Dr Freek van Eeden

School of Biosciences

Senior Lecturer

f.j.vaneeden@sheffield.ac.uk
+44 114 222 2348
C13, Firth Court

Full contact details

Dr Freek van Eeden
School of Biosciences
C13
Firth Court
Western Bank
Sheffield
S10 2TN
Profile
  • 2006- present: Senior Lecturer, University of Sheffield
  • 1999 - 2005: Junior Group Leader Hubrecht Laboratory, Utrecht, The Netherlands
  • 1997 - 1999: Post-doctoral worker, D. StJohnston Lab, Wellcome/CRC Inst. Cambridge UK
  • 1992 - 1997: PhD, C. Nüsslein-Volhard Lab. Max Planck Inst. für Entwicklungsbiologie, Tübingen, Germany
  • 1986 - 1992 MSc. Wageningen Agricultural University, The Netherlands
Research interests

Using the zebrafish as a genetic tool to study development and disease. We are interested in understanding the role of the patched genes in Hedgehog signaling. In addition, we have created a knockout for the von Hippel Lindau disease (VHL) gene and are interested in modeling VHL deficient cancers in zebrafish.

Understanding VHL and hypoxic signalling in Cancer

The zebrafish provides a powerful organism to model human development and disease.  We are exploiting and developing the zebrafish, e.g. by creating such disease models, by using knockout technology like CRISPR, or by looking for chemicals that can modify disease-relevant phenotypes.

One of our current projects, models the human Von Hippel Lindau disease,  caused  by mutation of the VHL gene. VHL is a negative regulator of the Hypoxia Inducible Factor (HIF) signalling pathway, which is vital for development and survival of many tumours. However, this is not the only function of VHL and over the years numerous others have been identified. We found that in zebrafish, the functions of human VHL have been split over two genes, which we named vhl and vhl-like (vll).

Interestingly, we found that the fish vhl gene has an important role in HIF regulation, as mutants we made by reverse genetics show all hallmarks of an inappropriate hypoxic response under normoxic conditions. The role of vll was initially enigmatic, null mutants that we created in this gene were viable and fertile. However, using a unique and novel in vivo reporter for genome stability that we created, we discovered that the vll gene is important for maintaining genome stability, which is a major driver for tumour initiation. This is what we are currently trying to understand better.

Current collaborations: Sherif El-Khamisy (genome stability), Albert Ong (pkd2 model), Jane McKeating (Birmingham), Francesco Argenton (Padua) (both glucocorticoid-HIF interaction).

Publications

Show: Featured publications All publications

Journal articles

  • Baranasic D, Hörtenhuber M, Balwierz PJ, Zehnder T, Mukarram AK, Nepal C, Várnai C, Hadzhiev Y, Jimenez-Gonzalez A, Li N , Wragg J et al (2022) . Nature Genetics, 54(7), 1037-1050.
  • Leventea E, Zhu Z, Fang X, Nikolaeva Y, Markham E, Hirst RA, Van Eeden F & Malicki J (2021) . Proceedings of the National Academy of Sciences, 118(28).
  • Fang X, Peden AA, van Eeden FJM & Malicki JJ (2021) . Journal of Cell Science, 134(6).
  • Zaksauskaite R, Thomas RC, van Eeden F & El-Khamisy SF (2021) . Science Advances, 7(5).
  • Vettori A, Greenald D, Wilson GK, Peron M, Facchinello N, Markham E, Sinnakaruppan M, Matthews LC, McKeating JA, Argenton F & van Eeden FJM (2017) . Proceedings of the National Academy of Sciences, 114(37), 9948-9953.
  • Wilkinson RN, Elworthy S, Ingham PW & van Eeden FJM (2017) . BioTechniques, 62(1), xxiv.
  • Greenald D, Jeyakani J, Pelster B, Sealy I, Mathavan S & van Eeden FJ (2015) . BMC Genomics, 16(1).
  • Wilkinson RN, Elworthy S, Ingham PW & van Eeden FJM (2013) . Biotechniques, 55(6), 314-316.
  • Watson O, Novodvorsky P, Gray C, Rothman AMK, Lawrie A, Crossman DC, Haase A, McMahon K, Gering M, Van Eeden FJM & Chico TJA (2013) . Cardiovasc Res, 100(2), 252-261.
  • Kettleborough RN, Busch-Nentwich EM, Harvey SA, Dooley CM, de Bruijn E, van Eeden F, Sealy I, White RJ, Herd C, Nijman IJ , Fényes F et al (2013) . Nature, 496, 494-497.
  • Santhakumar K, Judson EC, Elks PM, McKee S, Elworthy S, van Rooijen E, Walmsley SS, Renshaw SA, Cross SS & van Eeden FJM (2012) . Cancer Res, 72(16), 4017-4027.
  • Elks PM, van Eeden FJ, Dixon G, Wang X, Reyes-Aldasoro CC, Ingham PW, Whyte MKB, Walmsley SR & Renshaw SA (2011) . Blood, 118(3), 712-722.
  • van Eeden FJ, Granato M, Schach U, Brand M, Furutani-Seiki M, Haffter P, Hammerschmidt M, Heisenberg CP, Jiang YJ, Kane DA , Kelsh RN et al (1996) . Development, 123, 153-164.

