Professor Simon Foster
School of Biosciences
West Riding Chair in Microbiology
West Riding Chair in Microbiology
Full contact details
School of Biosciences
Firth Court
Western Bank
Sheffield
S10 2TN
- Profile
-
Career history
- 2020 - present: West Riding Chair in Microbiology
- 2017 - present: Faculty Director Research and Innovation, University of Sheffield
- 2008 - 2017: Director Krebs Institute, University of Sheffield
- 1999 - present: Professor of Molecular Microbiology, University of Sheffield
- 1993 - 2002: Royal Society University Research Fellow, University of Sheffield
- 1990 - 1993: J.G. Graves Medical Research Fellow, University of Sheffield
- 1986 - 1990: Broodbank Fellow, University of Cambridge
- 1984 - 1986: PhD, University of Cambridge
- 1983 - 1984: PhD, University of Leeds
- Research interests
-
Bacterial cell wall architecture and dynamics
The cell wall is essential for bacterial life and its synthesis is the target of crucial antibiotics such as penicillin and vancomycin. We determine the structure and function of the cell wall to elucidate not only how it permits cell growth but also how antibiotics lead to death. We use the infamous “super bug” Staphylococcus aureus as our target organism to address key fundamental questions of bacterial life and death.
Our primary goals are to:
- determine the molecular structure of the cell wall and how it changes during growth, at a resolution never previously achieved in any organism, using our world-leading microscopy approaches.
- use this information to then establish how the cell wall acts as the interface between a cell and its environment.
- bring together our findings to establish the basic mechanisms underpinning growth, the action of antibiotics and antibiotic resistance across bacteria.
Staphylococcus aureus disease
S. aureus is a major human pathogen of increasing importance due to the spread of antibiotic resistance. Our research spans from the fundamental through to translational approaches to develop new control regimes. We use a range of models to investigate host:pathogen interaction.
Our primary goals are to:
- elucidate S. aureus infection dynamics to determine how this organism is able to cause disease.
- investigate the cellular and molecular mechanisms of infection from both the host and pathogen perspective.
- use this information to better inform vaccine development and the use of antibiotics to treat infection.
Research Keywords
Microbiology, Staphylococcus aureus, pathogenicity, cell wall structure
- Publications
-
Show: Featured publications All publications
Featured publications
Journal articles
- . PLoS Pathogens, 16(7), ---.
- . Nature, 582(7811), 294-297.
- . Nature Microbiology, 3(8), 881-890.
- . PLOS Pathogens, 14(6).
- . Nature Communications, 9.
- . Elife, 7.
- . Proceedings of the National Academy of Sciences, 112(51), 15725-15730.
- . mBio, 6(4).
- . SCIENCE, 346(6209), 641-646.
- . PLoS Pathog, 10(2), e1003959.
- . Cell Microbiol, 14(10), 1600-1619.
- . Mol Microbiol, 80(2), 542-555.
- . Nat Commun, 1, 26.
- . Proc Natl Acad Sci U S A, 105(38), 14603-14608.
All publications
Journal articles
- . mBio, e0172825.
- . Science Advances, 11(15).
- . Annual Review of Microbiology, 78(1), 293-310.
- . Current Microbiology, 81.
- . Science, 386(6721), 573-580.
- , 1-10.
- . Molecular Microbiology, 121(1), 98-115.
- . mBio, 14(5).
- . Frontiers in Microbiology, 14.
- . Scientific Reports, 13(1), 1-11.
- . Science Advances, 9(3).
- . ACS Chemical Biology, 17(12), 3298-3305.
- . Antimicrobial Agents and Chemotherapy, 66(12).
- . Communications Biology, 5(1).
- . mBio, 13(4).
- . Frontiers in Microbiology, 13.
- . Microbiology and Molecular Biology Reviews, 86(2).
- . Proceedings of the National Academy of Sciences, 118(44).
- . ACS Nano, 15(10), 16011-16018.
- . PLoS Pathogens, 17(9).
- . Autophagy, 17(6), 1448-1457.
- . PLoS Pathogens, 17(3).
