Professor Mike Williamson

School of Biosciences

Personal Chair

Professor Mike Williamson
Profile picture of Professor Mike Williamson
m.williamson@sheffield.ac.uk
+44 114 222 4224
Firth Court

Full contact details

Professor Mike Williamson
School of Biosciences
Firth Court
Western Bank
Sheffield
S10 2TN
Profile

My research concentrates on protein structure and function, mainly by means of NMR, and is described in more detail below. I have written two books (The Nuclear Overhauser Effect, with David Neuhaus, 1989, second edition 2000; and How Proteins Work, Garland Science, 2011) and about 250 papers. I teach on the biochemical basis of human disease, signalling, membranes, and metabolic pathways. 

I was Head of the Department of Molecular Biology and Biotechnology from 2017-2021, at which point the three biology departments merged to become the School of Biosciences. I have had many other administrative roles in the university and the department.

I was (2009-2011) Chair of the; also (2009-2012) Chair of the Biochemical Society theme panel II (Molecular structure and function); (2009-2013) a member of BBSRC Committee D (Molecules, Cells and Industrial Biotechnology); (2005-2009) secretary of ; and (2018-) a member of Council of the

Career history

1975-1978 Natural Sciences, Clare College, Cambridge University (I)
1978-1981 PhD "Structural Studies on Some Antibiotics", supervised by Dudley Williams
1981-1984 Junior Research Fellow, Churchill College, Cambridg
1992-1983 SERC/NATO overseas research fellow, ETH Zürich, with Kurt Wüthrich
1984-1990 Team leader, Bio-NMR, Roche Products Ltd, Welwyn Garden City
1990-current University of Sheffield (appointed Professor in 2001)
2017-2021 Head of Department of Molecular Biology and Biotechnology
1995 Fellow of the Royal Society of Chemistry and chartered chemist
1997 Japan Society for the Promotion of Science (JSPS) invitation fellow
2001 ScD, University of Cambridge
2008-9 Visiting professor, Kinki University, Japan
2009 Visiting professor, Osaka University, Japan
2015 Special invited professor, Kyoto University, Japan

Research interests

During my PhD I used NMR to look at the structure and interactions of antibiotics mainly related to , still a vital drug in the constant battle against bacterial drug resistance. This led to an interest in the NOE, where I worked first on 1D NOEs, showing that by using a viscous solvent you can make small molecules behave like bigger ones, and determined the definitive structure of vancomycin.

Around this time, Wüthrich was developing 2D NMR as a way of studying proteins, so after my PhD I got a research fellowship to work in his lab, where I was lucky enough to work on the first NMR structure of a globular protein (see his 2002 ).

Since then, I have worked both on NMR methodology and on determination of protein structures by NMR. In methodology, I have worked in five main areas:

The nuclear Overhauser effect (NOE)
Chemical shifts in proteins
Relaxation
Study of proteins using high pressure
Validation of protein structures in solution

Publications

Show: Featured publications All publications

Journal articles

  • Hancock LP, Allwood EG, Palmer JS, Ayscough KR & Williamson MP (2025) . Scientific Reports, 15(1).
  • Williamson MP (2024) . Life, 14(5).
  • Williamson MP (2023) . Life, 13(4).
  • Hobbs B, Drant J & Williamson MP (2022) . Journal of Biomolecular NMR, 76(4), 153-163.
  • Fowler NJ & Williamson MP (2022) . Structure, 30(7), 925-933.e2.
  • Fowler NJ, Sljoka A & Williamson MP (2021) . Structure, 29(12), 1430-1439.e2.
  • Southam HM, Williamson MP, Chapman JA, Lyon RL, Trevitt CR, Henderson PJF & Poole RK (2021) . Antioxidants, 10(6).
  • Fowler NJ, Sljoka A & Williamson MP (2020) . Nature Communications, 11(-), ---.
  • Gonzalez-Delgado LS, Walters-Morgan H, Salamaga B, Robertson AJ, Hounslow AM, Jagielska E, SabaÅ‚a I, Williamson MP, Lovering AL & Mesnage S (2020) . Nature Chemical Biology, 16(1), 24-30.
  • Bye JW, Baxter NJ, Hounslow AM, Falconer RJ & Williamson MP (2016) . ACS Omega, 1(4), 669-679.
  • Mesnage S, Dellarole M, Baxter NJ, Rouget J-B, Dimitrov JD, Wang N, Fujimoto Y, Hounslow AM, Lacroix-Desmazes S, Fukase K , Foster SJ et al (2014) . Nat Commun, 5, 4269.
  • Williamson MP, Hounslow AM, Ford J, Fowler K, Hebditch M & Hansen PE (2013) . Chem Commun (Camb), 49(84), 9824-9826.
  • Williamson MP (2013) . Prog Nucl Magn Reson Spectrosc, 73, 1-16.
  • Kitahara R, Hata K, Li H, Williamson MP & Akasaka K (2013) . Progress in Nuclear Magnetic Resonance Spectroscopy, 71, 35-58.
  • Wilton DJ, Kitahara R, Akasaka K, Pandya MJ & Williamson MP (2009) . Biophys J, 97(5), 1482-1490.
  • Jöbstl E, O'Connell J, Fairclough JPA & Williamson MP (2004) . Biomacromolecules, 5(3), 942-949.
  • Charlton AJ, Baxter NJ, Khan ML, Moir AJG, Haslam E, Davies AP & Williamson MP (2002) . J Agric Food Chem, 50(6), 1593-1601.
  • Kay BK, Williamson MP & Sudol P (2000) The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains. FASEB J, 14(2), 231-241.
  • Baxter NJ & Williamson MP (1997) . J Biomol NMR, 9(4), 359-369.
  • Williamson MP (1994) . Biochem J, 297 ( Pt 2)(Pt 2), 249-260.
  • WILLIAMSON MP, HAVEL TF & WUTHRICH K (1985) SOLUTION CONFORMATION OF PROTEINASE INHIBITOR-IIA FROM BULL SEMINAL PLASMA BY H-1 NUCLEAR MAGNETIC-RESONANCE AND DISTANCE GEOMETRY. J MOL BIOL, 182(2), 295-315.
  • WILLIAMSON MP & WILLIAMS DH (1981) STRUCTURE REVISION OF THE ANTIBIOTIC VANCOMYCIN - THE USE OF NUCLEAR OVERHAUSER EFFECT DIFFERENCE SPECTROSCOPY. J AM CHEM SOC, 103(22), 6580-6585.
  • Southam HM, Smith TW, Lyon RL, Liao C, Trevitt CR, Middlemiss LA, Cox FL, Chapman JA, El-Khamisy SF, Hippler M , Williamson MP et al () . Redox Biology, 18, 114-123.

All publications

Books

  • Williamson M (2012) How Proteins Work. Garland Science.
  • Williamson MP (2009) .
  • Neuhaus D & Williamson MP (1989) The Nuclear Overhauser Effect in Structural and Conformational Analysis. Wiley.