All publications

Journal articles

  • Fargher E, Keatinge M, Pearce O, Piepponen P, Panula P, van Eeden FJM, MacDonald RB & Bandmann O (2025) . npj Parkinson's Disease, 11(1).
  • Thomas RC, Zaksauskaite R, Al-Kandari NY, Hyde AC, Abugable AA, El-Khamisy SF & van Eeden FJ (2024) . Nucleic Acids Research, 52(18), 11014-11028.
  • Almansouri T, Waller R, Wharton SB, Heath PR, Matthews FE, Brayne C, van Eeden F & Simpson JE (2024) . International Journal of Molecular Sciences, 25(8).
  • Baranasic D, Hörtenhuber M, Balwierz PJ, Zehnder T, Mukarram AK, Nepal C, Várnai C, Hadzhiev Y, Jimenez-Gonzalez A, Li N , Wragg J et al (2022) . Nature Genetics, 54(7), 1037-1050.
  • Bowley G, Kugler E, Wilkinson R, Lawrie A, Eeden F, Chico TJA, Evans PC, Noël ES & Serbanovic‐Canic J (2022) . British Journal of Pharmacology, 179(5), 900-917.
  • Derrick CJ, Sánchez-Posada J, Hussein F, Tessadori F, Pollitt EJG, Savage AM, Wilkinson RN, Chico TJ, van Eeden FJ, Bakkers J & Noël ES (2022) . Cardiovascular Research, 118(1), 226-240.
  • Marchi D & van Eeden FJM (2021) . Cells, 10(12).
  • Shafique F, Ali S, Almansouri TS, Eeden FV, Shafi N, Khalid M, Khawaja S, Andleeb S & Hassan M (2021) . Brazilian Journal of Biology, 83.
  • Leventea E, Zhu Z, Fang X, Nikolaeva Y, Markham E, Hirst RA, Van Eeden F & Malicki J (2021) . Proceedings of the National Academy of Sciences, 118(28).
  • Łysyganicz PK, Pooranachandran N, Liu X, Adamson KI, Zielonka K, Elworthy S, van Eeden FJ, Grierson AJ & Malicki JJ (2021) . Frontiers in Cell and Developmental Biology, 9.
  • Fang X, Peden AA, van Eeden FJM & Malicki JJ (2021) . Journal of Cell Science, 134(6).
  • Zaksauskaite R, Thomas RC, van Eeden F & El-Khamisy SF (2021) . Science Advances, 7(5).
  • Plant T, Eamsamarng S, Sanchez-Garcia MA, Reyes L, Renshaw SA, Coelho P, Mirchandani AS, Morgan J-M, Ellett FE, Morrison T , Humphries D et al (2020) . Journal of Clinical Investigation, 130(6), 3221-3237.
  • Marchi D, Santhakumar K, Markham E, Li N, Storbeck K-H, Krone N, Cunliffe VT & van Eeden FJM (2020) . PLOS Genetics, 16(5), ---.
  • Kim HR, Santhakumar K, Markham E, Baldera D, Greenald D, Bryant HE, El-Khamisy SF & van Eeden FJ (2020) . Oncotarget, 11(13), 1109-1130.
  • Metzner A, Griffiths JD, Streets AJ, Markham E, Philippou T, Van Eeden FJM & Ong ACM (2020) . Scientific Reports, 10(1).
  • Arhatte M, Gunaratne GS, Boustany CE, Kuo IY, Moro C, Duprat F, Plaisant M, Duval H, Li D, Picard N , Couvreux A et al (2019) . Nature Communications, 10(1).
  • Savage AM, Kurusamy S, Chen Y, Jiang Z, Chhabria K, MacDonald RB, Kim HR, Wilson HL, van Eeden FJM, Armesilla AL , Chico TJA et al (2019) . Nature Communications, 10.
  • Cayuela ML, B.M. Klaes K, Godinho Ferreira M, Henriques CM, Van Eeden F, Varga M, Vierstraete J & Mione MC (2019) . Frontiers in Cell and Developmental Biology, 6.
  • Jiang Z, Evans T, Savage AM, Loose M, Chico TJA, van Eeden FJM & Wilkinson RN (2018) .
  • van Rooijen E, van de Hoek G, Logister I, Ajzenberg H, Knoers NVAM, van Eeden F, Voest EE, Schulte-Merker S & Giles RH (2018) . Nephron, 138(4), 310-323.
