Professor Craig Murdoch

BSc (Hons), PhD

School of Clinical Dentistry

Professor in Oral Bioscience

Craig Murdoch STAFF
Profile picture of Craig Murdoch STAFF
c.murdoch@sheffield.ac.uk
+44 114 215 9367
19 Claremont Crescent

Full contact details

Professor Craig Murdoch
School of Clinical Dentistry
19 Claremont Crescent
Sheffield
S10 2TA
Profile

After graduating with a BSc dual honours in Biochemistry/Microbiology I gained a PhD at the Institute of Child Health, University of Sheffield investigating the role of chemokine receptors on endothelial and epithelial cells within the research group of Prof Adam Finn. Following a brief spell researching the pathogenesis of pneumococcal pneumonia, I spent five years working as a post-doctoral researcher in Prof Claire Lewis’s group on tumour-associated macrophages in the Department of Oncology at the University of Sheffield Medical School.

I was appointed Lecturer at the School of Clinical Dentistry in 2006, Senior Lecturer in 2012, Reader in 2015 and then to Personal Chair in 2019 where my research encompasses understanding the molecular mechanism of oral disease.

Research interests

My main interests are centred on oral epithelial biology and the molecular mechanisms of oral diseases and their systemic sequalae. I am particularly interested in how immune cells are recruited to diseased oral sites and how they interact with other cells/microbes within the local microenvironment. As part of this research my group has developed novel tissue engineered in vitro models of both healthy and diseased oral mucosa to investigate pathogenic mechanisms. I have a long-standing track record of developing and utilising in vitro 3D tissue constructs and zebrafish larvae as direct replacements for animal models and have used these experimental models to study the role of oral microorganisms in mucosal and systemic disease. I am also involved with projects aimed at developing novel oral patches for mucosal drug delivery (with AFYX Therapeutics) and how mathematical modelling of oral tissue can aid the development of drug delivery systems (with University of Liverpool) and non-invasive diagnostics for the detection and management of oral pre-malignant lesions (with Zilico).

Current projects include:

  • Role of innate immune cells in head and neck cancer. 
  • Development of tissue engineered immunocompetent oral mucosal and skin models. 
  • Host-pathogen interactions at the mucosal surface. 
  • Use of zebrafish to examine the role of oral microbes in systemic disease. 
  • Novel forms of oral mucosal drug delivery and the role of xenobiotic metabolising enzymes in the oral mucosa.

Research group

  • Amy Harding (PDRA): Development and validation of tissue-engineered skin equivalents to detect skin irritation. (Rohto Pharmaceutical Company Limited) with Dr Helen Colley & Dr Simon Danby. 
  • Bethany Ollington: Use of immune-competent tissue engineered oral mucosal equivalents to model oral infection. (with Dr Helen Colley, MRC DiMeN Studentship) 
  • Inmaculada Barragan Vazquez: Tissue engineered modelling of atopic dermatitis (with Dr Helen Colley & Dr Simon Danby, Almirall S.A.-funded PhD Studentship) 
  • Asma El-Howati: Development of tissue engineered oral inflammatory lesions (with Dr Helen Colley, Funded by Libyan Government Scholarship) 
  • Antonia Cutts: Use of in vitro and in vivo zebrafish embryo infection models to investigate the role of oral microorganisms in cardiovascular disease. (with Prof Graham Stafford, University Faculty Studentship) 
  • Klaudia Slowik: The role of xenobiotic metabolising enzymes in drug delivery for prevention of alveolar osteitis. (with Dr Helen Colley, EPSRC-Funded Studentship) 
  • Jake Edmans: Peptide delivery using electrospun mucoadhesive patches (with Dr Helen Colley, Dr Seb Spain and Prof Paul Hatton, EPSRC Centre for Doctoral Training in Polymers and Soft Matter/ AFYX Therapeutics studentship) 
  • Asmaa Zanki: Fabrication of dentures with anti-fungal properties by additive manufacturing. (with Prof Paul Hatton - Funded by Kuwait Government Scholarship)
Publications

