Professor Alex Rothman
MA, BM BCh, MRes, PhD, MRCP, EEGC
School of Medicine and Population Health
Professor of Cardiology
Honorary Consultant Cardiologist
+44 114 215 9521
Full contact details
School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
I trained in medicine at Cambridge and Oxford, and joined the University of Sheffield in 2008 as an Academic Clinical Fellow.
Following an MRC Clinical Research Training Fellowship, an NIHR Clinical Lectureship and a Wellcome Trust Clinical Research Development Fellowship I am now an Honorary Consultant Cardiologist and Academic Training Lead at Sheffield Teaching Hospitals NHS Trust, and Professor of Cardiology at the University of Sheffield.
- Research interests
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Our translational studies have developed new drugs and devices that now have regulatory approvals and established reimbursement. Our current work focuses on the pathology and physiology of pulmonary hypertension and heart failure, and the development of novel therapeutic strategies, clinical trial methodologies and remote clinical evaluation. Fellows and students working with the group have been awarded national and international awards, and gained external funding for their research.
Current projects
- MRC Experimental Medicine: Pulmonary Hypertension: intensification and personalisation of combination Rx (PHoenix), £1.7m MRC, £0.5m Abbott, (PI), MR/W026279/1
- Sotatercept extension of PHoenix, £1m (PI)
- MRC DPFS: Emapunil for pulmonary arterial hypertension, £1.9m (Co-I), APP57948
- EPSRC Project: CVD-NET - Networks of Cardiovascular Digital Twins, £10m (Co-I and clinical study lead), EP/Z531297/1
- EPSRC Project: GLUTRONICS - Glucose-fuelled ultra-low power implantable bioelectronics, £2.2m (Co-I), EP/Z536027/1
- Innovate UK Innovate UK Biomedical Catalyst: Addition of continuous cardiac output measurement to improve care of chronic cardiac patients at home, £500k (Co-I)
- Innovate UK Biomedical Catalyst: Comprehensive remote monitoring system for Congestive Heart Failure, £499k (Co-I), TS/Y02477X/1
- BHF Clinical Research Training Fellowship: Assessment of fluid status in animal models of heart failure and pulmonary Hypertension, £313k, FS/CRTF/23/24465
- NIHR Efficacy and Mechanism Evaluation: Positioning Imatinib for Pulmonary Arterial Hypertension, £1.2m (Co-I), NIHR128465
- BHF Innovation Award, £300k (PI), HI/B3/24/370100
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . Cell, 188(10), 2603-2620.e18.
- . American Journal of Respiratory and Critical Care Medicine, 211(6), 1018-1027.
- . Circulation Research, 135(2), 320-331.
- . Pulmonary Circulation, 14(1).
- . The Lancet Digital Health, 5(7), E467-E476.
- . JACC: Basic to Translational Science, 8(4), 386-388.
- . ESC Heart Failure, 9(6), 3858-3867.
- . Heart, 108, 1392-1400.
- . Thorax, 76(10), 1032-1035.
- . Pulmonary Circulation, 11(4).
- . JACC: Cardiovascular Imaging, 14(6), 1271-1272.
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- . European Journal of Heart Failure, 22(10), 1912-1919.
- . JACC: Cardiovascular Interventions, 13(8), 989-999.
- . American Journal of Respiratory and Critical Care Medicine, 201(4), 458-468.
- . Hypertension, 75(2), 477-482.
- . EuroIntervention, 15(8), 722-730.
- . The New England Journal of Medicine, 378, 196-200.
- . American Journal of Respiratory and Critical Care Medicine, 196(11).
- . American Journal of Respiratory and Critical Care Medicine, 196(2).
- . Epigenomics.
- . Journal of Clinical Investigation, 126(7), 2495-2508.
- . JACC: Cardiovascular Interventions, 8(15), 2013-2023.
- . Circulation: Cardiovascular Interventions, 8(11), e002569-e002569.
- . CIRCULATION-CARDIOVASCULAR INTERVENTIONS, 8.
- . Prog Mol Biol Transl Sci, 124, 43-63.