Journal articles

  • Mizushima M, Mizuno T, Toda M, Williamson MP & Suzuki Y (2025) . Journal of the American Chemical Society, 147(40), 36805-36814.
  • Hancock LP, Allwood EG, Palmer JS, Ayscough KR & Williamson MP (2025) . Scientific Reports, 15(1).
  • Hancock LP, Palmer JS, Allwood EG, Smaczynska-de Rooij II, Hodder AJ, Rowe ML, Williamson MP & Ayscough KR (2025) . Communications Biology, 8(1).
  • O’Dea F, Seargeant AJ, Hurcum J, do Aido-Machado R, Rowe ML, Baxter NJ, Waltho JP, Sayers JR & Williamson MP (2025) . Journal of Biomolecular NMR, 79(3), 155-162.
  • Davis JL, Norwood JS, Smith RE, O'Dea F, Chellappa K, Rowe ML, Williamson MP, Stafford GP, Vinogradov E, Maes E , Guérardel Y et al (2025) . Carbohydrate Polymers, 349, 122983-122983.
  • Davis JL, Norwood JS, Smith RE, O'Dea F, Chellappa K, Rowe ML, Williamson MP, Stafford GP, Vinogradov E, Maes E , Guérardel Y et al (2025) . Carbohydrate Polymers, 347.
  • Williamson MP (2024) . Life, 14(5).
  • Trevitt CR, Yashwanth Kumar DR, Fowler NJ & Williamson MP (2024) . Communications Chemistry, 7(1).
  • Galley NF, Greetham D, Alamán-Zárate MG, Williamson MP, Evans CA, Spittal WD, Buddle JE, Freeman J, Davis GL, Dickman MJ , Wilcox MH et al (2024) . Journal of Biological Chemistry, 300(1).
  • Hassan MU, Chaudhuri RR & Williamson MP (2023) . Protein Science, 32(11).
  • Asakura T & Williamson MP (2023) . International Journal of Biological Macromolecules, 245.
  • Fowler NJ, Albalwi MF, Lee S, Hounslow AM & Williamson MP (2023) . Structure, 31(8), 975-986.e3.
  • Williamson MP (2023) . Life, 13(4).
  • Hassan MU & Williamson MP (2023) . Saudi Journal of Biological Sciences, 30(2).
  • Makwana MV, Williamson MP, Jackson RFW & Muimo R (2022) . PLoS ONE, 17(9).
  • Hobbs B, Drant J & Williamson MP (2022) . Journal of Biomolecular NMR, 76(4), 153-163.
  • Lyon RF, Southam HM, Trevitt CR, Liao C, El-Khamisy SF, Poole RK & Williamson MP (2022) . Biochemical Journal, 479(13), 1429-1439.
  • Davis JL, Hounslow AM, Baxter NJ, Mesnage S & Williamson MP (2022) . Biomolecular NMR Assignments, 16, 247-251.
  • Abosamaha A, Williamson MP & Gilmour DJ (2022) . Access Microbiology, 4(5).
  • Fowler NJ & Williamson MP (2022) . Structure, 30(7), 925-933.e2.
  • Fowler NJ, Sljoka A & Williamson MP (2021) . Structure, 29(12), 1430-1439.e2.
  • Southam HM, Williamson MP, Chapman JA, Lyon RL, Trevitt CR, Henderson PJF & Poole RK (2021) . Antioxidants, 10(6).
  • Hassan MU, Nayab H, Shafique F, Williamson MP, Almansouri TS, Asim N, Shafi N, Attacha S, Khalid M, Ali N & Akbar N (2020) . BioMed Research International, 2020, 1-17.
  • Fowler NJ, Sljoka A & Williamson MP (2020) . Nature Communications, 11(-), ---.
  • Asakura T, Ogawa T, Naito A & Williamson MP (2020) . International Journal of Biological Macromolecules, 164, 3974-3983.
  • Hassan MU, Nayab H, Rehman TU, Williamson MP, Haq KU, Shafi N & Shafique F (2020) . BioMed Research International, 2020.
  • Gonzalez-Delgado LS, Walters-Morgan H, Salamaga B, Robertson AJ, Hounslow AM, Jagielska E, SabaÅ‚a I, Williamson MP, Lovering AL & Mesnage S (2020) . Nature Chemical Biology, 16(1), 24-30.
  • Iwakawa N, Baxter NJ, Wai DCC, Fowler NJ, Morales RAV, Sugase K, Norton RS & Williamson MP (2019) . Scientific Reports, 9(1).
  • Wakamoto T, Ikeya T, Kitazawa S, Baxter NJ, Williamson MP & Kitahara R (2019) . Protein Science, 28(11), 1993-2003.
  • Smith RE, Salamaga B, Szkuta P, Hajdamowicz N, Prajsnar TK, Bulmer GS, Fontaine T, KoÅ‚odziejczyk J, Herry J-M, Hounslow AM , Williamson MP et al (2019) . PLoS Pathogens, 15(5).
  • Williamson MP (2019) . Natural Product Communications, 14(5).
  • Fairbanks SD, Robertson CC, Keene FR, Thomas JA & Williamson MP (2019) . Journal of the American Chemical Society, 141(11), 4644-4652.
  • Williamson MP & Kitahara R (2019) . Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1867(3), 350-358.
  • Pandya MJ, Schiffers S, Hounslow AM, Baxter NJ & Williamson MP (2018) . Frontiers in Molecular Biosciences, 5.
  • Kudhair BK, Hounslow AM, Rolfe MD, Crack JC, Hunt DM, Buxton RS, Smith LJ, Le Brun NE, Williamson MP & Green J (2017) . Nature Communications, 8(1).
  • Baxter NJ, Zacharchenko T, Barsukov IL & Williamson MP (2017) . Structure, 25(12), 1856-1866.
  • Heyam A, Coupland CE, Dégut C, Haley RA, Baxter NJ, Jakob L, Aguiar PM, Meister G, Williamson MP, Lagos D & Plevin MJ (2017) . Nucleic Acids Research, 45(21), 12577-12584.
  • Blanchet P, Bebin M, Bruet S, Cooper GM, Thompson ML, Duban-Bedu B, Gerard B, Piton A, Suckno S, Deshpande C , Clowes V et al (2017) . PLoS Genetics, 13(8).
  • Eaton JD & Williamson MP (2017) . Bioscience Reports, 37(3).
  • Bye JW, Baxter NJ, Hounslow AM, Falconer RJ & Williamson MP (2016) . ACS Omega, 1(4), 669-679.
  • Yasid NA, Rolfe MD, Green J & Williamson MP (2016) . Royal Society Open Science, 3(8).
  • Rawlings AE, Bramble JP, Hounslow AM, Williamson MP, Monnington AE, Cooke DJ & Staniland SS (2016) . Chemistry - A European Journal, 22(23), 7885-7894.
  • Xu Y, Streets AJ, Hounslow AM, Tran U, Jean-Alphonse F, Needham AJ, Vilardaga J-P, Wessely O, Williamson MP & Ong ACM (2016) . Journal of the American Society of Nephrology, 27(4), 1159-1173.
  • Hollingshead S, Kopecna J, Armstrong DR, Bucinska L, Jackson PJ, Chen GE, Dickman MJ, Williamson MP, Sobotka R & Hunter CN (2016) . Frontiers in Plant Science, 7.
  • Xu Y, Ong ACM, Williamson MP & Hounslow AM (2015) . Biomolecular NMR Assignments, 9(2), 369-373.
  • Asakura T, Okushita K & Williamson MP (2015) . Macromolecules, 48(8), 2345-2357.
