Professor Christopher Newman

MA, PhD, FRCP

School of Medicine and Population Health

Emeritus Professor of Clinical Cardiology

C.Newman@sheffield.ac.uk
The Medical School

Full contact details

Professor Christopher Newman
School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

For enquiries, contact SMPH-West-Operational@sheffield.ac.uk

I joined the University in 1995 following an MRC Clinician Scientist Fellowship spent at the National Institute for Medical Research and Royal Postgraduate Medical School (1989-1992) and the University of Cambridge (1992-1995).

I was appointed as Director of the Clinical Research Facility in 2004, a joint initiative between the University and Sheffield Teaching Hospitals NHS Foundation Trust.

The NIHR Sheffield CRF has units both at the Royal Hallamshire Hospital and Northern General Hospital.

Research interests

My main research interest is in non-viral gene delivery, particularly the use of high frequency ultrasound to promote plasmid-mediated vascular gene delivery.

I also have interests in site specific targeting of gene therapy vectors, the vascular biology of pulmonary hypertension, the pathophysiology of sudden death in young diabetics, new approaches to the analysis of gene expression in acute coronary syndromes and links between the pathobiology of osteoporosis and cardiovascular disease. 

Publications

Show: Featured publications All publications

Journal articles

  • Hameed AG, Arnold ND, Chamberlain J, Pickworth JA, Paiva C, Dawson S, Cross S, Long L, Zhao L, Morrell NW , Crossman DC et al (2012) . J Exp Med, 209(11), 1919-1935.
  • Condliffe R, Pickworth JA, Hopkinson K, Walker SJ, Hameed AG, Suntharaligam J, Soon E, Treacy C, Pepke-Zaba J, Francis SE , Crossman DC et al (2012) . Pulm Circ, 2(1), 21-27.
  • Sheridan PJ, Marques JLB, Newman CMH, Heller SR & Clayton RH (2010) . Europace, 12(4), 553-560.
  • Newman CM, Crosdale DJ, Fisher KD, Briggs SS, Norman KE, Seymour LW & Hellewell PG (2009) . J Gene Med, 11(4), 326-334.
  • Newman CMH, Starkey I, Buller N, Seabra-Gomes R, Kirby S, Hettiarachchi J, Cumberland D & Hillis WS (2005) . Eur J Clin Pharmacol, 61(10), 733-742.
  • Akowuah EF, Gray C, Lawrie A, Sheridan PJ, Su C-H, Bettinger T, Brisken AF, Gunn J, Crossman DC, Francis SE , Baker AH et al (2005) . Gene Ther, 12(14), 1154-1157.
  • Sheridan PJ, Lawrie A, Crossman DC, Holt CM & Newman CM (2005) . J Gene Med, 7(3), 375-385.
  • Lawrie A, Brisken AF, Francis SE, Wyllie D, Kiss-Toth E, Qwarnstrom EE, Dower SK, Crossman DC & Newman CM (2003) . Ultrasound Med Biol, 29(10), 1453-1461.