Journal articles

  • Edmans JG, El-Howati A, Slowik KM, Colley HE, Murdoch C, Hatton PV & Armes SP (2025) . ACS Applied Materials & Interfaces, 17(24), 35140-35154.
  • Lin Z, Lang Z-Q, Guo L, Walker DC, Matella M, Wang M & Murdoch C (2025) . Scientific Reports, 15.
  • Widziolek M, Mieszkowska A, Marcinkowska M, Salamaga B, Folkert J, Rakus K, Chadzinska M, Potempa J, Stafford GP, Prajsnar TK & Murdoch C (2025) . PLOS Pathogens, 21(1).
  • El-Howati A, Edmans JG, Santocildes-Romero ME, Madsen LS, Murdoch C & Colley HE (2025) . Journal of Investigative Dermatology, 145(6), 1447-1458.
  • Slowik KM, Edmans JG, Harrison S, Edwards SM, Bolt R, Spain SG, Hatton PV, Murdoch C & Colley HE (2024) . Journal of Controlled Release, 376, 253-265.
  • Edwards SM, Harding AL, Leedale JA, Webb SD, Colley HE, Murdoch C & Bearon RN (2024) . International Journal of Pharmaceutics, 666.
  • Edmans JG, Harrison S, Hatton PV, Murdoch C, Spain SG & Colley HE (2024) . Biomaterials Advances, 157.
  • Edmans JG, Murdoch C, Hatton PV, Madsen LS, Santocildes-Romero ME, Spain SG & Colley HE (2024) . Biomedical Materials & Devices, 2(1), 444-453.
  • El-Howati A, Thornhill M, Colley H & Murdoch C (2023) . Oral Diseases, 29(4), 1400-1415.
  • Edmans JG, Ollington B, Colley HE, Santocildes-Romero ME, Siim Madsen L, Hatton PV, Spain SG & Murdoch C (2022) . Journal of Controlled Release, 350, 146-157.
  • Heath JP, Hunter KD, Murdoch C & Walker DC (2022) . Sensors, 22(15).
  • Farrugia C, Stafford GP, Gains AF, Cutts AR & Murdoch C (2022) . Journal of Periodontology, 93(9), 1421-1433.
  • Niklander SE, Murdoch C & Hunter KD (2021) . Frontiers in Oral Health, 2.
  • Ollington B, Colley HE & Murdoch C (2021) . Tissue Engineering Part C: Methods, 27(8), 462-471.
  • West H, Roberts F, Sweeney P, Walker-Samuel S, Leedale J, Colley H, Murdoch C, Shipley RJ & Webb S (2021) . PLoS ONE, 16(7).
  • Harding AL, Murdoch C, Danby S, Hasan MZ, Nakanishi H, Furuno T, Hadad S, Turner R & Colley HE (2021) . JID Innovations, 1(2).
  • McRae MP, Kerr AR, Janal MN, Thornhill M, Redding S, Vigneswaran N, Kang SK, Niederman R, Christodoulides NJ, Trochesset DA , Murdoch C et al (2021) . Journal of Dental Research, 100(5), 479-486.
  • Farrugia C, Stafford GP, Potempa J, Wilkinson RN, Chen Y, Murdoch C & Widziolek M (2021) . The FEBS Journal, 288(5), 1479-1495.
  • Said Z, Murdoch C, Hansen J, Siim Madsen L & Colley HE (2021) . European Journal of Oral Sciences, 129(2).
  • Al-Sahaf S, Hendawi NB, Ollington B, Bolt R, Ottewell PD, Hunter KD & Murdoch C (2021) . Frontiers in Oral Health, 2.
  • Farrugia C, Stafford GP & Murdoch C (2020) . Journal of Dental Research, 99(13), 1494-1501.
  • Mouhat M, Moorehead R & Murdoch C (2020) . Biomaterial Investigations in Dentistry, 7(1), 146-157.
  • Ferreira SBDS, Hoshino LVDC, Slowik K, Baesso ML, Murdoch C, Colley H & Bruschi ML (2020) . European Journal of Pharmaceutical Sciences, 151.
  • Edmans JG, Murdoch C, Santocildes-Romero ME, Hatton PV, Colley HE & Spain SG (2020) . Materials Science and Engineering: C, 112.
  • Clitherow KH, Binaljadm TM, Hansen J, Spain SG, Hatton PV & Murdoch C (2020) . ACS Biomaterials Science & Engineering, 6(7), 4087-4095.
  • Edmans JG, Clitherow KH, Murdoch C, Hatton PV, Spain SG & Colley HE (2020) . Pharmaceutics, 12(6).
  • Leedale JA, Kyffin JA, Harding AL, Colley HE, Murdoch C, Sharma P, Williams DP, Webb SD & Bearon RN (2020) . Interface Focus, 10(2).
  • McRae MP, Modak SS, Simmons GW, Trochesset DA, Kerr AR, Thornhill MH, Redding SW, Vigneswaran N, Kang SK, Christodoulides NJ , Murdoch C et al (2020) . Cancer Cytopathology, 128(3), 207-220.
  • Ferreira SBDS, Braga G, Oliveira ÉL, da Silva JB, Rosseto HC, de Castro Hoshino LV, Baesso ML, Caetano W, Murdoch C, Colley HE & Bruschi ML (2019) . Beilstein Journal of Nanotechnology, 10, 2304-2328.