- . Journal of Cell Science, 134(5).
- . Frontiers in Immunology, 11.
- . iScience, 23(11).
- . Chemical Science, 11(33), 8828-8838.
- . ACS Nano, 14(7), 8287-8298.
- . PLoS Pathogens, 16(7), ---.
- . Nature, 582(7811), 294-297.
- .
- . mBio, 11(1).
- . International Journal of Molecular Sciences, 20(22).
- . Chemical Science.
- . Open Forum Infectious Diseases, 6(Supplement_2), S904-S904.
- . Molecular Microbiology, 112(4), 1116-1130.
- . PLoS ONE, 14(4).
- .
- . Access Microbiology, 1(1A).
- . Frontiers in Immunology, 10.
- . Microbiology, 165(4), 367-385.
- . Nature Microbiology, 3(8), 881-890.
- . PLOS Pathogens, 14(6).
- . Nature Communications, 9.
- . Scientific Reports, 8.
- . Elife, 7.
- . Methods Mol Biol, 1736, 17-27.
- . Methods Mol Biol, 1736, 147-156.
- . Infection and Immunity, 85(11).
- . Frontiers in Microbiology, 8.
- . Science Immunology, 2(8).
- . PLoS Pathogens, 13(1).
- . Autophagy, 12(11), 2069-2084.
- . Antimicrobial Agents and Chemotherapy.
- . Methods in Molecular Biology, 1440, 3-9.
- . FEMS Microbiology Letters, 363(9), fnw087-fnw087.
- . The Lancet Infectious Diseases, 16(2), 239-251.
- . CELLULAR MICROBIOLOGY, 18(1), 80-96.
- . Proceedings of the National Academy of Sciences, 112(51), 15725-15730.
- . mBio, 6(4).
- . International Journal of Molecular Sciences, 16(8), 16710-16727.
- . Diabetes, 64(8), 2991-2995.
- . Nature Genetics, 47(4), 361-366.
- . Archives of Microbiology, 197(2), 245-267.
- . Biophysical Journal, 108(2), 198a-199a.
- . Microbiology, 161(3), 621-627.
- . Biophysical Journal, 107(11), 2538-2545.
- . Molecular Microbiology, 94(5), 1041-1064.
- . SCIENCE, 346(6209), 641-646.
- . Nat Commun, 5, 4269.
- . Nanotechnology, 25(28).
- . Antimicrob Agents Chemother, 58(7), 3599-3609.
- . Molecular Microbiology, 92(2), 273-286.
- . Mol Microbiol, 91(5), 862-874.
- . PLoS Pathog, 10(2), e1003959.
- . Infect Immun, 81(11), 4271-4279.
- , 1, 1401-1407.
- . Nat Commun, 4, 1496.
- . J Bacteriol, 194(22), 6066-6073.
- . The American Journal of Pathology, 181(4), 1327-1337.
- . Cell Microbiol, 14(10), 1600-1619.
- . J Med Microbiol, 61(Pt 6), 766-779.
- . PLoS One, 7(2), e31506.
- . FEMS Microbiol Lett, 329(1), 93-100.
- . Mol Microbiol, 82(5), 1096-1109.
- . Molecular Microbiology, 82(5), 1096-1109.
- . Mol Microbiol, 80(2), 542-555.
- . Microbiology (Reading), 157(Pt 3), 666-676.
- . Arch Microbiol, 193(2), 125-135.
- . Nature Communications, 1(3).
- . Nat Commun, 1, 26.
- . Journal of Innate Immunity, 2(1), 87-92.
- . BMC Microbiol, 9, 266.
- . NAT CHEM, 1(8), 662-667.
- . Rev Sci Instrum, 80(9), 093707.
- . Curr Opin Pharmacol, 9(5), 552-557.
- . J TRAUMA, 67(3), 624-627.
- . BMC Genomics, 10, 291.
- . Clin Exp Immunol, 157(2), 216-224.
- . Infect Immun, 77(6), 2408-2416.
- . Ultramicroscopy, 109(7), 775-780.