All publications

Journal articles

  • Arnold ND, Pickworth JA, West LE, Dawson S, Carvalho JA, Casbolt H, Braithwaite AT, Iremonger J, Renshall L, Germaschewski V , McCourt M et al (2019) . Nature Communications, 10(1).
  • Stansfield R, Gossiel F, Morton A, Newman C & Eastell R (2014) . Bone, 69, 1-5.
  • Hameed AG, Arnold ND, Chamberlain J, Pickworth JA, Paiva C, Dawson S, Cross S, Long L, Zhao L, Morrell NW , Crossman DC et al (2012) . J Exp Med, 209(11), 1919-1935.
  • Condliffe R, Pickworth JA, Hopkinson K, Walker SJ, Hameed AG, Suntharaligam J, Soon E, Treacy C, Pepke-Zaba J, Francis SE , Crossman DC et al (2012) . Pulm Circ, 2(1), 21-27.
  • Walsh JS, Newman C & Eastell R (2012) . Trends in Endocrinology & Metabolism, 23(4), 163-168.
  • Eastell R, Newman C & Crossman DC (2010) . Archives of Biochemistry and Biophysics, 503(1), 78-83.
  • Sheridan PJ, Marques JLB, Newman CMH, Heller SR & Clayton RH (2010) . Europace, 12(4), 553-560.
  • Newman CM, Crosdale DJ, Fisher KD, Briggs SS, Norman KE, Seymour LW & Hellewell PG (2009) . J Gene Med, 11(4), 326-334.
  • Lawrie A, Waterman E, Southwood M, Evans D, Suntharalingam J, Francis S, Crossman D, Croucher P, Morrell N & Newman C (2008) . The American Journal of Pathology, 172(1), 256-264.
  • Su CH, Yeh H-I, Hou CJ-Y, Thierry B, Newman C & Tsai C-H (2007) The effects of ultrasound on polymer-mediated gene transfer in vitro. INTERNATIONAL JOURNAL OF CARDIOLOGY, 122, 49-50.
  • Newman CMH & Bettinger T (2007) . Gene Ther, 14(6), 465-475.
  • Siotia AK, Morton AC, Mofidi S, Wales C, Newman C & Gunn J (2007) . Heart, 93, 251-252.
  • Newman CMH, Starkey I, Buller N, Seabra-Gomes R, Kirby S, Hettiarachchi J, Cumberland D & Hillis WS (2005) . Eur J Clin Pharmacol, 61(10), 733-742.
  • Akowuah EF, Gray C, Lawrie A, Sheridan PJ, Su C-H, Bettinger T, Brisken AF, Gunn J, Crossman DC, Francis SE , Baker AH et al (2005) . Gene Ther, 12(14), 1154-1157.
  • Sheridan PJ, Lawrie A, Crossman DC, Holt CM & Newman CM (2005) . J Gene Med, 7(3), 375-385.
  • Lee SP, Yeoh L, Harris ND, Davies CM, Robinson RT, Leathard A, Newman C, Macdonald IA & Heller SR (2004) . Diabetes, 53(6), 1535-1542.
  • Lawrie A, Brisken AF, Francis SE, Wyllie D, Kiss-Toth E, Qwarnstrom EE, Dower SK, Crossman DC & Newman CM (2003) . Ultrasound Med Biol, 29(10), 1453-1461.
  • Parker AL, Newman C, Briggs S, Seymour L & Sheridan PJ (2003) . Expert Reviews in Molecular Medicine, 5(22), 1-15.
  • Akowuah EF, Sheridan PJ, Cooper GJ & Newman C (2003) . The Annals of Thoracic Surgery, 76(3), 959-966.
  • Campbell S & Newman C (2003) National audit of myocardial infarction project. Journal of Clinical Excellence, 4(4), 375.
  • Robinson RTCE, Harris ND, Ireland RH, Lee S, Newman C & Heller SR (2003) . Diabetes, 52(6), 1469-1474.
  • Gunn J, Morton AC, Wales C, Newman CMH, Crossman DC & Cumberland DC (2003) . Heart, 89(2), 127-131.
  • Sheridan P, Holt C, Newman C & Crossman D (2002) . Clinical Science, 103(s47), 14P-14P.
  • Rhodes M (2002) . BMJ, 324(7339), 709-709.