  • Swidergall M, Khalaji M, Solis NV, Moyes DL, Drummond RA, Hube B, Lionakis MS, Murdoch C, Filler SG & Naglik JR (2019) . The Journal of Infectious Diseases, 220(9), 1477-1488.
  • Leedale J, Colley HE, Gaskell H, Williams DP, Bearon RN, Chadwick AE, Murdoch C & Webb SD (2019) . Computational Toxicology, 12.
  • Sah P, Patel P, Chandrashekar C, Martena S, Ballal M, Hegde M, Guddattu V, Murdoch C, Sharma M & Radhakrishnan R (2019) . Journal of Investigative and Clinical Dentistry, 10(4).
  • Al-Zubidi M, Widziolek M, Court EK, Gains AF, Smith RE, Ansbro K, Alrafaie A, Evans C, Murdoch C, Mesnage S , Douglas CWI et al (2019) . Infection and Immunity, 87(11), e00512-e00519.
  • Clitherow KH, Murdoch C, Spain SG, Handler AM, Colley HE, Stie MB, Mørck Nielsen H, Janfelt C, Hatton PV & Jacobsen J (2019) . Molecular Pharmaceutics, 16(9), 3948-3956.
  • Kyffin JA, Cox CR, Leedale J, Colley HE, Murdoch C, Mistry P, Webb SD & Sharma P (2019) . Current Protocols in Toxicology, 81(1).
  • Tomlinson L, Lu ZQ, Bentley RA, Colley HE, Murdoch C, Webb SD, Cross MJ, Copple IM & Sharma P (2019) . Biomedicine and Pharmacotherapy, 112.
  • Mariño-Crespo Ó, Cuevas-Álvarez E, Harding AL, Murdoch C, Fernández-Briera A & Gil-Martín E (2019) . Histology and Histopathology, 34(8), 953-963.
  • Kyffin JA, Sharma P, Leedale J, Colley HE, Murdoch C, Harding AL, Mistry P & Webb SD (2019) . Toxicology in Vitro, 55, 160-172.
  • Al-Sahaf S, Hunter KD, Bolt R, Ottewell PD & Murdoch C (2019) . International Journal of Cancer, 144(2), 334-344.
  • Colley HE, Said Z, Santocildes-Romero ME, Baker SR, D'Apice K, Hansen J, Madsen LS, Thornhill MH, Hatton PV & Murdoch C (2018) . Biomaterials, 178, 134-146.
  • Hearnden V, Murdoch C, D'Apice K, Duthie S, Hayward NJ & Powers HJ (2018) . BMJ Open, 8(8).
  • Leedale J, Sharkey KJ, Colley HE, Norton ÁM, Peeney D, Mason CL, Sathish JG, Murdoch C, Sharma P & Webb SD (2018) . iScience, 4, 84-96.
  • Smith SA, Colley HE, Sharma P, Slowik KM, Sison-Young R, Sneddon A, Webb SD & Murdoch C (2018) . Experimental Dermatology, 27(5), 473-475.
  • Hearnden V, Powers HJ, Elmogassabi A, Lowe R & Murdoch C (2018) . European Journal of Nutrition, 57(4), 1321-1332.
  • Walladbegi J, Smith SA, Grayson A, Murdoch C, Jontell M & Colley HE (2018) . Journal of Oral Pathology and Medicine, 47(5), 477-483.
  • Grayson A, Hearnden VL, Bolt R, Jebreel A, Colley HE & Murdoch C (2018) . Journal of Tissue Engineering and Regenerative Medicine, 12(3), e1636-e1646.
  • Morse DJ, Wilson MJ, Wei X, Lewis MAO, Bradshaw DJ, Murdoch C & Williams DW (2018) . Journal of medical microbiology, 67(3), 364-375.
  • Kyffin JA, Sharma P, Leedale J, Colley HE, Murdoch C, Mistry P & Webb SD (2018) . Toxicol In Vitro, 48, 262-275.
  • Bolt R, Foran B, Murdoch C, Lambert DW, Thomas S & Hunter KD (2018) . Carcinogenesis, 39(2), 170-179.
  • Madden JC, Webb S, Enoch SJ, Colley HE, Murdoch C, Shipley R, Sharma P, Yang C & Cronin MTD (2017) . Computational Toxicology, 3, 44-57.
  • Santocildes-Romero ME, Hadley L, Clitherow KH, Hansen J, Murdoch C, Colley HE, Thornhill M & Hatton PV (2017) . ACS Applied Materials and Interfaces, 9(13), 11557-11567.
  • Naylor KL, Widziolek M, Hunt S, Conolly M, Hicks M, Potempa J, Murdoch C, Douglas CWI & Stafford GP (2017) . MicrobiologyOpen, 6(1).
  • Jennings L, Colley HE, Ong J, Panagakos F, Masters J, Trivedi H, Murdoch C & Whawell S (2016) . Tissue Eng Part C Methods, 22(12), 1108-1117.
  • Widziolek M, Prajsnar TK, Tazzyman S, Stafford GP, Potempa J & Murdoch C (2016) . Scientific Reports, 6, 36023-36023.
  • Abram TJ, Floriano PN, Christodoulides N, James R, Kerr AR, Thornhill MH, Redding SW, Vigneswaran N, Speight PM, Vick J , Murdoch C et al (2016) . Oral Oncology, 60, 103-111.
  • Bolt R, Lambert D, Murdoch C, Thomas S, Foran B & Hunter K (2016) . European Journal of Cancer, 61, S60-S60.
  • Gaskell H, Sharma P, Colley HE, Murdoch C, Williams DP & Webb SD (2016) . Toxicology Research.
