Dr Martin Zeidler

School of Biosciences

Reader in Cell Signalling

m.zeidler@sheffield.ac.uk
+44 114 222 6094 (Lab phone)
Firth Court

Full contact details

Dr Martin Zeidler
School of Biosciences
Firth Court
Western Bank
Sheffield
S10 2TN
Profile

Brief career history

  • 2007-present: Reader, University of Sheffield, UK.
  • 2006-2007: Senior Lecturer, University of Sheffield, UK.
  • 2001-2006: Emmy Noether Independent Group Leader, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
  • 1996-2001: Postdoctoral Fellow, Department of Genetics, Harvard Medical School, Boston, MA, USA
  • 1991-1996: Pre-doctoral student at the European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
  • 1987-1991: BSc in Biology with European Studies (German), The University of Sussex, Brighton, UK.
Research interests

Research interests

My lab is interested in identifying and analysing regulators of the JAK/STAT pathway– a signaling cascade frequently misactivated in haematopoietic malignancies.

We use both high throughput RNAi screening technologies and developmental genetic assays in Drosophila to determine the mechanisms of action of pathway regulators and their interactions in vivo.

JAK/STAT signalling in development and disease

My lab studies the regulators and roles of the JAK/STAT signal transduction cascade using a combination of human cell based approaches, Drosophila-based genetic screening and in vivo biology.

This work is aimed at generating insights into human inflammatory and haematopoietic disease.

The JAK/STAT pathway transduces the signals provided by multiple cytokines, growth factors and interferons. As a consequence, it plays a central role in development, cellular proliferation, stem cell maintenance, haematopoiesis and immunity.

In addition, inappropriate pathway activation is also linked to a wide range of human diseases including cancers, leukaemias, myeloproliferative neoplasms (MPNs) and inflammatory diseases such as rheumatoid arthritis.

Conserved throughout evolution, the pathways biological roles have also been largely maintained and as a result, many of the findings made in low complexity model systems such as Drosophila are applicable to humans.

The Zeidler lab has collaborations with a number of high profile groups including that of Tony Green (Cambridge) and Stefan Constantinescu (Brussels).

I have also collaborated and co-supervised joint PhD students with the Strutt and Smythe labs (BMS) and the Bellantuono lab (Human Metabolism).

In the future, I anticipate working more closely on Drosophila haematopoiesis (with lab of Iwan Evans) and on inflammatory aspects of JAK/STAT signalling humans.

In addition, we are also developing Zebrafish models of human myeloproliferative neoplasms in collaboration with the laboratory of Dr Rob Wilkinson (Cardiovascular Science). Insights gained from this work will also inform analysis using patient material which will be undertaken with Sally Thomas and John Snowden (NHS, Haematology).

Finally, ‘drug repurposing’ relating to our discovery of Methotrexate as a potent inhibitor of JAK/STAT pathway signalling will also be pursued.

Publications

Show: Featured publications All publications

Journal articles

  • Chinnaiya K, Lawson MA, Thomas S, Haider MT, Down J, Chantry AD, Hughes D, Green A, Sayers JR, Snowden JA & Zeidler MP (2017) . Haematologica, 102(6).
  • Thomas S, Fisher KH, Snowden JA, Danson SJ, Brown S & Zeidler MP (2015) . PLoS ONE, 10(7).
  • Wells RE, Barry JD, Warrington SJ, Cuhlmann S, Evans P, Huber W, Strutt D & Zeidler MP (2013) . Development, 140(18), 3858-3868.
  • Bausek N & Zeidler MP (2013) Gα73Î’ is a downstream effector of JAK/STAT signaling and a regulator of Rho1 in Drosophila hematopoiesis. J Cell Sci.
  • Müller P, Kuttenkeuler D, Gesellchen V, Zeidler MP & Boutros M (2005) . Nature, 436(7052), 871-875.

