Professor Kate Ren

BSc (York), MPhil (Cantab), PhD (Sheffield)

School of Medicine and Population Health

Professor of Statistical Health Technology Assessment

s.ren@sheffield.ac.uk
+44 114 222 0696
Regent Court (ScHARR)

Full contact details

Professor Kate Ren
School of Medicine and Population Health
Regent Court (ScHARR)
30 Regent Street
Sheffield
S1 4DA
Profile

I joined SCHARR in 2011 after completing a PhD in Probability and Statistics, specialising in Bayesian methods in clinical trial design at the University of Sheffield. My expertise lies in the development and application of Bayesian methods in Health Technology Assessment. My research interests include evidence synthesis methods (in particular indirect treatment comparisons with single-arm trials), survival extrapolation and structured expert elicitation.

I work as a member of SCHARR-TAG (an external assessment group for NICE technology appraisals). I have extensive experience in critiquing statistical methods used in NICE single technology appraisal submissions. I am also a member of NICE Appraisal Committee C.

I am an NIHR Advanced Fellow, currently working on a project titled “Improving the robustness of health technology funding decisions when evidence is from single-arm trials”.

Research interests
  • Network meta-analysis
  • Indirect treatment comparisons
  • Population-adjusted indirect comparisons
  • Survival extrapolation
  • Structured expert elicitation
  • Bayesian statistics in clinical trials and health economics
Publications

Show: Featured publications All publications

Journal articles

  • Ren S, Squires H, Hock E, Kaltenthaler E, Rawdin A & Alifrangis C (2019) . PharmacoEconomics, 37(9), 1073-1080.
  • Pennington B, Ren S, Barton S, Bacelar M & Edwards SJ (2019) . PharmacoEconomics, 37(8), 985-993.
  • Ren S, Bermejo I, Simpson E, Wong R, Scott D, Young A & Stevenson M (2018) . PharmacoEconomics, 36, 769-778.
  • Ren S, Oakley JE & Stevens JW (2018) . Medical Decision Making, 38(4), 531-542.
  • Ren S, Minton J, Whyte S, Latimer N & Stevenson M (2017) . Value in Health, 20(9), a758-a758.
  • Bojke L, Manca A, Asaria M, Mahon R, Ren S & Palmer S (2017) . PharmacoEconomics, 35(8), 767-776.
  • Jackson C, Stevens J, Ren S, Latimer N, Bojke L, Manca A & Sharples L (2017) . Medical Decision Making, 37(4), 377-390.
  • Pandor A, Thokala P, Goodacre S, Poku E, Stevens JW, Ren S, Cantrell A, Perkins GD, Ward M & Penn-Ashman J (2015) . Health Technology Assessment, 19(42), 1-102.
  • Ren S & Oakley JE (2014) . Statistics in Medicine, 33(1), 31-45.