- The Effect of Interleukin-1 Receptor Antagonist Therapy on Markers of Inflammation in Non-ST Elevation Acute Coronary Syndromes: The MRC-ILA Heart Study. CIRCULATION, 128(22).
- . Cardiovasc Res, 100(2), 252-261.
- Intracellular retention of mutant retinoschisin is the pathological mechanism underlying X-linked retinoschisis. Human molecular genetics, 11(24), 3097-3105.
- . The Journal of Heart and Lung Transplantation.
All publications
Journal articles
- . Pulmonary Circulation, 15(4).
- .
- . American Journal of Respiratory and Critical Care Medicine, 211(8), 1533-1534.
- . Pulmonary Circulation, 15(3).
- . Respirology.
- . Open Heart, 12(1).
- . European Respiratory Journal, 65(6).
- . European Respiratory Review, 34(176).
- . Cell, 188(10), 2603-2620.e18.
- . Journal of the American College of Cardiology, 85(12), 2189-2189.
- . American Journal of Respiratory and Critical Care Medicine, 211(6), 1018-1027.
- . Angiology.
- . Journal of Cardiovascular Magnetic Resonance, 27(1), 101133-101133.
- . ERJ Open Research, 11(3).
- . BMC Pulmonary Medicine, 24(1).
- . European Heart Journal, 45(Supplement_1).
- . European Heart Journal, 45(Supplement_1).
- . European Heart Journal, 45(Supplement_1).
- . Annals of the American Thoracic Society, 22(3).
- . The Journal of Heart and Lung Transplantation, 43(10), 1629-1639.
- . Pulmonary Circulation, 14(3).
- . Expert Review of Cardiovascular Therapy, 22(7), 339-345.
- . Circulation Research, 135(2), 320-331.
- . Heart, 110(16), 1048-1055.
- . Frontiers in Radiology, 4.
- . BMJ Open, 14(3).
- . Pulmonary Circulation, 14(1).
- . European Respiratory Journal, 63(3).
- . JACC: Basic to Translational Science, 9(2), 257-259.
- . Radiology, 310(2).
- . BMJ Open, 14(1).
- . JMIR mHealth and uHealth, 11(1).
- . Scientific Reports, 13(1).
- . Circulation, 148(Suppl_1).
- . Circulation, 148(Suppl_1).
- . Medicina, 59(11).
- The Left Atrial Area Derived Cardiovascular Magnetic Resonance Left Ventricular Filling Pressure Equation Shows Superiority over Integrated Echocardiography. Medicina (Kaunas, Lithuania), 59(11).
- . European Respiratory Journal, 62(2).
- . The Lancet Digital Health, 5(7), E467-E476.
- . JACC: Basic to Translational Science, 8(4), 386-388.
- . Frontiers in Cardiovascular Medicine, 10.
- . International Journal of Cardiology, 371, 363-370.
- . Cardiovascular Research, 118(Supplement_2).
- . Radiology, 304(3), E56-E56.
- . ESC Heart Failure, 9(6), 3858-3867.
- . Radiology, 305(2), 431-440.
- . Radiology, 305(1).
- . ERJ Open Research, 8(2).
- . Heart, 108, 1392-1400.
- . European Heart Journal, 43(26), 2511-2522.
- . European Heart Journal - Digital Health, 3(2), 265-275.
- . Journal of Cardiovascular Magnetic Resonance, 24(1).
- . Frontiers in Cardiovascular Medicine, 9.
- . Nature Communications, 12.
- . Thorax, 76(10), 1032-1035.
- . Pulmonary Circulation, 11(4).
- . European Stroke Journal, 6(3), 283-290.
- . EBioMedicine, 69.
- Design of a randomised, double-blind, crossover, placebo-controlled trial of effects of sildenafil on cerebrovascular function in small vessel disease: Oxford haemodynamic adaptation to reduce pulsatility trial (OxHARP). European stroke journal, 6(3), 283-290.
- . Canadian Journal of Cardiology, 37(10), 1530-1538.
- . JACC: Cardiovascular Imaging, 14(6), 1271-1272.
