Professor Richard Clayton

PhD

School of Computer Science

Professor of Computational Physiology

Director of School - Research and Innovation

Member of the Complex Systems Modelling research group

Richard Clayton profile photo
Profile picture of Richard Clayton profile photo
r.h.clayton@sheffield.ac.uk
Regent Court (DCS)

Full contact details

Professor Richard Clayton
School of Computer Science
Regent Court (DCS)
211 Portobello
Sheffield
S1 4DP
Profile

Richard Clayton has a first degree in Applied Physics and Electronics from the University of Durham, and a PhD in Medical Physics from the University of Newcastle upon Tyne. After completing his PhD, Richard continued research at the Freeman Hospital in Newcastle upon Tyne, funded by British Heart Foundation junior and intermediate fellowships.

The main focus of these projects was on understanding the electrical mechanisms that underlie life-threatening disorders of heart rhythm, based on the analysis of data recorded from patients. A move to the University of Leeds, funded by a British Heart Foundation Lectureship enabled Richard to work on developing mechanistic models of cardiac electrophysiology in the human heart.

Richard Clayton was appointed Senior Lecturer in the School of Computer Science in Sheffield in 2003, promoted to Reader in Computer Science in 2008, and Professor of Computational Physiology in 2014. He is a core member of the , and serves on the INSIGNEO board.

Research interests

Richard Clayton’s research interests are focussed on developing physics-based and mechanistic computational models and simulations as tools to examine the structure and function of human tissues and organs. This theme aligns with the recently established INSIGNEO institute for in-silico medicine in Sheffield.

Richard Clayton has had a long running interest in developing computational models to investigate the mechanisms that initiate and sustain dangerous disorders of heart rhythm in the human heart, and this has been funded through grants and fellowships from the British Heart Foundation.

Recent funding from EPSRC will develop techniques to handle the quantification and propagation of uncertainty within multiscale models of physiology.

