Professor Joseph P.A. Harrity
School of Mathematical and Physical Sciences
Chemistry Recruitment Lead
Professor of Synthetic Organic Chemistry
Full contact details
School of Mathematical and Physical Sciences
Dainton Building
13 Brook Hill
Sheffield
S3 7HF
- Profile
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Prof. Harrity obtained his BSc (Hons.) in Chemistry from the University of Strathclyde in 1991, followed by a PhD from the same institution in 1994. He was a Postdoctoral Research Fellow at Boston College, USA from 1994 to 1997, after which he became a Lecturer at the University of Sheffield. Here he was promoted to Senior Lecturer and Reader. He was promoted to Professor in 2009.
In October 2012, Prof. Harrity was appointed to a 3 year Royal Society Industry Fellowship to undertake a collaboration with Peakdale Molecular. During this time, he worked with Peakdale to develop novel functionalised intermediates on commercially relevant scales, thereby introducing new scaffolds into their catalogue portfolio.
Awards
- Pfizer Discovery Award (2004)
- AstraZeneca Research Award (2006)
- Royal Society Industry Fellowship (2012-2015)
- RSC Bader Award (2018)
- Research interests
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Synthesis provides the opportunity to design and prepare specific molecules whilst exploring novel processes that further develop the field of organic chemistry. In this context, our programme has concentrated on new and selective carbon-carbon bond forming strategies for the preparation of functionalised synthetic Intermediates. A summary of projects currently under investigation is outlined below:
Synthesis of Heteroaromatic Boronic acid Derivatives: Aromatic boronic acids are extremely useful and versatile substrates in modern organic chemistry. We have developed a strategically novel approach to these compounds through cycloaddition reactions of alkynylboronic esters. To date, this approach has allowed us to generate a range of boronic acids based on benzene, pyridine, pyrazole, thiophene, indoles amongst others.
Natural products Synthesis: We have developed a [3 + 3] annelation approach to functionalised nitrogen and oxygen heterocycles. This chemistry has provided a platform for the synthesis of a range of alkaloid and marine natural products.
- Publications
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Journal articles
- . J Org Chem.
- . The Journal of Organic Chemistry, 90(16).
- . Chemistry – A European Journal, 30(21).
- . The Journal of Organic Chemistry, 89(3), 1552-1555.
- . Organic Letters, 25(35), 6555-6559.
- . Angewandte Chemie International Edition.
- . Chemistry – A European Journal, 28(56).
- . The Journal of Organic Chemistry, 87(15), 9764-9768.
- . Angewandte Chemie, 133(17), 9498-9501.
- . Organic Letters, 23(7), 2811-2815.
- . Angewandte Chemie International Edition, 60(17), 9412-9415.
- . Journal of Medicinal Chemistry, 64(6), 3299-3319.
- . ChemMedChem, 16(2), 328-334.
- . ChemMedChem, 15(17), 1634-1638.
- . ACS Pharmacology & Translational Science, 3(4), 706-719.
- . Synlett, 31(12), 1182-1184.
- . Scientific Reports, 10(1).
- . Chemistry – A European Journal, 26(1), 155-159.
- . Organic Letters, 21(17), 6821-6824.
- . ChemMedChem, 13(24), 2600-2600.
- . ChemMedChem, 13(24), 2618-2626.
- . Chemistry - A European Journal, 24(38), 9530-9534.
- . Organic and Biomolecular Chemistry, 16(22), 4159-4169.
- . Organic Letters, 20(1), 198-200.
- . Organic Letters, 20(1), 201-203.
- . Synlett, 29(03), 349-353.
- . Chemistry - A European Journal, 23(56).
- . Chemistry - A European Journal , 23(56), 13830-13857.
- . Tetrahedron, 73(22), 3160-3172.
- . Chemistry - A European Journal.
- . Organic and Biomolecular Chemistry, 15(7), 1575-1579.
- . Journal of Organic Chemistry, 82(3), 1688-1696.
- . Synthesis.
- . Journal of Organic Chemistry.
- . Journal of Medicinal Chemistry, 59(20), 9473-9488.
- . Chemistry - A European Journal, 22(37).
- . Chemistry - A European Journal, 22(37), 13000-13003.
