Professor Claire Lewis

School of Medicine and Population Health

Emeritus Professor

claire.lewis@sheffield.ac.uk
Floor E, The Medical School

Full contact details

Professor Claire Lewis
School of Medicine and Population Health
Floor E
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk

After completing my DPhil (PhD) in the Department of Physiology, Anatomy and Genetics in Oxford in 1986, I held two postdoctoral positions and a Lectureship in the Medical School there before moving to join the Medical School in Sheffield in 1996.  I currently hold a Personal Chair in Molecular & Cellular Pathology and head a team of pre and postdoctoral scientists.

I was awarded a DSc by Oxford University in 2006 for my contribution to the field of tumour inflammation research.  During my career, my group has filed numerous patent applications and worked with various collaborators in the commercial sector.  I also enjoyed running a spin-out company and was delighted to receive Cancer Research Horizon's Woman Entrepreneur Award in 2022.

Research interests

Our research is focused mainly on the role of inflammatory cells called macrophages in tumour progression and responses to conventional anti-cancer treatments like chemotherapy and irradiation.

We have also developed ways of using these cells to target therapeutic genes and viruses to tumours. Our work was reported in the national press (,) and is mainly funded by grants from Breast Cancer Now, Prostate Cancer UK, The European Union, Cancer Research UK and Team Verrico.

Publications

Show: Featured publications All publications

Journal articles

  • Al-janabi H, Moyes K, Allen R, Fisher M, Crespo M, Gurel B, Rescigno P, de Bono J, Nunns H, Bailey C , Junker-Jensen A et al (2024) . Journal for ImmunoTherapy of Cancer, 12(7).
  • Coulton A, Murai J, Qian D, Thakkar K, Lewis CE & Litchfield K (2024) . Nature Communications, 15.
  • Moamin MR, Allen R, Woods SL, Brown JE, Nunns H, Juncker-Jensen A & Lewis CE (2023) . Frontiers in Immunology, 14.
  • Kwan A, Howard F, Winder N, Atkinson E, Jailani A, Patel PB, Allen R, Ottewell PD, Shaw GC, Conner J , Wilson C et al (2022) . Future Pharmacology, 2(4), 444-459.
  • Iscaro A, Jones C, Forbes N, Mughal A, Howard FN, Janabi HA, Demiral S, Perrie Y, Essand M, Weglarz A , Cruz LJ et al (2022) . Nanomedicine: Nanotechnology, Biology and Medicine, 40.
  • Al-Janabi H & Lewis CE (2021) . Cancer Research, 81(21), 5399-5400.
  • Boussommier-Calleja A, Atiyas Y, Haase K, Headley M, Lewis C & Kamm RD (2019) . Biomaterials, 198, 180-193.
  • Keklikoglou I, Cianciaruso C, Güç E, Squadrito ML, Spring LM, Tazzyman S, Lambein L, Poissonnier A, Ferraro GB, Baer C , Cassará A et al (2019) . Nature Cell Biology, 21(2), 190-202.
  • Yang M, McKay D, Pollard JW & Lewis CE (2018) . Cancer Research, 78(19), 5492-5503.

All publications

Books

  • Staton C, Lewis CE & Bicknell R (2007) Angiogenesis Assays: A Critical Appraisal of Current Techniques. Wiley-Blackwell.