Publications

Journal articles

  • Saxton H, Taylor DJ, Faulkner G, Halliday I, Newman T, Schenkel T, Morris PD, Clayton RH & Xu X (2025) . PLoS One, 20(6).
  • Tonko JB, Sattler S, Dalgas Nissen S, Jerltorp K, Seshan S, Chow A, Jespersen T, Clayton R & Lambiase P (2025) . EP Europace, 27(Supplement_1).
  • Sridhar S & Clayton RH (2025) . Scientific Reports, 15(1).
  • Holland BL, Monk NAM, Clayton RH & Osborne CP (2025) . in silico Plants, 7(1).
  • Weiner OJF, Das M, Clayton RH, McComb JM, Murray A, Parry G & Lord SW (2025) . The Journal of Heart and Lung Transplantation, 44(2), 204-212.
  • Mamalakis M, Banerjee A, Ray S, Wilkie C, Clayton RH, Swift AJ, Panoutsos G & Vorselaars B (2024) . Neural Computing and Applications, 36(30), 18841-18862.
  • Saxton H, Xu X, Schenkel T, Clayton RH & Halliday I (2024) . PLoS Computational Biology, 20(7).
  • Dharmaprani D, Tiver K, Salari Shahrbabaki S, Jenkins EV, Chapman D, Strong C, Quah JX, Tonchev I, O’Loughlin L, Mitchell L , Tung M et al (2024) . Circulation: Arrhythmia and Electrophysiology, 17(7).
  • Clayton RH & Sridhar S (2024) . Frontiers in Physiology, 15.
  • Sridhar S & Clayton RH (2024) . Scientific Reports, 14(1).
  • Dharmaprani D, Jenkins E, Tiver K, Quah J, Mitchell L, Tung M, Ahmad W, Stoyanov N, Aguilar M, Nash M , Clayton R et al (2023) . Heart, Lung and Circulation, 32, S196-S196.
  • Jenkins EV, Dharmaprani D, Schopp M, Quah JX, Tiver K, Mitchell L, Nash MP, Clayton RH, Pope K & Ganesan AN (2023) . Chaos: An Interdisciplinary Journal of Nonlinear Science, 33(6).
  • Mamalakis M, Garg P, Nelson T, Lee J, Swift AJ, Wild JM & Clayton RH (2023) . Artificial Intelligence in Medicine, 143.
  • Corrado C, Roney CH, Razeghi O, Lemus JAS, Coveney S, Sim I, Williams SE, O’Neill MD, Wilkinson RD, Clayton RH & Niederer SA (2023) . Computers in Biology and Medicine, 153, 106528-106528.
  • Mamalakis M, Garg P, Nelson T, Lee J, Swift AJ, Wild JM & Clayton RH (2023) . Computerized Medical Imaging and Graphics, 103.
  • Coveny S, Roney C, Corrado C, Wilkinson R, Oakley J, Niederer S & Clayton R (2022) . Scientific Reports, 12.
  • Jenkins EV, Dharmaprani D, Schopp M, Quah JX, Tiver K, Mitchell L, Xiong F, Aguilar M, Pope K, Akar FG , Roney CH et al (2022) . Frontiers in Physiology, 13.
  • Jenkins E, Dharmaprani D, Schopp M, Xian Quah J, Tiver K, Mitchell L, Nash M, Clayton R & Ganesan A (2022) . Heart, Lung and Circulation, 31, S116-S116.
  • Lee JMS, Nelson TA, Clayton RH & Kelland NF (2022) . Journal of Arrhythmia, 38(1), 77-85.
  • Dharmaprani D, Jenkins EV, Quah JX, Lahiri A, Tiver K, Mitchell L, Bradley CP, Hayward M, Paterson DJ, Taggart P , Clayton RH et al (2022) . Heart Rhythm, 19(2), 295-305.
  • Mamalakis M, Swift AJ, Vorselaars B, Ray S, Weeks S, Ding W, Clayton RH, Mackenzie LS & Banerjee A (2021) . Computerized Medical Imaging and Graphics, 94.
  • Bernjak A, Iqbal A, Heller S & Clayton R (2021) . Journal of the Royal Society Interface, 18(184).
  • Coveney S, Corrado C, Oakley JE, Wilkinson RD, Niederer SA & Clayton RH (2021) . Frontiers in Physiology, 12, 765622.
  • Mamalakis M, Garg P, Nelson T, Lee J, Wild JM & Clayton RH (2021) . Computerized Medical Imaging and Graphics, 93.
  • Roney CH, Child N, Porter B, Sim I, Whitaker J, Clayton RH, Laughner JI, Shuros A, Neuzil P, Williams SE , Razavi RS et al (2021) . Frontiers in Physiology, 12.
  • Coveny S, Corrado C, Oakley J, Wilkinson R, Niederer S & Clayton R (2021) . Frontiers in Physiology, 12.
  • Dharmaprani D, Jenkins E, Aguilar M, Quah JX, Lahiri A, Tiver K, Mitchell L, Kuklik P, Meyer C, Willems S , Clayton R et al (2021) . Frontiers in Physiology, 11(1).
  • Dharmaprani D, Jenkins E, Quah J, Lahiri A, Tiver K, Mitchell L, Bradley C, Hayward M, Paterson D, Taggart P , Clayton R et al (2021) . Heart, Lung and Circulation, 30, S144-S145.
  • Coveney S, Corrado C, Roney CH, O’Hare D, Williams SE, O’Neill MD, Niederer SA, Clayton RH, Oakley JE & Wilkinson RD (2020) . Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 378(2173), ---.
  • Clayton RH, Aboelkassem Y, Cantwell CD, Corrado C, Delhaas T, Huberts W, Lei CL, Ni H, Panfilov AV, Roney C & dos Santos RW (2020) . Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 378(2173).
  • Mirams GR, Niederer SA & Clayton RH (2020) . Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 378(2173), 20200119-20200119.
  • Coveney S & Clayton RH (2020) . Frontiers in Physiology, 11.
  • Corrado C, Razeghi O, Roney C, Coveney S, Williams S, Sim I, O'Neill M, Wilkinson R, Oakley J, Clayton R & Niederer S (2020) . Medical Image Analysis, 61.
  • Coveney S, Corrado C, Roney C, Wilkinson R, Oakley J, Lindgren F, Williams S, O'Neill M, Niederer S & Clayton R (2020) . IEEE Transactions on Biomedical Engineering, 67(1), 99-109.
  • Nelson T, Garg P, Clayton RH & Lee J (2019) . Arrhythmia & Electrophysiology Review, 8(3), 191-201.
  • Melis A, Moura F, Larrabide I, Janot K, Clayton RH, Narata AP & Marzo A (2019) . Journal of Biomechanics, 90, 24-32.
  • Coveney S & Clayton RH (2018) . Progress in Biophysics & Molecular Biology, 139, 43-58.
  • Clayton RH (2018) . Frontiers in Physiology, 9.
  • Child N, Clayton RH, Roney CR, Laughner JI, Shuros A, Neuzil P, Petru J, Jackson T, Porter B, Bostock J , Niederer SA et al (2018) . Circulation: Arrhythmia and Electrophysiology, 11(6).
  • Robson J, Aram P, Nash MP, Bradley CP, Hayward M, Paterson DJ, Taggart P, Clayton RH & Kadirkamanathan V (2018) . Annals of Biomedical Engineering, 46(6), 864-876.
  • Johnston BM, Coveney S, Chang ETY, Johnston PR & Clayton RH (2018) . Medical & Biological Engineering & Computing, 56(5), 761-780.
  • Melis A, Clayton RH & Marzo A (2017) . International Journal for Numerical Methods in Biomedical Engineering, 33(12).
  • Chang ETY, Bernjak A, Nelson T, Smith G, Lee J & Clayton RH (2017) . EP Europace, 19(suppl_1), i13-i13.
  • Mirams GR, Pathmanathan P, Gray RA, Challenor P & Clayton RH (2016) . Journal of Physiology, 594(23), 6833-6847.
  • Chang ETY, Lin YT, Galla T, Clayton RH & Eatock J (2016) . PLoS ONE, 11(4).
  • Chang ET, Strong M & Clayton RH (2015) . PLoS One, 10(8).
  • Chang ETY, Strong M & Clayton RH (2015) . PLoS ONE, 10(6).
  • Clayton RH & Nash MP (2015) . Cardiac Electrophysiology Clinics, 7(1), 49-58.
  • Clayton RH & Bishop MJ (2015) . Drug Discovery Today: Disease Models, 14, 17-22.
  • Kazbanov IV, Clayton RH, Nash MP, Bradley CP, Paterson DJ, Hayward MP, Taggart P & Panfilov AV (2014) . PLoS Computational Biology, 10(11).
  • Taggart P, Orini M, Hanson B, Hayward M, Clayton R, Dobrzynski H, Yanni J, Boyett M & Lambiase PD (2014) . Prog Biophys Mol Biol, 115(2-3), 252-260.
  • Clayton RH (2013) . Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBS, 1526-1529.
  • Steinacher A, Leyser O & Clayton RR (2012) . Journal of Theoretical Biology, 296, 84-94.
  • Niederer SA, Kerfoot E, Benson AP, Bernabeu MO, Bernus O, Bradley C, Cherry EM, Clayton R, Fenton FH, Garny A , Heidenreich E et al (2011) . PHILOS T R SOC A, 369(1954), 4331-4351.
  • Clayton RH, Nash MP, Bradley CP, Panfilov AV, Paterson DJ & Taggart P (2011) . Progress in Biophysics and Molecular Biology, 107(1), 101-111.
  • Bradley CP, Clayton RH, Nash MP, Mourad A, Hayward M, Paterson DJ & Taggart P (2011) . Circ Arrhythm Electrophysiol, 4(5), 684-691.
  • Clayton RH, Nash MP, Bradley CP, Panfilov AV, Paterson DJ & Taggart P (2011) . Prog Biophys Mol Biol, 107(1), 101-111.
  • Fry CH, Sadananda P, Wood DN, Thiruchelvam N, Jabr RI & Clayton R (2011) . NEUROUROL URODYNAM, 30(5), 692-699.
  • Smith N, Waters S, Hunter P & Clayton R (2011) . Progress in Biophysics and Molecular Biology, 104(1-3), 1-1.
  • Clayton RH, Bernus O, Cherry EM, Dierckx H, Fenton FH, Mirabella L, Panfilov AV, Sachse FB, Seemann G & Zhang H (2011) . Prog Biophys Mol Biol, 104(1-3), 22-48.
  • Clayton RH (2010) Re-entry in a model of ischaemic ventricular tissue. Computing in Cardiology, 37, 181-184.
  • Clayton RH, Abdalhamid S, Bloor R, Kyprianou G, Kotagiri K, Lee J, Mane A & White R (2010) Transmural changes in fibre helix angle in normal and failing canine ventricles. Computing in Cardiology, 37, 915-918.
  • Garnett P, Steinacher A, Stepney S, Clayton R & Leyser O (2010) . BIOESSAYS, 32(9), 828-835.
  • Sheridan PJ, Marques JLB, Newman CMH, Heller SR & Clayton RH (2010) . Europace, 12(4), 553-560.
  • Clayton RH (2009) . PHYSICA D, 238(11-12), 951-961.
  • ten Tusscher KHWJ, Mourad A, Nash MP, Clayton RH, Bradley CP, Paterson DJ, Hren R, Hayward M, Panfilov AV & Taggart P (2009) . EXP PHYSIOL, 94(5), 553-562.
  • Scarle S & Clayton RH (2009) . Med Biol Eng Comput, 47(3), 291-300.
  • Clayton RH (2008) . Chaos, 18(4), 043127.
  • Clayton R & Nash M (2008) , 175-193.
  • Clayton RH & Panfilov AV (2008) . Prog Biophys Mol Biol, 96(1-3), 19-43.
  • Nash MP, Mourad A, Bradley CP, Paterson DJ, Clayton RH, Sutton PM, Hayward M & Taggart P (2007) . Circulation, 116(suppl_16).
  • Clayton RH & Scarle S (2006) Re-entry by early afterdepolarisations in a computational model. Computers in Cardiology, 33, 221-224.
  • Mourad A, Nash MP, Clayton RH, Bradley CP, Sutton PM, Hayward M, Paterson DJ & Taggart P (2006) . Iet Conference Publications(520), 47.
  • Holden AV, Aslanidi OV, Benson AP, Clayton RH, Halley G, Li P & Tong WC (2006) . J BIOL PHYS, 32(3-4), 355-368.
  • Scarle S & Clayton RH (2006) . Chaos, 16(3), 033115.
  • Nash MP, Mourad A, Clayton RH, Sutton PM, Bradley CP, Hayward M, Paterson DJ & Taggart P (2006) . CIRCULATION, 114(6), 536-542.
  • Clayton RH & Taggart P (2006) . Heart Rhythm, 3(5), S309-S310.
  • Mourad A, Nash MP, Clayton RH, Sutton PM, Bradley CP, Hayward M, Paterson DJ & Taggart P (2006) . Heart Rhythm, 3(5), S264-S264.
  • Benson AP, Clayton RH, Holden AV, Kharche S & Tong WC (2006) . PHILOS T R SOC A, 364(1842), 1313-1327.
  • Crampin EJ, Smith NP, Langham AE, Clayton RH & Orchard CH (2006) . PHILOS T R SOC A, 364(1842), 1171-1186.
  • Nash MP, Bradley CP, Sutton PM, Clayton RH, Kallis P, Hayward MP, Paterson DJ & Taggart P (2006) . EXP PHYSIOL, 91(2), 339-354.
  • Clayton RH, Zhuchkova EA & Panfilov AV (2006) . Prog Biophys Mol Biol, 90(1-3), 378-398.
  • Aslanidi OV, Biktashev VN, Biktasheva IV, Clayton RH & Holden AV (2005) . Studies in Multidisciplinarity, 3(C), 389-410.
  • Clayton RH & Taggart P (2005) . Biomed Eng Online, 4, 54.
  • Aslanidi OV, Clayton RH, Lambert JL & Holden AV (2005) . J THEOR BIOL, 237(4), 369-381.
  • Clayton RH & Holden AV (2005) . Biomed Eng Online, 4, 11.
  • Clayton RH & Holden AV (2004) . Prog Biophys Mol Biol, 85(2-3), 473-499.
  • Clayton RH & Holden AV (2004) . IEEE Trans Biomed Eng, 51(1), 28-34.
  • Clayton RH & Holden AV (2003) Virtual tissue engineering of the heart. INT J BIFURCAT CHAOS, 13(12), 3531-3534.
  • Clayton RH & Holden AV (2003) . Phys Med Biol, 48(1), 95-111.
  • Smye SW & Clayton RH (2002) . Med Eng Phys, 24(9), 565-574.
  • Clayton RH & Holden AV (2002) . Physiol Meas, 23(4), 707-726.
  • Aslanidi OV, Bailey A, Biktashev VN, Clayton RH & Holden AV (2002) . Chaos, 12(3), 843-851.
  • Clayton RH & Holden AV (2002) . Phys Med Biol, 47(10), 1777-1792.
  • Clayton RH & Holden AV (2002) . Phys Med Biol, 47(2), 225-238.
  • Clayton RH & Holden AV (2002) From excitable media to virtual cardiac tissue. CHAOS SOLITON FRACT, 13(8), 1579-1580.
  • Clayton RH (2001) . Physiol Meas, 22(3), R15-R34.
  • Clayton RH, Bailey A, Biktashev VN & Holden AV (2001) . J Theor Biol, 208(2), 215-225.
  • Whittam AM, Clayton RH, Lord SW, McComb JM & Murray A (2000) Heart rate and blood pressure variability in normal subjects compared with data from beat-to-beat models developed from de Boer's model of the cardiovascular system. PHYSIOL MEAS, 21(2), 305-318.
  • Clayton RH & Murray A (1999) . Physiol Meas, 20(2), 159-166.
  • Clayton RH & Murray A (1999) . Med Biol Eng Comput, 37(3), 354-358.
  • Murray A, Whittam AM, Clayton RH, Lord SW & McComb JM (1998) Computer simulation of heart rate and blood pressure changes, and comparison with clinical data. IEE Colloquium Digest(526), 8/3.
  • (1998) . Clinical Science, 95(5), 575-575.
  • Clayton RH & Murray A (1998) Comparison of techniques for time-frequency analysis of the ECG during human ventricular fibrillation. IEE P-SCI MEAS TECH, 145(6), 301-306.
  • Lord SW, Clayton RH, Hall MC, Gray JC, Murray A, McComb JM & Kenny RA (1998) . Clin Sci (Lond), 95(5), 575-581.
  • Clayton RH, Campbell RW & Murray A (1998) . IEEE Eng Med Biol Mag, 17(1), 39-55.
  • Bowman AJ, Clayton RH, Murray A, Reed JW, Subhan MM & Ford GA (1997) . Eur J Clin Invest, 27(5), 443-449.
  • Clayton RH, Campbell RWF & Murray A (1997) Time-frequency analysis of ventricular arrhythmias. IEE Colloquium Digest(6), 6/4.
  • Bowman AJ, Clayton RH, Murray A, Reed JW, Subhan MF & Ford GA (1997) . Age Ageing, 26(4), 289-294.
  • Lord SW, Clayton RH, Mitchell L, Dark JH, Murray A & McComb JM (1997) . Heart, 77(6), 532-538.
  • Lord SW, Clayton RH, Hall MCS, Bishop J, Murray A, McComb JM & Kenny RA (1997) Baroreflex sensitivity may be estimated using spectral analysis. Heart, 77(SUPPL. 1), P32.
  • Clayton RH, Murray A & Campbell RW (1995) . J Cardiovasc Electrophysiol, 6(8), 616-624.
  • Clayton RH, Murray A & Campbell RW (1995) . Pacing Clin Electrophysiol, 18(10), 1876-1881.
  • Clayton RH, Bowman AJ, Ford GA & Murray A (1995) . Physiol Meas, 16(2), 131-139.
  • BOWMAN AJ, CLAYTON RH, MURRAY A & FORD GA (1995) EFFECTS OF AEROBIC ON BAROREFLEX SENSITIVITY IN HEALTHY SEDENTARY ELDERLY SUBJECTS. J AM GERIATR SOC, 43(9), SA77-SA77.
  • Clayton RH, Murray A & Campbell RW (1995) . Eur Heart J, 16(8), 1115-1119.
  • Murray A, Clayton RH & Campbell RW (1995) . Resuscitation, 29(2), 113-117.
  • Bowman AJ, Clayton RH, Murray A & Ford GA (1995) . Age and Ageing, 24(suppl 2), P3-P3.
  • Murray A, Allen J, Allen V, Clayton RH, McLaughlin NB & Relf GT (1994) . Physiol Meas, 15(3), 235-242.
  • Clayton RH, Murray A & Pearson DT (1994) . Perfusion, 9(3), 163-171.
  • Clayton RH, Murray A & Campbell RW (1994) . Med Biol Eng Comput, 32(2), 217-220.
  • Clayton RH, Murray A & Campbell RW (1994) . Eur Heart J, 15(2), 184-188.
  • Clayton RH, Murray A & Campbell RW (1993) . Med Biol Eng Comput, 31(2), 111-117.
  • Clayton RH, Murray A, Higham PD & Campbell RW (1993) . Lancet, 341(8837), 93-95.
  • Murray A, Clayton RH & Campbell RW (1993) . Resuscitation, 26(2), 163-172.
  • Clayton RH, Pearson DT & Murray A (1992) . Clin Phys Physiol Meas, 13(2), 167-177.
  • Murray A, Lawrence GP & Clayton RH (1991) Repeatability of dynamic eye pupil response measurement using the Pupilscan instrument.. Clin Phys Physiol Meas, 12(4), 377-385.
  • Clayton RH, Pearson DT & Murray A (1990) . Clin Phys Physiol Meas, 11(4), 327-332.
  • Pfeifer PM, Pearson DT & Clayton RH (1988) . Anaesthesia, 43(8), 677-682.
  • Pearson DT, Clayton R, Murray A & McArdle B (1988) . Perfusion, 3(1), 55-63.
  • PEARSON DT, POSLAD SJ, MURRAY A & CLAYTON R (1987) EXTRACORPOREAL-CIRCULATION MATERIAL EVALUATION - MICROEMBOLI. LIFE SUPPORT SYST, 5(1), 53-67.
  • Holland BL, Monk NAM, Clayton RH & Osborne CP () . in silico Plants (isP), 1(1).
  • Lin YT, Chang ETY, Eatock J, Galla T & Clayton RH () . Interface, 14(128).
  • Johnstone RH, Chang ETY, Bardenet R, De Boer T, Gavaghan DJ, Pathmanathan P, Clayton RH & Mirams GR () . Journal of Molecular and Cellular Cardiology.

Book chapters

  • Ramzan F, Kiberu Y, Jathanna N, Jamil-Copley S, Clayton RH & Chen C (2025) In Cafolla D, Rittman T & Ni H (Ed.), Lecture Notes in Computer Science (pp. 279-292). Springer Cham
  • Clayton RH & Hose DR (2017) , Cardiovascular Biomechanics (pp. 107-126). Springer International Publishing
  • Clayton RH (2013) , Encyclopedia of Systems Biology (pp. 1638-1640). Springer New York
  • Clayton R & Nash M (2008) Modelling the mammalian heart. In Grierson C & Hetherington A (Ed.), Practical systems biology (pp. 175-193). Taylor and Francis Group
  • Clayton RH & Nash MP (2008) Modelling the mammalian heart In Grierson C & Hetherington AM (Ed.), Practical systems biology Taylor & Francis Group
  • Aslanidi OV, Biktashev VN, Biktasheva IV, Clayton RH & Holden AV (2006) Towards understanding the physical basis of re-entrant cardiac arrhythmias, MULTIDISCIPLINARY APPROACHES TO THEORY IN MEDICINE (pp. 389-410).

Conference proceedings

  • Tonko JB, Sattler S, Dalgas-Nissen S, Jerltorp K, Friderichsen L, Castelein J, Saljic A, Linz D, Jespersen T, Chow A , Clayton R et al (2025) . Cardiac rhythm management (pp a142.2-a1a143)
  • Bernjak A, Heller SR & Clayton RH (2019) Can computational modelling explain the dead in bed syndrome?. DIABETOLOGIA, Vol. 62 (pp S46-S46)
  • Chang ETY, Coveney S & Clayton RH (2017) . Functional Imaging and Modelling of the Heart 2017, Proceedings, Vol. 10263 (10263) (pp 249-259). Toronto, ON, Canada
  • Bernjak A, Chow E, Lee J, Iqbal A, Lubina-Solomon A, Walkinshaw E, Macdonald IA, Heller SR, Clayton RH & Sheridan PJ (2017) Pharmacological autonomic blockade during experimental hypoglycaemia exacerbates cardiac repolarisation abnormalities. DIABETOLOGIA, Vol. 60 (pp S74-S74)
  • Bernjak A, Chow E, Lee J, Iqbal A, Lubina-Solomon A, Walkinshaw E, Heller SR, Clayton RH & Sheridan PJ (2017) Pharmacological Autonomic Blockade Exacerbates Cardiac Repolarization Abnormalities during Experimental Hypoglycemia. DIABETES, Vol. 66 (pp A95-A95)
  • Chang ETY & Clayton RH (2016) . 2015 Computing in Cardiology Conference (CinC) (pp 857-860). 2015 Computing in Cardiology Conference (CinC), 6 September 2015 - 6 September 2015.
  • Chang ETY & Clayton RH (2015) . 2015 Computing in Cardiology Conference (CinC) (pp 441-444), 6 September 2015 - 9 September 2015.
  • Eatock J, Lin YT, Chang ETY, Galla T & Clayton RH (2015) . 2015 Computing in Cardiology Conference (CinC) (pp 265-268), 6 September 2015 - 9 September 2015.
  • Chang ETY & Clayton RH (2014) Parameter sensitivity analysis of a human atrial cell model using multivariate regression. Computing in Cardiology, Vol. 41(January) (pp 521-524)
  • Malyala S & Clayton RH (2014) The effect of scar tissue on complexity of activation patterns in simulated human ventricular fibrillation. Computing in Cardiology, Vol. 41(January) (pp 1133-1136)
  • Clayton RH & Malyala S (2013) Clustering of Re-entry Close to Scar Boundaries in Ventricular Tissue during Simulated Ventricular Fibrillation. Computing in Cardiology, Vol. 40 (pp 1131-1134). Barcelona
  • Clayton RH & Abbasi M (2013) A Comparison of Two Models of Human Ventricular Tissue: Simulated Ischaemia and Re-entry. Computing in Cardiology, Vol. 40 (pp 385-388). Barcelona
  • Clayton RH, Bradley CP, Nash MP, Mourad A, Hayward M, David P & Peter T (2009) Transient Type II Ventricular Fibrillation During Global Ischemia in the in-situ Human Heart. CIRCULATION, Vol. 120(18) (pp S630-S630)
  • Skolidis G, Clayton RH & Sanguinetti G (2008) Automatic Classification of Arrhythmic Beats Using Gaussian Processes. COMPUTERS IN CARDIOLOGY 2008, VOLS 1 AND 2 (pp 921-924)
  • Clayton RH, Bradley CP, Nash MP, Varma S, Mourad A, Paterson DJ, Hayward M & Taggart P (2008) Epicardial Mapping of Ventricular Fibrillation in the Human Heart during Ischaemia and Reperfusion. COMPUTERS IN CARDIOLOGY 2008, VOLS 1 AND 2 (pp 1029-1032)
  • Nash MP, Mourad A, Bradley CP, Paterson DJ, Clayton RH, Sutton PM, Hayward M & Taggart P (2007) Is human ventricular fibrillation different from experimental models?. CIRCULATION, Vol. 116(16) (pp 278-278)
  • Nash MP, Mourad A, Bradley CP, Paterson DJ, Clayton RH, Sutton PM, Hayward M & Taggart P (2007) Mobility of epicardial rotors during human ventricular fibrillation. CIRCULATION, Vol. 116(16) (pp 278-278)
  • Handley JW, Brodlie KW & Clayton RH (2006) Multi-variate visualization of cardiac virtual tissue. 19TH IEEE INTERNATIONAL SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS, PROCEEDINGS (pp 665-670)
  • Handley JW, Brodfie KW & Clayton RH (2006) Model based visualization of cardiac virtual tissue. Proceedings of the UK e-Science All Hands Meeting 2006 (pp 233-240)
  • Mourad A, Nash MP, Clayton RH, Bradley CP, Paterson DJ, Sutton PM, Hayward M & Taggart P (2005) Early ventricular fibrillation in the human heart is sustained by a small number of re-entrant sources. CIRCULATION, Vol. 112(17) (pp U131-U131)
  • Zhuchkova E & Clayton R (2005) Methods for identifying and tracking phase singularities in computational models of re-entrant fibrillation. FUNCTIONAL IMAGING AND MODELING OF HEART, PROCEEDINGS, Vol. 3504 (pp 246-255)
  • Kharche S, Zhang H, Clayton RC & Holden AV (2005) . Lecture Notes in Computer Science, Vol. 3504 (pp 153-161)
  • Kharche S, Zhang H, Clayton R & Holden AV (2004) Simulation of hypertrophy in rat left ventricular cells. Computers in Cardiology 2004, Vol 31, Vol. 31 (pp 513-516)
  • Clayton RH, Holden AV & Tong WC (2003) Can endogenous, noise-triggered early after-depolarizations initiate reentry in a modified Luo-Rudy ventricular virtual tissue?. INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, Vol. 13(12) (pp 3835-3843)
  • Aslanidi OV, Clayton RH, Holden AV, Phillips HK & Ward RJ (2003) Vulnerability to reentry, and drift, stability and breakdown of spiral waves in a linear gradient of G(K) in a Luo-Rudy 1 virtual ventricular tissue. INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, Vol. 13(12) (pp 3865-3871)
  • Chen M, Tucker JV, Clayton RH & Holden AV (2003) Constructive volume geometry applied to visualization of cardiac anatomy and electrophysiology. INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, Vol. 13(12) (pp 3591-3604)
  • Clayton RH & Holden AV (2003) Dynamics and interaction of filaments during reentry and fibrillation in mammalian virtual ventricular tissue. INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, Vol. 13(12) (pp 3733-3745)
  • Chen M, Clayton RH, Holden AV & Tucker JV (2003) Visualising cardiac anatomy using constructive volume geometry. FUNCTIONAL IMAGING AND MODELING OF THE HEART, PROCEEDINGS, Vol. 2674 (pp 30-38)
  • Clayton RH & Holden AV (2002) Simulating the ECG of ventricular tachyarrhythmias. COMPUTERS IN CARDIOLOGY 2002, VOL 29, Vol. 29 (pp 321-324)
  • Clayton RH & Holden AV (2002) Filament dynamics in a computational model of re-entrant fibrillation in anatomically detailed canine ventricular anatomy. SECOND JOINT EMBS-BMES CONFERENCE 2002, VOLS 1-3, CONFERENCE PROCEEDINGS (pp 1417-1418)
  • Clayton RH & Holden AV (2002) Regional differences in action potential duration and stability of re-entry: insights from computational models. JOURNAL OF PHYSIOLOGY-LONDON, Vol. 544 (pp 3P-3P)
  • Clayton RH, Parkinson K & Holden AV (2002) Re-entry in computational models of ischaemic myocardium. CHAOS SOLITONS & FRACTALS, Vol. 13(8) (pp 1671-1683)
  • Small M, Yu DJ, Harrison RG, Clayton R, Eftestol T, Sunde K & Steen PA (2001) Temporal evolution of nonlinear dynamics in ventricular arrhythmia. INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, Vol. 11(10) (pp 2531-2548)
  • Aslanidi OV, Clayton RH & Holden AV (2001) Re-entry in the Luo-Rudy ventricular tissue model with different models of Ca2+ dynamics. COMPUTERS IN CARDIOLOGY 2001, VOL 28, Vol. 28 (pp 233-236)
  • Aslanidi OV, Biktashev VN, Clayton RH & Holden AV (2001) Differential meander of re-entrant spiral waves in mammalian virtual ventricular tissue. JOURNAL OF PHYSIOLOGY-LONDON, Vol. 536 (pp 71P-71P)
  • Clayton RH & Holden AV (2000) Computational simulation of multiple wavelet re-entry and fibrillatory conduction shows differences in the ECG characteristics of each mechanism. COMPUTERS IN CARDIOLOGY 2000, VOL 27, Vol. 27 (pp 343-346)
  • Clayton RH, Bailey A, Biktashev VN & Holden AV (1999) Re-entrant arrhythmias in simulations of the Long-QT syndrome. COMPUTERS IN CARDIOLOGY 1999, VOL 26 (pp 121-124)
  • Clayton RH, Yu DJ, Small M, Biktashev VN, Harrison RG & Holden AV (1999) Linear and nonlinear characteristics of ECG signals produced by simulations of ventricular tachyarrhythmias. COMPUTERS IN CARDIOLOGY 1999, VOL 26 (pp 479-482)
  • Whittam AM, Clayton RH, Lord SW, McComb JM & Murray A (1998) Computer modelling of heart rate and blood pressure. COMPUTERS IN CARDIOLOGY 1998, VOL 25, Vol. 25 (pp 149-152)
  • Clayton RH, Lord SW, McComb JM & Murray A (1997) Comparison of autoregressive and Fourier transform based techniques for estimating RR interval spectra. COMPUTERS IN CARDIOLOGY 1997, VOL 24, Vol. 24 (pp 379-382)
  • Clayton RH, Campbell RWF & Murray A (1997) Time-frequency analysis of human polymorphic ventricular tachycardia. COMPUTERS IN CARDIOLOGY 1997, VOL 24, Vol. 24 (pp 97-100)
  • Clayton RH & Murray A (1997) Model based investigation of cardiovascular variability. IEE Colloquium Digest(9) (pp 6/3)
  • Clayton RH, Campbell RWF & Murray A (1996) Relation between intracardiac and surface ECG signals during the onset of human ventricular fibrillation. COMPUTERS IN CARDIOLOGY 1996 (pp 341-344)
  • Clayton RH, Murray A & Campbell RWF (1995) Frequency analysis of ventricular fibrillation. IEE Colloquium Digest(43) (pp 3/4)
  • Clayton RH, Bowman AJ, Ford GA & Murray A (1995) Comparison of techniques for estimating baroreflex gain from heart rate and blood pressure spectra. COMPUTERS IN CARDIOLOGY 1995 (pp 301-304)
  • CLAYTON RH & MURRAY A (1993) ESTIMATION OF THE ECG SIGNAL SPECTRUM DURING VENTRICULAR-FIBRILLATION USING THE FAST FOURIER-TRANSFORM AND MAXIMUM-ENTROPY METHODS. COMPUTERS IN CARDIOLOGY 1993, PROCEEDINGS (pp 867-870)
  • Clayton RH, Murray A, Whittam AM & Campbell RWF (1992) Automatic recording of ventricular fibrillation. Computers in Cardiology (pp 685-688)
  • Clayton RH, Murray A & Campbell RWF (1991) Changes in the surface ECG frequency spectrum during the onset of ventricular fibrillation. Computers in Cardiology (pp 515-518)
  • Coveney S, Corrado C, Roney C, D. Wilkinson R, Oakley J, niederer S & H. Clayton" R () . Computing in Cardiology Conference (CinC)
  • Corrado C, Williams S, Sim I, Coveney S, O'Neill M, Wilkinson R, Oakley J, Clayton R & Niederer S () . 2018 Computing in Cardiology Conference (CinC), Vol. 45. Maastricht, The Netherlands, 23 September 2018 - 23 September 2018.
  • Abbasi M & Clayton RH () Formulation of ATP sensitive K+ current and action potential shape in models of human ventricular myocytes. Computing in Cardiology, Vol. 41 (pp 201-201). Cambridge, 7 September 2014 - 10 September 2014.
  • Abbasi M & Clayton R () Formulation of ATP sensitive K+ Current and Action Potential Shape in Models of Human Ventricular Myocytes. Computing in Cardioliogy, Vol. 41 (pp 201-204). Cambridge, MA (USA), 7 September 2014 - 7 September 2014.
  • Small M, Yu DJ, Clayton RH, Simonotto J & Harrison RG () . Computers in Cardiology 2000. Vol.27 (Cat. 00CH37163) (pp 525-528)
  • Clayton RH, Murray A & Campbell RWF () . Proceedings Computers in Cardiology (pp 155-158)

