Professor Albert CM Ong
MA, DM, FRCP, FAoP, FISN, FERA
School of Medicine and Population Health
Professor of Renal Medicine
+44 114 215 9542
Full contact details
School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
Albert Ong is Professor of Renal Medicine at the University of Sheffield, UK. He studied medicine at the University of Oxford and trained as a clinician-scientist at University College London and Oxford. Early in his career, he held senior research fellowships from Kidney Research UK and the Wellcome Trust. His research has focussed on the molecular basis of cyst formation, the genetic basis for disease variability and drug discovery in autosomal dominant polycystic kidney disease (ADPKD) for which he received the ISN Lillian Jean Kaplan International Prize. He founded and directs specialist services for people with ADPKD and other genetic kidney diseases at the Sheffield Kidney Institute. A key opinion leader, he continues to provide strategic advice and leadership in the kidney field. He currently serves as Co-Director of the MRC-NIHR UK Renal Ciliopathies National Network (CILIAREN) and was formerly a member of the ERA Council.
- Research interests
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ADPKD is the most common genetic disease affecting the kidney with an estimated prevalence of 1 in 1000. It is the fourth most common cause of kidney failure globally and affects around 10% of people on kidney replacement therapy. The mechanisms underlying cyst formation have been intensely studied but remain incompletely understood. The process of cyst formation can be broadly divided into two phases ie cyst initiation and cyst expansion. Variants in two genes, PKD1 and PKD2, account for over 90% of all cases of ADPKD.
The Ong lab aims to develop novel therapies to prevent or inhibit cyst formation in ADPKD by studying the molecular basis underlying cyst initiation and cyst expansion. Our studies around cyst initiation have mainly focussed on investigating the functions of PKD1, PKD2 and related genes or proteins within the PKD1/Polycystin1 network. Work around cyst expansion seeks to elucidate the role of non-coding RNAs and RNA metabolism in disease progression. The lab employs human-derived cellular models, model organisms, experimental models, computational modelling, clinical and genetic data from deeply phenotyped cohorts to study disease mechanisms with a primary focus on clinical translation.
Current projects:
- Polycystin regulation of actin structure and dynamics through compartmentalised GTPase signalling
- Non-coding RNAs as biomarkers of disease activity and as therapeutic targets
- RNA-binding proteins as key mediators of disease initiation and progression in ADPKD
- Complex genetics underlying very-early onset PKD
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . American Journal of Kidney Diseases.
- . Nature.
- . Kidney International, 107(2), 234-254.
- . Nature Reviews Nephrology, 20(7), 473-485.
- . Kidney International Reports, 9(2), 249-256.
- . Kidney International Reports, 8(5), 989-1001.
- . American Journal of Kidney Diseases.
- . Journal of Medical Genetics.
- . Kidney International, 100(3), 513-515.
- . Genetics in Medicine, 23(4), 689-697.
- . JCI Insight, 5(16).
- . Cellular Signalling, 71.
- . Nature Reviews Nephrology, 14(3), 146-148.
- . The Lancet, 389(10081), 1780-1782.
- . Kidney International, 88(4), 699-710.
- . The Lancet, 385(9981), 1993-2002.
- . Lancet, 361(9359), 774-776.
All publications
Journal articles
- . American Journal of Kidney Diseases.
- . BMC Medicine, 23(1).
- . Kidney International.
- . Journal of Translational Medicine, 23.
- . Communications Medicine, 5.
- . Kidney International, 108(1), 105-118.
- . Nature.
- . BMC Nephrology, 26(1).
- . Kidney International, 107(2), 234-254.
- . Kidney International, 107(2), S1-S239.
- . American Journal of Kidney Diseases.
- . Value in Health, 27(12), S493-S493.
- Clinical spectrum and prognosis of the atypical polycystic kidney disease caused by monoallelic loss-of-function IFT140 variants. NEPHROLOGY DIALYSIS TRANSPLANTATION, 39, I213-I214.