- . Chemistry - A European Journal, 22(35), 12430-12438.
- . Org. Biomol. Chem..
- . Organic Letters, 18(14), 3434-3437.
- . European Journal of Organic Chemistry, 2016(16), 2789-2792.
- . Angewandte Chemie, 128(19), 5928-5930.
- . Angewandte Chemie International Edition, 55(19), 5834-5836.
- . Synlett, 27(11), 1674-1676.
- . Catalysis Science and Technology, 6(13), 4718-4723.
- . European Journal of Organic Chemistry, 2016(1), 83-86.
- . Chemistry - A European Journal, 21(41), 14342-14346.
- . Chemical Communications, 51(27), 5914-5916.
- . Journal of Organic Chemistry , 80(4), 2467-2472.
- . Chemistry - A European Journal, 21(8), 3257-3263.
- . Organic Letters, 17(2), 390-392.
- . Chemistry - A European Journal, 21(6), 2701-2704.
- . Chemistry - A European Journal, 20(40), 12889-12893.
- . J Am Chem Soc, 136(24), 8642-8653.
- . Org Biomol Chem, 12(20), 3201-3210.
- . Tetrahedron Letters, 55(6), 1255-1257.
- . Chem Commun (Camb), 50(21), 2735-2737.
- . Org Lett, 15(16), 4222-4225.
- . Tetrahedron Letters.
- . J Org Chem, 78(8), 4049-4064.
- . Tetrahedron.
- . Org Biomol Chem, 10(45), 9058-9066.
- . Org Lett, 14(20), 5354-5357.
- . Org Lett, 14(18), 4858-4861.
- Investigation of the Origins of Regiochemical Control in [4+2] Cycloadditions of 2-Pyrones and Alkynylboronates. Synthesis, 44.
- . Angewandte Chemie, 124(26), 6508-6511.
- . Angew Chem Int Ed Engl, 51(26), 6402-6405.
- . Chem Commun (Camb), 47(35), 9804-9806.
- Regioselectivity studies of sydnone cycloaddition reactions of azine-substituted alkynes. Tetrahedron Letters.
- . Tetrahedron Letters, 52(13), 1506-1508.
- . Angewandte Chemie, 123(12), 2821-2824.
- . Angew Chem Int Ed Engl, 50(12), 2769-2772.
- On the use of 2-(trimethylsilyl)iodobenzene as a benzyne precursor. Tetrahedron Letters.
- . Chem Commun (Camb), 46(46), 8770-8772.
- . Org Lett, 12(21), 4832-4835.
- . Chem Commun (Camb), 46(28), 5154-5156.
- . J Org Chem, 75(11), 3893-3896.
- . Tetrahedron, 66(3), 553-568.
- . J Org Chem, 75(3), 984-987.
- . Org Lett, 12(1), 160-163.
- . Tetrahedron Letters, 50(39), 5539-5541.
- . Org Biomol Chem, 7(19), 4052-4056.
- . J Am Chem Soc, 131(22), 7762-7769.
- . Synthesis(1), 133-137.
- . J Org Chem, 74(1), 396-400.
- . Chem Commun (Camb)(4), 436-438.
- . Synlett(17), 2647-2650.
- . Tetrahedron, 64(13), 2951-2961.
- . J Org Chem, 73(5), 1946-1953.
- . Org Lett, 10(5), 781-783.
- . Tetrahedron, 64(5), 767.
- . Tetrahedron, 64(5), 866-873.
- . J Org Chem, 73(3), 1128-1130.
- . Angewandte Chemie, 119(45), 8810-8812.
- . Angew Chem Int Ed Engl, 46(45), 8656-8658.
- . Synlett(18), 2885-2887.
- . Org Lett, 9(20), 3941-3943.
- . Tetrahedron Letters, 48(24), 4165-4168.
- . Tetrahedron, 63(15), 3081-3092.
- . J Org Chem, 72(9), 3467-3477.
- . J Am Chem Soc, 129(9), 2691-2699.
- . Beilstein J Org Chem, 3, 8.
- . Org Lett, 8(24), 5597-5600.
- . Org Biomol Chem, 4(23), 4278-4280.