  • Eaton SEM, Euinton HA, Newman CM, Weetman AP & Bennet WM (2002) . Clin Endocrinol (Oxf), 56(1), 33-38.
  • Newman CM, Lawrie A, Brisken AF & Cumberland DC (2001) . Echocardiography, 18(4), 339-347.
  • Lawrie A, Brisken AF, Francis SE, Cumberland DC, Crossman DC & Newman CM (2000) . Gene Ther, 7(23), 2023-2027.
  • Gunn J, Malik N, Arnold N, Shepherd L, Holt C, Campbell E, Newman C, Crossman D & Cumberland D (2000) Small stent, small vessel is not equivalent to standard stent, standard vessel.. AMERICAN JOURNAL OF CARDIOLOGY, 86(8A), 42I-42I.
  • Gunn J, Malik N, Arnold N, Shepherd L, Holt C, Campbell E, Newman C, Crossman D & Cumberland D (2000) Effects of arterial taper upon in-stent restenosis in very small coronary vessels.. AMERICAN JOURNAL OF CARDIOLOGY, 86(8A), 117I-117I.
  • Gunn J, Malik N, Arnold N, Shepherd L, Holt C, Campbell E, Newman C, Crossman C & Cumberland D (2000) Are we achieving intended dimensions in stenting very small coronary arteries?. AMERICAN JOURNAL OF CARDIOLOGY, 86(8A), 42I-42I.
  • Townsend CF, Francis SE & Newman CM (2000) Mammalian suppressor of sgv-1 (MSS1), a putative transcription factor and differentiation related gene, is upregulated in explant derived compared with enzyme dispersed human aortic vascular smooth muscle cells in vitro. J AM COLL CARDIOL, 35(2), 49A-49A.
  • Lawrie A, Brisken AF, Francis SE, Tayler DI, Chamberlain J, Crossman DC, Cumberland DC & Newman CM (1999) . Circulation, 99(20), 2617-2620.
  • Townsend CF, Newman CM & Francis SE (1999) . Methods Mol Med, 30, 39-46.
  • Malik N, Gunn J, Holt CM, Shepherd L, Francis SE, Newman CM, Crossman DC & Cumberland DC (1998) . Heart, 80(5), 509-516.
  • Malik N, Gunn J, Arnold N, Newman CMH, Crossman DC & Cumberland DC (1998) Overlapping stents: No alteration in neointima formation.. CIRCULATION, 98(17), 189-189.
  • Malik N, Francis SE, Holt CM, Gunn J, Thomas GL, Shepherd L, Chamberlain J, Newman CM, Cumberland DC & Crossman DC (1998) . Circulation, 98(16), 1657-1665.
  • Malik N, Gunn J, Holt CM, Francis SE, Arnold N, Newman CMH, Crossman DC & Cumberland DC (1998) Aorto-ostial stent: Procedural, angiographic and histological evaluation in porcine coronary arteries.. AMERICAN JOURNAL OF CARDIOLOGY, 82(7A), 68S-68S.
  • Yusof NM, Malik N, Gunn J, Anthonies S, Newman CMH, Crossman DC & Cumberland DC (1998) Assessment of the safety and efficacy of supersaturated oxygen solution: A novel method of reducing myocardial ischaemia in PTCA.. AMERICAN JOURNAL OF CARDIOLOGY, 82(7A), 100S-100S.
  • Lawrie A, Brisken AF, Chamberlain JC, Francis SE, Tayler DI, Crossman DC, Cumberland DC & Newman CM (1998) 1MHz ultrasound enhances transfection of porcine aortic endothelial cells in vitro and oligonucleotide uptake in an organ culture model.. AM J CARDIOL, 82(7A), 29S-29S.
  • Malik N (1998) . Journal of the American College of Cardiology, 31(2), 22A-22A.
  • Malik N (1998) . Journal of the American College of Cardiology, 31(2), 414A-414A.