- . Nephrology Dialysis Transplantation, 39(Supplement_1).
- . Kidney International Reports, 9(7), 2067-2083.
- . Kidney International Reports.
- . Nature Reviews Nephrology, 20(7), 473-485.
- . Kidney360, 5(5), 715-723.
- . The Lancet, 403(10433), 1279-1289.
- . The Journal of Gene Medicine, 26(2).
- . Trials, 25(1).
- . Nephrology Dialysis Transplantation, 39(6), 956-966.
- . Frontiers in Immunology, 14.
- . PLOS ONE, 19(1).
- . Kidney International Reports, 9(2), 249-256.
- . Seminars in Nephrology, 43(2).
- . Frontiers in Cell and Developmental Biology, 11.
- . Human Mutation, 2023.
- . Orphanet Journal of Rare Diseases, 18(1).
- . Advances in Kidney Disease and Health, 30(3), 294-302.
- . Clinical Kidney Journal.
- . Nephrology Dialysis Transplantation.
- . Kidney International Reports, 8(3), S244-S245.
- . Kidney International Reports, 8(5), 989-1001.
- . Nephrology Dialysis Transplantation, 38(3), 527-531.
- . Clinical Kidney Journal, 16(3), 403-407.
- . Clinical Kidney Journal, 16(1), 61-68.
- . American Journal of Kidney Diseases.
- . European Journal of Preventive Cardiology.
- . Journal of Medical Genetics.
- . Kidney Medicine, 4(10).
- . Journal of Hepatology, 77(Suppl 1), S814-S814.
- . Clinical Kidney Journal, 15(8), 1439-1446.
- . BMJ Open, 12(6).
- . Clinical Kidney Journal, 15(11), 2063-2071.
- . Kidneys, 11(1), 37-39.
- . Clinical Kidney Journal, 15(6), 1034-1036.
- . Nephrology Dialysis Transplantation, 37(7), 1201-1208.
- . Clinical Kidney Journal, 15(6), 1160-1168.
- . Human Molecular Genetics, 31(10), 1560-1573.
- . The American Journal of Human Genetics, 109(1), 136-156.
- . Nephrology Dialysis Transplantation, 37(5), 825-839.
- . Human Molecular Genetics, 31(2), 232-243.
- . Kidney International, 100(3), 513-515.
- . Genetics in Medicine, 23(4), 689-697.
- . Clinical Kidney Journal, 14(7), 1715-1718.
- . American Journal of Kidney Diseases, 77(2), 255-263.
- . Renal Failure, 43(1), 1-15.
- . Kidney International, 98(6), 1589-1604.
- . International Journal of Molecular Sciences, 21(23).
- . BMJ Open, 10(10).
- . Journal of the American Society of Nephrology, 31(10S), 502-502.
- . Journal of the American Society of Nephrology, 31(10S), 502-502.
- . American Journal of Kidney Diseases, 76(3), 361-373.
- . JCI Insight, 5(16).
- . Cellular Signalling, 72.
- . Kidney International, 98(2), 420-435.
- . Kidney International, 98(2), 404-419.
- . Kidney International, 98(2), 476-487.
- . American Journal of Kidney Diseases, 76(2), 213-223.
- . Nature, 584(7819), E2-E2.
- . Nature, 583, 90-95.
- . Cellular Signalling, 71.
- . Nephrology Dialysis Transplantation, 35(Supplement_3).
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- . Nephrology Dialysis Transplantation, 35(2), 198-203.
- . BMJ Open, 10(1).
- . Scientific Reports, 10(1).
- . Kidney International, 97(2), 370-382.
- . Nephrology, 24(12), 1214-1224.
- . Frontiers in Neurology, 10.
- . European Radiology, 29(8), 4188-4197.
- . Proceedings of the National Academy of Sciences, 116(27), 13320-13329.
- . Kidney International Reports, 4(7), S48-S48.
- . Kidney International Reports, 4(7), S148-S148.
- . Radiology, 290(3), 769-782.