All publications

Journal articles

  • Ramirez Moreno M, Quinton A, Jacobsen E, Stempor PA, Zeidler MP & Bulgakova NA (2025) . PLoS Genetics, 21(7).
  • Mullenger J, Zeidler M & Fragiadaki M (2024) . Journal of the American Society of Nephrology, 35(10S).
  • Francis S, King T & Zeidler MP (2024) . Frontiers in Medicine, 11.
  • Brooks EC, Zeidler MP, Ong ACM & Evans IR (2024) . Frontiers in Immunology, 14.
  • Mullenger JL, Zeidler MP & Fragiadaki M (2023) . International Journal of Molecular Sciences, 24(16).
  • Chen Z, Cordero J, Alqarni AM, Slack C, Zeidler MP & Bellantuono I (2022) . The Journals of Gerontology: Series A, 77(8), 1494-1502.
  • Coates JA, Brooks E, Brittle AL, Armitage EL, Zeidler MP & Evans IR (2021) . Elife, 10.
  • Moore R, Vogt K, Acosta-Martin A, Shire P, Zeidler M & Smythe E (2020) . Journal of Cell Science, 133.
  • Chen Z, Cordero J, Slack C, Zeidler M & Bellantuono I (2020) .
  • Alqarni AM & Zeidler MP (2020) . Biochemical Society Transactions, 48(2), 559-567.
  • Gremese E, Alivernini S, Tolusso B, Zeidler MP & Ferraccioli G (2019) . Journal of Leukocyte Biology, 106(5), 1063-1068.
  • Francis S, Thomas S, Luben R, Sousos N, Mead A, Snowden JA & Zeidler MP (2019) . British Journal of Haematology, 187(3).
  • Bellantuono I, Chen Z, Slack C, Cordero J & Zeidler M (2018) . Innovation in Aging, 2(suppl_1), 545-545.
  • Fisher KH, Fragiadaki M, Pugazhendhi D, Bausek N, Arredondo MA, Thomas SJ, Brown S & Zeidler MP (2018) . Journal of Cell Science, 131.
  • Fragiadaki M & Zeidler MP (2018) . Journal of Biological Chemistry , 293, 9570-9579.
  • Chinnaiya K, Lawson MA, Thomas S, Haider MT, Down J, Chantry AD, Hughes D, Green A, Sayers JR, Snowden JA & Zeidler MP (2017) . Haematologica, 102(6).
  • Fisher KH, Stec W, Brown S & Zeidler MP (2016) . Molecular Biology of the Cell, 27(3), 434-441.
  • Thomas SJ, Snowden JA, Zeidler MP & Danson SJ (2015) . British Journal of Cancer, 113(3), 365-371.
  • Thomas S, Fisher KH, Snowden JA, Danson SJ, Brown S & Zeidler MP (2015) . PLoS ONE, 10(7).
  • Thomas S, Fisher K, Snowden J, Danson S, Brown S & Zeidler M (2015) . The Lancet, 385, S98-S98.
  • Bausek N & Zeidler MP (2014) . Development, 141(3), e308-e308.
  • Zeidler MP & Bausek N (2013) The Drosophila JAK-STAT pathway. JAK-STAT, 2(3).
  • Stec W, Vidal O & Zeidler MP (2013) . Mol Biol Cell, 24(18), 3000-3009.
  • Wells RE, Barry JD, Warrington SJ, Cuhlmann S, Evans P, Huber W, Strutt D & Zeidler MP (2013) . Development, 140(18), 3858-3868.
  • Johnstone K, Wells RE, Strutt D & Zeidler MP (2013) . PLoS One, 8(5), e65076.
  • Bausek N & Zeidler MP (2013) Gα73Î’ is a downstream effector of JAK/STAT signaling and a regulator of Rho1 in Drosophila hematopoiesis. J Cell Sci.
  • Fisher KH, Wright VM, Taylor A, Zeidler MP & Brown S (2012) . BMC Genomics, 13, 506.
  • Bausek N & Zeidler MP (2012) Matters of the heart. JAK-STAT, 1(3), 208-210.
  • Sun FF, Johnson JE, Zeidler MP & Bateman JR (2012) . G3 (Bethesda), 2(5), 551-553.
  • Müller P, Pugazhendhi D & Zeidler MP (2012) Modulation of human JAK-STAT pathway signaling by functionally conserved regulators. JAK-STAT, 1(1), 34-43.
  • Stec WJ & Zeidler MP (2011) . J Signal Transduct, 2011, 894510.
  • Wright VM, Vogt KL, Smythe E & Zeidler MP (2011) . Cellular Signalling, 23(5), 920-927.
  • Wright VM, Vogt KL, Smythe E & Zeidler MP (2011) . Cell Signal, 23(5), 920-927.
  • Vidal OM, Stec W, Bausek N, Smythe E & Zeidler MP (2010) . Development, 137(21), e2107-e2107.
  • Vidal OM, Stec W, Bausek N, Smythe E & Zeidler MP (2010) . J Cell Sci, 123(Pt 20), 3457-3466.
  • Bina S, Wright VM, Fisher KH, Milo M & Zeidler MP (2010) . EMBO Rep, 11(3), 201-207.
  • Rivas ML, Cobreros L, Zeidler MP & Hombría JC-G (2008) . EMBO Rep, 9(11), 1114-1120.
  • Brown S & Zeidler MP (2008) . Curr Opin Genet Dev, 18(5), 455-460.
  • Elliott GC & Zeidler MP (2008) . Insect Mol Biol, 17(5), 475-483.
  • Müller P, Boutros M & Zeidler MP (2008) . Semin Cell Dev Biol, 19(4), 360-369.
  • Arbouzova NI & Zeidler MP (2006) . Development, 133(14), 2605-2616.
  • Mukherjee T, Schäfer U & Zeidler MP (2006) . Genetics, 172(3), 1683-1697.
  • Brown S, Zeidler MP & Hombría JEC-G (2006) . Dev Dyn, 235(4), 958-966.
  • Arbouzova NI, Bach EA & Zeidler MP (2006) . Curr Biol, 16(1), 80-88.
  • Karsten P, Plischke I, Perrimon N & Zeidler MP (2006) . Cell Signal, 18(6), 819-829.
  • Hombría JC-G, Brown S, Häder S & Zeidler MP (2005) . Dev Biol, 288(2), 420-433.
  • Müller P, Kuttenkeuler D, Gesellchen V, Zeidler MP & Boutros M (2005) . Nature, 436(7052), 871-875.
  • Mukherjee T, Hombría JC-G & Zeidler MP (2005) . Oncogene, 24(15), 2503-2511.
  • Zeidler MP, Tan C, Bellaiche Y, Cherry S, Häder S, Gayko U & Perrimon N (2004) . Nat Biotechnol, 22(7), 871-876.
  • Bach EA, Vincent S, Zeidler MP & Perrimon N (2003) . Genetics, 165(3), 1149-1166.
  • Karsten P, Häder S & Zeidler MP (2002) . Mech Dev, 117(1-2), 343-346.
  • Zeidler MP, Perrimon N & Strutt DI (2000) . Dev Biol, 228(2), 181-196.
  • Zeidler MP & Perrimon N (2000) . Curr Biol, 10(18), R682-R684.
  • Zeidler MP, Bach EA & Perrimon N (2000) . Oncogene, 19(21), 2598-2606.
  • Zeidler MP, Perrimon N & Strutt DI (1999) . Curr Biol, 9(23), 1363-1372.
  • Zeidler MP, Perrimon N & Strutt DI (1999) . Genes Dev, 13(10), 1342-1353.
  • Zeidler MP & Mlodzik M (1997) . Biol Chem, 378(10), 1119-1124.
  • Zeidler MP, Yokomori K, Tjian R & Mlodzik M (1996) . Genes Dev, 10(1), 50-59.
  • Thompson KS, Zeidler MP & Bacon JP (1994) . J Comp Neurol, 347(4), 553-569.
  • Yokomori K, Zeidler MP, Chen JL, Verrijzer CP, Mlodzik M & Tjian R (1994) . Genes Dev, 8(19), 2313-2323.