Journal articles

  • Al-janabi H, Moyes K, Allen R, Fisher M, Crespo M, Gurel B, Rescigno P, de Bono J, Nunns H, Bailey C , Junker-Jensen A et al (2024) . Journal for ImmunoTherapy of Cancer, 12(7).
  • Coulton A, Murai J, Qian D, Thakkar K, Lewis CE & Litchfield K (2024) . Nature Communications, 15.
  • Moamin MR, Allen R, Woods SL, Brown JE, Nunns H, Juncker-Jensen A & Lewis CE (2023) . Frontiers in Immunology, 14.
  • Kwan A, Howard F, Winder N, Atkinson E, Jailani A, Patel PB, Allen R, Ottewell PD, Shaw GC, Conner J , Wilson C et al (2022) . Future Pharmacology, 2(4), 444-459.
  • Iscaro A, Jones C, Forbes N, Mughal A, Howard FN, Janabi HA, Demiral S, Perrie Y, Essand M, Weglarz A , Cruz LJ et al (2022) . Nanomedicine: Nanotechnology, Biology and Medicine, 40.
  • Juncker-Jensen A, Stavrou N, Moamin M, Nagy M, Allen R, Cox A & Lewis C (2021) . Journal for ImmunoTherapy of Cancer, 9(Suppl 2), A867-A867.
  • Al-Janabi H & Lewis CE (2021) . Cancer Research, 81(21), 5399-5400.
  • Greene C, O'Doherty E, Abdullahi Sidi F, Bingham V, Fisher NC, Humphries MP, Craig SG, Harewood L, McQuaid S, Lewis C & James J (2021) . Biopreservation and Biobanking, 19(4), 324-331.
  • Kwan A, Winder NJ, Atkinson E, Al-Janabi HH, Allen RJ, Hughes R, Moamin MR, Louie R, Evans D, Hutchinson M , Capper DT et al (2020) . Mol Cancer Ther.
  • Rohwer N, Jumpertz S, Erdem M, Egners A, Warzecha KT, Fragoulis A, Kühl AA, Kramann R, Neuss S, Rudolph I , Endermann T et al (2019) . Oncogene, 38(28), 5670-5685.
  • Boussommier-Calleja A, Atiyas Y, Haase K, Headley M, Lewis C & Kamm RD (2019) . Biomaterials, 198, 180-193.
  • Keklikoglou I, Cianciaruso C, Güç E, Squadrito ML, Spring LM, Tazzyman S, Lambein L, Poissonnier A, Ferraro GB, Baer C , Cassará A et al (2019) . Nature Cell Biology, 21(2), 190-202.
  • Yang M, McKay D, Pollard JW & Lewis CE (2018) . Cancer Research, 78(19), 5492-5503.
  • Lapenna A, De Palma M & Lewis CE (2018) . Nature Reviews Immunology, 18(11), 689-702.
  • Lewis CE, Harney AS & Pollard JW (2016) . Cancer Cell, 30(1), 18-25.
  • Hughes R, Qian B-Z, Rowan C, Muthana M, Keklikoglou I, Olson OC, Tazzyman S, Danson S, Addison C, Clemons M , Gonzalez-Angulo AM et al (2015) . Cancer Research, 75(17), 3479-3491.
  • Muthana M, Kennerley AJ, Hughes R, Fagnano E, Richardson J, Paul M, Murdoch C, Wright F, Payne C, Lythgoe MF , Farrow N et al (2015) . Nature Communications, 6.
  • Galluzzi L, Vacchelli E, Bravo-San Pedro J-M, Buque A, Senovilla L, Baracco EE, Bloy N, Castoldi F, Abastado J-P, Agostinis P , Apte RN et al (2014) . Oncotarget, 5(24), 12472-12508.
  • (2014) , 5(24).
  • Highley JR, Gebril OH, Simpson JE, Wharton SB, Kirby J, O'Brien JT, Barber R, Kalaria RN, Brayne C, Lewis CE , Shaw PJ et al (2014) . Journal of Aging Science, 2(1).
  • Chen Y-Y, Brown NJ, Jones R, Lewis CE, Mujamammi AH, Muthana M, Seed MP & Barker MD (2014) . Angiogenesis, 17(1), 207-219.
  • De Palma M & Lewis CE (2013) . CANCER CELL, 23(3), 277-286.
  • Muthana M, Rodrigues S, Chen Y-Y, Welford A, Hughes R, Tazzyman S, Essand M, Morrow F & Lewis CE (2013) . Cancer Res, 73(2), 490-495.