- . Kidney International, 94(6), 1053-1068.
- . Nephrology Dialysis Transplantation, 33(Suppl 2), ii4-ii14.
- . American Journal of Kidney Diseases, 71(6), 912-913.
- . Nephrology Dialysis Transplantation, 33(4), 563-573.
- . BMC Nephrology, 19.
- . Nature Reviews Nephrology, 14(3), 146-148.
- . Nephrology Dialysis Transplantation, 33(8), 1310-1316.
- . Trials, 18.
- . Nephrology Dialysis Transplantation, 32(12), 2144-2144.
- . Journal of the American Society of Nephrology, 28(10), 2973-2984.
- . Nephrology Dialysis Transplantation, 32(suppl_3), iii94-iii94.
- . The Lancet, 389(10081), 1780-1782.
- . American Journal of Physiology - Renal Physiology, 312(4), F577-F588.
- . Kidney International.
- . Lancet, 389, S90.
- . F1000Research, 5, 2029-2029.
- . Nephrology Dialysis Transplantation, 31(suppl_1), i22-i23.
- . Journal of the American Society of Nephrology, 27(4), 1159-1173.
- . Nephrology Dialysis Transplantation, 31(3), 337-348.
- . Nephrology Dialysis Transplantation, 31(7), 1130-1140.
- . BMJ Open, 5(11).
- . Kidney International, 88(4), 699-710.
- . Journal of Biological Chemistry, 290(39), 23888-23896.
- . The Lancet, 385(9987), 2576-2576.
- . Nephrology Dialysis Transplantation, 30(suppl_3), iii63-iii63.
- . Nephrology Dialysis Transplantation, 30(suppl_3), iii190-iii190.
- . The Lancet, 385(9981), 1993-2002.
- . Biomolecular NMR Assignments, 9(2), 369-373.
- . TRANSPLANTATION, 99(5), 1023-1029.
- . Kidney International, 88(1), 17-27.
- . Seminars in Nephrology, 35(2), 197-207.
- . Nephrology Dialysis Transplantation, 30(2), 197-203.
- . Nephrology Dialysis Transplantation, 29(12), 2353-2353.
- . Value in Health, 17(7), A564-A564.
- . Nephrology Dialysis Transplantation, 29(suppl_4), iv26-iv32.
- . Nephrology Dialysis Transplantation, 29(suppl 4), iv15-iv25.
- . Nephrology Dialysis Transplantation, 29(suppl 4), iv121-iv123.
- . Nephrology Dialysis Transplantation, 29(suppl 4), iv106-iv112.
- . The Lancet, 383(9931), 1844-1859.
- . Nephrol Dial Transplant, 29 Suppl 3, iii73-iii78.
- . Kidney International, 86(6), 1244-1252.
- . Pharmacol Res, 80, 43-51.
- . Small, 10(1), 60-65.
- . Pflugers Archiv European Journal of Physiology, 1-14.
- . Nephron Clin Pract, 124(1-2), 31-37.
- . British Journal of Clinical Pharmacology, 76(4), 524-535.
- . ACS Nano, 7(9), 8214-8223.
- . Plos One, 8(8).
- . Nephrol Dial Transplant, 28(11), 2661-2663.
- . QJM, 106(7), 639-646.
- . Hum Mol Genet, 22(10), 1924-1939.
- . Am J Physiol Heart Circ Physiol, 304(1), H33-H41.
- . Pediatr Nephrol, 28(1), 33-49.
- . Nephrology Dialysis Transplantation, 27(1), 67-69.
- . NEPHRON CLINICAL PRACTICE, 120(1), C25-C34.
- . QJM, 105(7), 693-696.
- mTOR signaling is differentially affected in human renal cells with PKD1 or PKD2 mutations. PEDIATR NEPHROL, 26(9), 1648-1648.
- . Contrib Nephrol, 172, 200-209.
- . J Biol Chem, 286(21), 18994-19000.