  • Williamson MP (2015) , 109-127.
  • Asakura T, Ohata T, Kametani S, Okushita K, Yazawa K, Nishiyama Y, Nishimura K, Aoki A, Suzuki F, Kaji H , Ulrich AS et al (2014) . Macromolecules, 48(1), 28-36.
  • Mesnage S, Dellarole M, Baxter NJ, Rouget J-B, Dimitrov JD, Wang N, Fujimoto Y, Hounslow AM, Lacroix-Desmazes S, Fukase K , Foster SJ et al (2014) . Nat Commun, 5, 4269.
  • Okushita K, Asano A, Williamson MP & Asakura T (2014) . Macromolecules, 47(13), 4308-4316.
  • Kitazawa S, Kameda T, Kumo A, Yagi-Utsumi M, Baxter NJ, Kato K, Williamson MP & Kitahara R (2014) . BIOCHEMISTRY, 53(3), 447-449.
  • Williamson MP (2014) . Progress in Nuclear Magnetic Resonance Spectroscopy.
  • Wilson T, Costa PJ, Félix V, Williamson MP & Thomas JA (2013) . J Med Chem, 56(21), 8674-8683.
  • Williamson MP, Hounslow AM, Ford J, Fowler K, Hebditch M & Hansen PE (2013) . Chem Commun (Camb), 49(84), 9824-9826.
  • Williamson MP (2013) . Prog Nucl Magn Reson Spectrosc, 73, 1-16.
  • Kitazawa S, Kameda T, Yagi-Utsumi M, Sugase K, Baxter NJ, Kato K, Williamson MP & Kitahara R (2013) . Biochemistry, 52(11), 1874-1885.
  • Kitahara R, Hata K, Li H, Williamson MP & Akasaka K (2013) . Progress in Nuclear Magnetic Resonance Spectroscopy, 71, 35-58.
  • Moody RG & Williamson MP (2013) . FEBS Open Bio, 3, 71-77.
  • Kumo A, Kitazawa S, Kameda T, Baxter NJ, Williamson MP & Kitahara R (2013) . Seibutsu Butsuri, 53(supplement1-2), S160-S160.
  • Williamson MP & Potts JR (2012) . Biochem Soc Trans, 40(5), 945-949.
  • (2012) . Nature Structural & Molecular Biology, 19(9), 854-860.
  • Kitazawa S, Kameda T, Yagi M, Sugase K, Baxter N, Kato K, Williamson MP & Kitahara R (2012) . Seibutsu Butsuri, 52(supplement), S87-S87.
  • Asakura T, Okonogi M, Horiguchi K, Aoki A, Saitô H, Knight DP & Williamson MP (2012) . Angewandte Chemie, 124(5), 1238-1241.
  • Asakura T, Okonogi M, Horiguchi K, Aoki A, Saito H, Knight DP & Williamson MP (2012) . ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(5), 1212-1215.
  • Tomlinson JH & Williamson MP (2012) . J Biomol NMR, 52(1), 57-64.
  • Trotter EW, Rolfe MD, Hounslow AM, Craven CJ, Williamson MP, Sanguinetti G, Poole RK & Green J (2011) . Plos One, 6(9).
  • Williamson MP (2011) . ChemInform, 42(18).
  • Ullah S, Ishimoto T, Williamson MP & Hansen PE (2011) . J PHYS CHEM B, 115(12), 3208-3215.
  • Tomlinson JH & Williamson MP (2011) Amide temperature coefficients in the protein G B1 domain. Journal of Biomolecular NMR, 1-8.
  • Ratcliffe EC, Tunnicliffe RB, Ng IW, Adams PG, Qian P, Holden-Dye K, Jones MR, Williamson MP & Hunter CN (2011) . Biochim Biophys Acta, 1807(1), 95-107.
  • Tomlinson JH, Green VL, Baker PJ & Williamson MP (2010) . Proteins, 78(14), 3000-3016.
  • Williamson MP & Sutcliffe MJ (2010) . Biochem Soc Trans, 38(4), 875-878.
  • Correia MAS, Abbott DW, Gloster TM, Fernandes VO, Prates JAM, Montanier C, Dumon C, Williamson MP, Tunnicliffe RB, Liu ZY , Flint JE et al (2010) . BIOCHEMISTRY-US, 49(29), 6193-6205.
  • Wilson T, Williamson MP & Thomas JA (2010) . Org Biomol Chem, 8(11), 2617-2621.
  • Giamarchi A, Feng S, Rodat-Despoix L, Xu YX, Bubenshchikova E, Newby LJ, Hao JZ, Gaudioso C, Crest M, Lupas AN , Honore E et al (2010) . EMBO J, 29(7), 1176-1191.
  • Waywell P, Gonzalez V, Gill MR, Adams H, Meijer AJHM, Williamson MP & Thomas JA (2010) . Chemistry – A European Journal, 16(8), 2324-2324.
  • Waywell P, Gonzalez V, Gill MR, Adams H, Meijer AJHM, Williamson MP & Thomas JA (2010) . Chemistry, 16(8), 2407-2417.
  • Tomlinson JH, Craven CJ, Williamson MP & Pandya MJ (2010) . Proteins, 78(7), 1652-1661.
  • Waywell P, Thomas JA & Williamson MP (2010) . Org Biomol Chem, 8(3), 648-654.
  • Long J, Garner TP, Pandya MJ, Craven CJ, Chen P, Shaw B, Williamson MP, Layfield R & Searle MS (2010) . J MOL BIOL, 396(1), 178-194.
  • Wilton DJ, Kitahara R, Akasaka K, Pandya MJ & Williamson MP (2009) . Biophys J, 97(5), 1482-1490.
  • Suzuki Y, Takahashi R, Shimizu T, Tansho M, Yamauchi K, Williamson MP & Asakura T (2009) . J PHYS CHEM B, 113(29), 9756-9761.
  • Wilton DJ, Kitahara R, Akasaka K & Williamson MP (2009) . J Biomol NMR, 44(1), 25-33.
  • Tomlinson JH, Ullah S, Hansen PE & Williamson MP (2009) . J Am Chem Soc, 131(13), 4674-4684.
  • Williamson MP & Craven CJ (2009) . J Biomol NMR, 43(3), 131-143.
  • Nakazawa Y, Suzuki Y, Williamson MP, Saito H & Asakura T (2009) . CHEM PHYS LIPIDS, 158(1), 54-60.
  • Cioffi M, Hunter CA, Packer MJ, Pandya MJ & Williamson MP (2009) . J Biomol NMR, 43(1), 11-19.
  • Wilton DJ, Ghosh M, Chary KVA, Akasaka K & Williamson MP (2008) . Nucleic Acids Res, 36(12), 4032-4037.
  • Bocian W, Kawecki R, Bednarek E, Sitkowski J, Williamson MP, Hansen PE & Kozerski L (2008) . CHEM-EUR J, 14(9), 2788-2794.
  • Wilton DJ, Tunnicliffe RB, Kamatari YO, Akasaka K & Williamson MP (2008) . Proteins, 71(3), 1432-1440.
  • Nagy T, Tunnicliffe RB, Higgins LD, Walters C, Gilbert HJ & Williamson MP (2007) . J MOL BIOL, 373(3), 612-622.
  • Cicortas Gunnarsson L, Montanier C, Tunnicliffe RB, Williamson MP, Gilbert HJ, Nordberg Karlsson E & Ohlin M (2007) . Biochemical Journal, 406(2), 209-214.
  • Moody RG, Phillips-Jones MK & Williamson MP (2007) . BIOMOL NMR ASSIGM, 1(1), 11-12.
  • Tunnicliffe RB, Ratcliffe EC, Hunter CN & Williamson MP (2006) . FEBS Lett, 580(30), 6967-6971.
  • Williamson MP, McCormick TG, Nance CL & Shearer WT (2006) . J Allergy Clin Immunol, 118(6), 1369-1374.
  • Williamson MP, Suzuki Y, Bourne NT & Asakura T (2006) . Biochem J, 397(3), 483-490.