  • Speight PM, Abram TJ, Floriano PN, James R, Vick J, Thornhill MH, Murdoch C, Freeman C, Hegarty AM, D'Apice K , Kerr AR et al (2015) . Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 120(4), 474-482.e2.
  • Muthana M, Kennerley AJ, Hughes R, Fagnano E, Richardson J, Paul M, Murdoch C, Wright F, Payne C, Lythgoe MF , Farrow N et al (2015) . Nature Communications, 6.
  • Darda L, Hakami F, Morgan R, Murdoch C, Lambert DW & Hunter KD (2015) . PLoS One, 10(4).
  • Boadi J, Fernandes J, Mittar S, Hearnden V, Lu Z, MacNeil SM, Thornhill MH, Murdoch C, Hunter KD & Matcher SJ (2015) . Sovremennye Tehnologii v Medicine, 7(1), 60-67.
  • Murdoch C, D'Apice K, Brown B, Hearnden V, Speight P, Hegarty A, Healey J, Highfield P, Tidy J & Thornhill M (2014) . International Journal of Nanomedicine, 9(1), 4521-4532.
  • Colley HE, Hearnden V, Avila-Olias M, Cecchin D, Canton I, Madsen J, MacNeil S, Warren N, Hu K, McKeating JA , Armes SP et al (2014) . Mol Pharm, 11(4), 1176-1188.
  • Pinnock A, Murdoch C, Moharamzadeh K, Whawell S & Douglas CWI (2014) . Microbes Infect, 16(4), 310-319.
  • Sorrell I, Shipley RJ, Hearnden V, Colley HE, Thornhill MH, Murdoch C & Webb SD (2014) . Nanomedicine: Nanotechnology, Biology and Medicine, 10(2), 339-348.
  • Tazzyman S, Murdoch C, Harrison J, Yeomans J & Muthana M (2014) . Hypoxia, 2, 185-196.
  • Al-Husari M, Murdoch C & Webb SD (2014) . Journal of Mathematical Biology, 69(4), 839-873.
  • Stafford P, Higham J, Pinnock A, Murdoch C, Douglas CWI, Stafford GP & Lambert DW (2013) . Mol Oral Microbiol, 28(5), 366-378.
  • Murdoch C, Speight PM, D'Apice K, Hearnden V, Hegarty A, Tidy J, Healey J, Brown B & Thornhill MH (2013) . Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 116(3), e201-e201.
  • Wayakanon K, Thornhill MH, Douglas CWI, Lewis AL, Warren NJ, Pinnock A, Armes SP, Battaglia G & Murdoch C (2013) . FASEB J, 27(11), 4455-4465.
  • Colley HE, Eves PC, Pinnock A, Thornhill MH & Murdoch C (2013) . Int J Radiat Biol, 89(11), 907-914.
  • West L, Lowman DW, Mora-Montes HM, Grubb S, Murdoch C, Thornhill MH, Gow NAR, Williams D & Haynes K (2013) . J Biol Chem, 288(30), 22006-22018.
  • Tazzyman S, Niaz H & Murdoch C (2013) . Semin Cancer Biol, 23(3), 149-158.
  • Pal A, Melling G, Hinsley EE, Kabir TD, Colley HE, Murdoch C & Lambert DW (2013) . J Oral Pathol Med, 42(4), 309-314.
  • Elbarghati L, Azzouz L, Murdoch C, Corke K, Burton J & Lewis C (2012) . Egyptian Journal of Pathology, 32(2), 217-226.
  • Moharamzadeh K, Colley H, Murdoch C, Hearnden V, Chai WL, Brook IM, Thornhill MH & Macneil S (2012) . J Dent Res, 91(7), 642-650.
  • Murdoch C, Aziz HA, Fang HY, Jezan H, Musaid R & Muthana M (2011) . Journal of Ethnopharmacology, 138(3), 780-787.
  • Smith LE, Hearnden V, Lu Z, Smallwood R, Hunter KD, Matcher SJ, Thornhill MH, Murdoch C & MacNeil S (2011) . J Biomed Opt, 16(11), 116015.
  • Colley HE, Hearnden V, Jones AV, Weinreb PH, Violette SM, MacNeil S, Thornhill MH & Murdoch C (2011) . British Journal of Cancer, 105(10), 1582-1592.
  • Coffelt SB, Chen Y-Y, Muthana M, Welford AF, Tal AO, Scholz A, Plate KH, Reiss Y, Murdoch C, De Palma M & Lewis CE (2011) . J Immunol, 186(7), 4183-4190.
  • Cleary IA, Reinhard SM, Miller CL, Murdoch C, Thornhill MH, Lazzell AL, Monteagudo C, Thomas DP & Saville SP (2011) . Microbiology (Reading), 157(Pt 6), 1806-1815.
  • Muthana M, Giannoudis A, Scott SD, Fang H-Y, Coffelt SB, Morrow FJ, Murdoch C, Burton J, Cross N, Burke B , Mistry R et al (2011) . Cancer Res, 71(5), 1805-1815.
  • Tazzyman S, Barry ST, Ashton S, Wood P, Blakey D, Lewis CE & Murdoch C (2011) . Int J Cancer, 129(4), 847-858.
  • Yadev NP, Murdoch C, Saville SP & Thornhill MH (2011) . Microbial Pathogenesis, 50(6), 278-285.
  • Dogan S, Zhang Q, Pridmore AC, Mitchell TJ, Finn A & Murdoch C (2011) . Microbes and Infection, 13(1), 65-75.