  • Muthana M, Richardson J, Rodrigues S & Lewis C (2013) . BIO-PROTOCOL, 3(13).
  • Gheryani N, Coffelt SB, Gartland A, Rumney RMH, Kiss-Toth E, Lewis CE, Tozer GM, Greaves DR, Dear TN & Miller G (2013) . Genesis, 51(1), 41-49.
  • De Palma M & Lewis CE (2011) CANCER Macrophages limit chemotherapy. NATURE, 472(7343), 303-304.
  • Abigail WF, Biziato D, Coffelt SB, Nucera S, Fisher M, Pucci F, Serio CD, Naldini L, De Palma M, Tozer GM & Lewis CE (2011) . Cancer Research, 71(8_Supplement), 2849-2849.
  • Owen MR, Stamper IJ, Muthana M, Richardson GW, Dobson J, Lewis CE & Byrne HM (2011) . Cancer Res, 71(8), 2826-2837.
  • Lewis CE & Ferrara N (2011) . Cancer Cell, 19(4), 431-433.
  • Welford AF, Biziato D, Coffelt SB, Nucera S, Fisher M, Pucci F, Di Serio C, Naldini L, De Palma M, Tozer GM & Lewis CE (2011) . J Clin Invest, 121(5), 1969-1973.
  • Coffelt SB, Chen Y-Y, Muthana M, Welford AF, Tal AO, Scholz A, Plate KH, Reiss Y, Murdoch C, De Palma M & Lewis CE (2011) . J Immunol, 186(7), 4183-4190.
  • Muthana M, Giannoudis A, Scott SD, Fang H-Y, Coffelt SB, Morrow FJ, Murdoch C, Burton J, Cross N, Burke B , Mistry R et al (2011) . Cancer Res, 71(5), 1805-1815.
  • Tazzyman S, Barry ST, Ashton S, Wood P, Blakey D, Lewis CE & Murdoch C (2011) . Int J Cancer, 129(4), 847-858.
  • Krajewska E, Lewis C, Staton C, MacGowan A & MacNeil S (2011) . Journal of Tissue Engineering and Regenerative Medicine, 5(5), 363-374.
  • Coffelt SB, Tal AO, Scholz A, De Palma M, Patel S, Urbich C, Biswas SK, Murdoch C, Plate KH, Reiss Y & Lewis CE (2010) . Cancer Res, 70(13), 5270-5280.
  • Biswas SK & Lewis CE (2010) . J Leukoc Biol, 88(5), 877-884.
  • Coffelt SB, Lewis CE, Naldini L, Brown JM, Ferrara N & De Palma M (2010) . Am J Pathol, 176(4), 1564-1576.
  • Krajewska E, Lewis CE, Chen Y-Y, Welford A, Tazzyman S & Staton CA (2010) . Br J Cancer, 102(3), 594-601.
  • Tazzyman S, Lewis CE & Murdoch C (2009) . Int J Exp Pathol, 90(3), 222-231.
  • Fang H-Y, Hughes R, Murdoch C, Coffelt SB, Biswas SK, Harris AL, Johnson RS, Imityaz HZ, Simon MC, Fredlund E , Greten FR et al (2009) . Blood, 114(4), 844-859.
  • Coffelt SB, Hughes R & Lewis CE (2009) . Biochim Biophys Acta, 1796(1), 11-18.
  • Ryan RM, Green J, Williams PJ, Tazzyman S, Hunt S, Harmey JH, Kehoe SC & Lewis CE (2009) . Gene Ther, 16(3), 329-339.
  • Hagemann T, Biswas SK, Lawrence T, Sica A & Lewis CE (2009) . BLOOD, 113(14), 3139-3146.
  • Simpson JE, Hosny O, Wharton SB, Heath PR, Holden H, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R , Kalaria RN et al (2009) . Stroke, 40(2), 369-375.
  • Elbarghati L, Murdoch C & Lewis CE (2008) . Immunobiology, 213(9-10), 899-908.
  • Murdoch C, Muthana M, Coffelt SB & Lewis CE (2008) . Nat Rev Cancer, 8(8), 618-631.
  • Muthana M, Scott SD, Farrow N, Morrow F, Murdoch C, Grubb S, Brown N, Dobson J & Lewis CE (2008) . Gene Ther, 15(12), 902-910.
  • Larsen M, Tazzyman S, Lund EL, Junker N, Lewis CE, Kristjansen PEG & Murdoch C (2008) . CANCER LETT, 265(2), 239-249.
  • Biswas SK, Sica A & Lewis CE (2008) Plasticity of macrophage function during tumor progression: Regulation by distinct molecular mechanisms. J IMMUNOL, 180(4), 2011-2017.