All publications

Journal articles

  • Harnan S, Navega Biz A, Hamilton J, Whyte S, Simpson E, Ren S, Cooper K, Clowes M, Abulafi M, Ball A , Benton SC et al (2025) . Health Technology Assessment, 29(46).
  • Goodacre S, Pandor A, Thokala P, Ren S, Essat M, Ren S, Clowes M, Cooper G, Hinchliffe R, Reed M , Thomas S et al (2025) . Health Technology Assessment, 29(45), 1-36.
  • Simpson E, Carroll C, Sutton A, Forsyth J, Rayner A, Ren S, Franklin M & Wood E (2025) . British Journal of Psychology.
  • Woods B, Kearns B, Schmitt L, Jankovic D, Rothery C, Harnan S, Hamilton J, Scope A, Ren S, Bojke L , Wilcox M et al (2025) . Applied Health Economics and Health Policy, 23(4), 753-754.
  • Breeze P, Pidd K, Pollard D, Ren S, Bates S, Thomas C, Ahern A, Griffin S & Brennan A (2025) . International Journal of Obesity, 49(8), 1598-1607.
  • Ren S, Ren S, Welton NJ & Strong M (2025) . Research Synthesis Methods, 16(3), 509-527.
  • (2025) OP15 Cost-Effectiveness Of Quantitative Fecal Immunochemical Tests For Detecting Suspected Colorectal Cancer In The Context Of Colonoscopy Capacity Constraints. International journal of technology assessment in health care, 40(Suppl 1), S7-S7.
  • (2025) PP09 Fecal Immunochemical Tests For Patients With Symptoms Suggestive Of Colorectal Cancer: A Systematic Review And Multiple-Threshold Meta-Analysis. International journal of technology assessment in health care, 40(Suppl 1), S56-S57.
  • Harnan S, Hamilton J, Simpson E, Clowes M, Navega Biz A, Whyte S, Ren S, Cooper K, Abulafi M, Ball A , Beton S et al (2025) . Colorectal Disease, 27(1).
  • Woods B, Kearns B, Schmitt L, Jankovic D, Rothery C, Harnan S, Hamilton J, Scope A, Ren S, Bojke L , Wilcox M et al (2025) . Applied Health Economics and Health Policy, 23(1), 5-17.
  • Harnan S, Hamilton J, Simpson E, Clowes M, Biz AN, Whyte S, Ren S, Cooper K, Ball A, Benton S , Carten R et al (2024) . International Journal of Technology Assessment in Health Care, 40(S1), S56-S57.
  • Biz AN, Stevenson M, Whyte S, Hamilton J, Ren S, Heathcote L, Simpson E, Cooper K, Clowes M, Ball A , Benton S et al (2024) . International Journal of Technology Assessment in Health Care, 40(S1), S7-S7.
  • Harnan S, Hamilton J, Simpson E, Clowes M, Biz AN, Whyte S, Ren K, Cooper K, Abulafi M, Ball A , Benton S et al (2024) . Value in Health, 27(12).
  • Forsyth J, Wong R & Ren K (2024) . Value in Health, 27(12), S620-S620.
  • Forsyth J, Mitra S, Wong R, Srivastava T & Ren K (2024) . Value in Health, 27(12), S375-S375.
  • Ren K & Forsyth J (2024) . Value in Health, 27(12), S636-S636.
  • Grand T, Thokala P, Ren K, Regnier S, Oudin Åström D, Awad SF, Bidani A & Krismer PF (2024) . Value in Health, 27(12), S120-S120.
  • Combe E, Jones D, Knight H, Laskier V, Ren K, Wright T, Böing EA & Trivedi P (2024) . Value in Health, 27(12), S39-S39.
  • Wheat H, Ren K & Stevenson MD (2024) . Value in Health, 27(12), S449-S449.
  • Knowles M, Kroep S & Ren K (2024) . Value in Health, 27(12), S480-S480.
  • Harnan S, Kearns B, Scope A, Schmitt L, Jankovic D, Hamilton J, Srivastava T, Hill H, Ku CC, Ren S , Rothery C et al (2024) . Health Technology Assessment, 28(73).
  • Shah B, Challagulla S, Xu S, Williams R, Ren S, Srivastava T, Gautam R & Yang K (2024) . Clinical Lymphoma Myeloma and Leukemia, 24, S516-S517.
