Professor Jim A. Thomas
School of Mathematical and Physical Sciences
Professor of Bio-inorganic Chemistry
Full contact details
School of Mathematical and Physical Sciences
Dainton Building
13 Brook Hill
Sheffield
S3 7HF
- Profile
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Prof. Thomas obtained a BSc in Chemistry from the University of Reading in 1982 and a PhD from the University of Birmingham in 1993. After his PhD he became a Royal Society European Exchange Fellow at the Universite Louis Pasteur in Strasbourg in 1993, followed by a postdoctoral fellowship at the University of Sheffield in 1994. In 1995 he was appointed as a Royal Society University Research Fellow.
In 2004 he was appointed lecturer and promoted to senior lecturer (2007), reader (2010), and professor (2015).
- Qualifications
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- PGCE (1983)
- Research interests
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My group is particularly interested in using photochemically and/or electrochemically active metal centres to produce functional molecular architectures. Most of our work is inspired in some way by biological systems. For example, by using a combination of hydrogen and coordination bonding we are investigating the metal-ion directed self-assembly of hosts and sensors for anions, bioanions and biomolecules.
Using a similar approach we are creating hosts that function as molecular devices such as ion-gated switches. Finally, we are very interested at the way oligonuclear luminescent coordination complexes interact with biomolecules such as DNA. This work includes in cellulo studies aimed at identifying new optical imaging probes with multiple output modalities and also potential novel therapeutic leads.
- Publications
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Journal articles
- . Nat Rev Chem.
- . Dalton Transactions.
- . Dalton Transactions, 54(20), 8241-8250.
- . ACS Infectious Diseases, 10(9), 3346-3357.
- . Journal of the American Chemical Society, 146(18), 12836-12849.
- . Dalton Transactions, 53(17), 7282-7291.
- . Journal of Medicinal Chemistry, 66(10), 6922-6937.
- . Chemistry A European Journal, 29(34).
- . Acta Crystallographica Section E Crystallographic Communications, 79(4), 356-360.
- . Chemistry A European Journal, 29(11).
- . RSC Medicinal Chemistry, 14(1), 65-73.
- . Chemical Society Reviews, 51(24), 9882-9916.
- . Angew Chem Weinheim Bergstr Ger, 134(27), e202117449.
- . Angewandte Chemie International Edition, 61(27).
- . Chemistry A European Journal, 28(5).
- . Journal of the American Chemical Society, 143(48), 20442-20453.
- . Angewandte Chemie (German Edition), 133(38), 21120-21127.
- . Angewandte Chemie International Edition, 60(38), 20952-20959.
- . Environmental Technology Reviews, 10(1), 213-223.
- . ACS Pharmacology & Translational Science, 4(1), 168-178.
- . Materials Chemistry Frontiers, 5(3), 1268-1282.
- . Chemical Science, 12(10), 3768-3785.
- . Chemical Science, 11(33), 8936-8944.
- . Chemical Science, 11(33), 8828-8838.
- . Chemical Science, 11(33), 8928-8935.
- . Chemical Communications, 56(57), 7945-7948.
- . Journal of the American Chemical Society, 142(10), 4639-4647.
- . CHEMICAL SCIENCE, 11(9), 2566-2566.
- . Chemical Communications, 56(10), 1464-1480.
- . Journal of the American Chemical Society, 142(2), 1101-1111.
- . Chemical Science.
- . ACS Nano, 13(5), 5133-5146.
- . Chemical Science, 10(12), 3502-3513.
- . Journal of the American Chemical Society, 141(11), 4644-4652.
- . Journal of the American Chemical Society, 141(7), 2925-2937.
- . Chemical Communications, 55(4), 521-524.
- . Bioconjugate Chemistry, 29(11), 3532-3543.
- . Crystal Growth and Design, 18(11), 7199-7206.
- . Dalton Transactions, 47(35), 12300-12307.
- . Nanoscale, 10(22), 10596-10608.