  • Murdoch C, Reeves KJ, Hearnden V, Colley H, Massignani M, Canton I, Madsen J, Blanazs A, Armes SP, Lewis AL , Macneil S et al (2010) . Nanomedicine (Lond), 5(7), 1025-1036.
  • Cleary IA, Mulabagal P, Reinhard SM, Yadev NP, Murdoch C, Thornhill MH, Lazzell AL, Monteagudo C, Thomas DP & Saville SP (2010) . Eukaryot Cell, 9(9), 1363-1373.
  • Coffelt SB, Tal AO, Scholz A, De Palma M, Patel S, Urbich C, Biswas SK, Murdoch C, Plate KH, Reiss Y & Lewis CE (2010) . Cancer Res, 70(13), 5270-5280.
  • Khurram SA, Whawell SA, Bingle L, Murdoch C, McCabe BM & Farthing PM (2010) . J Pathol, 221(2), 153-163.
  • Grubb SEW, Murdoch C, Sudbery PE, Saville SP, Lopez-Ribot JL & Thornhill MH (2009) . Infect Immun, 77(9), 3872-3878.
  • Tazzyman S, Lewis CE & Murdoch C (2009) . Int J Exp Pathol, 90(3), 222-231.
  • Fang H-Y, Hughes R, Murdoch C, Coffelt SB, Biswas SK, Harris AL, Johnson RS, Imityaz HZ, Simon MC, Fredlund E , Greten FR et al (2009) . Blood, 114(4), 844-859.
  • Hearnden V, Lomas H, Macneil S, Thornhill M, Murdoch C, Lewis A, Madsen J, Blanazs A, Armes S & Battaglia G (2009) . Pharm Res, 26(7), 1718-1728.
  • Elbarghati L, Murdoch C & Lewis CE (2008) . Immunobiology, 213(9-10), 899-908.
  • Murdoch C, Muthana M, Coffelt SB & Lewis CE (2008) . Nat Rev Cancer, 8(8), 618-631.
  • Grubb SEW, Murdoch C, Sudbery PE, Saville SP, Lopez-Ribot JL & Thornhill MH (2008) . Infect Immun, 76(10), 4370-4377.
  • Muthana M, Scott SD, Farrow N, Morrow F, Murdoch C, Grubb S, Brown N, Dobson J & Lewis CE (2008) . Gene Ther, 15(12), 902-910.
  • Larsen M, Tazzyman S, Lund EL, Junker N, Lewis CE, Kristjansen PEG & Murdoch C (2008) . CANCER LETT, 265(2), 239-249.
  • Pahler JC, Tazzyman S, Erez N, Chen YY, Murdoch C, Nozawa H, Lewis CE & Hanahan D (2008) . Neoplasia, 10(4), 329-339.
  • De Palma M, Murdoch C, Venneri MA, Naldin L & Lewis CE (2007) . TRENDS IMMUNOL, 28(12), 519-524.
  • Murdoch C, Tazzyman S, Webster S & Lewis CE (2007) Expression of Tie-2 by human monocytes and their responses to angiopoietin-2. J.Immunol., 178(11), 7405-7411.
  • Webb SD, Owen MR, Byrne HM, Murdoch C & Lewis CE (2007) . B MATH BIOL, 69(5), 1747-1776.
  • Faber J, Schuessler T, Finn A, Murdoch C, Zenz W, Habermehl P, Meyer CU, Zabel BU, Schmitt HJ, Zepp F & Knuf M (2007) . PEDIATR INFECT DIS J, 26(3), 243-246.
  • Faber J, Meyer CU, Gemmer C, Russo A, Finn A, Murdoch C, Zenz W & Mannhalter C (2006) . PEDIATR INFECT DIS J, 25(1), 80-81.
  • Murdoch C, Muthana M & Lewis CE (2005) . J Immunol, 175(10), 6257-6263.
  • Murdoch C & Lewis CE (2005) . Int J Cancer, 117(5), 701-708.
  • Lewis C & Murdoch C (2005) . Am J Pathol, 167(3), 627-635.
  • Murdoch C, Giannoudis A & Lewis CE (2004) . Blood, 104(8), 2224-2234.
  • Zhang Q, Arnaoutakis K, Murdoch C, Lakshman R, Race G, Burkinshaw R & Finn A (2004) . Pediatr Infect Dis J, 23(4), 307-313.
  • Lakshman R, Murdoch C, Race G, Burkinshaw R, Shaw L & Finn A (2003) . Arch Dis Child, 88(3), 211-214.
  • Murdoch C, Read RC, Zhang Q & Finn A (2002) . J Infect Dis, 186(9), 1253-1260.
  • Rao WH, Murdoch C, Johnson JR, Evans GS & Finn A (2001) . Urol Res, 29(2), 102-107.
  • Murdoch C (2000) . Immunol Rev, 177, 175-184.
  • Murdoch C & Finn A (2000) Chemokine receptors and their role in inflammation and infectious diseases.. Blood, 95(10), 3032-3043.
  • Murdoch C & Finn A (2000) . Blood, 95(10), 3032-3043.
  • Murdoch C & Finn A (2000) . J Vasc Res, 37(1), 1-7.
  • Murdoch C, Monk PN & Finn A (1999) . Immunology, 98(1), 36-41.
  • Prest SJ, Rees RC, Murdoch C, Marshall JF, Cooper PA, Bibby M, Li G & Ali SA (1999) Chemokines induce the cellular migration of MCF-7 human breast carcinoma cells: Subpopulations of tumour cells display positive and negative chemotaxis and differential in vivo growth potentials. CLIN EXP METASTAS, 17(5), 389-396.
  • Murdoch C, Monk PN & Finn A (1999) . Cytokine, 11(9), 704-712.
  • Murdoch C, Monk PN, Pease JE, Barker MD & Finn A (1997) . Immunology Letters, 56, 101-101.