  • Shah B, Challagulla S, Xu S, Williams R, Ren S, Srivastava T, Gautam R & Yang K (2024) . Clinical Lymphoma Myeloma and Leukemia, 24, S227-S227.
  • Ren S, Essat M, Pandor A, Goodacre S, Ren S, Clowes M, Bima P, Toyofuku M, McLatchie R & Bossone E (2024) . PLOS ONE, 19(6).
  • Essat M, Goodacre S, Pandor A, Ren S, Ren S & Clowes M (2024) . Annals of Emergency Medicine, 84(4), 409-421.
  • Srivastava T, Gupta A, Gautam R, Hriday K & Ren S (2024) . Value in Health, 27(6), S403-S404.
  • Woods B, Schmitt L, Jankovic D, Kearns B, Scope A, Ren S, Srivastava T, Ku CC, Hamilton J, Rothery C , Bojke L et al (2024) . Health Technology Assessment, 28(28), 1-238.
  • Grand TS, Ren S, Hall J, Åström DO, Regnier S & Thokala P (2024) . PharmacoEconomics, 42(6), 619-631.
  • Ren S, Ren S, Welton NJ & Strong M (2024) . Research Synthesis Methods, 15(4), 657-670.
  • Dunnewind N, Ainsworth C, Ren S & Kroep S (2023) . Value in Health, 26(12), S557-S557.
  • Ren S & Ren S (2023) . Value in Health, 26(12), S424-S424.
  • Metry A, Pandor A, Ren S, Shippam A, Clowes M, Dark P, McMullan R & Stevenson M (2023) . Health Technology Assessment, 27(14).
  • Zhu D, Ren S, Mills K, Hull J & Dhariwal M (2023) . Ophthalmology and Therapy, 12(2), 1157-1171.
  • Thokala P, Srivastava T, Smith R, Ren S, Whittington MD, Elvidge J, Wong R & Uttley L (2023) . PharmacoEconomics, 41(3), 227-237.
  • Duro EM, Julious SA & Ren S (2022) . BMC Medical Research Methodology, 22(1).
  • Mandrik O, Fotheringham J, Ren S, Tice JA, Chapman RH, Stevenson MD, Pearson SD, Herron-Smith S, Agboola F & Thokala P (2022) . Clinical Journal of the American Society of Nephrology, 17(3), 385-394.
  • Thokala P, Fuller GW, Goodacre S, Keating S, Herbert E, Perkins GD, Rosser A, Gunson I, Miller J, Ward M , Bradburn M et al (2021) . BMC Emergency Medicine, 21.
  • Thokala P, Stevenson M, Kumar VM, Ren S, Ellis AG & Chapman RH (2020) . Cost Effectiveness and Resource Allocation, 18.
  • Leaviss J, Davis S, Ren S, Hamilton J, Scope A, Booth A, Sutton A, Parry G, Buszewicz M, Moss-Morris R & White P (2020) . Health Technology Assessment, 24(46).
  • Hart R, Burns D, Ramaekers B, Ren S, Gladwell D, Sullivan W, Davison N, Saunders O, Sly I, Cain T & Lee D (2020) . PharmacoEconomics, 38, 765-776.
  • Kearns B, Stevens J, Ren S & Brennan A (2020) . PharmacoEconomics, 38(2), 193-204.
  • Ren S, Squires H, Hock E, Kaltenthaler E, Rawdin A & Alifrangis C (2019) . PharmacoEconomics, 37(9), 1073-1080.
  • Laskier V, Guy H, Fisher M, Neuman WR, Bucior I, Cohen AT & Ren S (2019) . Journal of Medical Economics, 22(10), 1063-1072.
  • Pennington B, Ren S, Barton S, Bacelar M & Edwards SJ (2019) . PharmacoEconomics, 37(8), 985-993.
  • Simpson EL, Ren S, Hock ES, Stevens JW, Binard A, Pers Y-M, Archer R, Paisley S, Stevenson MD, Herpin C & Ghabri S (2019) . International Journal of Technology Assessment in Health Care, 35(1), 36-44.
  • Uttley L, Bermejo I, Ren S, Martyn-St James M, Wong R, Scott DL, Young A & Stevenson M (2018) . Pharmacoeconomics, 36(9), 1063-1072.
  • Ren S, Bermejo I, Simpson E, Wong R, Scott D, Young A & Stevenson M (2018) . PharmacoEconomics, 36, 769-778.
  • Bermejo I, Ren S, Simpson E, Clowes M, Scott DL, Young A & Stevenson M (2018) . Pharmacoeconomics, 36(12), 1427-1437.