  • Pahler JC, Tazzyman S, Erez N, Chen YY, Murdoch C, Nozawa H, Lewis CE & Hanahan D (2008) . Neoplasia, 10(4), 329-339.
  • Lewis C (2008) Research alert: Gene therapy - Microscopic magnets attached to human cells offer hope for cancer treatment. Biomedical Materials(JUNE), 10.
  • Simpson JE, Ince PG, Higham CE, Gelsthorpe CH, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN , Brayne C et al (2007) . Neuropathol Appl Neurobiol, 33(6), 670-683.
  • De Palma M, Murdoch C, Venneri MA, Naldin L & Lewis CE (2007) . TRENDS IMMUNOL, 28(12), 519-524.
  • Staton CA, Lewis C & Bicknell R (2007) . Angiogenesis Assays: A Critical Appraisal of Current Techniques.
  • Lewis CE, De Palma M & Naldini L (2007) . Cancer Res, 67(18), 8429-8432.
  • Lewis CE & Hughes R (2007) . Breast Cancer Res, 9(3), 209.
  • Murdoch C, Tazzyman S, Webster S & Lewis CE (2007) . J Immunol, 178(11), 7405-7411.
  • Simpson JE, Fernando MS, Clark L, Ince PG, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C , Shaw PJ et al (2007) . Neuropathol Appl Neurobiol, 33(4), 410-419.
  • Staton CA, Stribbling SM, García-Echeverría C, Bury JP, Tazzyman S, Lewis CE & Brown NJ (2007) . J Thromb Haemost, 5(4), 846-854.
  • Webb SD, Owen MR, Byrne HM, Murdoch C & Lewis CE (2007) . B MATH BIOL, 69(5), 1747-1776.
  • Lin EY, Li J-F, Gnatovskiy L, Deng Y, Zhu L, Grzesik DA, Qian H, Xue X-N & Pollard JW (2006) . Cancer Research, 66(23), 11238-11246.
  • Fernando MS, Simpson JE, Matthews F, Brayne C, Lewis CE, Barber R, Kalaria RN, Forster G, Esteves F, Wharton SB , Shaw PJ et al (2006) . Stroke, 37(6), 1391-1398.
  • Lewis CE & Pollard JW (2006) . Cancer Res, 66(2), 605-612.
  • Brockington A, Wharton SB, Fernando M, Gelsthorpe CH, Baxter L, Ince PG, Lewis CE & Shaw PJ (2006) . J Neuropathol Exp Neurol, 65(1), 26-36.
  • Ryan RM, Green J & Lewis CE (2006) . Bioessays, 28(1), 84-94.
  • MacRae EJ, Giannoudis A, Ryan R, Brown NJ, Hamdy FC, Maitland N & Lewis CE (2006) . Prostate, 66(5), 470-494.
  • Bingle L, Lewis CE, Corke KP, Reed MWR & Brown NJ (2006) . Br J Cancer, 94(1), 101-107.
  • Staton CA & Lewis CE (2005) . J Cell Mol Med, 9(2), 286-302.
  • Murdoch C, Muthana M & Lewis CE (2005) . J Immunol, 175(10), 6257-6263.
  • Murdoch C & Lewis CE (2005) . Int J Cancer, 117(5), 701-708.
  • Brockington A, Kirby J, Eggitt D, Schofield E, Morris C, Lewis CE, Ince PG & Shaw PJ (2005) . NEUROGENETICS, 6(2), 101-104.
  • Franks SJ, Byrne HM, Underwood JCE & Lewis CE (2005) . J Theor Biol, 232(4), 523-543.
  • Lewis C & Murdoch C (2005) . The American Journal of Pathology, 167(3), 627-635.
  • Staton CA, Stribbling SM, Tazzyman S, Hughes R, Brown NJ & Lewis CE (2004) . Int J Exp Pathol, 85(5), 233-248.
  • Stribbling SM, Bury JP, Corke KP, Lewis CE & Brown NJ (2004) . Microcirculation, 11(6), 552-553.
  • Staton CA, Brown NJ, Rodgers G, Corke KP, Tazzyman S, Underwood JCE & Lewis CE (2004) . Microcirculation, 11(6), 531-532.
  • Brockington A, Lewis C, Wharton S & Shaw PJ (2004) . Neuropathology and Applied Neurobiology, 30(5), 427-446.
  • Murdoch C, Giannoudis A & Lewis CE (2004) . Blood, 104(8), 2224-2234.