  • Laguri C, Stenzel RA, Donohue TJ, Phillips-Jones MK & Williamson MP (2006) . Biochemistry, 45(25), 7872-7881.
  • Jöbstl E, Howse JR, Fairclough JPA & Williamson MP (2006) . J Agric Food Chem, 54(12), 4077-4081.
  • Potter CA, Jeong EL, Williamson MP, Henderson PJF & Phillips-Jones MK (2006) . FEBS LETT, 580(13), 3206-3210.
  • Leon-Kempis MDR, Guccione E, Mulholland F, Williamson MP & Kelly DJ (2006) . Mol Microbiol, 60(5), 1262-1275.
  • Tunnicliffe RB, Waby JL, Williams RJ & Williamson MP (2005) . Structure, 13(11), 1677-1684.
  • Jöbstl E, Fairclough JPA, Davies AP & Williamson MP (2005) . J Agric Food Chem, 53(20), 7997-8002.
  • Williamson MP (2005) . Biochem Soc Trans, 33(Pt 3), 503-506.
  • Exley RM, Shaw J, Mowe E, Sun YH, West NP, Williamson M, Botto M, Smith H & Tang CM (2005) . Journal of Experimental Medicine , 201(10), 1637-1645.
  • Tunnicliffe RB, Bolam DN, Pell G, Gilbert HJ & Williamson MP (2005) . J Mol Biol, 347(2), 287-296.
  • Flint J, Bolam DN, Nurizzo D, Taylor EJ, Williamson MP, Walters C, Davies GJ & Gilbert HJ (2005) . J BIOL CHEM, 280(25), 23718-23726.
  • Bocian W, Kawecki R, Bednarek E, Sitkowski J, Pietrzyk A, Williamson MP, Hansen PE & Kozerski L (2004) . CHEM-EUR J, 10(22), 5776-5787.
  • Jöbstl E, O'Connell J, Fairclough JPA & Williamson MP (2004) . Biomacromolecules, 5(3), 942-949.
  • McCormick TG, Nance CL, Williamson MP & Shearer WT (2004) . Journal of Allergy and Clinical Immunology, 113(2), S256-S256.
  • Nakano E, Williamson MP, Williams NH & Powers HJ (2004) . Biochim Biophys Acta, 1688(1), 33-42.
  • Abou-Hachem M, Olsson F, Williamson MP, Hreggvidsson GO, Kristjansson JK & Karlsson EN (2003) . BIOCATAL BIOTRANSFOR, 21(4-5), 253-260.
  • Williamson MP, Akasaka K & Refaee M (2003) . Protein Sci, 12(9), 1971-1979.
  • Laguri C, Phillips-Jones MK & Williamson MP (2003) . Nucleic Acids Res, 31(23), 6778-6787.
  • Williamson MP (2003) . Proteins, 53(3), 731-739.
  • Pell G, Williamson MP, Walters C, Du H, Gilbert HJ & Bolam DN (2003) . Biochemistry, 42(31), 9316-9323.
  • Refaee M, Tezuka T, Akasaka K & Williamson MP (2003) . J Mol Biol, 327(4), 857-865.
  • Williamson MP, Refaee M & Akasaka K (2003) . Seibutsu Butsuri, 43(supplement), S7-S7.
  • Jakeman DL, Ivory AJ, Blackburn GM & Williamson MP (2003) . J Biol Chem, 278(13), 10957-10962.
  • Horsburgh GJ, Atrih A, Williamson MP & Foster SJ (2003) . Biochemistry, 42(2), 257-264.
  • Charlton AJ, Haslam E & Williamson MP (2002) . J Am Chem Soc, 124(33), 9899-9905.
  • Abou-Hachem M, Karlsson EN, Simpson PJ, Linse S, Sellers P, Williamson MP, Jamieson SJ, Gilbert HJ, Bolam DN & Holst O (2002) . BIOCHEMISTRY-US, 41(18), 5720-5729.
  • Simpson PJ, Jamieson SJ, Abou-Hachem M, Karlsson EN, Gilbert HJ, Holst O & Williamson MP (2002) . Biochemistry, 41(18), 5712-5719.
  • Jamieson SJ, Williamson MP, Abou-Hachem M, Nordberg Karlsson E & Simpson PJ (2002) Letter to the Editor: Virtually complete H-1, C-13 and N-15 resonance assignments of the second family 4 xylan binding module of Rhodothermus marinus xylanase 10A. J BIOMOL NMR, 22(2), 187-188.
  • Charlton AJ, Baxter NJ, Khan ML, Moir AJG, Haslam E, Davies AP & Williamson MP (2002) . J Agric Food Chem, 50(6), 1593-1601.
  • Potter CA, Ward A, Laguri C, Williamson MP, Henderson PJF & Phillips-Jones MK (2002) . J MOL BIOL, 320(2), 201-213.
  • Williamson MP (2002) Chemical dreams. CHEM BRIT, 38(1), 19-19.
  • Raghothama S, Eberhardt RY, Simpson P, Wigelsworth D, White P, Hazlewood GP, Nagy T, Gilbert HJ & Williamson MP (2001) . Nat Struct Biol, 8(9), 775-778.
  • Xie HF, Gilbert HJ, Charnock SJ, Davies GJ, Williamson MP, Simpson PJ, Raghothama S, Fontes CMGA, Dias FMV, Ferreira LMA & Bolam DN (2001) . BIOCHEMISTRY-US, 40(31), 9167-9176.
  • Leighton MP, Kelly DJ, Williamson MP & Shaw JG (2001) . Microbiology (Reading), 147(Pt 6), 1473-1482.
  • Xie HF, Bolam DN, Nagy T, Szabo L, Cooper A, Simpson PJ, Lakey JH, Williamson MP & Gilbert HJ (2001) . BIOCHEMISTRY-US, 40(19), 5700-5707.
  • Iwadate M, Asakura T, Dubovskii PV, Yamada H, Akasaka K & Williamson MP (2001) Pressure-dependent changes in the structure of the melittin alpha-helix determined by NMR. J BIOMOL NMR, 19(2), 115-124.
  • Kozerski L, Mazurek AP, Kawecki R, Bocian W, Krajewski P, Bednarek E, Sitkowski J, Williamson MP, Moir AJG & Hansen PE (2001) A nicked duplex decamer DNA with a PEG(6) tether. NUCLEIC ACIDS RES, 29(5), 1132-1143.
  • Bolam DN, Xie HF, White P, Simpson PJ, Hancock SM, Williamson MP & Gilbert HJ (2001) Evidence for synergy between family 2b carbohydrate binding modules in Cellulomonas fimi xylanase 11A. BIOCHEMISTRY-US, 40(8), 2468-2477.
  • Iwadate M, Nagao E, Williamson MP, Ueki M & Asakura T (2000) Structure determination of [Arg8]vasopressin methylenedithioether in dimethylsulfoxide using NMR. EUR J BIOCHEM, 267(14), 4504-4510.
  • Simpson PJ, Xie H, Bolam DN, Gilbert HJ & Williamson MP (2000) . J Biol Chem, 275(52), 41137-41142.
  • Kikuchi J, Williamson MP, Shimada K & Asakura T (2000) Structure and dynamics of photosynthetic membrane-bound proteins in Rhodobacter Sphaeroides, studied with solid-state NMR spectroscopy. PHOTOSYNTH RES, 63(3), 259-267.
  • Conroy MJ, Westerhuis WH, Parkes-Loach PS, Loach PA, Hunter CN & Williamson MP (2000) . J Mol Biol, 298(1), 83-94.
  • Kay BK, Williamson MP & Sudol P (2000) The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains. FASEB J, 14(2), 231-241.