  • Ren S, Oakley JE & Stevens JW (2018) . Medical Decision Making, 38(4), 531-542.
  • Ren S, Minton J, Whyte S, Latimer N & Stevenson M (2017) . Value in Health, 20(9), a758-a758.
  • Sadler S, Holmes M, Ren S, Holden S, Jha S & Thokala P (2017) . BJGP Open, 1(3).
  • Uttley L, Whyte S, Gomersall T, Ren S, Wong R, Chambers D & Tappenden P (2017) . PharmacoEconomics , 35(7), 717-726.
  • Bojke L, Manca A, Asaria M, Mahon R, Ren S & Palmer S (2017) . PharmacoEconomics, 35(8), 767-776.
  • Jackson C, Stevens J, Ren S, Latimer N, Bojke L, Manca A & Sharples L (2017) . Medical Decision Making, 37(4), 377-390.
  • Cooper KL, Martyn-St James M, Kaltenthaler E, Dickinson K, Cantrell A, Ren S, Wylie K, Frodsham L & Hood C (2017) . Sexual Medicine, 5(1), e1-e18.
  • James MM-S, Cooper K, Ren S, Kaltenthaler E, Dickinson K, Cantrell A, Wylie K, Frodsham L & Hood C (2017) . European Urology Focus, 3(1), 119-129.
  • Tappenden P, Harnan S, Ren S, Thokala P, Wong R, Mukuria C, Green C, Pledge S & Tidy J (2016) . PharmacoEconomics.
  • Tappenden P, Ren S, Archer R, Harvey R, Martyn-St James M, Basarir H, Stevens J, Lobo A & Hoque S (2016) . PharmacoEconomics, 34(10), 1023-1038.
  • Morrell CJ, Sutcliffe P, Booth A, Stevens J, Scope A, Stevenson M, Harvey R, Bessey A, Cantrell A, Dennis CL , Ren S et al (2016) . Health Technology Assessment , 20(37).
  • Archer R, Tappenden P, Ren S, Martyn-St James M, Harvey R, Basarir H, Stevens J, Carroll C, Cantrell A, Lobo A & Hoque S (2016) . Health Technoogyl Assessment, 20.
  • Martyn-St James M, Cooper K, Ren K, Kaltenthaler E, Dickinson K, Cantrell A, Wylie K, Frodsham L & Hood C (2016) . Sexual Health, 13(2), 114-123.
  • Essat M, Tappenden P, Ren S, Bessey A, Archer R, Wong R, Lobo A & Hoque S (2015) . Pharmacoeconomics.
  • Pandor A, Thokala P, Goodacre S, Poku E, Stevens JW, Ren S, Cantrell A, Perkins GD, Ward M & Penn-Ashman J (2015) . Health Technology Assessment, 19(42), 1-102.
  • Goodacre S, Stevens JW, Pandor A, Poku E, Ren S, Cantrell A, Bounes V, Mas A, Payen D, Petrie D , Roessler MS et al (2014) . Academic Emergency Medicine, 21(9), 960-970.
  • Carroll C, Hummel S, Leaviss J, Ren S, Stevens JW, Cantrell A & Michaels J (2014) . Br J Surg, 101(9), 1040-1052.
  • Leaviss J, Sullivan W, Ren S, Everson-Hock E, Stevenson M, Stevens JW, Strong M & Cantrell A (2014) . Health Technol Assess, 18(33), 1-120.
  • Ren S & Oakley JE (2014) . Statistics in Medicine, 33(1), 31-45.
  • Leaviss J, Hummel S, Carroll C, Ren S, Stevens JW, Everson-Hock E, Cantrell A, Stevenson M & Michaels J (2014) Clinical and cost-effectiveness of minimally invasive techniques for the treatment of varicosis: Systematic review and economic evaluation. Vasomed, 26(4), 210-211.
  • Uttley L, Kearns B, Ren S & Stevenson M (2013) . Pharmacoeconomics, 31(11), 981-990.
  • Carroll C, Hummel S, Leaviss J, Ren S, Stevens JW, Everson-Hock E, Cantrell A, Stevenson M & Michaels J (2013) . Health Technol Assess, 17(48), i-141.
  • Shah B, Challagulla S, Xu S, Williams R, Ren S, Srivastava T, Gautam R, Yang K, Saba NS & Tam CS () . Leukemia & Lymphoma, 1-11.
  • Harnan S, Ren S, Gomersall T, Everson-Hock ES, Sutton A, Dhanasiri S & Kulasekararaj A () . Acta Haematologica, 136(1), 23-42.