- . Am J Physiol Renal Physiol, 300(6), F1375-F1384.
- . Medicine, 39(2), 119-125.
- . NEPHRON CLIN PRACT, 118(1), C3-C8.
- . Mol Biol Cell, 21(22), 3853-3865.
- . EMBO J, 29(7), 1176-1191.
- . Biophysical Journal, 98(3), 344a-344a.
- Structural and Molecular Basis of the Assembly of the TRPP2/PKD1 Complex. BIOPHYSICAL JOURNAL, 98(3), 343A-343A.
- . BMJ, 339, b4204-b4204.
- . BMJ, 339, b3763.
- . Am J Pathol, 175(4), 1493-1503.
- . Proceedings of the National Academy of Sciences of the United States of America, 106(28), 11558-11563.
- . Exp Physiol, 94(8), 914-927.
- . Nephron Clin Pract, 112(4), c230-c241.
- . Journal of Cell Science, 122(10), 1702.
- . J Cell Sci, 122(Pt 9), 1410-1417.
- . Clin Med (Lond), 9(3), 278-283.
- . J Biol Chem, 283(42), 28471-28479.
- . EMBO J, 27(9), 1345-1356.
- . Nephron Physiol, 108(1), p1-p7.
- . Kidney Int, 72(2), 157-165.
- . J Am Soc Nephrol, 18(2), 560-569.
- . American Journal of Pathology, 170(3), 830-842.
- . Transplantation, 83(1), 36-40.
- . Human Molecular Genetics, 16(3), 265-275.
- . Nephrol Dial Transplant, 21(8), 2078-2084.
- . Hum Mol Genet, 15(9), 1465-1473.
- . Am J Kidney Dis, 45(6), 1096-1099.
- . Kidney Int, 67(4), 1234-1247.
- . J BIOL CHEM, 279(26), 27472-27481.
- . Nephron Exp Nephrol, 93(2), e80.
- . J Am Soc Nephrol, 14(7), 1804-1815.
- . Lancet, 361(9376), 2196-2201.
- . Medicine, 31(5), 32-35.
- . Lancet, 361(9359), 774-776.
- . Nephrol Dial Transplant, 17(12), 2138-2144.
- Genotype/phenotype correlations in ADPKD: Vascular complications.. J AM SOC NEPHROL, 13, 40A-40A.
- Polycystin-1 mediates cell-cell adhesion in PKD1 transgenic and non-transgenic lines. J AM SOC NEPHROL, 13, 46A-46A.
- . J Biol Chem, 277(23), 20763-20773.
- . Exp Nephrol, 8(4-5), 208-214.
- Polycystin expression in the kidney and other tissues: Complexity, consensus and controversy. EXP NEPHROL, 8(4-5), 208-214.
- Endothelin antagonists in renal disease. KIDNEY INT, 57(4), 1778-1794.
- Polycystin expression in PKD-1, infantile PKD-1 and TSC-2/PKD-1 cystic tissue: heterogenous expression of the normal allele in cystic epithelia.. KIDNEY INT, 55(6), 2559-2559.
- . Kidney Int, 55(5), 2091-2116.
- Characterisation and expression of the PKD-1 protein, polycystin, in renal and extrarenal tissues.. KIDNEY INT, 55(5), 2091-2091.
- An unusual complication of pregnancy. NEPHROL DIAL TRANSPL, 14(5), 1324-1326.
- . Nephrol Dial Transplant, 14(5), 1324-1326.
- Cyst formation in ADPKD: new insights from natural and targeted mutants. NEPHROL DIAL TRANSPL, 14(3), 544-546.
- . Nephrol Dial Transplant, 14(3), 544-546.
- . Am J Pathol, 154(6), 1721-1729.
- . Kidney Int, 56(4), 1324-1333.
- . Endothelium, 6(1), 61-70.
- Characterisation, cellular expression, tissue localisation and developmental modulation of the PKD-1 product, polycystin.. J AM SOC NEPHROL, 8, A1744-A1744.