  • Ponyi T, Szabo L, Nagy T, Orosz L, Simpson PJ, Williamson MP & Gilbert HJ (2000) Trp22, Trp24, and Tyr8 play a pivotal role in the binding of the family 10 cellulose-binding module from Pseudomonas xylanase A to insoluble ligands. BIOCHEMISTRY-US, 39(5), 985-991.
  • Raghothama S, Simpson PJ, Szabó L, Nagy T, Gilbert HJ & Williamson MP (2000) . Biochemistry, 39(5), 978-984.
  • Kikuchi J, Asakura T, Hasuda K, Ito T, Ohwaku K, Araki H & Williamson MP (2000) An advantage for use of isotope labeling and NMR chemical shifts to analyze the structure of four homologous IgG-binding domains of staphylococcal protein A. J BIOCHEM BIOPH METH, 42(1-2), 35-47.
  • Charlton AJ, Davis AL, Jones DP, Lewis JR, Davies AP, Haslam E & Williamson MP (2000) The self-association of the black tea polyphenol theaflavin and its complexation with caffeine. J CHEM SOC PERK T 2(2), 317-322.
  • ABOU HACHEM M, NORDBERG KARLSSON E, BARTONEK-ROXÃ… E, RAGHOTHAMA S, SIMPSON PJ, GILBERT HJ, WILLIAMSON MP & HOLST O (2000) . Biochemical Journal, 345(1), 53-53.
  • Abou Hachem M, Karlsson EN, Bartonek-Roxa E, Raghothama S, Simpson PJ, Gilbert HJ, Williamson MP & Holst O (2000) Carbohydrate-binding modules from a thermostable Rhodothermus marinus xylanase: cloning, expression and binding studies. BIOCHEM J, 345, 53-60.
  • Jakeman DL, Bernstein B, Hol W, Williams DM, Williamson MP & Blackburn GM (1999) Highly potent bisphosphonate ligands for phosphoglycerate kinase and protein binding studies. PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 146, 533-536.
  • GILL J, RIXON JE, BOLAM DN, MCQUEEN-MASON S, SIMPSON PJ, WILLIAMSON MP, HAZLEWOOD GP & GILBERT HJ (1999) . Biochemical Journal, 342(2), 473-473.
  • Gill J, Rixon JE, Bolam DN, McQueen-Mason S, Simpson PJ, Williamson MP, Hazlewood GP & Gilbert HJ (1999) The type II and X cellulose-binding domains of Pseudomonas xylanase A potentiate catalytic activity against complex substrates by a common mechanism. BIOCHEM J, 342, 473-480.
  • Simpson PJ, Bolam DN, Cooper A, Ciruela A, Hazlewood GP, Gilbert HJ & Williamson MP (1999) . Structure, 7(7), 853-864.
  • Ueki M, Ikeo T, Iwadate M, Asakura T, Williamson MP & Slaninova J (1999) Solid phase synthesis and biological activities of [Arg(8)]-vasopressin methylenedithioether. BIOORG MED CHEM LETT, 9(13), 1767-1772.
  • Atrih A, Bacher G, Allmaier G, Williamson MP & Foster SJ (1999) . J Bacteriol, 181(13), 3956-3966.
  • Iwadate M, Asakura T & Williamson MP (1999) C-alpha and C-beta carbon-13 chemical shifts in proteins from an empirical database. J BIOMOL NMR, 13(3), 199-211.
  • Southall SM, Simpson PJ, Gilbert HJ, Williamson G & Williamson MP (1999) . FEBS Lett, 447(1), 58-60.
  • Kikuchi J, Asakura T, Loach PA, Parkes-Loach PS, Shimada K, Hunter CN, Conroy MJ & Williamson MP (1999) A light-harvesting antenna protein retains its folded conformation in the absence of protein-lipid and protein-pigment interactions. BIOPOLYMERS, 49(5), 361-372.
  • Furman B, Krajewski P, Kaluza Z, Thurmer R, Voelter W, Kozerski L, Williamson MP & Chmielewski M (1999) Stereochemical model of [2+2]cycloaddition of chlorosulfonyl isocyanate to chiral vinyl ethers. J CHEM SOC PERK T 2(2), 217-224.
  • Bayley MJ, Jones G, Willett P & Williamson MP (1998) . Protein Sci, 7(2), 491-499.
  • Iwadate M, Asakura T & Williamson MP (1998) The structure of the melittin tetramer at different temperatures - An NOE-based calculation with chemical shift refinement. EUR J BIOCHEM, 257(2), 479-487.
  • Baxter NJ, Hosszu LL, Waltho JP & Williamson MP (1998) . J Mol Biol, 284(5), 1625-1639.
  • Jakeman DL, Ivory AJ, Williamson MP & Blackburn GM (1998) . J Med Chem, 41(23), 4439-4452.
  • Williams DM, Jakeman DL, Vyle JS, Williamson MP & Blackburn GM (1998) . Bioorg Med Chem Lett, 8(18), 2603-2608.
  • Atrih A, Zöllner P, Allmaier G, Williamson MP & Foster SJ (1998) . J Bacteriol, 180(17), 4603-4612.
  • Nagy T, Simpson P, Williamson MP, Hazlewood GP, Gilbert HJ & Orosz L (1998) All three surface tryptophans in Type IIa cellulose binding domains play a pivotal role in binding both soluble and insoluble ligands. FEBS LETT, 429(3), 312-316.
  • Bolam DN, Ciruela A, McQueen-Mason S, Simpson P, Williamson MP, Rixon JE, Boraston A, Hazlewood GP & Gilbert HJ (1998) Pseudomonas cellulose-binding domains mediate their effects by increasing enzyme substrate proximity. BIOCHEM J, 331, 775-781.
  • KOZERSKI L, KRAJEWSKI P, PUPEK K, BLACKWELL PG & WILLIAMSON MP (1997) . ChemInform, 28(51).
  • Khan ML, Haslam E & Williamson MP (1997) Structure and conformation of the procyanidin B-2 dimer. MAGN RESON CHEM, 35(12), 854-858.
  • Asakura T, Demura M, Date T, Miyashita N, Ogawa K & Williamson MP (1997) NMR study of silk I structure of Bombyx mori silk fibroin with N-15- and C-13-NMR chemical shift contour plots. BIOPOLYMERS, 41(2), 193-203.
  • Williamson MP & Asakura T (1997) . Methods Mol Biol, 60, 53-69.
  • Williamson MP, Le Gal-Coëffet MF, Sorimachi K, Furniss CS, Archer DB & Williamson G (1997) . Biochemistry, 36(24), 7535-7539.
  • Rogers MJ, Xiong X, Ji X, Mönkkönen J, Russell RG, Williamson MP, Ebetino FH & Watts DJ (1997) . Pharm Res, 14(5), 625-630.
  • Baxter NJ, Lilley TH, Haslam E & Williamson MP (1997) . Biochemistry, 36(18), 5566-5577.
  • Kozerski L, Krajewski P, Pupek K, Blackwell PG & Williamson MP (1997) Towards stereochemical and conformational assignment in flexible molecules using NOEs and molecular modelling. J CHEM SOC PERK T 2(9), 1811-1818.
  • Baxter NJ & Williamson MP (1997) . J Biomol NMR, 9(4), 359-369.