- . Synlett(14), 2272-2274.
- . Chem Commun (Camb)(31), 3323-3325.
- . Org Lett, 8(14), 3089-3091.
- Highly substituted pyridazines (Angew. Chem. Int. Ed 2005, 44, 3889). LETT ORG CHEM, 3(2), 78-78.
- . Tetrahedron Letters, 47(3), 331-333.
- . J Org Chem, 70(24), 10046-10056.
- . Tetrahedron, 61(28), 6707-6714.
- . Org Lett, 7(14), 2993-2996.
- . Angewandte Chemie, 117(25), 3957-3960.
- . Angew Chem Int Ed Engl, 44(25), 3889-3892.
- . Org Biomol Chem, 3(8), 1349-1358.
- . Synlett(5), 860-862.
- . J Org Chem, 70(1), 207-213.
- . Tetrahedron, 60(40), 8869-8880.
- . Tetrahedron Letters, 45(16), 3189-3191.
- . Synlett(1), 140-142.
- . Org Biomol Chem, 2(1), 8-23.
- . Org Lett, 5(19), 3427-3429.
- . J Org Chem, 68(11), 4392-4399.
- . J Org Chem, 68(11), 4286-4292.
- . Tetrahedron Letters, 43(44), 7851-7854.
- . Angewandte Chemie, 114(14), 2696-2699.
- . Angew Chem Int Ed Engl, 41(14), 2584-2587.
- . Chem Commun (Camb)(14), 1542-1543.
- . Chem Commun (Camb)(14), 1546-1547.
- . Acta Crystallogr C, 58(Pt 3), o168-o169.
- . Synlett(12), 2071-2073.
- . Tetrahedron Letters, 42(51), 9055-9057.
- . J Org Chem, 66(10), 3525-3532.
- . Synlett(10), 1596-1598.
- . Chem Commun (Camb)(17), 1558-1559.
- . Chemical Communications(12), 1035-1036.
- . Chemical Communications(20), 2107-2108.
- . Tetrahedron Letters, 40(17), 3481-3484.
- . Tetrahedron Letters, 40(16), 3247-3250.
- . Journal of the American Chemical Society, 121(4), 791-799.
- Preparation, characterization, and metathesis activity of a novel, recyclable ruthenium alkylidene complex.. ABSTR PAP AM CHEM S, 216, U393-U393.
- . Journal of the American Chemical Society, 120(10), 2343-2351.
- . Journal of Organometallic Chemistry, 532(1-2), 219-227.
- . Journal of the American Chemical Society, 119(6), 1488-1489.
- . Angewandte Chemie International Edition in English, 35(15), 1668-1671.
- . Journal of the American Chemical Society, 118(15), 3779-3780.
- . Synlett, 1996(12), 1184-1186.
- . Tetrahedron Letters, 34(18), 2995-2998.
- . Tetrahedron, 49(25), 5565-5576.
- . Angewandte Chemie.
- . Molecules, 19(12), 21324-21334.
Conference proceedings
- Pd-catalyzed synthesis of highly functionalized piperidines. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 254
Patents
- WO2018211275 - COMPOUNDS. Appl. 22 Nov 2018.
- Aminoalkylimidazole Derivatives and their use in Medicine. Appl. 01 Jan 1970.
- Teaching interests
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Organic Chemistry
- Teaching activities
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Undergraduate and postgraduate taught modules
- Introduction to organic synthesis 2 (Level 2)
This lecture course will discuss the α-functionalisation of carbonyl derivatives and related compounds. Specifically, alkylation and acylation reactions will be introduced and their applications in synthesis described. Simple examples highlighting chemoselective oxidation and reduction processes will also be discussed. - Aromatics in Synthesis (Level 3)
This course explores the react - Stereoselective Synthesis (Level 4)
This module gives a broad overview on current methods for controlling stereochemistry in organic synthesis. Key concepts in controlling relative and absolute stereochemistry will be introduced and illustrated.
Support Teaching:
- Tutorials: Level 1 General Chemistry.
Laboratory Teaching:
- Level 2 Organic Laboratories
- Level 3 Organic Laboratories
- Level 4 Research Project
- Introduction to organic synthesis 2 (Level 2)