- Polycystin expression in PKD-1, infantile PKD-1 and TSC-2/PKD-1 cystic kidney: Evidence against a two-hit disease mechanism in cyst initiation.. J AM SOC NEPHROL, 8, A1745-A1745.
- The polycystic kidney disease 1 (PKD-1) gene: An important clue in the study of renal cyst formation. Journal of the Royal College of Physicians of London, 31(2), 141-146.
- Renal disease. II. The polycystic kidney disease 1 (PKD-1) gene: an important clue in the study of renal cyst formation.. J R Coll Physicians Lond, 31(2), 141-146.
- . Lancet, 349(9058), 1039-1040.
- . Am J Hum Genet, 60(6), 1399-1410.
- Mutation defection in polycystic kidney disease 1 (PKD1) gene.. J AM SOC NEPHROL, 7(9), A1856-A1856.
- . Hum Mol Genet, 5(4), 539-542.
- . Proc Natl Acad Sci U S A, 93(4), 1524-1528.
- Surprising new roles for endothelins - Mutant mice reveal the first clear links to human disease. British Medical Journal, 312(7025), 195-196.
- . Nephrol Dial Transplant, 11(2), 251-257.
- Surprising new roles for endothelins - Mutant mice reveal the first clear links to human disease. BRIT MED J, 312(7025), 195-196.
- . BMJ, 312(7025), 195-196.
- Screening the 3' region of the polycystic kidney disease 1 (PKD1) gene reveals six novel mutations. AM J HUM GENET, 58(1), 86-96.
- . Bone, 18(2), 159-169.
- Screening the 3' region of the polycystic kidney disease 1 (PKD1) gene reveals six novel mutations.. Am J Hum Genet, 58(1), 86-96.
- CHARACTERIZATION OF THE POLYCYSTIC-KIDNEY-DISEASE-1 (PKD1) PROTEIN, POLYCYSTIN. J AM SOC NEPHROL, 6(3), 713-713.
- ENDOTHELIN DEPENDENT AND INDEPENDENT GROWTH SYSTEMS INVOLVED IN HUMAN PROXIMAL TUBULAR AUTOREGENERATION. J AM SOC NEPHROL, 6(3), 773-773.
- . Bone, 16(6), 679-679.
- A HYPOXIA-INDUCIBLE, ENDOTHELIN-1 MEDIATED, AUTOCRINE GROWTH LOOP INVOLVED IN HUMAN RENAL TUBULAR REGENERATION. KIDNEY INT, 47(2), 693-693.
- Cell-cell cross-talk in the pathogenesis of renal interstitial fibrosis. Kidney International Supplement(49), S-48-S-50.
- . Kidney Int, 48(2), 390-401.
- AUTOREGENERATION OF HUMAN PROXIMAL TUBULAR CELLS MEDIATED BY A HYPOXIA-INDUCIBLE ENDOTHELIN-1 (ET-1) GROWTH LOOP. J AM SOC NEPHROL, 5(3), 699-699.
- Human tubular-derived endothelin in the paracrine regulation of renal interstitial fibroblast function.. Exp Nephrol, 2(2), 134.
- HUMAN TUBULAR-DERIVED ENDOTHELIN IN THE PARACRINE REGULATION OF RENAL INTERSTITIAL FIBROBLAST FUNCTION. EXP NEPHROL, 2(2), 134-134.
- . Kidney Int, 45(2), 345-351.
- . Kidney Int, 45(3), 753-762.
- . Am J Kidney Dis, 23(2), 205-209.
- . Nephrol Dial Transplant, 9(5), 471-472.
- . Kidney Int, 46(5), 1315-1321.
- . Eur J Clin Invest, 23(5), 259-265.
- . Nephrol Dial Transplant, 8(8), 748-753.
- ISOLATION OF THE NA+/H+ ANTIPORTER GENE EXPRESSED IN HUMAN PROXIMAL TUBULE CELLS. DIABETOLOGIA, 35, A56-A56.