  • Blanchard L, Hunter CN & Williamson MP (1997) . J Biomol NMR, 9(4), 389-395.
  • Williamson MP & Asakura T (1997) Protein chemical shifts., 60, 53-69.
  • Sorimachi K, Le Gal-Coëffet MF, Williamson G, Archer DB & Williamson MP (1997) . Structure, 5(5), 647-661.
  • Charlton AJ, Baxter NJ, Lilley TH, Haslam E, McDonald CJ & Williamson MP (1996) . FEBS Lett, 382(3), 289-292.
  • Mehmood Z, Williamson MP, Kelly DE & Kelly SL (1996) Human cytochrome P450 3A4 is involved in the biotransformation of the herbicide 2,4-dichlorophenoxyacetic acid. ENVIRON TOXICOL PHAR, 2(4), 397-401.
  • Sorimachi K, Jacks AJ, Le Gal-Coëffet MF, Williamson G, Archer DB & Williamson MP (1996) . J Mol Biol, 259(5), 970-987.
  • Baxter NJ, Williamson MP, Lilley TH & Haslam E (1996) Stacking interactions between caffeine and methyl gallate. J CHEM SOC FARADAY T, 92(2), 231-234.
  • Williams DM, Jakeman DL, Vyle JS, Williamson MP & Blackburn GM (1996) Synthesis and kinetic studies of bisubstrate analogues of phosphoglycerate kinase. COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 61, S88-S91.
  • Mehmood Z, Williamson MP, Kelly DE & Kelly SL (1996) . Chemosphere, 33(4), 759-769.
  • Jacks AJ, Sorimachi K, Le Gal-Coëffet MF, Williamson G, Archer DB & Williamson MP (1995) . Eur J Biochem, 233(2), 568-578.
  • Le Gal-Coëffet MF, Jacks AJ, Sorimachi K, Williamson MP, Williamson G & Archer DB (1995) . Eur J Biochem, 233(2), 561-567.
  • KOZERSKI L, KAWECKI R, KRAJEWSKI P, GLUZINSKI P, PUPEK K, HANSEN PE & WILLIAMSON MP (1995) SEARCHING CONFORMATIONAL SPACE IN FLEXIBLE MOLECULES USING NOES AND MOLECULAR MODELING. J ORG CHEM, 60(11), 3533-3538.
  • Williamson MP, Kikuchi J & Asakura T (1995) . J Mol Biol, 247(4), 541-546.
  • ASAKURA T, TAOKA K, DEMURA M & WILLIAMSON MP (1995) THE RELATIONSHIP BETWEEN AMIDE PROTON CHEMICAL-SHIFTS AND SECONDARY STRUCTURE IN PROTEINS. J BIOMOL NMR, 6(3), 227-236.
  • WILLIAMSON MP, TREVITT C & NOBLE JM (1995) NMR-STUDIES OF DEXTRAN OLIGOMER INTERACTIONS WITH MODEL POLYPHENOLS. CARBOHYD RES, 266(2), 229-235.
  • Murray NJ, Williamson MP, Lilley TH & Haslam E (1994) . Eur J Biochem, 219(3), 923-935.
  • Murray NJ & Williamson MP (1994) . Eur J Biochem, 219(3), 915-921.
  • BLACKBURN GM, JAKEMAN DL, IVORY AJ & WILLIAMSON MP (1994) SYNTHESIS OF PHOSPHONATE ANALOGS OF 1,3-BISPHOSPHOGLYCERIC ACID AND THEIR BINDING TO YEAST PHOSPHOGLYCERATE KINASE. BIOORG MED CHEM LETT, 4(21), 2573-2578.
  • Rogers MJ, Ji X, Russell RG, Blackburn GM, Williamson MP, Bayless AV, Ebetino FH & Watts DJ (1994) . Biochem J, 303 ( Pt 1)(Pt 1), 303-311.
  • Williamson MP (1994) . Biochem Soc Trans, 22(1), 140-144.
  • Williamson MP (1994) . Biochem J, 297 ( Pt 2)(Pt 2), 249-260.
  • KIKUCHI J, FUJITA K, WILLIAMSON MP & ASAKURA T (1994) STRUCTURE-ANALYSIS OF PROTEINS BY A COMBINATION OF DISTANCE GEOMETRY CALCULATION AND H-1-NMR CHEMICAL-SHIFT CALCULATION. KOBUNSHI RONBUNSHU, 51(6), 409-413.
  • Luck G, Liao H, Murray NJ, Grimmer HR, Warminski EE, Williamson MP, Lilley TH & Haslam E (1994) . Phytochemistry, 37(2), 357-371.
  • WILLIAMSON MP & WALTHO JP (1993) . ChemInform, 24(12).
  • Machado RS, Guest JR & Williamson MP (1993) . FEBS Lett, 323(3), 243-246.
  • Williamson MP (1993) . Nat Prod Rep, 10(3), 207-232.
  • CUMMINGS SP, WILLIAMSON MP & GILMOUR DJ (1993) TURGOR REGULATION IN A NOVEL HALOMONAS SPECIES. ARCH MICROBIOL, 160(4), 319-323.
  • Williamson MP (1993) . Methods Mol Biol, 17, 69-85.
  • Turner SL, Russell GC, Williamson MP & Guest JR (1993) . Protein Eng, 6(1), 101-108.
  • WILLIAMSON MP & ASAKURA T (1993) EMPIRICAL COMPARISONS OF MODELS FOR CHEMICAL-SHIFT CALCULATION IN PROTEINS. J MAGN RESON SER B, 101(1), 63-71.
  • Anson M, Blackburn GM, Ivory AJ, Jakeman DL, Littlechild JA & Williamson MP (1993) . Collection of Czechoslovak Chemical Communications, 58(s1), 109-112.
  • WILLIAMSON G, BELSHAW NJ, NOEL TR, RING SG & WILLIAMSON MP (1992) O-GLYCOSYLATION AND STABILITY - UNFOLDING OF GLUCOAMYLASE INDUCED BY HEAT AND GUANIDINE-HYDROCHLORIDE. EUR J BIOCHEM, 207(2), 661-670.
  • Williamson MP & Asakura T (1992) . FEBS Lett, 302(2), 185-188.
  • WILLIAMSON MP & WALTHO JP (1992) PEPTIDE STRUCTURE FROM NMR. CHEM SOC REV, 21(4), 227-236.
  • Rogers MJ, Russell RG, Blackburn GM, Williamson MP & Watts DJ (1992) . Biochem Biophys Res Commun, 189(1), 414-423.
  • WILLIAMSON G, BELSHAW NJ & WILLIAMSON MP (1992) O-GLYCOSYLATION IN ASPERGILLUS GLUCOAMYLASE - CONFORMATION AND ROLE IN BINDING. BIOCHEM J, 282, 423-428.
  • ASAKURA T, NIIZAWA Y & WILLIAMSON MP (1992) DETERMINATION OF THE MAGNETIC-ANISOTROPY OF THE OXYGEN ATOM AND H-1 CHEMICAL-SHIFT CALCULATION OF PROTEINS. J MAGN RESON, 98(3), 646-653.
  • WILLIAMSON MP, MURRAY NJ & WALTHO JP (1992) IMPROVED EXPERIMENTS FOR THE ASSIGNMENT OF CROWDED PEPTIDE SPECTRA. J MAGN RESON, 100(3), 593-597.
  • Williamson MP, Asakura T, Nakamura E & Demura M (1992) . J Biomol NMR, 2(1), 83-98.
  • WILLIAMSON MP (1991) . ChemInform, 22(32).
  • Robbins AH, McRee DE, Williamson M, Collett SA, Xuong NH, Furey WF, Wang BC & Stout CD (1991) . Journal of Molecular Biology, 221(4), 1269-1293.
  • WILLIAMSON MP & ASAKURA T (1991) CALCULATION OF CHEMICAL-SHIFTS OF PROTONS ON ALPHA CARBONS IN PROTEINS. J MAGN RESON, 94(3), 557-562.
  • WILLIAMSON MP (1991) NMR IN PROTEIN STUDIES. CHEM BRIT, 27(4), 335-337.
  • Williamson MP, Davies JS & Thomas WA (1991) . Journal of the Chemical Society Perkin Transactions 2(5), 601-606.
  • Williamson MP (1990) . Biopolymers, 29(10-11), 1423-1431.
  • Williamson MP & Madison VS (1990) . Biochemistry, 29(12), 2895-2905.