- . International Journal of Cardiovascular Imaging, 37(10), 3019-3025.
- . European Heart Journal. Acute Cardiovascular Care, 10(Supplement_1).
- . Platelets, 32(4), 555-559.
- . Quantitative imaging in medicine and surgery, 11(4), 1470-1482.
- Preclinical testing of a novel pericardial left ventricular assist device (PALVAD). European Heart Journal. Acute Cardiovascular Care, 10(Suppl 1).
- . International Journal of Cardiology, 331, 316-321.
- . ESC Heart Failure, 8(1), 566-576.
- . Annals of the American Thoracic Society, 18(1), 34-43.
- . European Journal of Heart Failure, 23(1), 175-185.
- .
- . European Heart Journal, 41(Supplement_2).
- . European Journal of Heart Failure, 22(10), 1912-1919.
- . Pulmonary Circulation, 10(4).
- . Journal of the American College of Cardiology, 76(17), B77-B77.
- . Cardiovascular Diagnosis and Therapy, 10(5), 1735-1767.
- . European Radiology, 30(9), 4918-4929.
- . ESC Heart Failure, 7(4), 1791-1800.
- . Scientific Reports, 10(1).
- . Scientific Reports, 10(1).
- . Canadian Journal of Cardiology, 36(6), 852-859.
- . JACC: Cardiovascular Interventions, 13(8), 989-999.
- . European Respiratory Journal, 55(4), 2000314-2000314.
- . American Journal of Respiratory and Critical Care Medicine, 201(4), 458-468.
- . ESC Heart Failure, 7(3), 865-872.
- . Hypertension, 75(2), 477-482.
- . Nature Communications, 10(1).
- . EuroIntervention, 15(8), 722-730.
- . Frontiers in Cardiovascular Medicine, 6.
- . Frontiers in Medicine, 6.
- . Pulmonary Circulation, 9(2).
- . Clinical Radiology, 74(6), 435-436.
- . BioMed Research International, 2019.
- . European Respiratory Journal, 52(3).
- . Journal of Thoracic Disease, 10(S26), S3084-S3087.
- . Journal of the American Heart Association, 7(13).
- . The New England Journal of Medicine, 378, 196-200.
- . Annals of Behavioral Medicine, 52(6), 501-512.
- . Journal of Thoracic Disease, 9(12), 4922-4925.
- . American Journal of Respiratory and Critical Care Medicine, 196(11).
- . Pulmonary Circulation, 7(4), 768-776.
- . American Journal of Respiratory and Critical Care Medicine, 196(2).
- . Cardiovascular Research .
- . Epigenomics.
- . Journal of Clinical Investigation, 126(7), 2495-2508.
- . Circulation: Cardiovascular Interventions, 9(1).
- . JACC: Cardiovascular Interventions, 8(15), 2013-2023.
- . Circulation, 132(suppl_3).
- . Circulation, 132(suppl_3).
- . Circulation, 132(suppl_3).
- . Circulation: Cardiovascular Interventions, 8(11), e002569-e002569.
- . CIRCULATION-CARDIOVASCULAR INTERVENTIONS, 8.
- . PLoS One, 10(10).
- . British Journal of Cardiology, 21, 118-119.
- . Prog Mol Biol Transl Sci, 124, 43-63.
- The Effect of Interleukin-1 Receptor Antagonist Therapy on Markers of Inflammation in Non-ST Elevation Acute Coronary Syndromes: The MRC-ILA Heart Study. CIRCULATION, 128(22).
- . Cardiovasc Res, 100(2), 252-261.
- . Annals of Behavioral Medicine, 38(S1), 4-17.
- Intracellular retention of mutant retinoschisin is the pathological mechanism underlying X-linked retinoschisis. Human molecular genetics, 11(24), 3097-3105.
- . JMIR mHealth and uHealth, 13, e67117-e67117.
- . JMIR Research Protocols, 11(7), e36666-e36666.
- . Interventional Cardiology Review, 16.
- . The Journal of Heart and Lung Transplantation.