  • Pickering J, Cunliffe VT, Van Eeden F & Borycki A-G (2017) . Matrix Biology, 62, 58-74.
  • Carreño Gutiérrez H, O’Leary A, Freudenberg F, Fedele G, Wilkinson R, Markham E, van Eeden F, Reif A & Norton WHJ (2017) . European Neuropsychopharmacology.
  • Vettori A, Greenald D, Wilson GK, Peron M, Facchinello N, Markham E, Sinnakaruppan M, Matthews LC, McKeating JA, Argenton F & van Eeden FJM (2017) . Proceedings of the National Academy of Sciences, 114(37), 9948-9953.
  • Baxendale S, van Eeden F & Wilkinson R (2017) , 179-197.
  • Wilkinson RN, Elworthy S, Ingham PW & van Eeden FJM (2017) . BioTechniques, 62(1), xxiv.
  • Valentim AM, Eeden FJ, Strähle U & Olsson IAS (2016) . EMBO reports, 17(12), 1688-1689.
  • Kim HR, Greenald D, Vettori A, Markham E, Santhakumar K, Argenton F & van Eeden F (2016) . Methods in Cell Biology.
  • Njegic AM, Chico TJA, van Eeden FJ & Watson OJ (2015) . Atherosclerosis, 244, E8-E9.
  • Greenald D, Jeyakani J, Pelster B, Sealy I, Mathavan S & van Eeden FJ (2015) . BMC Genomics, 16(1).
  • Elks PM, Renshaw SA, Meijer AH, Walmsley SR & van Eeden FJ (2015) . Disease Models & Mechanisms, 8(11), 1349-1360.
  • Novodvorsky P, Watson O, Gray C, Wilkinson RN, Reeve S, Smythe C, Beniston R, Plant K, Maguire R, M K Rothman A , Elworthy S et al (2015) . PLoS One, 10(10).
  • Wilkinson RN & van Eeden FJM (2014) . Prog Mol Biol Transl Sci, 124, 93-122.
  • Wilkinson RN, Jopling C & van Eeden FJM (2014) . Prog Mol Biol Transl Sci, 124, 65-91.
  • Elks PM, van der Vaart M, Walmsley SR, van Eeden FJ, Spaink HP, Meijer AH & Renshaw SA (2014) Hypoxic signalling modulates neutrophil nitric oxide in a zebrafish tuberculosis model. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 44, 12-12.
  • Wilkinson RN, Elworthy S, Ingham PW & van Eeden FJM (2013) . Biotechniques, 55(6), 314-316.
  • Elks PM, Brizee S, van der Vaart M, Walmsley SR, van Eeden FJ, Renshaw SA & Meijer AH (2013) . PLoS Pathog, 9(12), e1003789.
  • Maurya AK, Ben J, Zhao Z, Lee RTH, Niah W, Ng ASM, Iyu A, Yu W, Elworthy S, van Eeden FJM & Ingham PW (2013) . PLoS Genet, 9(12), e1003955.
  • Watson O, Novodvorsky P, Gray C, Rothman AMK, Lawrie A, Crossman DC, Haase A, McMahon K, Gering M, Van Eeden FJM & Chico TJA (2013) . Cardiovasc Res, 100(2), 252-261.
  • Chowdhury R, Candela-Lena JI, Chan MC, Greenald DJ, Yeoh KK, Tian Y-M, McDonough MA, Tumber A, Rose NR, Conejo-Garcia A , Demetriades M et al (2013) . ACS Chem Biol, 8(7), 1488-1496.
  • Kettleborough RN, Busch-Nentwich EM, Harvey SA, Dooley CM, de Bruijn E, van Eeden F, Sealy I, White RJ, Herd C, Nijman IJ , Fényes F et al (2013) . Nature, 496, 494-497.
  • Basten SG, Davis EE, Gillis AJM, van Rooijen E, Stoop H, Babala N, Logister I, Heath ZG, Jonges TN, Katsanis N , Voest EE et al (2013) . PLoS Genet, 9(4), e1003384.
  • Thompson AAR, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L, Parmar S, Shaw G, McGrath EE , Formenti F et al (2013) . Blood, 123(3), 366-376.
  • Santhakumar K, Judson EC, Elks PM, McKee S, Elworthy S, van Rooijen E, Walmsley SS, Renshaw SA, Cross SS & van Eeden FJM (2012) . Cancer Res, 72(16), 4017-4027.
