MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 40
- Simultaneous imaging of lung structure and function with triple nuclear MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 40
- . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- . ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- . ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- . ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- . ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- . ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- . ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- . ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- . ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
Preprints
- , Cold Spring Harbor Laboratory.
- Teaching interests
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- Supervision of research projects for students undertaking MSc and PhD projects.
- Training postdoctoral researchers and PhD students in 129Xe polarisation and NMR physics.