Dr Indrajit Lahiri

School of Biosciences

Lecturer in Electron Microscopy

Indro_pic - Indrajit Lahiri
Profile picture of Indro_pic - Indrajit Lahiri
i.lahiri@sheffield.ac.uk
D14A, Firth Court

Full contact details

Dr Indrajit Lahiri
School of Biosciences
D14A
Firth Court
Western Bank
Sheffield
S10 2TN
Profile

2022 - present: Lecturer in Electron Microscopy, University of Sheffield

2019-2022: Assistant Professor, IISER Mohali, India

2015-2019: Postdoctoral Researcher, University of California, San Diego, USA

2014-2015: Postdoctoral Researcher, Harvard University, USA

2008-2014: PhD, State University of New York at Albany, USA

Research interests

We study the essential processes of genome replication, repair and compaction in eukaryotic parasites belonging to the phylum Apicomplexa.
Apicomplexans cause deadly diseases like malaria (Plasmodium sp.) and toxoplasmosis (Toxoplasma sp.). These parasites affect over 200 million people worldwide each year. Our interest lies in understanding how apicomplexans carry out DNA transactions within the context of their host - specifically how these processes occur in an organelle called the 'apicoplast'. To answer this question we use electron cryomicroscopy, fast enzyme kinetics, next-generation DNA sequencing and associated biochemical and biophysical techniques.

Publications

Journal articles

  • Kumari A, Enache T, Craggs TD, Pata JD & Lahiri I (2025) . Nucleic Acids Res, 53(19).
  • Stevenson SR, Tzokov SB, Lahiri I, Ayscough KR & Bullough PA (2025) . Structure, 33(3), 435-442.e3.
  • Sarsam RD, Xu J, Lahiri I, Gong W, Li Q, Oh J, Zhou Z, Hou P, Chong J, Hao N , Li S et al (2024) . Proceedings of the National Academy of Sciences, 121(3).
  • Karasmanis EP, Reimer JM, Kendrick AA, Nguyen KHV, Rodriguez JA, Truong JB, Lahiri I, Reck-Peterson SL & Leschziner AE (2023) . Nature Structural & Molecular Biology, 30(9), 1357-1364.
  • Kumari A, Yadav A & Lahiri I (2022) . Biochemistry, 61(21), 2319-2333.
  • Mondal AK, Sengupta N, Singh M, Biswas R, Lata K, Lahiri I, Dutta S & Chattopadhyay K (2022) . Journal of Biological Chemistry, 298(10).
  • Pata JD, Yin YW & Lahiri I (2022) . Frontiers in Molecular Biosciences, 9.
  • Gillies JP, Reimer JM, Karasmanis EP, Lahiri I, Htet ZM, Leschziner AE & Reck-Peterson SL (2022) . Elife, 11.
  • Sharon I, Haque AS, Grogg M, Lahiri I, Seebach D, Leschziner AE, Hilvert D & Schmeing TM (2021) . Nature Chemical Biology, 17(10), 1101-1110.
  • Fagan SP, Mukherjee P, Jaremko WJ, Nelson-Rigg R, Wilson RC, Dangerfield TL, Johnson KA, Lahiri I & Pata JD (2021) . Nucleic Acids Research, 49(14), 8324-8338.
  • Deniston CK, Salogiannis J, Mathea S, Snead DM, Lahiri I, Matyszewski M, Donosa O, Watanabe R, Böhning J, Shiau AK , Knapp S et al (2020) . Nature, 588(7837), 344-349.
  • Lahiri I, Xu J, Han BG, Oh J, Wang D, DiMaio F & Leschziner AE (2019) . Journal of Structural Biology, 207(3), 270-278.
  • Cianfrocco MA, Lahiri I, DiMaio F & Leschziner AE (2018) . Journal of Structural Biology, 203(3), 230-235.
  • Xu J, Lahiri I, Wang W, Wier A, Cianfrocco MA, Chong J, Hare AA, Dervan PB, DiMaio F, Leschziner AE & Wang D (2017) . Nature, 551(7682), 653-657.
  • Mukherjee P, Wilson RC, Lahiri I & Pata JD (2014) . Journal of Biological Chemistry, 289(10), 6323-6331.
  • Lahiri I, Mukherjee P & Pata JD (2013) . Plos One, 8(5).
  • Mukherjee P, Lahiri I & Pata JD (2013) . Nucleic Acids Research, 41(9), 5024-5035.
  • Bakker SE, Bergeron J, Bharadwaj A, Bhella D, Bullough P, Chau P-L, Frank RAW, Jakobi AJ, Joseph AP, Kühlbrandt W , Lahiri I et al () . Faraday Discussions, 240, 229-242.

Preprints

  • Kumari A, Enache T, Craggs TD, Pata JD & Lahiri I (2025) , Cold Spring Harbor Laboratory.
  • Stevenson SR, Tzokov SB, Lahiri I, Ayscough KR & Bullough PA (2024) , Cold Spring Harbor Laboratory.
  • Sarsam RD, Xu J, Lahiri I, Gong W, Oh J, Zhou Z, Chong J, Hao N, Li S, Wang D & Leschziner AE (2023) , Cold Spring Harbor Laboratory.
  • Leschziner A, Karasmanis E, Reimer J, Kendrick A, Rodriguez J, Truong J, Lahiri I & Reck-Peterson S (2022) , Springer Science and Business Media LLC.
  • Karasmanis E, Reimer J, Kendrick A, Rodriguez J, Truong J, Lahiri I, Reck-Peterson S & Leschziner A (2022) , bioRxiv.
  • Gillies J, Reimer J, Karasmanis E, Lahiri I, Htet ZM, Leschziner A & Reck-Peterson S (2021) , bioRxiv.
  • Deniston C, Salogiannis J, Mathea S, Snead D, Lahiri I, Donosa O, Watanabe R, Böhning J, Shiau A, Knapp S , Villa E et al (2020) , bioRxiv.
Research group

Ms. Anamika Kumari (BBSRC White Rose DTP PhD student)

Dr. Anjali Yadav (Postdoctoral researcher)

Teaching activities

MBB409

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