  • Derome AE & Williamson MP (1990) . Journal of Magnetic Resonance 1969, 88(1), 177-185.
  • WILLIAMSON MP (1990) SECONDARY-STRUCTURE DEPENDENT CHEMICAL-SHIFTS IN PROTEINS. BIOPOLYMERS, 29(10-11), 1428-1431.
  • Williamson MP (1989) . FEBS Letters, 254(1-2), 171-173.
  • Williamson MP, Davis PD, Broadhurst MJ & Nixon JS (1989) . Biochim Biophys Acta, 997(1-2), 9-14.
  • Williamson MP (1989) . J Mol Biol, 206(2), 407-410.
  • Williamson MP, Humm G & Crisp AJ (1989) . Br J Rheumatol, 28(1), 23-27.
  • WILLIAMSON MP, HUMM G & CRISP AJ (1989) H-1 NUCLEAR MAGNETIC-RESONANCE INVESTIGATION OF SYNOVIAL-FLUID COMPONENTS IN OSTEO-ARTHRITIS, RHEUMATOID-ARTHRITIS AND TRAUMATIC EFFUSIONS. BRIT J RHEUMATOL, 28(1), 23-27.
  • ANG S, WILLIAMSON MP & WILLIAMS DH (1988) . ChemInform, 19(44).
  • ANG SG, WILLIAMSON MP & WILLIAMS DH (1988) STRUCTURE ELUCIDATION OF A GLYCOPEPTIDE ANTIBIOTIC, OA-7653. J CHEM SOC PERK T 1(7), 1949-1956.
  • WILLIAMSON MP & NEUHAUS D (1987) . ChemInform, 18(45).
  • WILLIAMSON MP (1987) . MAGNETIC RESONANCE IN CHEMISTRY, 25(4), 356-361.
  • KEELER J, NEUHAUS D & WILLIAMSON MP (1987) THE NUCLEAR OVERHAUSER EFFECT IN STRONGLY COUPLED SPIN SYSTEMS. J MAGN RESON, 73(1), 45-68.
  • WILLIAMSON MP & NEUHAUS D (1987) SYMMETRY IN NOE SPECTRA. J MAGN RESON, 72(2), 369-375.
  • WILLIAMSON MP, HALL MJ & HANDA BK (1986) . European Journal of Biochemistry, 158(3), 527-536.
  • WILLIAMSON MP, HANDA BK & HALL MJ (1986) SECONDARY STRUCTURE OF A HERPES-SIMPLEX VIRUS GLYCOPROTEIN-D ANTIGENIC DOMAIN. INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, 27(5), 562-568.
  • Williamson MP & Williams DH (1985) 1 H N.M.R. Studies of the structure of ristocetin a and of its complexes with bacterial cell wall analogues in aqueous solution. Journal of the Chemical Society, Perkin Transactions 1, 949-956.
  • WILLIAMSON MP, HAVEL TF & WUTHRICH K (1985) SOLUTION CONFORMATION OF PROTEINASE INHIBITOR-IIA FROM BULL SEMINAL PLASMA BY H-1 NUCLEAR MAGNETIC-RESONANCE AND DISTANCE GEOMETRY. J MOL BIOL, 182(2), 295-315.
  • WILLIAMSON MP & WILLIAMS DH (1985) H-1-NMR STUDIES OF THE STRUCTURE OF RISTOCETIN-A AND OF ITS COMPLEXES WITH BACTERIAL-CELL WALL ANALOGS IN AQUEOUS-SOLUTION. J CHEM SOC PERK T 1(5), 949-956.
  • BARNA JCJ, WILLIAMS DH & WILLIAMSON MP (1985) STRUCTURAL FEATURES THAT AFFECT THE BINDING OF TEICOPLANIN, RISTOCETIN-A, AND THEIR DERIVATIVES TO THE BACTERIAL CELL-WALL MODEL N-ACETYL-D-ALANYL-D-ALANINE. J CHEM SOC CHEM COMM(5), 254-256.
  • WILLIAMSON MP & WILLIAMS DH (1984) HYDROPHOBIC INTERACTIONS AFFECT HYDROGEN-BOND STRENGTHS IN COMPLEXES BETWEEN PEPTIDES AND VANCOMYCIN OR RISTOCETIN. EUR J BIOCHEM, 138(2), 345-348.
  • WUTHRICH K, STROP P, EBINA S & WILLIAMSON MP (1984) A GLOBULAR PROTEIN WITH SLOWER AMIDE PROTON-EXCHANGE FROM AN ALPHA-HELIX THAN FROM ANTIPARALLEL BETA-SHEETS. BIOCHEM BIOPH RES CO, 122(3), 1174-1178.
  • WILLIAMSON MP, MARION D & WUTHRICH K (1984) SECONDARY STRUCTURE IN THE SOLUTION CONFORMATION OF THE PROTEINASE INHIBITOR-IIA FROM BULL SEMINAL PLASMA BY NUCLEAR MAGNETIC-RESONANCE. J MOL BIOL, 173(3), 341-359.
  • WILLIAMSON MP, WILLIAMS DH & HAMMOND SJ (1984) INTERACTIONS OF VANCOMYCIN AND RISTOCETIN WITH PEPTIDES AS A MODEL FOR PROTEIN-BINDING. TETRAHEDRON, 40(3), 569-577.
  • WILLIAMS DH, WILLIAMSON MP, BUTCHER DW & HAMMOND SJ (1983) DETAILED BINDING-SITES OF THE ANTIBIOTICS VANCOMYCIN AND RISTOCETIN-A - DETERMINATION OF INTERMOLECULAR DISTANCES IN ANTIBIOTIC SUBSTRATE COMPLEXES BY USE OF THE TIME-DEPENDENT NOE. J AM CHEM SOC, 105(5), 1332-1339.
  • WILLIAMSON MP (1983) PURE ABSORPTION PHASE PROTON 2D J-RESOLVED SPECTROSCOPY. J MAGN RESON, 55(3), 471-474.
  • WILLIAMSON MP, GAUVREAU D, WILLIAMS DH & WARING MJ (1982) STRUCTURE AND CONFORMATION OF 14 ANTIBIOTICS OF THE QUINOXALINE GROUP DETERMINED BY H-1-NMR. J ANTIBIOT, 35(1), 62-66.
  • HAMMOND SJ, WILLIAMSON MP, WILLIAMS DH, BOECK LD & MARCONI GG (1982) ON THE BIOSYNTHESIS OF THE ANTIBIOTIC VANCOMYCIN. J CHEM SOC CHEM COMM(6), 344-346.
  • WILLIAMSON MP & WILLIAMS DH (1981) STRUCTURE REVISION OF THE ANTIBIOTIC VANCOMYCIN - THE USE OF NUCLEAR OVERHAUSER EFFECT DIFFERENCE SPECTROSCOPY. J AM CHEM SOC, 103(22), 6580-6585.
  • Williamson MP & Williams DH (1981) Erratum: Manipulation of the nuclear overhauser effect by the use of a viscous solvent: The solution conformation of the antibiotic echinomycin (Journal of the Chemical Society, Chemical Communications (1981) (165)). Journal of the Chemical Society Chemical Communications(9), 440.
  • WILLIAMSON MP & WILLIAMS DH (1981) A C-13 NUCLEAR MAGNETIC-RESONANCE STUDY OF RISTOCETIN-A AND RISTOCETIN-B AND THEIR DERIVATIVES. J CHEM SOC PERK T 1(5), 1483-1491.
  • WILLIAMSON MP & WILLIAMS DH (1981) MANIPULATION OF THE NUCLEAR OVERHAUSER EFFECT BY THE USE OF A VISCOUS SOLVENT - THE SOLUTION CONFORMATION OF THE ANTIBIOTIC ECHINOMYCIN. J CHEM SOC CHEM COMM(4), 165-166.
  • BONGINI A, FEENEY J, WILLIAMSON MP & WILLIAMS DH (1981) ASSIGNMENT OF THE C-13 SPECTRUM OF VANCOMYCIN AND ITS DERIVATIVES. J CHEM SOC PERK T 2(1), 201-206.
  • WILLIAMSON MP & WILLIAMS DH (1980) A C-13 NMR-STUDY OF THE CARBOHYDRATE PORTION OF RISTOCETIN-A. TETRAHEDRON LETT, 21(43), 4187-4188.
  • WILLIAMS DH, RAJANANDA V, BOJESEN G & WILLIAMSON MP (1979) STRUCTURE OF THE ANTIBIOTIC RISTOCETIN-A. J CHEM SOC CHEM COMM(20), 906-908.
  • Southam HM, Smith TW, Lyon RL, Liao C, Trevitt CR, Middlemiss LA, Cox FL, Chapman JA, El-Khamisy SF, Hippler M , Williamson MP et al () . Redox Biology, 18, 114-123.