  • Owen MR, Byrne HM & Lewis CE (2004) . J THEOR BIOL, 226(4), 377-391.
  • Staton CA, Brown NJ, Rodgers GR, Corke KP, Tazzyman S, Underwood JCE & Lewis CE (2004) . Blood, 103(2), 601-606.
  • Peters CL, Morris CJ, Mapp PI, Blake DR, Lewis CE & Winrow VR (2004) . ARTHRITIS RHEUM, 50(1), 291-296.
  • Ameri K, Lewis CE, Raida M, Sowter H, Hai TW & Harris AL (2004) . BLOOD, 103(5), 1876-1882.
  • Staton CA, Brown NJ & Lewis CE (2003) . Expert Opin Biol Ther, 3(7), 1105-1120.
  • Daly ME, Makris A, Reed M & Lewis CE (2003) . J Natl Cancer Inst, 95(22), 1660-1673.
  • Burke B, Giannoudis A, Corke KP, Gill D, Wells M, Ziegler-Heitbrock L & Lewis CE (2003) . Am J Pathol, 163(4), 1233-1243.
  • Franks SJ, Byrne HM, Mudhar HS, Underwood JCE & Lewis CE (2003) Mathematical modelling of comedo ductal carcinoma in situ of the breast. MATH MED BIOL, 20(3), 277-308.
  • Franks SJ, Byrne HM, King JR, Underwood JCE & Lewis CE (2003) . J MATH BIOL, 47(5), 424-452.
  • Breward CJW, Byrne HM & Lewis CE (2003) . B MATH BIOL, 65(4), 609-640.
  • Ameri K, Burke B, Lewis CE & Harris AL (2002) . Br J Cancer, 87(10), 1173-1181.
  • Baluch CJ, Burke B, Corke K, Wells M, Smith J, Tidy J, Coleman R & Lewis CE (2002) Expression of hypoxia inducible factor-1 in metastatic tumour's in ovarian cancer: link with p53 expression and relevance to hypoxia-targeted gene therapies for disseminated disease. J PATHOL, 198, 5A-5A.
  • Burke B, Sumner S, Maitland N & Lewis CE (2002) Macrophages in gene therapy: cellular delivery vehicles and in vivo targets. J LEUKOCYTE BIOL, 72(3), 417-428.
  • Breward CJW, Byrne HM & Lewis CE (2002) . J MATH BIOL, 45(2), 125-152.
  • Brown NJ, Staton CA, Rodgers GR, Corke KP, Underwood JCE & Lewis CE (2002) . Br J Cancer, 86(11), 1813-1816.
  • Bingle L, Brown NJ & Lewis CE (2002) . J Pathol, 196(3), 254-265.
  • Burke B, Tang N, Corke KP, Tazzyman D, Ameri K, Wells M & Lewis CE (2002) . J Pathol, 196(2), 204-212.
  • Kelly CE, Leek RD, Byrne HM, Cox SM, Harris AL & Lewis CE (2002) . Journal of Theoretical Medicine, 4(1), 21-39.
  • Breward CJW, Byrne HM & Lewis CE (2001) Modelling the interactions between tumour cells and a blood vessel in a microenvironment within a vascular tumour. EUR J APPL MATH, 12, 529-556.
  • Crowther M, Brown NJ, Bishop ET & Lewis CE (2001) Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors.. J Leukoc Biol, 70(4), 478-490.
  • Burton JL, Wells JM, Corke KP, Maitland NJ, Harndy FC & Lewis CE (2001) Hypoxic macrophages accumulate in avascular, hypoxic areas of prostate cancer and benign prostatic hyperplasia.. J PATHOL, 195, 33A-33A.
  • Hehlgans T, Seitz C, Lewis C & Männel DN (2001) . Journal of Interferon & Cytokine Research, 21(9), 757-762.
  • Donovan D, Brown NJ, Bishop ET & Lewis CE (2001) . Angiogenesis, 4(2), 113-121.
  • Gammack D, Byrne HM & Lewis CE (2001) Estimating the selective advantage of mutant p53 tumour cells to repeated rounds of hypoxia. B MATH BIOL, 63(1), 135-166.
  • Bootle-Wilbraham CA, Tazzyman S, Thompson WD, Stirk CM & Lewis CE (2001) . Angiogenesis, 4(4), 269-275.