- mir-140-5p and SMURF1 regulate pulmonary arterial hypertension. Journal of Clinical Investigation.
Conference proceedings
- . Pulmonary hypertension (pp PA2492-PA2492)
- . Pulmonary hypertension (pp PA1622-PA1622)
- . OP2 Identification of high-risk patients and treatment targets in pulmonary arterial hypertension using artificial intelligence-derived right ventricular remodelling patterns (pp A1.2-A1)
- . Heart failure (pp A170.1-A170)
- . The Royal College of Radiologists Open, Vol. 1 (pp 100096-100096)
- . ‘Right here, right now’ – Bench to bedside in pulmonary vascular disease (pp A32.1-A32)
- . Pulmonary hypertension (pp PA3490-PA3490)
- . Basic Science (pp A298.2-A300)
- . Acute coronary syndromes & Interventional Cardiology (pp A81.1-A81)
- . Stable IHD/Prevention/Hypertension/Lipids (pp A230-A232)
- . Heart Failure (pp A186-A187)
- . Heart Failure (pp A182-A184)
- . Heart Failure (pp A181-A182)
- . Heart Failure (pp A179-A181)
- . Heart Failure (pp A159-A161)
- . Heart Failure (pp A156.2-A159)
- . D106. HOT OFF THE PRESSES! LATE BREAKERS IN PULMONARY VASCULAR DISEASE (pp A6731-A6731)
- . B57. INTERMEDIATES, CORRELATES, AND SURROGATES, OH MY!: NOVEL END POINTS AND ASSESSMENTS IN PVD (pp A3735-A3735)
- . Abstracts (pp A25.1-A25)
- . 13.01 - Pulmonary hypertension (pp 1295-1295)
- . 13.01 - Pulmonary hypertension (pp 347-347)
- . 13.01 - Pulmonary hypertension (pp 1618-1618)
- . Thorax, Vol. 77(Suppl 1) (pp a58-a59). Westminster, London, United Kingdom, 23 November 2022 - 23 November 2022.
- . ‘The Sixth Sense’ – Prognostication in pulmonary vascular disease (pp A57.2-A58)
- . Thorax, Vol. 77(Suppl 1) (pp a55-a56). Westminster, London, United Kingdom, 23 November 2022 - 23 November 2022.
- . ‘Contagion’ – The impact of COVID-19 (pp A125.1-A125)
- . ‘Mission (Im)possible I’ – Pulmonary vascular disease (pp A101.1-A101)
- . ‘The Sixth Sense’ – Prognostication in pulmonary vascular disease (pp A57.1-A57)
- . ‘Mission (Im)possible I’ – Pulmonary vascular disease (pp A100-A101)
- . Circulation, Vol. 146(Suppl_1)
- . Circulation, Vol. 146(Suppl_1)
- . American Journal of Respiratory and Critical Care Medicine, Vol. 205 (pp a2285-a2285). American Thoracic Society 2022 International Conference, 13 May 2022 - 13 May 2022.
- . Circulation, Vol. 144(Suppl_1)
- . Heart, Vol. 107(Suppl 3) (pp a17-a18). Virtual conference, 12 October 2021 - 12 October 2021.
- . Heart failure (pp A93.1-A93)
- . Heart failure (pp A91-A91)
- Heart Rhythm versus Heart Rate Control Strategy in Patients With Pre-Capillary Pulmonary Hypertension and Atrial Arrhythmias. CIRCULATION, Vol. 144
- Remote pulmonary artery pressure monitoring: a multinational European perspective. EUROPEAN JOURNAL OF HEART FAILURE, Vol. 23 (pp 114-115)
- . Circulation, Vol. 142(Suppl_3) (pp A15636). Virtual conference, 15 November 2020 - 15 November 2020.
- . Pulmonary hypertension (pp 1497-1497)
- . Pulmonary hypertension (pp 1540-1540)
- . D63. PULMONARY EMBOLISM: CASE REPORTS AND LATE BREAKING (pp A7278-A7278)
- . Pulmonary hypertension (pp OA496-OA496)
- An accurate, multi-parametric cardiovascular magnetic resonance model to predict mean pulmonary artery pressure in pulmonary hypertension. EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, Vol. 20 (pp 214-215)
- . European Heart Journal - Cardiovascular Imaging, Vol. 20(Supplement_2). Venice, Italy, 2 May 2019 - 2 May 2019.