  • Wilkinson RN, Koudijs MJ, Patient RK, Ingham PW, Schulte-Merker S & van Eeden FJM (2012) . Blood, 120(2), 477-488.
  • Dooley CM, Kettleborough RN, Busch-Nentwich EM, Harvey SA, de Bruijn E, van Eeden F, Sealy I, White RJ, Scahill C, Herd C , Nijman IJ et al (2012) A systematic genome-wide knockout generation and analysis of zebrafish protein-coding gene function.. MOLECULAR BIOLOGY OF THE CELL, 23.
  • Sapetto-Rebow B, McLoughlin SC, O'Shea LC, O'Leary O, Willer JR, Alvarez Y, Collery R, O'Sullivan J, Van Eeden F, Hensey C & Kennedy BN (2011) . BMC Dev Biol, 11, 71.
  • Ben J, Elworthy S, Ng ASM, van Eeden F & Ingham PW (2011) . Development, 138(22), 4969-4978.
  • Elks PM, van Eeden FJ, Dixon G, Wang X, Reyes-Aldasoro CC, Ingham PW, Whyte MKB, Walmsley SR & Renshaw SA (2011) . Blood, 118(3), 712-722.
  • Renshaw SA, Elks P, Dixon G, Wang X, Ingham PW, van Eeden FJ, Whyte M & Walmsley SR (2011) . B36. AIRWAY IMMUNE MECHANISMS AND INFLAMMATION: ANIMAL MODELS, A2858-A2858.
  • Kettleborough RNW, de Bruijn E, van Eeden F, Cuppen E & Stemple DL (2011) . ZEBRAFISH: GENETICS, GENOMICS AND INFORMATICS, 3RD EDITION, 104, 121-127.
  • van Rooijen E, Santhakumar K, Logister I, Voest E, Schulte-Merker S, Giles R & van Eeden F (2011) , 105, 163-190.
  • van Rooijen E, Voest EE, Logister I, Bussmann J, Korving J, van Eeden FJ, Giles RH & Schulte-Merker S (2010) . Development, 137(11), e1106-e1106.
  • Kim HR, Richardson J, van Eeden F & Ingham PW (2010) . BMC Biol, 8, 65.
  • van Rooijen E, Voest EE, Logister I, Bussmann J, Korving J, van Eeden FJ, Giles RH & Schulte-Merker S (2010) . Dis Model Mech, 3(5-6), 343-353.
  • Hammond KL, van Eeden FJM & Whitfield TT (2010) . Development, 137(8), 1361-1371.
  • van Rooijen E, Voest EE, Logister I, Korving J, Schwerte T, Schulte-Merker S, Giles RH & van Eeden FJ (2009) . Blood, 113(25), 6449-6460.
  • Thomas NA, Koudijs M, van Eeden FJM, Joyner AL & Yelon D (2008) . Development, 135(22), 3789-3799.
  • van Rooijen E, Giles RH, Voest EE, van Rooijen C, Schulte-Merker S & van Eeden FJ (2008) . J Am Soc Nephrol, 19(6), 1128-1138.
  • Koudijs MJ, den Broeder MJ, Groot E & van Eeden FJ (2008) . BMC Dev Biol, 8, 15.
  • Knöll R, Postel R, Krätzner R, Hennecke G, Vacaru AM, Vakeel P, Knöll G, Schäfer K, Bos E, Hertog JD , Peters PJ et al (2007) . Circulation, 116(suppl_16).
  • Knöll R, Postel R, Wang J, Krätzner R, Hennecke G, Vacaru AM, Vakeel P, Schubert C, Murthy K, Rana BK , Kube D et al (2007) . Circulation, 116(5), 515-525.
  • Guryev V, Koudijs MJ, Berezikov E, Johnson SL, Plasterk RHA, van Eeden FJM & Cuppen E (2006) . Genome Res, 16(4), 491-497.
  • Koudijs MJ, den Broeder MJ, Keijser A, Wienholds E, Houwing S, van Rooijen EMHC, Geisler R & van Eeden FJM (2005) . PLoS Genet, 1(2), e19.
  • Kennedy BN, Stearns GW, Smyth VA, Ramamurthy V, van Eeden F, Ankoudinova I, Raible D, Hurley JB & Brockerhoff SE (2004) . Dev Biol, 270(2), 336-349.
  • Wienholds E, van Eeden F, Kosters M, Mudde J, Plasterk RHA & Cuppen E (2003) . Genome Res, 13(12), 2700-2707.
  • Hurlstone AFL, Haramis A-PG, Wienholds E, Begthel H, Korving J, Van Eeden F, Cuppen E, Zivkovic D, Plasterk RHA & Clevers H (2003) . Nature, 425(6958), 633-637.