Conference proceedings

  • Goodacre S, Ren S, Essat M, Pandor A, Ren S, Clowes M, Bima P, Toyofuku M, McLatchie R, Bossone E & Wilson S (2024) . RCEM Annual Scientific Conference 2024 Abstracts (pp A9.1-A9)
  • Combe E, Jones D, Knight H, Laskier V, Ren K, Wright T, Boing EA & Trivedi P (2024) COMPARATIVE EFFICACY OF ELAFIBRANOR AND SELADELPAR IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS: A NETWORK META-ANALYSIS. VALUE IN HEALTH, Vol. 27(12)
  • Srivastava T, Gupta A, Gautam R, Hriday K & Ren S (2024) ARE WE DEALING WITH HETEROGENEITY IN NETWORK META-ANALYSIS APPROPRIATELY? A REVIEW OF NICE SUBMISSIONS. VALUE IN HEALTH, Vol. 27(6) (pp S403-S404)
  • Shah B, Challagulla S, Xu S, Williams R, Ren S, Srivastava T, Gautam R & Yang K (2024) Indirect Comparison of Efficacy of Zanubrutinib Versus Acalabrutinib in the Treatment of Relapsed/Refractory (R/R) Mantle Cell Lymphoma (MCL). CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, Vol. 24 (pp S516-S517)
  • Ren K & Forsyth J (2024) ENHANCING EXPERT ELICITATION IN HEALTH TECHNOLOGY ASSESSMENT: PRACTICAL INSIGHTS AND RECOMMENDATIONS. VALUE IN HEALTH, Vol. 27(12)
  • Knowles M, Kroep S & Ren K (2024) COMPARATIVE EFFICACY OF TREATMENTS IN ADVANCED/METASTATIC PANCREATIC CANCER: DEMONSTRATING THE POWER OF MULTI-LEVEL NETWORK META REGRESSION. VALUE IN HEALTH, Vol. 27(12)
  • Grand T, Thokala P, Ren K, Regnier S, Astroem OD, Awad SF, Bidani A & Krismer PF (2024) USE OF DISEASE ANALOGUES TO INFORM HEALTH-ECONOMIC PARAMETERS FOR ECONOMIC EVALUATIONS OF RARE DISEASES: A CASE-STUDY OF MULTIPLE SYSTEM ATROPHY. VALUE IN HEALTH, Vol. 27(12) (pp S120-S120)
  • Forsyth J, Mitra S, Wong R, Srivastava T & Ren K (2024) CAN EXCESS HAZARD MODELS ENHANCE SURVIVAL ANALYSIS IN HEALTH TECHNOLOGY ASSESSMENTS?. VALUE IN HEALTH, Vol. 27(12) (pp S375-S375)
  • Forsyth J, Wong R & Ren K (2024) ARE WE MAKING EXPERT USE OF EXPERTS? A SCOPING REVIEW OF EXPERT ELICITATION IN SURVIVAL EXTRAPOLATION. VALUE IN HEALTH, Vol. 27(12) (pp S620-S620)
  • Wheat H, Ren K & Stevenson MD (2024) INVESTIGATING THE USE OF THE DIFFERENCE METHOD FOR SAMPLING MORE THAN TWO ORDERED VARIABLES. VALUE IN HEALTH, Vol. 27(12)
  • Dunnewind N, Ainsworth C, Ren S & Kroep S (2023) PRIORS ON BETWEEN- STUDY HETEROGENEITY IN BAYESIAN META-ANALYSIS MODELS: A SIMULATION STUDY USING HAMILTONIAN MONTE CARLO SAMPLING. VALUE IN HEALTH, Vol. 26(12) (pp S557-S557)
  • Ren S (2023) A NOVEL UNANCHORED SIMULATED TREATMENT COMPARISON APPROACH FOR TIME-TO-EVENT DATA. VALUE IN HEALTH, Vol. 26(12) (pp S424-S424)
  • Sultana N & Ren S (2022) REVIEW OF METHODS USED TO ESTIMATE TREATMENT EFFECTS AGAINST RELEVANT COMPARATORS USING EVIDENCE FROM SINGLE-ARM STUDIES IN NICE SINGLE TECHNOLOGY APPRAISALS. VALUE IN HEALTH, Vol. 25(12) (pp S10-S10)
  • Zhu D, Ren S, Mills K, Lemp-Hull J, Dhariwal M & Srivastava T (2022) RATE OF COMPLETE SPECTACLE INDEPENDENCE WITH A TRIFOCAL IOL: A SYSTEMATIC LITERATURE REVIEW AND META-ANALYSIS. VALUE IN HEALTH, Vol. 25(12) (pp S378-S378)
  • Ren S, Strong M & Welton N (2022) AN EXTENDED SIMULATED TREATMENT COMPARISON APPROACH ACCOUNTING FOR UNOBSERVED CONFOUNDING IN INDIRECT COMPARISONS FOR SINGLE-ARM TRIALS. VALUE IN HEALTH, Vol. 25(12) (pp S358-S358)
  • Thokala P, Stevenson M, Kumar VM, Ren S, Chapman R, Ellis A & Rind D (2019) . Value in Health, Vol. 22 (pp S337-S338)
  • Ren S, Oakley JE & Stevens JW (2017) . Value in Health, Vol. 20(9) (pp A770-A770)
  • Harnan S, Ren S, Gomersall T, Everson-Hock E, Sutton A, Dhanasiri S & Kulasekararaj A (2014) . Blood, Vol. 124(21) (pp 1934-1934)
  • Almond C, Stevens JW, Ren K & Batty A (2013) . Value in Health, Vol. 16(7) (pp A397-A397)