Book chapters

  • Moharamzadeh K, Colley H, Hearnden V & Murdoch C (2017) , Biomaterials for Oral and Dental Tissue Engineering (pp. 245-255). Elsevier
  • Akbari Z, Almeida L, Almela T, Amdjadi P, Amrollahi P, Ansari S, Bader R, Baghaban Eslaminejad M, Bardsley K, Bencharit S , Bindal P et al (2017) , Biomaterials for Oral and Dental Tissue Engineering (pp. xiii-xvii). Elsevier
  • Murdoch C & Finn A (2003) (pp. 38-57).

Conference proceedings

  • Slowik K, Edmans J, Spain S, Murdoch C, Hatton P & Colley H (2023) . Tissue Engineering Part A, Vol. 29(11-12) (pp 1530-1530). Krakow, Poland, 28 June 2022 - 28 June 2022.
  • Saad S, Murdoch C, Workman V, Hearnden V, Macneil S & Chapple CR (2023) . European Urology, Vol. 83 (pp S1190-S1190). Milan, Italy, 10 March 2023 - 10 March 2023.
  • Edmans J, Ollington B, Murdoch C, Spain S, Hatton P & Colley H (2023) ELECTROSPUN PATCH DELIVERY OF ANTI-TNF. F(AB) ANTIBODY FRAGMENT FOR THE TREATMENT OF ORAL MUCOSAL INFLAMMATORY DISEASES. TISSUE ENGINEERING PART A, Vol. 29(11-12) (pp 360-360)
  • Vazquez IB, Danby S, Garcia Gonzalez VM, Lopez Almagro R, Crespo Crespo MI, Colley H & Murdoch C (2023) AN IN VITRO IMMUNOCOMPETENT HUMAN TISSUE-ENGINEERED MODEL OF ATOPIC DERMATITIS FOR DRUG TESTING. TISSUE ENGINEERING PART A, Vol. 29(11-12) (pp 492-492)
  • Barragan Vazquez I, Danby S, Garcia Gonzalez VM, Lopez Almagro R, Colley HE & Murdoch C (2022) . British Journal of Dermatology, Vol. 187(1) (pp E29-E29). Virtual, 29 March 2021 - 29 March 2021.
  • Harding A, Danby S, Murdoch C, Hasan MZ & Colley H (2022) . British Journal of Dermatology, Vol. 187(1) (pp E31-E31). Virtual, 29 March 2021 - 29 March 2021.
  • Colley HE, Said Z, Santocildes-Romero ME, Baker SR, D'Apice K, Hansen J, Madsen LS, Thornhill MH, Hatton PV & Murdoch C (2018) . Oral Surgery Oral Medicine Oral Pathology and Oral Radiology, Vol. 126(4) (pp e204-e204). San Antonio, TX, USA, 10 April 2018 - 10 April 2018.
  • Webb S, Sharma P, Colley HE, Sneddon A, Shipley R, Leedale J, Smith S & Murdoch C (2018) . Applied In Vitro Toxicology , Vol. 4(1). London, UK, 23 November 2017 - 23 November 2017.
  • Amabebe E, Qiao H, Murdoch C & Anumba D (2018) Vaginal epithelial cells co-cultured with Lactobacillus and anaerobes differentially express acetate and CXCL8. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol. 125 (pp 90-90)
  • Amabebe E, Qiao H, Murdoch C & Anumba D (2018) Cervicovaginal Epithelial Cells Differentially Express Acetate and CXCL8 in Co-Culture with Preterm Birth-Associated Bacteria and Protective Lactobacillus Species.. REPRODUCTIVE SCIENCES, Vol. 25 (pp 187A-187A)
  • Shipley R, Webb SW, Madden J, Smith SA, Cronin M, Colley HE & Murdoch C (2018) Mathematical modelling predicts the spatial distribution of metabolism in skin. European Cells and Materials, Vol. 32 (pp 96-96)
  • Hadley L, Santocildes-Romero ME, Thornhill MH, Hansen J, Colley HE, Hatton PV & Murdoch C (2016) . Oral Diseases, Vol. 22((Suppl. 2)) (pp 10-13). Torino, Italy, 15 September 2016 - 15 September 2016.
  • Santocildes-Romero ME, Hadley L, Clitherow KH, Hansen J, Murdoch C, Colley HE, Thornhill MH & Hatton PV (2016) . Oral Diseases , Vol. 22 (pp 11-11). Torino, Italy, 15 September 2016 - 15 September 2016.
  • Hadley L, Colley HE & Murdoch C (2016) . Oral Diseases, Vol. 22(S2) (pp 10-11). Torino, Italy, 15 September 2016 - 15 September 2016.
  • Chasib NH, murdoch C & Colley HE (2016) . Oral Diseases (pp 10-10). Torino, 15 September 2016 - 15 September 2016.
  • Colley HE, D'Apice K, Baker SR, Hatton PV, Santocildes-Romero ME, Thornhill MH, Hansen J & Murdoch C (2016) . Oral Diseases , Vol. 22(S2) (pp 19-19). Torino, Italy, 15 September 2016 - 15 September 2016.
  • Grayson A, Hearnden VL, Colley H, Bolt R, Jabreel A & Murdoch C (2016) Isolation and immortalisation of tonsillar keratinocytes for three-dimensional tissue engineered tonsil mucosal models. European Cells and Materials, Vol. 31(Suppl 1) (pp 20-20). Uppsala, Sweden, 28 June 2016 - 28 June 2016.
  • Boadi J, Byers RA, Fernandes J, Mittar S, Hearnden V, Lu Z, MacNeil S, Thornhill M, Murdoch C, Hunter KD , McKechnie A et al (2016) . Photonic Therapeutics and Diagnostics XII (pp 72-72), 13 February 2016 - 18 February 2016.
  • Sarb JD, Murdoch C & Anumba D (2016) The Effect of Relaxin-2 and Tissue Inhibitors of Matrix Metalloproteinase-2 (TIMP-2) on the Expression Levels of Matrix Metalloproteinase-2 (MMP-2) by Co-Incubation of Endometrial Stromal and Trophoblast Cell Lines.. REPRODUCTIVE SCIENCES, Vol. 23 (pp 335A-335A)
  • Gaskell H, Sharma P, Colley H, Murdoch C, Antoine D, Sathish J, Williams D & Webb S (2015) . Toxicology Letters, Vol. 238(2) (pp S176-S176)
  • Sarb JD, Murdoch C & Anumba DOC (2015) Using 3-D Models To Investigate Trophoblast-Endometrial Interactions In Vitro. REPRODUCTIVE SCIENCES, Vol. 22 (pp 226A-226A)
  • Alkishi A, Khurram SA, Thornhill M & Murdoch C (2014) . Cancer Research, Vol. 74(19_Supplement) (pp 2091-2091)
  • Hunter K, Hakami F, Darda L, Lambert D, Murdoch C, Morgan R & Woll P (2013) The role of HOX genes in Head and Neck Squamous Cell Carcinoma (HNSCC). VIRCHOWS ARCHIV, Vol. 463(2) (pp 177-177)
  • Darda L, Lambert D, Morgan R, Murdoch C & Hunter K (2013) The role of miR-196a and HOXB9 in head and neck squamous cell carcinoma. EUROPEAN JOURNAL OF CANCER, Vol. 49 (pp S121-S121)