- . Chemical Communications, 54(30), 3735-3738.
- . Dalton Transactions, 47(14), 4931-4940.
- . Chemical Communications, 54(15), 1849-1852.
- . Chemical Science, 9(4), 841-849.
- . Analytical Chemistry, 89(22), 12087-12093.
- . Journal of the American Chemical Society, 139(44), 15907-15913.
- . Chemical Communications, 94(53), 12672-12675.
- . Angewandte Chemie, 129(41), 12802-12807.
- . New Journal of Chemistry , 41(14), 6911-6921.
- . Chemistry - A European Journal, 23(23), 5389-5389.
- . Dalton Transactions, 46, 6634-6644.
- . Dalton Transactions, 46(18).
- . Chemistry - A European Journal, 23(23), 5467-5477.
- . Chemistry - A European Journal, 22(17), 5996-6000.
- . Chemistry A European Journal, 22(9), 3139-3147.
- . Chemistry A European Journal, 21(33), 11865-11871.
- . Chemistry A European Journal, 21(39), 13723-13731.
- . ACS Applied Materials and Interfaces, 7(33), 18707-18716.
- . Chemical Society Reviews, 44(14), 4494-4500.
- . Chemistry - A European Journal, 21(25), 9185-9197.
- . Chemical Science, 6(7), 4373-4374.
- . Angewandte Chemie International Edition, 54(10), 3000-3003.
- . Angewandte Chemie, 127(10), 3043-3046.
- . Chemical Science, 6(2), 1334-1340.
- . Chemistry - A European Journal, 20(43), 14004-14011.
- . Angew Chem Int Ed Engl, 53(13), 3367-3371.
- . Chem Commun (Camb), 50(29), 3859-3861.
- . Chemistry - A European Journal.
- . J Med Chem, 56(21), 8674-8683.
- . Chemical Science.
- . Chemistry, 19(16), 5081-5087.
- . Angewandte Chemie, 124(48), 12273-12276.
- . Angew Chem Int Ed Engl, 51(48), 12107-12110.
- . Inorg Chem, 51(20), 10483-10494.
- . Coordination Chemistry Reviews.
- . ChemInform, 43(30).
- . Chem Soc Rev, 41(8), 3179-3192.
- . Inorg Chem, 51(1), 463-471.
- . Dalton Trans, 40(45), 12005-12016.
- . Chem Asian J, 6(9), 2339-2351.
- . Org Biomol Chem, 9(9), 3462-3470.
- . Chembiochem, 12(6), 877-880.
- . CHEMBIOCHEM, 12(4), 548-551.
- . Chemistry A European Journal, 17(7), 2002-2002.
- . Chemistry A European Journal, 17(7), 2089-2098.
- . Org Biomol Chem, 8(11), 2617-2621.
- . European Journal of Inorganic Chemistry, 2010(7), 995-995.
- . EUR J INORG CHEM(7), 1007-1012.
- . Chemistry, 16(8), 2407-2417.
- . Chemistry A European Journal, 16(8), 2324-2324.
- . Org Biomol Chem, 8(3), 648-654.
- . NAT CHEM, 1(8), 662-667.
- . J Phys Chem A, 113(46), 12754-12762.
- . CRYSTENGCOMM, 11(10), 2069-2077.
- . DALTON T(42), 9312-9321.
- . Inorganic Chemistry, 48(12), 5584-5584.
- . CHEM COMMUN(20), 2947-2949.
- Ru(II) complexes as DNA probes in cell imaging applications. ABSTR PAP AM CHEM S, 237, 511-511.
- . NAT CHEM, 1(1), 25-26.
- . Inorg Chem, 47(24), 11633-11643.
- . Inorg Chem, 47(24), 11551-11560.
- . POLYHEDRON, 27(12), 2577-2584.
- . Chem Commun (Camb)(16), 1868-1870.
- . POLYHEDRON, 27(2), 559-573.
- . ChemInform, 38(35).
- . Angewandte Chemie, 119(20), 3760-3762.