- TUBERCULOUS PERITONITIS COMPLICATING PERITONEAL-DIALYSIS - A CASE FOR EARLY DIAGNOSTIC LAPAROTOMY. NEPHROL DIAL TRANSPL, 7(5), 443-446.
- Tuberculous peritonitis complicating peritoneal dialysis: a case for early diagnostic laparotomy?. Nephrol Dial Transplant, 7(5), 443-446.
- . Clin Endocrinol (Oxf), 34(1), 43-49.
- . Int J Cardiol, 30(3), 364-366.
- Effects of noradrenaline infusion on cardiac output and systolic time intervals derived from electrical bioimpedance cardiography. British Journal of Clinical Pharmacology, 29(5).
- EFFECTS OF NORADRENALINE INFUSION ON CARDIAC-OUTPUT AND SYSTOLIC-TIME INTERVALS DERIVED FROM ELECTRICAL BIOIMPEDANCE CARDIOGRAPHY. BRIT J CLIN PHARMACO, 29(5), P639-P640.
- . Eur Heart J, 11(4), 368-371.
- . Nephrol Dial Transplant, 5(10), 904-905.
- . Postgrad Med J, 65(767), 660-661.
- . J Hypertens Suppl, 7(6), S166-S167.
- . Int J Cardiol, 21(1), 71-73.
- . Nephrology Dialysis Transplantation.
Book chapters
- , Oxford Textbook of Clinical Nephrology (pp. 2625-2626). Oxford University Press
- , Oxford Textbook of Clinical Nephrology (pp. 2627-2633). Oxford University Press
- , Genomic Medicine (pp. 369-392). Oxford University Press
- , Pathologies of Calcium Channels (pp. 491-522). Springer Berlin Heidelberg
- , Genomics and Clinical Medicine (pp. 195-212). Oxford University PressNew York, NY
- , Medicine and Surgery (pp. xi-xii). Elsevier
Conference proceedings
- . Clinical Kidney Journal, Vol. 18(7)
- A Polycystin-1-Bicaudal C1 complex regulates focal adhesion function through integrin beta-1, F-actin organisation and local translation in HKE cells. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 39 (pp I219-I219)
- . Abstracts (pp A86.1-A86)
- Patients with polcystic liver disease have longer waiting times but better clinical outcomes following liver transplantation in the UK. JOURNAL OF HEPATOLOGY, Vol. 77 (pp S814-S814)
- THE INTERACTION OF GENDER AND GENOTYPE IN THE DEVELOPMENT OF POLYCYSTIC LIVER DISEASE IN ADPKD. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 37 (pp I7-I7)
- FAMILIAL CLUSTERING OF A RARE UMOD VARIANT IN UNDIAGNOSED HEREDITARY NEPHROPATHY SUGGESTS THE PRESENCE OF A COMMON ANCESTRAL FOUNDER MUTATION. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 37 (pp I14-I15)
- . Nephrology Dialysis Transplantation, Vol. 36(Supplement 1) (pp i102). Berlin, Germany, 5 June 2021 - 5 June 2021.
- . Kidney International Reports, Vol. 5(3) (pp S185-S185). Abu Dhabi, United Arab Emirates, 26 March 2020 - 29 March 2020.
- REDUCED QUALITY OF LIFE IN ADPKD PATIENTS WITH CKD STAGE 1-3: THE CYSTIC I QUALITY OF LIFE STUDY. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 35 (pp 98-98)
- . Nephrology Dialysis Transplantation, Vol. 34 (pp i335). Budapest, Hungary, 14 June 2019 - 14 June 2019.
- . Nephrology Dialysis Transplantation, Vol. 34(Supplement 1) (pp i39). Budapest, Hungary, 13 June 2019 - 13 June 2019.
- . Ultraschall in der Medizin, Vol. 39(S01) (pp 34-35). Basel, Switzerland, 14 November 2018 - 14 November 2018.