  • Hollander AP, Corke KP, Freemont AJ & Lewis CE (2001) Expression of hypoxia-inducible factor la by macrophages in the rheumatoid synovium - Implications for targeting of therapeutic genes to the inflamed joint. ARTHRITIS RHEUM, 44(7), 1540-1544.
  • Burton JL, Wells JM, Corke KP, Maitland N, Hamdy FC & Lewis CE (2000) Macrophages accumulate in avascular, hypoxic areas of prostate tumours: implications for targeted therapeutic gene delivery to such sites.. J PATHOL, 192, 8A-8A.
  • Ferreux E, Lewis CE, Perrett CW & Wells M (2000) The role of p53 gene status in modulating the effects of hypoxia on human epithelial ovarian cancer cells. J PATHOL, 192, 10A-10A.
  • Landers RJ, Underwood JCE, Evans CA, Lawry J, Leek RD, Harris AL & Lewis CE (2000) Macrophage expression of urokinase receptors correlates with macrophage infiltration and angiogenesis in invasive carcinoma of the breast: Regulation by hypoxia. J PATHOL, 192, 20A-20A.
  • Bootle-Wilbraham CA, Tazzyman S, Marshall JM & Lewis CE (2000) Fibrinogen E-fragment inhibits the migration and tubule formation of human dermal microvascular endothelial cells in vitro.. Cancer Res, 60(17), 4719-4724.
  • Ameri K, Lewis CE, Burke B & Harris AL (2000) Characterisation of hypoxia responsive element activity under anoxia in breast cancer cells: Role of HIF-1 and ATF-4. BRIT J CANCER, 83, 11-11.
  • Leek RD, Hunt NC, Landers RJ, Lewis CE, Royds JA & Harris AL (2000) Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer. J PATHOL, 190(4), 430-436.
  • Griffiths L, Binley K, Iqball S, Kan O, Maxwell P, Ratcliffe P, Lewis C, Harris A, Kingsman S & Naylor S (2000) . Gene Therapy, 7(3), 255-262.
  • Lewis JS, Landers RJ, Underwood JC, Harris AL & Lewis CE (2000) Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas.. J Pathol, 192(2), 150-158.
  • Lewis JS, Lee JA, Underwood JC, Harris AL & Lewis CE (1999) . J Leukoc Biol, 66(6), 889-900.
  • Leek RD, Landers RJ, Harris AL & Lewis CE (1999) Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast. BRIT J CANCER, 79(5-6), 991-995.
  • Kingsman SM, Griffiths L, Binley K, Iqball S, Kan O, Maxwell P, Lewis C, Harris A & Naylor S (1999) . Nature Biotechnology, 17(S4), 38-38.
  • Ferreux E, Wells M, Perrett CP & Lewis CE (1999) Regulation of angiogenesis in ovarian cancer: role of p53, vascular endothelial growth factor and hypoxia.. J PATHOL, 189, 16A-16A.
  • Lewis JS, Landers RJ, Underwood JCE, Harris AL & Lewis CE (1999) Expression of vascular endothelial growth factor by macrophages is upregulated in poorly vascularised areas of breast carcinomas. J PATHOL, 189, 13A-13A.
  • Zhang L, Scott PAE, Turley H, Leek R, Lewis CE, Gatter KC, Harris AL, Mackenzie IZ, Rees MCP & Bicknell R (1998) Validation of anti-vascular endothelial growth factor (anti-VEGF) antibodies for immunohistochemical localization of VEGF in tissue sections: Expression of VEGF in the human endometrium. J PATHOL, 185(4), 402-408.
  • Landers RJ, Leek RD, Fox SB, Ng F, Harris AL & Lewis CE (1998) Association of tumour necrosis factor and its receptors with thymidine phosphorylase expression and metastasis in human breast cancer. J PATHOL, 182, A16-A16.