  • Lawrie A, Brisken AF, Francis SE, Tayler DI, Crossman DC, Cumberland DC & Newman CM (1998) Nigh frequency ultrasound enhances transfection of porcine vascular smooth muscle cells in vitro. J AM COLL CARDIOL, 31(2), 25A-25A.
  • Newman CM, Price A, Davies DW, Gray TA & Weetman AP (1998) . Heart, 79(2), 121-127.
  • Gunn J, Malik N, Holt C, Francis S, Shepherd L, Newman C, Crossman D & Cumberland D (1997) The BioDivYsio(R) stent: Morphometric superiority to the Palmaz-Schatz stent in the porcine coronary model. AMERICAN JOURNAL OF CARDIOLOGY, 80, TCT95-TCT95.
  • Aggarwal VK, Vennall GP, Davey PN & Newman C (1997) . Tetrahedron Letters, 38(14), 2569-2572.
  • Gunn J, Holt CM, Francis SE, Shepherd L, Grohmann M, Newman CM, Crossman DC & Cumberland DC (1997) . Circ Res, 80(4), 520-531.
  • Gunn J, Malik N, Shepherd L, Holt CM, Francis SE, Newman CMH, Crossman DC & Cumberland DC (1997) In-stent restenosis: More metal and more symmetry required?. Heart, 77(SUPPL. 1).
  • Newman CM, Bruun BC, Porter KE, Mistry PK, Shanahan CM & Weissberg PL (1995) . Arteriosclerosis, Thrombosis, and Vascular Biology, 15, 2010-2018.
  • Giannakouros T, Newman CMH, Armstrong J & Magee AI (1993) . Biochemical and Biophysical Research Communications, 192(3), 983-990.
  • McEwan JR, Newman C, Wharton J, Polak JM & MacDermot J (1993) . Regulatory Peptides, 44(1), 61-69.
  • Parenti M, Vigano MA, Newman CM, Milligan G & Magee AI (1993) A novel N-terminal motif for palmitoylation of G-protein alpha subunits. Biochem J, 291 ( Pt 2), 349-353.
  • Giannakouros T, Newman CM, Craighead MW, Armstrong J & Magee AI (1993) Post-translational processing of Schizosaccharomyces pombe YPT5 protein. In vitro and in vivo analysis of processing mutants. Journal of Biological Chemistry, 268, 24467-24474.
  • O'Shaughnessy KM, Newman CM & Warren JB (1992) Inhibition in the rat of nitric oxide synthesis in vivo does not attenuate the hypotensive action of acetylcholine, ATP or bradykinin. Experimental Physiology, 77, 285-292.
  • Newman CM, Giannakouros T, Hancock JF, Fawell EH, Armstrong J & Magee AI (1992) Post-translational processing of Schizosaccharomyces pombe YPT proteins. Journal of Biological Chemistry, 267, 11329-11336.
  • Newman CM, Maseri A, Hackett DR, el-Tamimi HM & Davies GJ (1990) Response of angiographically normal and atherosclerotic left anterior descending coronary arteries to acetylcholine. Am J Cardiol, 66, 1070-1076.
  • Newman CM, Warren JB, Taylor GW, Boobis AR & Davies DS (1990) Rapid tolerance to the hypotensive effects of glyceryl trinitrate in the rat: prevention by N-acetyl-L- but not N-acetyl-D-cysteine. Br J Pharmacol, 99, 825-829.
  • Uren NG, Ludman P, Newman C, Crake T & Cleland JG (1989) Cardiac catheterization as an outpatient procedure. BMJ, 298, 1310.
  • Frenneaux M, Stewart RA, Newman CM & Hallidie-Smith KA (1989) Enalapril for severe heart failure in infancy. Arch Dis Child, 64, 219-223.
  • Warren JB, Newman CM, Pixley FJ, Fuller RW & Dollery CT (1988) The importance of bradykinin and histamine in the skin response to antigen. Br J Clin Pharmacol, 26, 803-805.