- . J INVEST SURG, 21(5), 255-260.
- . PLOS ONE, 3(11).
- . The American Journal of Pathology, 173(6), 1657-1668.
- . Proc Natl Acad Sci U S A, 105(38), 14603-14608.
- . Cell Microbiol, 10(11), 2312-2325.
- . SHOCK, 29(4), 468-474.
- . FEMS Microbiology Reviews, 32(2), 259-286.
- S. aureus: A 'superbug'. Microbiology Today, 35(1), 18-21.
- . Infect Immun, 76(4), 1518-1526.
- . Surgical Infections, 8(5), 495-503.
- . J Bacteriol, 189(20), 7316-7325.
- . MICROB PATHOGENESIS, 43(5-6), 179-188.
- . Cell Host Microbe, 1(3), 199-212.
- . SHOCK, 27(5), 466-473.
- . SCAND J IMMUNOL, 65(6), 530-537.
- . BMC MICROBIOL, 7.
- . CRIT CARE MED, 35(12), 2775-2784.
- . J Bacteriol, 189(3), 1025-1035.
- . J ORTHOP RES, 25(2), 262-266.
- . BRIT J PHARMACOL, 148(6), 769-777.
- . Adv Microb Physiol, 51, 187-224.
- . J BACTERIOL, 188(17), 6070-6080.
- . Infect Immun, 74(8), 4644-4654.
- . SCAND J IMMUNOL, 64(1), 61-68.
- . J PERIODONTAL RES, 41(3), 208-213.
- . J Infect Dis, 193(8), 1098-1108.
- . SHOCK, 25(2), 141-146.
- Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo. J EXP MED, 203(1), 203-213.
- . CRIT CARE MED, 34(5), 1489-1496.
- . FEMS Immunol Med Microbiol, 43(3), 311-323.
- . INFECT IMMUN, 73(11), 7613-7619.
- . SHOCK, 24(3), 214-218.
- . J BIOL CHEM, 280(35), 30856-30863.
- . FEBS J, 272(11), 2854-2868.
- . Drug Discov Today, 10(9), 643-651.
- . J BACTERIOL, 187(5), 1751-1762.
- . CRIT CARE MED, 33(9), 1903-1912.
- . Critical Care Medicine, 32(Supplement), A18-A18.
- . Critical Care Medicine, 32(Supplement), A137-A137.
- . Infection and Immunity, 72(10), 6106-6111.
- . SHOCK, 22(4), 376-379.
- . Microbiology (Reading), 150(Pt 7), 2347-2355.
- . APPL ENVIRON MICROB, 70(6), 3493-3499.
- . Current Opinion in Microbiology, 7(3), 274-276.
- . J Mol Biol, 339(2), 265-278.
- . Infect Immun, 72(5), 3073-3076.
- . J Bacteriol, 186(6), 1579-1590.
- . INFECT IMMUN, 72(3), 1311-1317.
- . Mol Microbiol, 51(5), 1509-1519.
- Peptidoglycan of Staphylococcus aureus causes inflammation and organ injury in the rat. CRIT CARE MED, 32(2), 546-552.
- . MICROBES INFECT, 6(2), 202-206.
- . Microbiology (Reading), 150(Pt 2), 373-381.
- . Applied and Environmental Microbiology, 70(1), 96-103.
- . Microbiology (Reading), 150(Pt 1), 217-228.
- . Acta Crystallogr D Biol Crystallogr, 60(Pt 1), 166-168.
- . SHOCK, 20(5), 402-414.
- . Microbiology (Reading), 149(Pt 10), 2749-2758.
- . Microbial Pathogenesis, 35(3), 119-124.
- . J Bacteriol, 185(13), 3813-3820.
- An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. NAT IMMUNOL, 4(7), 702-707.
- . J Immunol, 170(10), 5268-5275.
- . P NATL ACAD SCI USA, 100(8), 4678-4683.
- . MICROBIOL-SGM, 149, 695-705.
- . J BIOL CHEM, 278(8), 5509-5512.
- . Surgical Infections, 4(2), 181-191.