Posters

  • Zhu D, Ren S, Mills K, Lemp-Hull J, Dhariwal M & Srivastava T (2022) MT2 Rate of Complete Spectacle Independence With a Trifocal IOL: A Systematic Literature Review and Meta-Analysis.
  • Ghabri S, Simpson EL, Ren S, Hock E, Archer R, Binard A, Pers Y, Stevens JW, Herpin C & Stevenson M (2018) PMS4 - RHEUMATOID ARTHRITIS TREATED WITH SIX-MONTHS OF FIRST-LINE BIOLOGIC OR BIOSIMILAR THERAPY: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS.
  • Ren S, Oakley J & Stevens JW (2018) Evidence synthesis with limited studies. HTAi 2018, Vancouver, Canada.
  • Ren S, Oakley J & Stevens JW (2017) Evidence synthesis for health technology assessment with limited studies.. . ISPOR Glasgow 2017.
  • Goodacre S, Pandor A, Poku E, Stevens JW, Ren S & Cantrell A (2015) Pre-hospital non-invasive ventilation for acute respiratory failure: a systematic review and network meta-analysis. 999 EMS Research Forum Conference.
  • Goodacre S (2014) PRE-HOSPITAL NON-INVASIVE VENTILATION FOR ACUTE RESPIRATORY FAILURE: A SYSTEMATIC REVIEW AND NETWORK META ANALYSIS.
  • Ren S, Cooper K, Cooper J, Smith H & Shaikh S A systematic review and network meta - analysis of pharmacological therapies used for patients with advanced Parkinson's disease (2014).

Preprints

  • Leaviss J, Booth A, Coyle D, Daly G, Davis S, Dawes H, Deary V, Dwivedi K, Forsyth J, Fryer K , McCormick S et al (2025) , Cold Spring Harbor Laboratory.
  • Duro E, Julious PS & Ren S (2022) , Research Square Platform LLC.
  • Thokala P, Fuller GW, Goodacre S, Keating S, Herbert E, Perkins G, Rosser A, Gunson I, Miller J, Ward M , Bradburn M et al (2021) , Springer Science and Business Media LLC.
  • Thokala P, Fuller GW, Goodacre S, Keating S, Herbert E, Perkins G, Rosser A, Gunson I, Miller J, Ward M , Bradburn M et al (2020) , Springer Science and Business Media LLC.
  • Thokala P, Fuller GW, Keating S, Herbert E, Rosser A, Gunson I, Miller J, Ward M, Bradburn M, Marsh M & Ren K (2020) , Springer Science and Business Media LLC.
  • Ren S, Oakley JE & Stevens JW (2017) , arXiv.
Grants
  • NIHR Evidence Synthesis Group (2023-2028, £4,507,538) Co-investigator.
  • NIHR Technology Assessment Reviews (2022-2027, £6,999,908) Co-investigator.
  • NIHR Advanced Fellowship (2021-2025, £368,269) Principal investigator.
  • NIHR HTA Programme: Effectiveness of interventions for fatigue in long-term conditions (2023-2025, £332,575) Co-investigator.
  • NIHR HTA Programme: Diagnostic strategies for suspected acute aortic syndrome (2023-2024, £184,095) Co-investigator.
  • NIHR HTA Programme: Medically unexplained symptoms: primary care intervention (2015-2017, £171,405) Co-investigator.
Teaching interests

Evidence synthesis, survival analysis

 

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