DAFNEplus research study
Developing and trialling the DAFNEplus (Dose Adjustment for Normal Eating) intervention. A lifelong approach to promote effective self-management in adults with type 1 diabetes.
¾Ã²Ý¸£Àû the study
The Clinical Trials Research Unit, ScHARR and the Department of Electronic and Electrical Engineering staff have been awarded a £3.4 million programme grant from the NIHR (National Institute for Health Research) Programme Grants for Applied Research.
The DAFNEplus research programme involves research groups from across the UK, and is led by Professor Simon Heller, Professor of Clinical Diabetes at the University of Sheffield and Research and Development Director at Sheffield Teaching Hospitals NHS Foundation Trust.
Aims
The aim is to re-develop and evaluate the programme to help people with type 1 diabetes (T1D) to be supported and motivated to manage their condition as part of their everyday lives, in the longer term.
The DAFNEplus programme will see the introduction of several programmes, models and changes to the existing DAFNE programme.
This will include behaviour change techniques and a structured model of support with new technology.
Once the research has completed, the aim is to provide the full programme as a sustained model of support rather than an initial standalone course.
Methods
Following a successful pilot study, a cluster randomised controlled trial (RCT) opened to recruitment in September 2018. Our initial timescales have been extended due to restrictions imposed by the Covid-19 pandemic.
The large-scale Randomised Control Trial (RCT) plans to recruit 660 patients to assess the effectiveness and cost-effectiveness of DAFNEplus. The primary outcome is blood glucose control, as well as quality of life and relevant psychological outcomes. The RCT also includes a qualitative sub-study and assessment of intervention fidelity.
A number of multi-disciplinary workstreams, outlined below, developed the intervention before the pilot study started in March 2017.
- Workstream 1: Revising the DAFNE Curriculum (Lead: Professor Simon Heller)
- Workstream 2: Developing structured support (Leads: Dr David Hopkins; Professor Simon Heller)
- Workstream 3: Technology (Lead: Dr Jackie Elliott)
For further information regarding the programme please contact the study team: dafneplus@sheffield.ac.uk
Follow the progress of the DAFNEplus programme grant on Twitter:
Central study staff
| Name | Role | Organisation | Contact |
| Chief Investigator | Sheffield Teaching Hospitals NHS Foundation Trust / University of Sheffield | s.heller@sheffield.ac.uk | |
| Study Manager | University of Sheffield | elaine.scott@sheffield.ac.uk | |
| CTRU Oversight | University of Sheffield | c.l.cooper@sheffield.ac.uk | |
| Jack Rose | Trials Support Officer | University of Sheffield | j.rose@sheffield.ac.uk |
| Jonathan Woodward | Research Assistant | University of Sheffield | jonathan.woodward@sheffield.ac.uk |
Sites and Principal Investigators
| Name and job title | Site |
| Dr Peter Hammond, Consultant Physician | Harrogate and District NHS Foundation Trust |
| Dr Mark Evans, Honorary Consultant Physician and Lecturer | Cambridge University Hospitals NHS Foundation Trust |
| Sarah Long, Senior Diabetes Dietitian | University College London Hospitals NHS Foundation Trust |
| Rosanne Dunkley, Specialist Community Diabetes Dietitian | Worcestershire Acute Hospitals NHS Foundation Trust |
| Dr Fiona Green, Consultant Physician | NHS Dumfries and Galloway |
| Dr Emma Wilmot, Consultant Diabetologist | Derby Teaching Hospitals NHS Foundation Trust |
| Dr Helen Hopkinson, Consultant Physician | Greater Glasgow and Clyde Health Board |
| Nardos Yemane, Senior Diabetes Specialist Dietitian | Guy's and St Thomas' NHS Foundation Trust |
| Tina Spence, Diabetes Specialist Nurse | South Tees Hospitals NHS Foundation Trust |
| Dr Tasso Gazis, Consultant in Endocrinology, Diabetes and General Medicine | Nottingham University Hospitals NHS Trust |
| Professor Thozhukat Sathyapalan, Honorary Consultant Endocrinologist | Hull University teaching Hospitals NHS Trust |
| Angela Thomas, Advanced Diabetes Specialist Nurse | Birmingham Community NHS Foundation Trust |
Co-investigators
| Name | Role | Institution |
| Senior Clinical Lecturer / Consultant Diabetologist | University of Sheffield | |
| Professor of Health Economics and Decision Modelling | University of Sheffield | |
| Senior Lecturer (Electrical and Electronic Engineering) | University of Sheffield | |
| Professor of Health and Social Science | University of Edinburgh | |
| Senior Lecturer (Health Psychology) | University of Surrey | |
| Senior Consultant Physician, Diabetologist | King’s College Hospital NHS Foundation Trust | |
| Simon Fisher | Patient Representative | DAFNE Online |
| Professor of Health Psychology | University College London | |
| Professor of Behavioural and Social Research in Diabetes | Deakin University, Australia | |
| Caroline Ferguson | DAFNE Educator and Diabetes Specialist Nurse | Chesterfield Royal Hospitals NHS Foundation Trust |
| Gill Thompson | National DAFNE Collaborative Manager | Northumbria Healthcare NHS Foundation Trust |
| Professor of Diabetic Medicine | King’s College London | |
| Professor of Health Services Research | University of Sheffield | |
| Professor of Health Psychology | University of Southampton |