- . GASTROENTEROLOGY, 124(1), 140-146.
- . Biochemistry, 42(2), 257-264.
- . Infect Immun, 70(12), 6680-6687.
- . Acta Crystallographica Section D Biological Crystallography, 58(12), 2138-2140.
- . J BACTERIOL, 184(21), 6007-6015.
- . Trends Microbiol, 10(11), 496-501.
- . J Bacteriol, 184(19), 5457-5467.
- . Microbiology (Reading), 148(Pt 8), 2383-2392.
- . Mol Microbiol, 44(5), 1269-1286.
- Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14.. Med Sci Monit, 8(5), BR149-BR156.
- An introduction to Staphylococcus aureus, and techniques for identifyingand quantifying S. aureus adhesins in relation to adhesion to biomaterials:Review. European Cells and Materials, 4, 39-60.
- Sirolimus interferes with the innate response to bacterial products in human whole blood by attenuation of IL-10 production. SCAND J IMMUNOL, 53(2), 184-191.
- . Microbiology (Reading), 147(Pt 11), 2925-2932.
- . J Mol Biol, 313(1), 111-122.
- . Arthritis Research and Therapy, 3(6), 375-380.
- . Acta Crystallographica Section D Biological Crystallography, 57(9), 1324-1325.
- . J Appl Microbiol, 91(2), 364-372.
- . Microbiology (Reading), 147(Pt 8), 2275-2284.
- . Infect Immun, 69(8), 5198-5202.
- Staphylococcus aureus surface protein topography. European Cells and Materials, 1(SUPPL. 2), 38-39.
- . Infect Immun, 69(6), 3744-3754.
- Peptidoglycan and lipoteichoic acid modify monocyte phenotype in human whole blood. CLIN DIAGN LAB IMMUN, 8(3), 515-521.
- . Microbiology (Reading), 147(Pt 5), 1259-1266.
- Negative and positive ion matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and positive ion nano-electrospray ionization quadrupole ion trap mass spectrometry of peptidoglycan fragments isolated from various Bacillus species. J MASS SPECTROM, 36(2), 124-139.
- . J Bacteriol, 183(2), 468-475.
- . Trends in Microbiology, 9(1), 45-45.
- Staphylococcus aureus accessory regulators: expression within biofilms and effect on adhesion. MICROBES INFECT, 3(8), 633-637.
- Peptidoglycan primes for LPS-induced release of proinflammatory cytokines in whole human blood. SHOCK, 16(3), 178-182.
- The selective guanylate cyclase inhibitor ODQ reduces multiple organ injury in rodent models of Gram-positive and Gram-negative shock. CRIT CARE MED, 29(8), 1599-1608.
- Aminoethyl-isothiourea inhibits leukocyte production of reactive oxygen species and proinflammatory cytokines induced by streptococcal cell wall coiviponents in hunian whole blood. SHOCK, 15(6), 455-460.
- A cell wall component from pathogenic and non-pathogenic gram-positive bacteria (peptidoglycan) synergises with endotoxin to cause the release of tumour necrosis factor-alpha, nitric oxide production, shock, and multiple organ injury/dysfunction in the rat. SHOCK, 15(2), 135-142.
- Peptidoglycan and lipoteichoic acid, components of the streptococcal cell wall, have marked and differential effects on adhesion molecule expression and the production of reactive oxygen species in human whole blood leukocytes. SCAND J CLIN LAB INV, 60(4), 311-321.
- Peptidoglycan and lipoteichoic acid from Staphylococcus aureus induce tumor necrosis factor alpha, interleukin 6 (IL-6), and IL-10 production in both T cells and monocytes in a human whole blood model. INFECT IMMUN, 68(7), 3965-3970.
- . Microbiology (Reading), 146 ( Pt 2), 249-262.
- . Trends in Microbiology, 8(1), 11-12.
- Membrane-permeable radical scavenger, tempol, reduces multiple organ injury in a rodent model of Gram-positive shock. CRIT CARE MED, 28(6), 1953-1961.