- PATIENT AND CAREGIVER BELIEFS, ATTITUDES AND PERSPECTIVES ON GENETIC SCREENING AND TESTING FOR AUTOSOMAL POLYCYSTIC KIDNEY DISEASE. NEPHROLOGY, Vol. 23 (pp 88-88)
- VERY EARLY-ONSET AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE DUE TO BI-ALLELIC MUTATIONS IN PKD1 AND PKD2. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 32 (pp 94-94)
- . Nephrology Dialysis Transplantation, Vol. 31 (pp 22-22). Vienna, Austria
- . Biophysical Journal, Vol. 110(3) (pp 611a-612a)
- SELECTIVE PROSTAGLANDIN E2 RECEPTOR BLOCKADE FOR THE TREATMENT OF AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 31 (pp 22-23)
- . Nephrology Dialysis Transplantation, Vol. 30(suppl_3) (pp iii85-iii86)
- INCREASED PSYCHOSOCIAL BURDEN AND ADVERSE QUALITY OF LIFE IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 30
- . NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 30
- DEVELOPMENT OF A MODEL TO PREDICT DISEASE PROGRESSION IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE (ADPKD). NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 29 (pp 75-75)
- . HEART, Vol. 97(20) (pp 12-12)
- Molecular genetic basis of inherited thrombocytopenia. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol. 7 (pp 342-342)
- Regulation of polycystin-1 mediated intercellular adhesion by phosphorylation in renal epithelia cells. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol. 14 (pp 575A-575A)
- A Ca2+-activated conductance in cultured mouse collecting duct cells.. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol. 14 (pp 80A-80A)
- Upregulation of polycystin-2 expression following experimental ischaemic renal injury.. J AM SOC NEPHROL, Vol. 13 (pp 113A-113A)
Preprints
- , eLife Sciences Publications, Ltd.
- , eLife Sciences Publications, Ltd.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Springer Science and Business Media LLC.
- Research group
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- Dr Andrew Streets
- Dr Manoj Valluru
- Dr Rebecca Walker
- Dr Joshua Griffiths
- Dr Matthew Gittus
- Mr Patryk Zarecki
- Ms Monica Neilan
- Mr Carl Wright
- Teaching activities
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I have had a long-standing commitment to postgraduate nephrology training especially to develop clinical and non-clinical academics in renal science and in enhancing nephrology training for young nephrologists for the developing ‘two-thirds’ world.
I was appointed Deputy Director for Clinical Academic Training at Sheffield (2020-2023), having served as Academic Programme Director for Nephrology (2013-2022). I was a member of the ISN Fellowship Committee (2019-2023), the Scientific Advisory Board of the ERA (2016-2022) and served on the UK Renal Association Executive committee as Chair of the International Committee (2009-2013).
- Professional activities and memberships
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National and International Committees
- European Renal Association – Council member (2021-2025)
- European Renal Association - Scientific Program Chair 61st ERA Congress 2024
- MRC-NIHR Renal Ciliopathies National Network – Co-Director
- CYSTic Consortium – Chief investigator
- ADPKD in Europe Consortium - Co-chair
- European ADPKD Forum – Faculty member
Editorial Boards
- Theme Editor, Nephrology Dialysis Transplantation
- Faculty of 1000 Medicine, Nephrology faculty
Advisory Boards
- Mayo Translational PKD Centre, Mayo Clinic, Rochester - External Faculty
- Renal Genomic England Clinical Interpretation Partnership (GeCIP) – Co-chair for Cystic Diseases (2017-2023)
- National Institute for Clinical Excellence (NICE) Technology Appraisal of Tolvaptan for ADPKD - Nominated Clinical Expert (2013-2015)
National and International Guidelines
- UK Kidney Association Working Group for Tolvaptan in ADPKD – Chair
- Kidney Diseases Improving Global Outcomes (KDIGO) ADPKD Guideline Initiative – Working group and Theme lead (2020-2025)
- Standardised Outcomes in Nephrology–PKD (SONG-PKD) – Steering committee