- . Angew Chem Int Ed Engl, 46(20), 3686-3688.
- . Chem Soc Rev, 36(6), 856-868.
- . CrystEngComm, 9(5), 361-361.
- . Chemical Society Reviews, 36(6), 1018-1018.
- Zwitterionic 2-(4-pyridyl)malondialdehyde sesquihydrate forms a helical, 3-D hydrogen-bonded lattice. CRYSTENGCOMM, 9(5), 360-363.
- . Inorg Chem, 46(2), 409-416.
- . Angewandte Chemie, 118(27), 4504-4506.
- . Angew Chem Int Ed Engl, 45(27), 4396-4398.
- . Int J Oncol, 28(6), 1571-1575.
- . Chemistry, 12(17), 4611-4619.
- . Dalton Trans(23), 2900-2906.
- . J Inorg Biochem, 100(8), 1314-1319.
- . Chemistry, 12(8), 2188-2195.
- . Chemistry A European Journal, 12(8), 2111-2111.
- . INORG CHIM ACTA, 359(3), 759-765.
- . Inorg Chem, 45(2), 821-827.
- . Dalton Trans(5), 705-709.
- . Inorganica Chimica Acta, 358(12), 3377-3383.
- . Chem Commun (Camb)(34), 4327-4329.
- . INORG CHIM ACTA, 358(7), 2292-2302.
- . Chemistry, 11(7), 2031-2046.
- . INORG CHIM ACTA, 358(4), 1113-1124.
- . INORG CHEM COMMUN, 8(4), 382-385.
- . Dalton Trans(1), 110-115.
- . Biochemistry, 43(43), 13657-13665.
- . Angewandte Chemie, 116(30), 4028-4031.
- . INORG CHIM ACTA, 357(10), 2827-2832.
- . Angew Chem Int Ed Engl, 43(30), 3938-3941.
- . ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 60, M662-M663.
- . Inorg Chem, 43(1), 317-323.
- . INORG CHIM ACTA, 355, 280-285.
- . ChemInform, 34(38).
- . CHEM SOC REV, 32(4), 215-224.
- . Chem Commun (Camb)(10), 1152-1153.
- . J CHEM SOC DALTON(24), 4732-4739.
- . CHEM COMMUN(21), 2540-2541.
- . Chem Commun (Camb)(18), 2026-2027.
- . INORG CHEM, 41(8), 2250-2259.
- Building blocks for self-assembly: half-sandwich complexes of the [Ru([9]aneS(3))(2+) metal center. INORG CHIM ACTA, 323(1-2), 157-162.
- Deprotonation of a ruthenium (II) complex incorporating a bipyrazole ligand leading to optical and electrochemical switching. INORG CHEM COMMUN, 4(9), 475-477.
- Atomic abacus. New Scientist, 165(2225), 40-43.
- Blast it. New Scientist(2250), 40-42.
- . Inorg Chem, 39(11), 2385-2390.
- Damage control. New Scientist(2120), 36-39.
- Gripping chemistry. NEW SCIENTIST, 160(2163), 36-39.
- Hydrogen-bond recognition of cyclic dipeptides in water. CHEM COMMUN(22), 2449-2450.
- Self-assembly of a supramolecular cube. CHEM COMMUN(16), 1681-1682.
- A highly coupled Ru-III-Ru-II system incorporating sulfur donor ligands. CHEM COMMUN(14), 1429-1430.
- . Chemical Communications(8), 769-770.
- Stereoisomerically controlled inorganic architectures: Synthesis of extended enantio- and diastereomerically pure ruthenium molecular wires and disks from enantiopure building blocks.. ABSTR PAP AM CHEM S, 213, 591-INOR.
- Characterisation of two different mixed-valence states in a strongly interacting dimolybdenum complex (Apr, pg 769, 1997). CHEMICAL COMMUNICATIONS(15), 1473-1473.