- . Microbiology (Reading), 146 ( Pt 1), 57-64.
- Stress resistance in Staphylococcus aureus. TRENDS MICROBIOL, 7(11), 458-462.
- . Mol Gen Genet, 262(2), 323-331.
- . J Bacteriol, 181(13), 3898-3903.
- . J Bacteriol, 181(13), 3956-3966.
- . Microbiology (Reading), 145 ( Pt 5), 1033-1041.
- . J Bacteriol, 181(2), 501-507.
- Evidence that the extracytoplasmic function sigma factor sigma(E) is required for normal cell wall structure in Streptomyces coelicolor A3(2). J BACTERIOL, 181(1), 204-211.
- . Antonie Van Leeuwenhoek, 75(4), 299-307.
- . Journal of Bacteriology, 180(23), 6082-6089.
- . J Bacteriol, 180(23), 6232-6241.
- . J Bacteriol, 180(23), 6082-6089.
- . Microbiology (Reading), 144 ( Pt 11), 3159-3169.
- . J Bacteriol, 180(17), 4603-4612.
- . Microbiology (Reading), 144 ( Pt 9), 2469-2479.
- Mechanism of gram-positive shock: Identification of peptidoglycan and lipoteichoic acid moieties essential in the induction of nitric oxide synthase, shock, and multiple organ failure. J EXP MED, 188(2), 305-315.
- . Microbiology (Reading), 144 ( Pt 7), 1755-1763.
- Molecular characterization of an autolytic amidase of Listeria monocytogenes EGD.. Microbiology (Reading, England), 144.
- . Microbiology (Reading), 144 ( Pt 5), 1359-1367.
- . J Bacteriol, 180(7), 1750-1758.
- . Microbiology (Reading), 144 ( Pt 1), 73-82.
- Autolysins during sporulation of Bacillus subtilis 168. FEMS MICROBIOL LETT, 157(1), 141-147.
- . FEMS Microbiol Lett, 152(1), 149-154.
- Purified Staphylococcus aureus lipoteichoic acid induces nitric oxide synthase activity in murine macrophages. BRIT J PHARMACOL, 120, P335-P335.
- . J Bacteriol, 178(21), 6173-6183.
- Lipoteichoic acid from S-aureus, but not from B-subtilis, synergises with B-subtilis peptidoglycan to cause hyporeactivity to noradrenaline and organ injury in rats. BRIT J PHARMACOL, 119, P18-P18.
- Importance of lipoteichoic acid and peptidoglycan in the induction of nitric oxide synthase in murine macrophages by gram-positive organisms. BRIT J PHARMACOL, 119, P62-P62.
- Lipoteichoic acid from various Gram-positive bacteria either alone or in combination with a fragment of peptidoglycan induce nitric oxide synthase in murine macrophages. BRIT J PHARMACOL, 119, P243-P243.
- . Microb Drug Resist, 2(1), 113-118.
- . J Bacteriol, 177(19), 5723-5725.
- . J Bacteriol, 177(13), 3855-3862.
- . Soc Appl Bacteriol Symp Ser, 23, 25S-39S.
- . Mol Microbiol, 8(2), 299-310.
- . FEMS Microbiol Lett, 110(3), 295-298.
- . J Gen Microbiol, 139(12), 3177-3184.
- . J Bacteriol, 174(2), 464-470.
- . J Gen Microbiol, 137(8), 1987-1998.
- . Nature Microbiology, 10(5), 1258-1258.
- . Nature Microbiology, 10(4), 813-816.
- . Physical Biology, 13(5), 055002-055002.
- . PLoS ONE, 4(10), e7567-e7567.
Book chapters
- , Handbook of Proteolytic Enzymes (pp. 1671-1677). Elsevier
- , Handbook of Proteolytic Enzymes (pp. 1401-1407). Elsevier
- Inhibiting glycogen synthase kinase 3β in sepsis (pp. 128-142).
- , Fourth International Conference on Advances in Steel Structures (pp. 933-940). Elsevier
- , Handbook of Proteolytic Enzymes (pp. 866-868). Elsevier
- , Handbook of Proteolytic Enzymes Second Edition Volume 1 Aspartic and Metallo Peptidases (pp. 866-868).