Conference proceedings

  • Hameed AG, Arnold ND, Chamberlain J, Pickworth JA, Paiva C, Dawson S, Cross S, Long L, Zhao L, Morrell NW , Crossman DC et al (2013) . The Lancet, Vol. 381 (pp S47-S47)
  • Hameed AG, Arnold ND, Chamberlain J, Pickworth J, Newman CMH, Crossman DC, Francis SE & Lawrie A (2012) . Heart, Vol. 98(Suppl 3) (pp A1.3-A1)
  • Stansfield R, Gossiel F, Morton A, Newman C & Eastell R (2012) TYPE I COLLAGEN DEGRADATION DURING TISSUE REPAIR: COMPARISON OF MECHANISMS FOLLOWING FRACTURE AND MYOCARDIAL INFARCTION. OSTEOPOROSIS INTERNATIONAL, Vol. 23 (pp S580-S581)
  • Stansfield⁎ R, Gossiel F, Morton A, Newman C & Eastell R (2012) . Bone, Vol. 50 (pp S119-S119)
  • Lawrie A, Hameed AG, Arnold N, Chamberlain J, Pickworth J, Dawson S, Newman CMH & Francis SE (2012) . D97. PULMONARY HYPERTENSION: NEW INSIGHTS INTO CAUSES AND TREATMENTS?
  • Condliffe R, Pickworth J, Hopkinson K, Hameed A, Walker S, Elliot C, Francis S, Newman C, Crossman D, Morton A , Kiely D et al (2011) . Thorax, Vol. 66(Suppl 4) (pp A34-A34)
  • Hameed AG, Arnold ND, Pickworth J, Chamberlain JC, Newman CMH, Crossman DC, Francis SE & Lawrie A (2011) . Thorax, Vol. 66(Suppl 4) (pp A3-A3)
  • Hameed AG, Chamberlain J, Arnold N, Newman C, Francis S, Crossman D & Lawrie A (2011) . B61. PULMONARY HYPERTENSION: EXPERIMENTAL MODELS I
  • Hameed AG, Chamberlain J, Arnold ND, Francis SE, Newman CMH, Crossman DC & Lawrie A (2010) . Thorax, Vol. 65(Suppl 4) (pp A68-A68)
  • Hameed AG, Vinogradova T, Francis SE, Newman CMH, Crossman DC & Lawrie A (2009) . THORAX, Vol. 64 (pp A8-A8)
  • Condliffe R, Hameed AG, Paiva C, Suntharalingam J, Francis SE, Newman CMH, Crossman DC, Morrell NW & Lawrie A (2009) . THORAX, Vol. 64 (pp A58-A59)
  • Vinogradova T, Hameed AG, Francis SE, Newman CMH, Crossman DC & Lawrie A (2009) . THORAX, Vol. 64 (pp A9-A9)
  • Paiva C, Francis SE, Newman CMH, Crossman DC & Lawrie A (2009) . THORAX, Vol. 64 (pp A9-A9)
  • Watt V, Soon E, Suntharalingam J, Paiva C, Hameed AG, Francis SE, Newman CM, Crossman DC, Morrell NW & Lawrie A (2009) OPG:TRAIL Ratio as a Potential Biomarker for Pulmonary Arterial Hypertension. CIRCULATION, Vol. 120(18) (pp S806-S806)
  • Robinson EJ, Marques JLB, Macdonald I, Newman CM & Heller SR (2009) Investigating Cardiac Autonomic Neuropathy and Sudden Death. The Effect of Neuropathy on Abnormal Cardiac Repolarisation during Sympatho-Adrenal Activation in Type 1 Diabetes. DIABETES, Vol. 58 (pp A170-A170)
  • Lawrie A, Paiva C, Southwood M, Suntharalingam J, Francis SE, Crossman DC, Morrell NW & Newman CMH (2008) THE OSTEOPROTEGERIN-TNF-RELATED APOPTOSIS-INDUCING LIGAND AXIS IN PULMONARY ARTERIAL HYPERTENSION. THORAX, Vol. 63 (pp A28-A28)
  • Lawrie A, Southwood M, Suntharalingam J, Francis SE, Crossman DC, Morrell NW, Morrell NW & Newman CM (2007) A potential role for TRAIL in the pathogenesis of pulmonary arterial hypertension. CIRCULATION, Vol. 116(16) (pp 59-59)
  • Lawrie A, Suntharalingham J, Southwood M, Francis S, Crossman D, Morrell N & Newman C (2007) A potential role for osteoprotegerin in idiopathic pulmonary arterial hypertension. HEART, Vol. 93 (pp A23-A24)