Book chapters

  • Fisher KH, Brown S & Zeidler MP (2013) (pp. 81-97).

Conference proceedings

  • Thomas SJ, Fisher K, Brown S, Snowden JA, Danson S & Zeidler M (2014) . Blood, Vol. 124(21) (pp 4577-4577)
  • Wells R, Strutt D & Zeidler M (2009) . MECHANISMS OF DEVELOPMENT, Vol. 126 (pp S176-S176)
  • Brown S, Smythe E, Strutt D, Whitworth A & Zeidler M (2009) . MECHANISMS OF DEVELOPMENT, Vol. 126 (pp S290-S290)
  • Åšlusarczyk A, Bryant HE, Chen E, Hitchcock I, Zeidler M, Chantry A & Thomas S () . The 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response (pp 17-17)

Preprints

  • Ramirez-Moreno M, Quinton A, Jacobsen E, Stempor PA, Zeidler MP & Bulgakova NA (2024) , Cold Spring Harbor Laboratory.
  • Brooks EC, Zeidler MP, Ong ACM & Evans IR (2023) , Cold Spring Harbor Laboratory.
  • Fisher KH, Fragiadaki M, Pugazhendhi D, Bausek N, Brown S & Zeidler MP (2017) , Cold Spring Harbor Laboratory.
  • Coates JA, Brittle A, Armitage EL, Zeidler MP & Evans IR () .
Grants

Funding

  • CR-UK Fellowship
  • UoS Schemes
  • Cancer Research UK
  • Wellcome Trust
Teaching activities

Undergraduate

  • BMS109 Lab Skills & Skills Sessions
  • BMS242/243 Principles of Developmental Biology
  • BMS301 Membrane Receptors
  • BMS356 Biomedical Technology & Drug Discovery (Co-ordinator)

Masters (MSc)

  • BMS6083 Practical Developmental Genetics
Professional activities and memberships
  • CR-UK Senior Cancer Research Fellow
  • Former Emmy Noether Career Development Fellow and CRUK Senior Cancer Research Fellow
  • Founder and academic director of the  (SRSF)
  • Supervised 13x PhD students
  • Journal Editor and reviewer for many journals and grant awarding bodies
  • Fellow of the Higher Education Academy (FHEA)
  • Teaching at all Undergraduate levels