- , Bacillus subtilisand Its Closest Relatives (pp. 21-41). ASM Press
Conference proceedings
- The role of augmenting material in Staphylococcus aureus interaction with macrophages. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol. 49 (pp 205-205)
- Identification of modulators of intestinal nerve activity from Staphylococcus aureus. NEUROGASTROENTEROLOGY AND MOTILITY, Vol. 30
- . European Biophysics Journal with Biophysics Letters, Vol. 46(Suppl 1) (pp S100-S100). Edinburgh, UK, 16 July 2017 - 16 July 2017.
- High resolution atomic force microscopy of living S. aureus bacterial cell wall. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Vol. 46 (pp S291-S291)
- High-resolution Atomic Force Microscopy (AFM) imaging of native biological membrane systems. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Vol. 46 (pp S368-S368)
- Death or alive? Correlating the cell wall structure of sacculi and living bacteria using AFM. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Vol. 46 (pp S295-S295)
- Effect of soluble mediators from Staphylococcus aureus on intestinal epithelial function and sensory signaling. NEUROGASTROENTEROLOGY AND MOTILITY, Vol. 29 (pp 128-128)
- Corneal infections: targeted eradication through antibiotic functionalized polymers. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol. 58(8)
- . Thorax, Vol. 71(Suppl 3) (pp A61.2-A62)
- . Journal of Infection, Vol. 71(6) (pp 684-684)
- New green emitting fluorochromes for Fluorescence Microscopy, specifically Structured Illumination Microscopy. Microscopy Microscience Congress 2015 (MMC 2015) (pp P2608-P2608). Manchester, 29 June 2015 - 2 July 2015.
- . THORAX, Vol. 68 (pp A140-A140)
- At least four glycosyltransferases are involved in the glycosylation of the plasmin-sensitive protein Pls in methicillin-resistant Staphylococcus aureus (MRSA). INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, Vol. 303 (pp 57-57)
- . THORAX, Vol. 64 (pp A36-A36)
- Subversion of neutrophil apoptosis by Staphylococcus aureus. THORAX, Vol. 62 (pp A114-A115)
- Systemic petidoglycan (PegG) stimulates proinflammatory responses in synergy with lipopolysaccharide (LPS) in an in vivo and in vitro porcine model.. SHOCK, Vol. 26 (pp 32-32)
- Carbohydrates and biology of staphylococcal infections. GLYCOBIOLOGY AND MEDICINE, Vol. 564 (pp 115-116)
- Peptidoglycan of S aureus induced the release of MMP-9 in human blood by degranulation of neutrophils.. SHOCK, Vol. 23 (pp 76-77)
- Synthetic CpG- and GpC oligonucleotides enhance the TNF alpha release induced by peptidoglycan but not by lipopolysaccharide.. SHOCK, Vol. 23 (pp 22-22)
- Monocyte cell surface receptor upregulation in response to stimulation with lipopolysaccharide and peptidoglycan. SHOCK, Vol. 21 (pp 21-21)
- Cytokine responses to combined administration of lipopolysaccharide (LPS) and peptidoglycan (PepG). SHOCK, Vol. 21 (pp 50-50)
- Bacterial endospores the ultimate survivors. INTERNATIONAL DAIRY JOURNAL, Vol. 12(2-3) (pp 217-223)
- THE ROLE AND REGULATION OF CELL-WALL STRUCTURAL DYNAMICS DURING DIFFERENTIATION OF ENDOSPORE-FORMING BACTERIA. JOURNAL OF APPLIED BACTERIOLOGY, Vol. 76 (pp S25-S39)
Posters
- Molecular Resolution of Gram Positive Bacteria Cell Wall using AFM.
Datasets
- .
- .
Preprints
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- Research group
- Teaching activities
-
- MBB323 Microbial Structure and Dynamics: Genes and Populations (Module Coordinator)
- MBB335 Bacterial Pathogenicity
Links