- Molecular wires: An electrochemical study of metal-metal interactions through chains of four carbon atoms (vol 15, pg 1409, 1996). POLYHEDRON, 15(12), 2103-2103.
- Mono- and bimetallic bipyridyl polyene complexes containing 17-electron molybdenum mononitrosyl centers: Electrochemical, spectroscopic, and magnetic studies. INORG CHEM, 35(3), 760-774.
- . Inorg Chem, 35(2), 289-296.
- Molecular wires: An electrochemical study of metal-metal interactions through chains of four carbon atoms. POLYHEDRON, 15(9), 1409-1414.
- Stereoisomerically controlled inorganic architectures: Synthesis of extended enantio- and diastereo-merically pure tris-ruthenium disks from enantiopure building blocks. CHEM COMMUN(22), 2603-2604.
- Stereoisomerically controlled inorganic architectures: Synthesis of enantio and diastereomerically pure ruthenium-palladium molecular rods from enantiopure building blocks. CHEM COMMUN(6), 701-702.
- THE SYNTHESES OF SOME PARAMAGNETIC STILBAZOLE COMPLEXES AND AN EVALUATION OF THEIR REDOX AND MESOGENIC PROPERTIES. POLYHEDRON, 14(17-18), 2499-2504.
- . ChemInform, 24(24).
- STRUCTURE OF ORTHORHOMBIC TRIPHENYLPHOSPHINE OXIDE - A REDETERMINATION AT ROOM-TEMPERATURE. ACTA CRYSTALLOGR C, 49, 355-357.
- AN EPR, MAGNETIC AND ELECTROCHEMICAL STUDY OF ELECTRON EXCHANGE AND INTERMETALLIC INTERACTION THROUGH POLYENE BRIDGES. J CHEM SOC CHEM COMM(24), 1796-1798.
- . Chem. Commun., 50(93), 14494-14497.
Book chapters
- (pp. 221-238). Wiley
- Self-Assembly: Definition and Kinetic and Thermodynamic Considerations In Atwood JL & Steed JW (Ed.), Encyclopedia of Supramolecular Chemistry Marcel Dekker Inc
Conference proceedings
- Radiotherapeutic Nanoparticles Containing a Ruthenium-Based Radiosensitizer for EGFR-Positive Oesophageal Cancer. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol. 44 (pp S771-S771)
- Tuning in cellulo targeting and function of metal complex bioprobes. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 249
- Ruthenium(II) metal complexes as mixed recognition substrates for DNA. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 241
- Ruthenium(II) polypyridyl complexes: In cellulo DNA binding and cytotoxicity. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 241
- INTRAMOLECULAR ELECTRON-TRANSFER ACROSS POLYENEBRIDGES. MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY SECTION A-MOLECULAR CRYSTALS AND LIQUID CRYSTALS, Vol. 234 (pp 103-108)
- Teaching interests
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Environmental Chemistry; Transition Metal Chemistry.
- Teaching activities
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Undergraduate and postgraduate taught modules
- Environmental Inorganic Chemistry (Level 2)
The aim of this module is to outline the ecological role of the inorganic components of the environment and the effect of both natural and anthrogenic (man-made) substances on the environment - Advanced coordination chemistry (Level 3)
This course explains how the coordination chemistry and physical properties of transition metals can be controlled and tuned through the use of specifically designed ligands. - Self-assembly and Molecular Devices (Level 4)
Using examples from the recent literature, this module introduces the concepts and key interactions used in chemistry beyond the molecule. - Metals in Medicine (Level 4)
This course will be introduce and discuss coordination complexes that function as basic biotechnological tools. The use of inorganic compounds in a variety of different medical applications will be discussed; from medical imaging through chemotherapy to uses as treatments for several different chronic diseases.
Support Teaching:
- Tutorials: Level 1 General Chemistry
- Skills for Success: Debates.
Laboratory Teaching:
- Level 3 Inorganic Laboratories
- Level 4 Research Project
- Environmental Inorganic Chemistry (Level 2)