  • Alkishi AM, Khurram SA, Thornhill MH & Murdoch C (2013) Sialyl Lewis A and sialyl Lewis X antigens mediate oral cancer cell binding to recombinant E-selectin and TNF-alpha-stimulated endothelial cells. EUROPEAN JOURNAL OF CANCER, Vol. 49 (pp S134-S134)
  • Colley HE, Hearnden V, Wayakanon K, Cecchin D, Armes S, Battaglia G, Murdoch C & Thornhill MH (2012) Tissue engineered models of oral disease for the study of a novel drug delivery system. ORAL DISEASES, Vol. 18
  • Colley HE, Hearnden V, Cecchin D, Armes S, Battaglia G, Murdoch C & Thornhill MH (2012) . EUROPEAN JOURNAL OF CANCER, Vol. 48 (pp S254-S254)
  • Hearnden V, Rehman IU, MacNeil S, Murdoch C, Thornhill MH, Hunter K & Colley HE (2012) . EUROPEAN JOURNAL OF CANCER, Vol. 48 (pp S287-S287)
  • Sorrell I, Webb SD, Shipley RJ, Hearnden VL, Colley HE & Murdoch C (2012) . Cancer Research, Vol. 72(8_Supplement) (pp 4918-4918)
  • Murdoch C, Thornhill MH, Fang H-Y, Hearnden V & Colley HE (2012) CXCL12/CXCR4 axis mediates recruitment of monocytes to oral cancer spheroids. ORAL DISEASES, Vol. 18 (pp 8-8)
  • Kerr AR, Thornhill MH, D'Apice K, Murdoch C, Speight P, Hegarty A, Redding SW, Vigneswaran N, Christodoulides N, Floriano PN & McDevitt JT (2012) Non-invasive lab-on-a-chip characterization of potentially malignant oral disorders. ORAL DISEASES, Vol. 18 (pp 4-4)
  • Evans T, Tazzyman S, Chico T, Thornhill M & Murdoch C (2012) Using zebrafish as an in vivo model to study Candida albicans-mediated systemic candidiasis. MYCOSES, Vol. 55 (pp 11-11)
  • Venn PW & Murdoch C (2012) Development of a static adhesion assay to identify host proteins exploited by Candida albicans. MYCOSES, Vol. 55 (pp 303-303)
  • Wayakanon K, Thornhill M, Douglas I, Battaglia G & Murdoch C (2010) . Proceedings of the IASTED International Conference on Nanotechnology and Applications Nana 2010 (pp 559-564)
  • Muthana M, Giannoudis A, Scott SD, Mistry R, Murdoch C, Coffelt S, Georgeopolous L, Hamdy F, Brown N, Maitland N & Lewis CE (2010) . DRUG DISCOVERY TODAY, Vol. 15(23-24) (pp 1097-1098)
  • Colley HE, Hearnden V, Murdoch C, Armes S, Battaglia G & Thornhill MH (2010) Using polymersomes to deliver chemotherapeutic agents to oral cancer cells. ORAL DIS, Vol. 16(6) (pp 527-527)
  • Higham JH, Murdoch CM, Douglas CWI & Thornhill MH (2010) Atherosclerosis and oral health: mechanisms for P.gingivalis survival in endothelial-cells. Oral Diseases, Vol. 16 (pp 516-516)
  • Yadev N, Bubeck S, Murdoch C, Saville SP, Lopez-Ribot J & Thornhill MH (2010) In vitro modelling of oral and vaginal candidiasis host-pathogen interactions. ORAL DIS, Vol. 16(6) (pp 517-517)
  • Hearnden V, Smith L, Colley H, Thornhill M, Murdoch C, Smallwood R, Matcher S & MacNeil S (2010) Using tissue-engineered oral cancer models to evaluate non-invasive diagnostic technologies. ORAL DIS, Vol. 16(6) (pp 518-518)
  • Fang H, Hughes R, Murdoch C, Coffelt S, Biswas SK, Imityaz HZ, Simon MC, Greten F, Rius J & Lewis CE (2010) Hypoxia inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing sustained hypoxia. EJC SUPPLEMENTS, Vol. 8(5) (pp 77-77)
  • Muthana M, Giannoudis A, Scott SD, Mistry R, Murdoch C, Georgeopolous L, Hamdy F, Brown N, Maitland N & Lewis CE (2010) Engineering Macrophages to Synthesize Recombinant Adenoviruses in Hypoxic Areas of Human Prostate Tumours. HUMAN GENE THERAPY, Vol. 21(4) (pp 488-488)
  • Murdoch C, Colley H, MacNeil S & Thornhill M (2009) . ORAL ONCOLOGY (pp 68-68)
  • Colley HE, MacNeil S, Jones AV, Thornhill MH & Murdoch C (2009) . ORAL ONCOLOGY (pp 160-160)
  • Hearnden V, Battaglia G, MacNeil S, Murdoch C & Thornhill M (2009) . ORAL ONCOLOGY (pp 66-66)
  • Hearnden V, Battaglia G, Murdoch C, Thornhill M & MacNeil S (2008) Imaging of polymersome penetration into 3D tissue engineered models of oral mucosa and head and neck cancer. European Cells and Materials, Vol. 16(SUPPL. 3) (pp 58)
  • Muthana M, Scott S, Farrow N, Murdoch C & Lewis C (2007) Magnetite nanoparticle-loaded macrophages enhance gene delivery to tumours. IMMUNOLOGY, Vol. 120 (pp 82-82)
  • Hughes R, Murdoch C, Fang HY & Lewis C (2007) Microenvironmental signals regulating the tumour-promoting functions of macrophages: role of hypoxia and necrotic debris. JOURNAL OF LEUKOCYTE BIOLOGY (pp 56-56)
  • Scott SD, Greco O, Murdoch C & Lewis C (2005) Radiation, hypoxia and chemotherapy-mediated gene therapy and the potential for tumour delivery via macrophages. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol. 63(2) (pp S137-S137)
  • Murdoch C, Lakshman R, Burkinshaw R, Shaw L & Finn A (2001) Effect of hepatavalent conjugate pneumococcal vaccine in infancy and booster polysaccharide vaccine at 13 months on nasopharyngeal carriage of S-pneumoniae in children aged 2 to 4 years. CLIN INFECT DIS, Vol. 33(7) (pp 1148-1148)
  • Murdoch C, Monk PN & Finn A (1998) CXC chemokine receptor expression on human endothelial cells. J VASC RES, Vol. 35(5) (pp 388-388)
  • Murdoch C, Barker MD, Pease JE, Finn A & Monk PN (1996) Leukocyte chemoattractant receptor expression on endothelial and epithelial cells. IMMUNOLOGY, Vol. 89 (pp OM115-OM115)
  • Murdoch C, Monk PN & Finn A (1996) Analysis of the endothelial panel reactivity against the type II alveolar epithelial cell line, A549.. TISSUE ANTIGENS, Vol. 48(4-II) (pp EC216-EC216)
Research group