  • Wienholds E, Koudijs MJ, van Eeden FJM, Cuppen E & Plasterk RHA (2003) . Nat Genet, 35(3), 217-218.
  • van der Sar AM, Musters RJP, van Eeden FJM, Appelmelk BJ, Vandenbroucke-Grauls CMJE & Bitter W (2003) . Cell Microbiol, 5(9), 601-611.
  • van Eeden FJ, Palacios IM, Petronczki M, Weston MJ & St Johnston D (2001) . J Cell Biol, 154(3), 511-523.
  • Odenthal J, van Eeden FJ, Haffter P, Ingham PW & Nüsslein-Volhard C (2000) . Dev Biol, 219(2), 350-363.
  • van Eeden FJ, Granato M, Odenthal J & Haffter P (1999) . Methods Cell Biol, 60, 21-41.
  • van Eeden F & St Johnston D (1999) . Curr Opin Genet Dev, 9(4), 396-404.
  • van Eeden FJ, Holley SA, Haffter P & Nüsslein-Volhard C (1998) Zebrafish segmentation and pair-rule patterning.. Dev Genet, 23(1), 65-76.
  • Chandrasekhar A, Warren JT, Takahashi K, Schauerte HE, van Eeden FJ, Haffter P & Kuwada JY (1998) . Mech Dev, 76(1-2), 101-115.
  • Schauerte HE, van Eeden FJ, Fricke C, Odenthal J, Strähle U & Haffter P (1998) . Development, 125(15), 2983-2993.
  • (1998) , 21-41.
  • Lauderdale JD, Pasquali SK, Fazel R, van Eeden FJ, Schauerte HE, Haffter P & Kuwada JY (1998) . Mol Cell Neurosci, 11(4), 194-205.
  • Chen JN, van Eeden FJ, Warren KS, Chin A, Nüsslein-Volhard C, Haffter P & Fishman MC (1997) . Development, 124(21), 4373-4382.
  • Furutani‐Seiki M, Jiang Y, Brand M, Heisenberg C, Houart C, Beuchle D, van Eeden FJM, Granato M, Haffter P, Hammerschmidt M , Kane DA et al (1996) . International Journal of Developmental Neuroscience, 14(S1), 80-80.
  • Granato M, van Eeden FJ, Schach U, Trowe T, Brand M, Furutani-Seiki M, Haffter P, Hammerschmidt M, Heisenberg CP, Jiang YJ , Kane DA et al (1996) . Development, 123, 399-413.
  • Karlstrom RO, Trowe T, Klostermann S, Baier H, Brand M, Crawford AD, Grunewald B, Haffter P, Hoffmann H, Meyer SU , Müller BK et al (1996) . Development, 123, 427-438.
  • Schilling TF, Piotrowski T, Grandel H, Brand M, Heisenberg CP, Jiang YJ, Beuchle D, Hammerschmidt M, Kane DA, Mullins MC , van Eeden FJ et al (1996) . Development, 123, 329-344.
  • Piotrowski T, Schilling TF, Brand M, Jiang YJ, Heisenberg CP, Beuchle D, Grandel H, van Eeden FJ, Furutani-Seiki M, Granato M , Haffter P et al (1996) . Development, 123, 345-356.
  • Kelsh RN, Brand M, Jiang YJ, Heisenberg CP, Lin S, Haffter P, Odenthal J, Mullins MC, van Eeden FJ, Furutani-Seiki M , Granato M et al (1996) . Development, 123, 369-389.
  • Odenthal J, Rossnagel K, Haffter P, Kelsh RN, Vogelsang E, Brand M, van Eeden FJ, Furutani-Seiki M, Granato M, Hammerschmidt M , Heisenberg CP et al (1996) . Development, 123, 391-398.
  • van Eeden FJ, Granato M, Schach U, Brand M, Furutani-Seiki M, Haffter P, Hammerschmidt M, Heisenberg CP, Jiang YJ, Kane DA , Kelsh RN et al (1996) . Development, 123, 255-262.
  • Chen JN, Haffter P, Odenthal J, Vogelsang E, Brand M, van Eeden FJ, Furutani-Seiki M, Granato M, Hammerschmidt M, Heisenberg CP , Jiang YJ et al (1996) . Development, 123, 293-302.
  • Ransom DG, Haffter P, Odenthal J, Brownlie A, Vogelsang E, Kelsh RN, Brand M, van Eeden FJ, Furutani-Seiki M, Granato M , Hammerschmidt M et al (1996) . Development, 123, 311-319.