Book chapters

  • Williamson MP (2019) , Encyclopedia of Analytical Science (pp. 264-271).
  • Williamson MP (2018) , Modern Magnetic Resonance (pp. 2133-2147). Springer International Publishing
  • Williamson MP (2018) , Modern Magnetic Resonance (pp. 995-1012). Springer International Publishing
  • Williamson MP (2018) , Reference Module in Chemistry, Molecular Sciences and Chemical Engineering Elsevier
  • Williamson MP (2017) , Modern Magnetic Resonance (pp. 1-15). Springer International Publishing
  • Williamson MP (2017) , Modern Magnetic Resonance (pp. 1-19). Springer International Publishing
  • Williamson MP (2005) , Encyclopedia of Analytical Science (pp. V6-V6-349).
  • Williamson MP (2005) , Encyclopedia of Analytical Science (pp. 342-349). Elsevier
  • Haslam E, Williamson MP, Baxter NJ & Charlton AJ (1999) , Phytochemicals in Human Health Protection, Nutrition, and Plant Defense (pp. 289-318). Springer US
  • Williamson MP, Havel TF & Wüthrich K (1995) , World Scientific Series in 20th Century Chemistry (pp. 319-339). WORLD SCIENTIFIC
  • Williamson MP () John Wiley & Sons, Ltd
  • Williamson MP () , Modern Magnetic Resonance (pp. 409-412). Springer Netherlands
  • Williamson MP () , Modern Magnetic Resonance (pp. 1357-1362). Springer Netherlands
  • Williamson MP () John Wiley & Sons, Ltd

Conference proceedings

  • Nance CL, Williamson MP, McCormick TG, Paulson SM & Shearer WT (2006) Epigallocatechin gallate, green tea catechin, binds to the T cell receptor, CD4. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol. 117(2) (pp S325-S325)
  • Miyauchi S, Nakazawa Y, Suzuki Y, Kurashina M, Sato H, Asakura T & Williamson MP (2005) Change in orientation and dynamics of DMPC molecules induced by aggregation of Aβ (1-40) molecules studied using solid state and solution NMR. Polymer Preprints Japan, Vol. 54(2) (pp 4983)
  • Nakazawa Y, Suzuki Y, Miyauchi S, Sato H, Williamson MP, Ando I & Asakura T (2005) Structural and dynamical studies of Aβ(1-40)-Ganglioside system with solid state and solution NMR. Polymer Preprints Japan, Vol. 54(1) (pp 727)
  • Nance CL, Williamson MP, McCormick TG & Shearer WT (2005) Binding of the green tea polyphenol, epigallocatechin gallate, to the CD4 receptor on human CD4+ T cells resulting in inhibition of HIV-1-gp120 binding. CLINICAL IMMUNOLOGY, Vol. 115 (pp S245-S246)
  • Williamson MP (2003) . MAGNETIC RESONANCE IN CHEMISTRY, Vol. 41 (pp S64-S69)
  • Haslam E, Williamson M & Charlton A (2000) Protein-polyphenol interactions. International Congress and Symposium Series Royal Society of Medicine(226) (pp 25-33)
  • Williamson MP, Simpson PJ, Bolam DN, Hazlewood GP, Ciruela A, Cooper A & Gilbert HJ (1999) How the N-terminal xylan-binding domain from C-fimi xylanase D recognises xylan. RECENT ADVANCES IN CARBOHYDRATE BIOENGINEERING(246) (pp 212-220)
  • Asakura T, Iwadate M, Demura M & Williamson MP (1999) Structural analysis of silk with C-13 NMR chemical shift contour plots. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, Vol. 24(2-3) (pp 167-171)
  • Charlton AJ, Baxter NJ, Haslam E & Williamson MP (1998) Salivary proteins as a defence against dietary tannins. COST 916 - POLYPHENOLS IN FOOD (pp 179-185)
  • Charlton AJ, Baxter NJ, Haslam E & Williamson MP (1998) Salivary proline-rich proteins as a defence against dietary tannins. COST 916 - POLYPHENOLS IN FOOD (pp 201-201)
  • PICKETT MW, WILLIAMSON MP & KELLY DJ (1994) AN ENZYME AND C-13-NMR STUDY OF CARBON METABOLISM IN HELIOBACTERIA. PHOTOSYNTHESIS RESEARCH, Vol. 41(1) (pp 75-88)
  • Madison VS, Fry DC, Wegrzynski BB, Williamson MP, Danho W, Heimer EP & Felix AM () . [1990] Proceedings of the Twelfth Annual International Conference of the IEEE Engineering in Medicine and Biology Society (pp 1612-1612)

Preprints

  • Davis JL, Norwood JS, Smith RE, O’Dea F, Chellappa K, Rowe ML, Williamson MP, Stafford GP, Vinogradov E, Maes E , Guérardel Y et al (2024) , Cold Spring Harbor Laboratory.
  • Williamson M, Trevitt C, Kumar Y & Fowler N (2023) , Springer Science and Business Media LLC.
  • Fowler NJ, Albalwi MF, Lee S, Hounslow AM & Williamson MP (2022) , Cold Spring Harbor Laboratory.
  • Fowler NJ & Williamson MP (2022) , Cold Spring Harbor Laboratory.
  • Fowler NJ, Sljoka A & Williamson MP (2021) , Cold Spring Harbor Laboratory.
  • Smith RE, Salamaga B, Szkuta P, Hajdamowicz N, Prajsnar TK, Bulmer G, Fontaine T, KoÅ‚odziejczyk J, Herry J-M, Hounslow A , Williamson MP et al (2018) , Cold Spring Harbor Laboratory.
Research group

My laboratory uses NMR (and other methods where appropriate) to determine the structure and dynamics of proteins in solution and to study their interactions with ligands. In addition we are developing new methods for characterising structures. Further details are in my web page and in the publications list. Recent work includes:

We continue to study protein structures, particularly if this illustrates function. Recent targets include the PLAT domain of human polycystin-1, which we show to recognise phosphatidyl serine and PI4P in the membrane; the protein Mms6, which helps assemble magnetite particles in magnetotactic bacteria; and the Wbl protein (Figure), which uses an Fe-S cluster to sense NO in M. tuberculosis and hence evade host defences.

We have studied how proteins recognize polysaccharides such as starch, cellulose, xylan and peptidoglycan in bacterial cell walls: for example, the LysM module which recognises peptidoglycan and chitin, as found in bacterial and fungal cell walls and invertebrate exoskeletons.

We have been developing new tools; in particular the use of high hydrostatic pressure to stabilise partially unfolded structures, and thus investigate functional conformational change in proteins. We have started looking at Rheo-NMR, to see how proteins align and aggregate in laminar flow.

We collaborate with numerous groups. These include a logstanding collaboration with Tetsuo Asakura on silk structure; a collaboration with Jim Thomas on ruthenium-based complexes that bind B-DNA and quadruplexes; a collaboration with Robert Poole on the so-called Carbon Monoxide Releasing Molecules (CORMs); and a study on how Hofmeister ions stabilise and/or solubilise proteins.

We have a longstanding interest in polyphenols such as those from tea, and in how they interact with the body. As part of this study, we have shown that the main component of green tea, epigallocatechin gallate (EGCG), has the potential to slow down HIV infection; and that EGCG can be transported effectively by binding to albumin in the blood.

Teaching activities

Projects and literature reviews at levels 3 and 4, and tutorial groups.

Level 3 modules

Biochemical Basis of Human Disease (module coordinator) - amyloid disease, obesity, inflammation and diabetes
Biochemical Signalling - principles, receptor tyrosine kinases, Notch and NF-kB
Protein folding and misfolding in disease

Level 2 modules

Biostructures, Energetics and Synthesis – biochemical pathways, membranes, nerve transmission and signalling
Ethics and Philosophy for Molecular Biosciences

Professional activities and memberships

Council of International Conference for Magnetic Resonance in Biological Systems (ICMRBS) since 2018.
Reviewing grant applications, papers, promotion cases. 
Editorial board of Biomolecules.

Links