PhD students:

  • Cher Farrugia: Use of in vitro and in vivo zebrafish embryo infection models to investigate the role of oral microorganisms in cardiovascular disease. (co-supervisor: Dr Graham Stafford, University Faculty Studentship)
  • Bethany Ollington: Immune-competent tissue engineered oral mucosal models to investigate xenobiotic metabolism. (co-supervisor: Dr Helen Colley, DiMeN MRC Studentship)
  • Inmaculada Barragan Vazquez: Tissue engineered modelling of atopic dermatitis (co-supervisors: Dr Helen Colley & Dr Simon Danby, Almirall S.A. funded PhD Studentship)
  • Asma El-Howati: Tissue engineered oral inflammatory lesions (lead supervisor: Dr Helen Colley, Funded by Libyan Government Scholarship)
  • Klaudia Slowik: The role of metabolising enzymes in drug delivery for prevention of alveolar osteitis. (lead supervisor: Dr Helen Colley, EPSRC Funded Studentship)
  • Jake Edmans: Peptide delivery using electrospun mucoadhesive patches (lead supervisor: Dr Helen Colley, EPSRC Centre for Doctoral Training in Polymers and Soft Matter)
  • Asmaa Zanki: Fabrication of dentures with anti-fungal properties by additive manufacturing. (lead supervisor: Prof. Paul Hatton - Funded by Kuwait Government Scholarship)
Teaching activities

Undergraduate:

Bachelor of Dental Surgery:

  • DEN11001 - The Human Body
  • DEN11002 - The Oral Cavity in Health and Disease
  • DEN21004 – Nutrition, Disease and Materials
  • DEN31002 - Integrated Human Disease
  • DEN41004 - Oral Disease

BSc Bio-Dental Science and Technology:

MbChB Medicine:

  • MEDU01 – Immunology

Post-Graduate Taught:

  • DEN616 – Tissue Engineering & Regenerative Dentistry (module lead) taught to both MSc in Dental Materials Science and MMedSci in Diagnostic Oral Pathology
  • OCP604 – MSc(Res) Translational Oncology (Chemokines in Cancer)
  • PGT research projects regularly supervised for MSc Dental Materials Science, MMedSci in Diagnostic Oral Pathology, MSc Molecular Medicine and MSc(Res) Translational Oncology.
Professional activities and memberships
  • British Association for Cancer Research National Executive Committee Member (2017 - 2021).
  • National Centre for the Replacement Refinement and Reduction of Animals (NC3R) Studentship Grant Review Board Member (2015 - 2020).
  • PlosOne Academic Editor.
  • Associate Editor Frontiers in Oral Health

Links