  • Jiang YJ, Brand M, Heisenberg CP, Beuchle D, Furutani-Seiki M, Kelsh RN, Warga RM, Granato M, Haffter P, Hammerschmidt M , Kane DA et al (1996) . Development, 123, 205-216.
  • Furutani-Seiki M, Jiang YJ, Brand M, Heisenberg CP, Houart C, Beuchle D, van Eeden FJ, Granato M, Haffter P, Hammerschmidt M , Kane DA et al (1996) . Development, 123, 229-239.
  • Whitfield TT, Granato M, van Eeden FJ, Schach U, Brand M, Furutani-Seiki M, Haffter P, Hammerschmidt M, Heisenberg CP, Jiang YJ , Kane DA et al (1996) . Development, 123, 241-254.
  • van Eeden FJ, Granato M, Schach U, Brand M, Furutani-Seiki M, Haffter P, Hammerschmidt M, Heisenberg CP, Jiang YJ, Kane DA , Kelsh RN et al (1996) . Development, 123, 153-164.
  • Brand M, Heisenberg CP, Jiang YJ, Beuchle D, Lun K, Furutani-Seiki M, Granato M, Haffter P, Hammerschmidt M, Kane DA , Kelsh RN et al (1996) . Development, 123, 179-190.
  • Heisenberg CP, Brand M, Jiang YJ, Warga RM, Beuchle D, van Eeden FJ, Furutani-Seiki M, Granato M, Haffter P, Hammerschmidt M , Kane DA et al (1996) . Development, 123, 191-203.
  • Odenthal J, Haffter P, Vogelsang E, Brand M, van Eeden FJ, Furutani-Seiki M, Granato M, Hammerschmidt M, Heisenberg CP, Jiang YJ , Kane DA et al (1996) . Development, 123, 103-115.
  • Brand M, Heisenberg CP, Warga RM, Pelegri F, Karlstrom RO, Beuchle D, Picker A, Jiang YJ, Furutani-Seiki M, van Eeden FJ , Granato M et al (1996) . Development, 123, 129-142.
  • Hammerschmidt M, Pelegri F, Mullins MC, Kane DA, Brand M, van Eeden FJ, Furutani-Seiki M, Granato M, Haffter P, Heisenberg CP , Jiang YJ et al (1996) . Development, 123, 143-151.
  • Kane DA, Maischein HM, Brand M, van Eeden FJ, Furutani-Seiki M, Granato M, Haffter P, Hammerschmidt M, Heisenberg CP, Jiang YJ , Kelsh RN et al (1996) . Development, 123, 57-66.
  • Mullins MC, Hammerschmidt M, Kane DA, Odenthal J, Brand M, van Eeden FJ, Furutani-Seiki M, Granato M, Haffter P, Heisenberg CP , Jiang YJ et al (1996) . Development, 123, 81-93.
  • Hammerschmidt M, Pelegri F, Mullins MC, Kane DA, van Eeden FJ, Granato M, Brand M, Furutani-Seiki M, Haffter P, Heisenberg CP , Jiang YJ et al (1996) . Development, 123, 95-102.
  • Haffter P, Granato M, Brand M, Mullins MC, Hammerschmidt M, Kane DA, Odenthal J, van Eeden FJ, Jiang YJ, Heisenberg CP , Kelsh RN et al (1996) . Development, 123, 1-36.
  • Kane DA, Hammerschmidt M, Mullins MC, Maischein HM, Brand M, van Eeden FJ, Furutani-Seiki M, Granato M, Haffter P, Heisenberg CP , Jiang YJ et al (1996) . Development, 123, 47-55.
  • Haffter P, Odenthal J, Mullins MC, Lin S, Farrell MJ, Vogelsang E, Haas F, Brand M, Van Eeden FJM, Furutani-Seiki M , Granato M et al (1996) Mutations affecting pigmentation and shape of the adult zebrafish. Roux S Archives of Developmental Biology, 206(4), 260-276.
  • Schulte-Merker S, van Eeden FJ, Halpern ME, Kimmel CB & Nüsslein-Volhard C (1994) . Development, 120(4), 1009-1015.
  • Nölling J, van Eeden FJ & de Vos WM (1993) . Mol Gen Genet, 240(1), 81-91.
  • Nölling J, van Eeden FJ, Eggen RI & de Vos WM (1992) . Nucleic Acids Res, 20(24), 6501-6507.