  • Royds JA, Dower SK, Qwarnstrom EE & Lewis CE (1998) . Mol Pathol, 51(2), 55-61.
  • Leek RD, Landers R, Fox SB, Ng F, Harris AL & Lewis CE (1998) Association of tumour necrosis factor alpha and its receptors with thymidine phosphorylase expression in invasive breast carcinoma. BRIT J CANCER, 77(12), 2246-2251.
  • CAMPBELL AP, SMITHSON J, LEWIS C, KETTLEWELL MGW, MORTENSEN N, JEWELL DP & McGEE JO (1996) . The Journal of Pathology, 180(4), 407-414.
  • Leek RD, Lewis CE, Whitehouse R, Greenall M, Clarke J & Harris AL (1996) Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Research, 56(20), 4625-4629.
  • O'Sullivan C & Lewis CE (1994) . The Journal of Pathology, 172(3), 229-235.
  • Leek RD, Harris AL & Lewis CE (1994) . Journal of Leukocyte Biology, 56(4), 423-435.
  • Bromley L, McCarthy SP, Stickland JE, Lewis CE & McGee JO (1994) . Journal of Immunological Methods, 167(1-2), 47-54.
  • Pusztai L, Clover LM, Cooper K, Starkey PM, Lewis CE & McGee JO (1994) . Br J Cancer, 70(2), 289-292.
  • Pusztai L, Lewis CE, Lorenzen J & McGee JO (1993) . The Journal of Pathology, 169(2), 191-201.
  • O'Sullivan C, Lewis CE, McGee JO & Harris AL (1993) . The Lancet, 342(8864), 148-149.
  • Pusztai L, Lewis CE & McGee JO (1993) . Br J Cancer, 67(2), 290-296.
  • Pusztai L, Lewis CE & McGee JO (1993) . Cytokine, 5(2), 169-172.
  • BAIGRIE R (1992) . Cytokine, 4(1), 63-65.
  • Lewis CE, McCracken D, Ling R, Richards PS, McCarthy SR & McGee JO (1991) . Immunological Reviews, 119(1), 23-39.
  • Lewis CE (1991) . Cytokine, 3(3), 184-188.
  • Lewis CE, Ramshaw AL, Lorenzen J & McGee JO (1991) . Cellular Immunology, 132(1), 158-167.
  • Lorenzen J, Lewis CE, McCracken D, Horak E, Greenall M & McGee JO (1991) . Br J Cancer, 64(3), 457-462.
  • Lewis CE, McCarthy SP, Richards PS, Lorenzen J, Horak E & O'D McGee J (1990) . Journal of Immunological Methods, 127(1), 51-59.
  • McCarthy SP, Lewis CE & McGee JO (1990) . Journal of Hepatology, 10(1), 90-98.
  • Lewis CE, McCarthy SP, Lorenzen J & McGee O'D. J (1990) Differential effects of LPS, IFN-γ and TNFα on the secretion of lysozyme by individual human mononuclear phagocytes: Relationship to cell maturity. Immunology, 69(3), 402-408.
  • Lewis CE, Mccarthy SP, Lorenzen J & Mcgee JOD (1989) . European Journal of Immunology, 19(11), 2037-2043.
  • Lewis CE, Richards PSM & Morris JF (1989) . Journal of Molecular Endocrinology, 2(1), 55-63.
  • Lewis CE, Clark A, Ashcroft SJH, Cooper GJS & Morris JF (1988) . Molecular and Cellular Endocrinology, 57(1-2), 41-49.
  • Cooper GJS, Willis AC, Reid KBM, Clark A, Baker CA, Turner RC, Lewis CE, Morris JF, Howland K & Rothbard JB (1987) . The Lancet, 330(8565), 966-966.
  • Clark A, Lewis CE, Willis AC, Cooper GJS, Morris JF, Reid KBM & Turner RC (1987) . The Lancet, 330(8553), 231-234.
  • Lewis CE, Fink G, Dow RC & Morris JF (1986) . Neuroendocrinology, 43(5), 584-589.
  • Lewis CE, Megson A, Morris JF & Charlton HM (1986) . Journal of Endocrinology, 111(3), 483-NP.
  • Lewis CE, Morris JF, Fink G & Johnson M (1986) . Journal of Endocrinology, 109(1), 35-NP.
  • Lewis CE, Morris JF & Fink G (1985) . Journal of Endocrinology, 106(2), 211-NP.