  • Lawrie A, Evans DJW, Waterman EA, Francis SE, Crossman DC & Newman CMH (2006) . Vascular Pharmacology, Vol. 45(3) (pp e106-e106)
  • Siotia A, Mofidi S, Morton A, Wales C, Newman C & Gunn J (2006) The impact of a policy of selective drug eluting stent implantation upon clinical resteosis: A 'real world' registry. HEART, Vol. 92 (pp A98-A98)
  • Akowuah E, Gray C, Sheridon P, Bettinger T, Res B, Brisken A, Gunn J, Crossman D, Francis S, Baker A & Newman C (2004) Ultrasound-mediated delivery of TIMP-3 plasmid DNA into saphenous vein leads to increased lumen size in a porcine interposition graft model. CIRCULATION, Vol. 110(17) (pp 161-161)
  • Akowuah E, Gray C, Francis S, Gunn J, Bettinger T, Brisken A, Crossman D & Newman C (2003) Adjunctive ultrasound exposure enhances gene delivery to vascular smooth muscle cells in vitro and to ex vivo and in vivo porcine saphenous vein grafts. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 92(6A) (pp 100L-100L)
  • Sheridan PJ, Crossman DC, Holt CM & Newman CM (2003) Modulation of non-viral vascular gene delivery by VP22-mediated intercellular protein transport. ATHEROSCLEROSIS, Vol. 169(1) (pp 200-201)
  • Sheridan PJ, Holt CM, Crossman DC & Newman CMH (2003) Enhancing the effective efficiency of non-viral vascular gene transfer by intercellular trafficking of VP22 fusion proteins. HEART, Vol. 89 (pp A16-A16)
  • Sheridan PJ, Holt CM, Crossman DC & Newman CMH (2002) Highly efficient bystander effect and intercellular trafficking of VP22-tghymidine kinase fusion proteins following non-viral transfection in vascular cells. CIRCULATION, Vol. 106(19) (pp 269-269)
  • Morton A, Wales C, Newman C, Crossman D, Cumberland D & Gunn J (2002) Drug-eluting stents: Maximizing benefit and minimizing costs.. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 90(6A) (pp 71H-71H)
  • Akowuah E, Morton A, Gray C, Zuk R, Crossman D, Gunn J & Newman C (2002) Endoluminal ultrasound enhances nonviral gene delivery from plasmid-coated stents.. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 90(6A) (pp 118H-119H)
  • Townsend CF, Francis SE, Chamberlain J, Gunn J, Crossman DC & Newman CMH (2001) Modulation of MSS1, a component of the 26S proteasome, in vascular smooth muscle cells in vitro and following experimental PTCA. EUROPEAN HEART JOURNAL, Vol. 22 (pp 3-3)
  • Lawrie A, Brisken AF, Francis SE, Crossman DC, Cumberland D & Newman CM (1999) Ultrasound-enhanced reporter gene expression following naked DNA transfection is markedly enhanced by the presence of microbubble contrast agents.. AM J CARDIOL, Vol. 84(6A) (pp 64P-65P)
  • Lawrie A, Brisken AF, Francis SE, Tayler DI, Crossman DC, Cumberland DC & Newman CM (1998) . Journal of the American College of Cardiology, Vol. 31 (pp 25-25)
  • Gunn J, Francis S, Holt C, Chamberlain J, Lambert D, Newman C, Crossman D & Cumberland D (1997) Is local drug delivery truly a low efficiency procedure?. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 80 (pp TC240-TC240)
Teaching activities

I organise and deliver teaching within modules of the undergraduate medical student curriculum. I teach on courses related to the ethics and governance of clinical research.

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