Book chapters

  • Allen C, Argenton F, Van Eeden FJ & Tiso N (2022) , Laboratory Fish in Biomedical Research (pp. 139-155). Elsevier

Conference proceedings

  • Almansouri T, Heath P, Wharton S, Van Eeden F & Simpson J (2022) Microarray approach to identifying the role of microglia in the pathogenesis of age-associated deep-subcortical white matter lesions. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
  • Elks P, van der Vaart M, van Eeden F, Spaink H, Walmsley S, Meijer A & Renshaw S (2014) Hypoxia signaling modulates neutrophil nitric oxide in a zebrafish tuberculosis model. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
  • Chico T, Watson O & van Eeden F (2013) . HEART, Vol. 99
  • Thompson AAR, Elks PM, Marriott HM, Higgins KR, Parmar S, Shaw G, Eamsamarng S, McGrath EE, Formenti F, Van Eeden FJ , Kinnula VL et al (2012) . THORAX, Vol. 67 (pp A1-A1)
  • Judson E, Santhakumar K & van Eeden F (2012) . VASCULAR PHARMACOLOGY, Vol. 56(5-6) (pp 355-356)
  • Holden BJ, van Eeden FJ, Ong ACM & Chico TJ (2011) . HEART, Vol. 97(20) (pp 12-12)
  • Watson OJ, van Eeden FJ, Gray C & Chico TJA (2011) . HEART, Vol. 97 (pp A43-A43)
  • Hammond K, van Eeden F & Whitfield T (2009) . MECHANISMS OF DEVELOPMENT, Vol. 126 (pp S155-S155)
  • Santhakumar K, van Rooijen E, McKee S, Voest E, Giles R & van Eeden F (2009) . MECHANISMS OF DEVELOPMENT, Vol. 126 (pp S60-S61)
  • Yelon D, Thomas NA, Koudijs M, Van Eeden F & Joyner AL (2008) . DEVELOPMENTAL BIOLOGY, Vol. 319(2) (pp 603-604)
  • Knoll R, Postel R, Kratzner R, