Professor Mark Dickman
School of Chemical, Materials and Biological Engineering
Professor in Bioanalytical Science and Engineering
Personal Chair
Chair of Research Committee
+44 114 222 7541
Full contact details
School of Chemical, Materials and Biological Engineering
Room D54
Sir Robert Hadfield Building
Mappin Street
Sheffield
S1 3JD
- Profile
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I obtained a First Class Honours Degree in Biochemistry/Chemistry at the University of Sheffield. I continued at the Krebs Institute, where I obtained my PhD. Following my PhD I joined a biotechnology company, Transgenomic LTD where I worked as a research scientist developing analytical techniques including DNA/RNA Chromatography. I joined the Dept of Chemical and Biological Engineering in 2003.
- Research interests
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Nucleic acid therapeutics including oligonucleotide therapeutics and mRNA vaccines/therapeutics are emerging as an important new class of drugs to treat a wide range of important diseases. My research focuses on the development and application analytical techniques to study biological molecules. In particular, bioseparations in conjunction with biological mass spectrometry are used to characterise and analyse nucleic acid therapeutics.
Key research interests:
- Bioseparations (HPLC)
- Biological Mass Spectrometry
- Nucleic Acids
- Oligonucleotide therapeutics
- mRNA vaccines/therapeutics
- RNAi biocontrols
- Analytics.
Industry Partners include:
- ThermoFisher
- AstraZeneca
- Syngenta
- RedShift Bio
- Publications
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Journal articles
- . RNA, 31, 1403-1418.
- . Genome Biology, 26.
- . Rapid Communications in Mass Spectrometry, 39(13).
- . Communications Chemistry, 8(1).
- . The Analyst, 150(5), 1012-1021.
- . Journal of Chromatography A, 1745.
- . Journal of Agricultural and Food Chemistry, 73(2), 1053-1061.
- . Biotechnology Journal, 19(11).
- Glycoprofile Comparison of the SARS-CoV-2 Spike Proteins Expressed in CHO and HEK Cell Lines. Marine Biotechnology.
- . Molecular Therapy - Nucleic Acids, 35(4).
- . Biotechnology and Bioengineering, 121(11), 3582-3599.
- . Frontiers in Molecular Biosciences, 11.
- . Journal of Chromatography A, 1719.
- . Journal of Biological Chemistry, 300(1).
- . Journal of Biological Chemistry, 300(1).
- . Nature Communications, 14.
- . Journal of Chromatography B, 1227.
- . The Plant Journal, 114(6).
- . Journal of Chromatography A, 1691.
- . Journal of the American Chemical Society, 145(2), 953-959.
- . Plant Communications, 4(1).
- . Photosynthesis Research, 155(3), 219-245.
- . Frontiers in Bioengineering and Biotechnology, 10.
- . Journal of Biological Chemistry, 298(9).
- . Analytical Chemistry, 94(20), 7339-7349.
- . Communications Biology, 5(1).
- . Journal of Chromatography A, 1670.
- . Science Advances, 8(6).
- . Plant Direct, 5(10).
- . Parasites & Vectors, 14(1).
- . Nature Plants, 7(3), 365-375.
- . Biotechnology and Bioengineering, 118(2), 1013-1021.
- . Science Advances, 7(3).
- . The Plant Journal, 105(1), 223-244.
- . Biochemical Journal, 477(20), 4021-4036.
- . Analyst, 144(16), 4985-4994.
- .
- . Applied and Environmental Microbiology, 86(1).
- . The Plant Cell, 31(12), 2912-2928.
- . Nature Plants, 5(8), 879-889.
- . Biochemical Journal, 476(13), 1875-1887.
- . Rapid Communications in Mass Spectrometry, 33(10), 897-906.
- . Scientific Reports, 9.
- . Journal of Chromatography B, 1104, 212-219.
- . European Journal of Neuroscience, 47(12), 1444-1456.
- . Cell Reports, 23(11), 3352-3365.
- . Rapid Communications in Mass Spectrometry, 32(7), 590-596.
- . Proteomics, 18(5-6).
- . Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1859(2), 119-128.
- . Nucleic Acids Research, 46(2), 873-885.
- . Analytical Chemistry, 89(24), 13567-13574.
- . Molecular Microbiology.
- . Journal of Chromatography A, 1484, 14-25.
- . Analytical Biochemistry, 512, 36-46.
- . ACS Synthetic Biology, 5(9), 948-954.
- . Clinical Pharmacology and Therapeutics.
- . Journal of Chromatography A, 1453, 43-53.
- . Journal of Bacteriology, 198(9), 1393-1400.
- . Journal of Chromatography A, 1440, 135-144.
- . Frontiers in Plant Science, 7.
- . Brain Pathology, 25(5), 565-574.
- . Drug Discovery Today: Disease Models, 12, 41-48.
- . European Urology Supplements, 14(2), e227-e227b.
- . RNA, 21(3), 347-359.
- . Nucleic Acids Research, 43(4), 2353-2366.
- , 133-145.
- . Molecular Cell , 56(4), 506-517.
- . Journal of Biological Chemistry, 289(43), 29927-29936.
- . Biochim Biophys Acta, 1837(10), 1769-1780.
- . Biochemical Journal, 462(2), 373-384.
- . Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1837, e118-e118.
- . Brain, 137(Pt 7), 2040-2051.
- . Neurology, 82(10_supplement).
- . Neurology, 82(10_supplement).
- . Plant Cell, 26(3), 1267-1279.
- . Anal Biochem, 447, 98-106.
- . Biochemistry, 52(43), 7575-7585.
- . Anal Biochem, 439(1), 47-49.
- . Biochem J, 450(2), 397-405.
- . EMBO Journal, 32(3), 385-394.
- . Insect Biochem Mol Biol, 43(2), 125-137.
- . Rsc Advances, 2(28), 10598-10604.
- . J Biol Chem, 287(33), 27823-27833.
- . Mol Microbiol, 84(6), 1062-1078.
- . ISME J, 6(4), 875-885.
- . Science, 334(6057), 821-824.
- . Proceedings of the National Academy of Sciences, 108(36), 15010-15010.
- . Anal Chem, 83(12), 4894-4901.
- . Proc Natl Acad Sci U S A, 108(25), 10092-10097.
- . Nature Structural and Molecular Biology, 18(5), 529-536.
- . Proteomics, 10(16), 2950-2960.
- . Nucleic Acids Res, 38(10), 3351-3361.
- . J Am Soc Mass Spectrom, 21(1), 88-96.
- . Curr Biol, 19(22), 1918-1924.
- . FEBS J, 276(14), 4109-4121.
- . J Chromatogr A, 1216(9), 1377-1382.
- . J PROTEOME RES, 7(10), 4326-4335.
- . SCIENCE, 321(5891), 960-964.
- . J Proteome Res, 7(6), 2253-2261.
- . Proteomics, 7(21), 3826-3834.
- . BIOCHEM J, 405, 617-623.
- . Anal Biochem, 360(2), 282-287.
- . RNA, 12(4), 691-696.
- . ANAL BIOCHEM, 350(1), 128-137.
- . J Chromatogr A, 1076(1-2), 83-89.
- Identification of nuclear protein complexes using open tube capillary chromatography. Aiche Annual Meeting Conference Proceedings, 1917.
- . J Biochem Biophys Methods, 58(1), 39-48.
- . J Mol Biol, 326(5), 1389-1401.
- . Eur J Biochem, 269(22), 5492-5501.
- . Anal Biochem, 309(2), 248-252.
- . RNA, 8(2), 247-251.
- . Eur J Biochem, 269(5), 1525-1533.
- . Anal Biochem, 301(2), 290-297.
- . J Mol Biol, 321(4), 591-599.
- Rapid, high precision analysis of DNA and RNA footprinting reactions utilising the WAVE (R) Nucleic Acid Fragment Analysis System.. AM J HUM GENET, 69(4), 468-468.
- Rapid analysis of biochemical modifications in DNA fragments - Visualisation of phosphorylation and cytosine deamination in single 15 minute analyses.. AM J HUM GENET, 69(4), 462-462.
- Analysis of nucleic acid modification enzyme reactions using IP RP HPLC. J MED GENET, 38, S71-S71.
- . Nucleic Acids Res, 29(7), 1565-1573.
- . Anal Biochem, 284(1), 164-167.
- Small Crispr Rnas Guide Antiviral Defense in Prokaryotes. Cancer Epidemiology Biomarkers and Prevention, 2(6), 531-535.
- . Frontiers in Immunology, 12.
- . The Analyst, 144(22), 6773-6773.
Book chapters
- Chromatin: The Biophysical Approach to Elucidating Structure and Function In Leroy NH & Fournier NT (Ed.), Cell cycle control (pp. 411-428). New York: Nova Biomedical.
Conference proceedings
- Defining the molecular targets for plant cysteine proteinases on parasitic nematode extracellular matrix. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 96(2) (pp A9-A10)
- . European Journal of Cancer, Vol. 50 (pp S98-S98)
- Characterization of Streptococcus thermophilus Csm complex mediated CRISPR interference in vitro. FEBS JOURNAL, Vol. 281 (pp 678-678)
- Oxidative stress and DNA damage in cerebral white matter lesions of the ageing human brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 40 (pp 33-34)
- Oxidative stress and DNA damage in cerebral white matter lesions of the ageing human brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 39 (pp 36-37)
- Analysis of the RNA component of human telomerase and its associated activity.. AMERICAN JOURNAL OF HUMAN GENETICS, Vol. 71(4) (pp 333-333)
Preprints
- , American Chemical Society (ACS).
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Wiley.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Wiley.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- Teaching activities
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CPE 240 Engineering From Living Systems 2
- Professional activities and memberships
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- Member Royal Society of Chemistry,
- Analytical Bioscience Committee Member (RSC)
- Member of the American Society for Mass Spectrometry
- Industrial partners
We work closely with a number of industrial partners including , , and .
Links