Reports

  • Carusi A (2015) In silico Clinical Trials: How Computer Simulations Will Transform the Biomedical Industry. An International Roadmap for an Industry-Driven Initiative.

Working papers

  • Argungu M, Bayram S, Brook B, Chakrabarti B, Clayton RH, Daly DM, Dyson RJ, Holloway C, Manhas V, Naire S , Shearer T et al () Modelling afferent nerve responses to bladder filling.

Datasets

  • Clayton R & Coveney S .

Preprints

  • Ramzan F, Kiberu Y, Jathanna N, Jamil-Copley S, Clayton RH, Chen & Chen (2025) CLAIM: Clinically-Guided LGE Augmentation for Realistic and Diverse Myocardial Scar Synthesis and Segmentation.
  • Saxton H, Xu X, Schenkel T, Clayton RH & Halliday I (2024) , Cold Spring Harbor Laboratory.
  • Holland BL, Monk NAM, Clayton RH & Osborne CP (2023) , Cold Spring Harbor Laboratory.
  • Dharmaprani D, Jenkins EV, Quah JX, Tiver K, Mitchell L, Tung M, Ahmad W, Stoyanov N, Aguilar M, Nash MP , Clayton RH et al (2023) , Cold Spring Harbor Laboratory.
  • Coveney S, Roney CH, Corrado C, Wilkinson RD, Oakley JE, Niederer SA & Clayton RH (2022) , arXiv.
  • Mamalakis M, Swift AJ, Vorselaars B, Ray S, Weeks S, Ding W, Clayton RH, Mackenzie LS & Banerjee A (2021) , arXiv.
  • Coveney S, Corrado C, Roney CH, O'Hare D, Williams SE, O'Neill MD, Niederer SA, Clayton RH, Oakley JE & Wilkinson RD (2020) , arXiv.
  • Coveney S & Clayton RH (2019) , Cold Spring Harbor Laboratory.
Grants
  • , EPSRC, 10/2024 - 09/2029, £8,844,328, as Co-PI
  • , EPSRC, 08/2023 - 08/2026, £3,211,468, as Co-PI
  • , EPSRC, 04/2022 - 03/2026, £314,026, as PI
  • , EPSRC, 03/2021 - 02/2026, £1,225,134, as Co-PI
  • SANO: , EC H2020, 08/2019 - 07/2026, £2,497,386, as Co-PI
  • PRIMAGE: , Empowered by imaging biomarkers, EC H2020, 12/2018 to 05/2023, £549,018, as Co-PI
  • Neurocardiac Interaction In Malignant Ventricular Arrhythmias And Sudden Cardiac Death, British Heart Foundation, 7/2017 to 03/2023, £128,604, as PI
  • , EPSRC, 05/17 to 04/22, £460,590, as PI
  • , EC H2020, 02/2016 to 01/2019, £401,801, as Co-PI
  • POEMS: , EPSRC, 04/2013 to 03/2017, £218,232, as PI
  • , EPSRC, 03/2013 - 09/2017, £1,565,382, as PI
  • Development of a novel diagnostic model of urinary dysfunction, Sheffield Hospitals Charitable Trust, 03/2014 to 08/2014, £15,715, as Co-PI
  • Determination of thresholds for the development of ventricular arrhythmias using computer modelling, Sheffield Hospitals Charitable Trust, 03/2010 to 12/2014, £48,370, as Co-PI
  • , EPSRC, 03/2008 to 03/2010, £85,491, as Co-PI
  • Initiation of re-entry and fibrillation in the ventricle: A mechanistic investigation using computational models, British Heart Foundation, 07/2004 to 06/2007, £97,443, as PI
Professional activities and memberships
  • Member of the  research group
  • Member of INSIGNEO board
  • Member of EPSRC review college

Links

Complex Systems Modelling research group