Book chapters

  • Staton CA & Lewis CE (2006) Alphastatin: a pluripotent inhibitor of activated endothelial cells In Siemann DW (Ed.), Vascular-targeted therapies in oncology (pp. 205-220). Wiley-Blackwell
  • Burke B, Lewis JS & Lewis CE (2000) , Cytokine Cell Biology (pp. 147-171). Oxford University PressOxford

Conference proceedings

  • Al-janabi H, Pu X, Muthana M, Wang N, Crespo M, Gurel B, De Bono J, Brown JE & Lewis CE (2021) . Cancer Research, Vol. 81(13_Supplement) (pp 2797-2797)
  • Moamin MR, Allen RJ, Stavrou N, Nagy M, Juncker-Jensen A & Lewis CE (2021) . Cancer Research, Vol. 81(13_Supplement) (pp 2720-2720)
  • Al-Janabi H, Pu X, Muthana M, Wang N, Crespo M, Gurel B, De Bono J, Brown JE & Lewis CE (2021) Changes in the phenotype of macrophages and CD8+T Cells in the perivascular niche of prostate tumours following androgen deprivation.. CANCER RESEARCH, Vol. 81(13)
  • Moamin MR, Allen RJ, Stavrou N, Nagy M, Juncker-Jensen A & Lewis CE (2021) Perivascular accumulation of immunosuppressive cells in the stroma of human triple negative breast carcinomas: implications for immunotherapy.. CANCER RESEARCH, Vol. 81(13)
  • Pu X, AL-Janabi H, Wang N, Muthana M, Brown J & Lewis C (2019) . Cancer Research, Vol. 79(13_Supplement)
  • Pu X, AL-Janabi H, Wang N, Muthana M, Brown J & Lewis C (2019) . Tumor Biology
  • Tazzyman S, Muthana M, Harrison J, Lewis C, Conner J & Chantry A (2015) . Journal of Clinical Oncology, Vol. 33(15_suppl) (pp e14035-e14035)
  • Hughes R, Murdoch C, Fang H-Y & Lewis C (2007) Microenvironmental signals regulating the tumour-promoting functions of macrophages: role of hypoxia and necrotic debris. JOURNAL OF LEUKOCYTE BIOLOGY (pp 56-56)
  • Ince PG, Fernando MS, Matthews F, Brayne C, Wharton SB, O'Brien JT, Lewis C, Kalaria RN, Shaw PJ & Simpson J (2006) Molecular markers of tissue hypoxia and glial pathology associated with incidental white matter lesions in the ageing brain. BRAIN PATHOLOGY, Vol. 16 (pp S92-S92)
  • Muthana M, Giannoudis A, Scott SD, Burke B, Mistry R, Hamdy F, Brown N, Maitland N & Lewis CE (2006) Engineering macrophages to synthesize recombinant adenoviruses in hypoxic areas of human prostate tumors. CANCER RESEARCH, Vol. 66(8)
  • Lewis CE, Leek R, Harris A & McGee JO (1995) . Journal of Leukocyte Biology, Vol. 57(5) (pp 747-751)
  • PUSZTAI L, LEWIS CE, LORENZEN J & MCGEE JO (1991) REGULATION OF BREAST-CANCER CELL-GROWTH BY TGF-BETA, IFN-GAMMA, IL6 AND IL4. JOURNAL OF PATHOLOGY, Vol. 163(2) (pp A170-A170)

Preprints

  • Al-janabi H, Moyes K, Allen R, Fisher M, Crespo M, Gurel B, Rescigno P, De Bono J, Nunns H, Bailey C , Juncker-Jensen A et al (2024) , Cold Spring Harbor Laboratory.
  • Rohwer N, Jumpertz S, Erdem M, Egners A, Warzecha KT, Fragoulis A, Kühl AA, Kramann R, Neuss S, Rudolph I , Endermann T et al (2018) , Cold Spring Harbor Laboratory.
Research group

Group Members

  • Professor Claire Lewis
  • Dr Mohammed Ridha (Postdoc)
  • Dr Haider Al-Janabi (Postdoc)
  • Katy Moyes (Postgraduate RA)
  • Richard Allen (PhD student)
Teaching interests
  • Acute and chronic inflammation
  • Angiogenesis in human diseases
  • Cancer
Professional activities and memberships

Journals

  • Member of the Editorial Board, Frontiers in Immunology.
  • Member of the Editorial Board, Cancer Research.
  • Member of the Editorial Board, Cancers.
  • Member of the Editorial Board, Journal of Clinical Investigation Insight.
  • Member of the Editorial Board, OncoImmunology.
  • Member of the Editorial Board, International Journal of Cancer.
  • Associate Editor, International Journal of Experimental Pathology.

Grant Awarding Bodies

  • Member, MRC/NIHR UK-US Cancer Skills Development Panel (2023 -  present).
  • Member, MRC Molecular & Cellular Medicines Board (2018-2022).
  • Member, PCUK Research Advisory Committee (2019-2022).
  • Member, Quinquennial Review Panel, MRC Human Immunology Unit, Oxford, Nov. 2016.
  • Member, Quinquennial Review Panel, Breast Cancer Now Manchester Research Unit, Feb. 2016.
  • Member, Senior Investigator Awards Committee, The Wellcome Trust, (2013).
  • Member of 3 Scientific Advisory Boards: ‘Cancer Immunotherapy’, Tumour Inflammation’ and ‘Metastasis’ for the Cancer Section of EU Framework 7 (2007- present).
  • Member, International Science Evaluation Panel (for biology, medicine and health), The Research Council, Norway (2011).
  • Member, AACR Basic Cancer Research Grants Scientific Review Committee (2010).
  • Chair, BBSRC Review Panel in Interdisciplinary Research (2005).
  • MRC College of Experts - Molecular and Cellular Medicine Board, (2004-current).
  • EPSRC Peer Review College (2006-2009).
  • Member, Scientific Advisory Board, Breast Cancer Campaign (1999-2002).