- . European Heart Journal - Cardiovascular Imaging, Vol. 20(Supplement_2). Venice, Italy, 2 May 2019 - 2 May 2019.
- . A105. GLORY DAYS: THE LATEST CLINICAL RESEARCH IN PAH (pp A2507-A2507)
- A novel cardiac magnetic resonance imaging model to predict level of mixed venous oxygen levels in pulmonary hypertension. EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, Vol. 20 (pp 121-121)
- . Fundamental mechanisms of pulmonary arterial hypertension (pp A27.1-A27)
- Expression of SMURF1 is Increased in Patients With Pulmonary Arterial Hypertension and SiRNA Inhibition of SMURF1 Reduces Pulmonary Artery Smooth Muscle Cell Proliferation. CIRCULATION, Vol. 138
- Prognostic Implications of Cardiopulmonary Exercise Testing in Congenital Heart Disease Associated with Pulmonary Arterial Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 197
- . European Heart Journal Supplements, Vol. 38(1). Barcelona, Spain, 26 August 2017 - 26 August 2017.
- . Thorax, Vol. 71(Suppl 3) (pp A220.2-A221)
- . 4.3 Pulmonary Circulation and Pulmonary Vascular Diseases (pp PA2426-PA2426)
- . HEART, Vol. 102 (pp A147-A147)
- . EUROPEAN RESPIRATORY JOURNAL, Vol. 48
- . Thorax, Vol. 70(Suppl 3) (pp A5.3-A6)
- . Thorax, Vol. 70(Suppl 3) (pp A3.1-A3)
- . Thorax, Vol. 69(Suppl 2) (pp A2-A3)
- . Heart, Vol. 100(Suppl 3) (pp A102.3-A103), 2 June 2014 - 4 June 2014.
- Novel OPG Protein Interactions Regulate Survival, Proliferation and PAH-Associated Gene Expression in Pulmonary Arterial Smooth Muscle Cells.. Heart, Vol. 100(Suppl 3:A102-3.)
- Bone Marrow Derived Osteoprotegerin Drives Experimental Pulmonary Arterial Hypertension In The Murine Sugen/hypoxia Model. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- Novel Osteoprotegerin Protein Interactions Regulate Pulmonary Arterial Smooth Muscle Cell Survival And Proliferation. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- Radio-Frequency Denervation Of The Pulmonary Artery Reduces Pulmonary Hypertension In An Acute Porcine Model. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- The Effect of Interleukin-1 Receptor Antagonist Therapy on Markers of Inflammation in Non-ST Elevation Acute Coronary Syndromes: The MRC-ILA Heart Study. Circulation, Vol. 128(A14792)
- The Effect of Interleukin-1 Receptor Antagonist Therapy on Markers of Inflammation in Non-ST Elevation Acute Coronary Syndromes: The MRC-ILA Heart Study. Circulation, Vol. 128(A14792)
- . HEART, Vol. 97(20) (pp 7-7)
- . HEART, Vol. 97 (pp A13-A13)
- RS1 mutations causing X-linked Juvenile Retinoschisis lead to intracellular retention of mutant retinoschisin.. AMERICAN JOURNAL OF HUMAN GENETICS, Vol. 71(4) (pp 554-554)
- Intracellular retention of mutant retinoschisin is the pathological mechanism underlying X-linked retinoschisis.. JOURNAL OF MEDICAL GENETICS, Vol. 39 (pp S15-S15)
Digital content
- . Retrieved from
Preprints
- , Cold Spring Harbor Laboratory.
- , JMIR Publications Inc..
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , JMIR Publications Inc..
- , Research Square Platform LLC.
- Teaching interests
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I enjoy lecturing clinical cardiology to both undergraduates and post-graduates and I teach clinical skills to medical students and doctors.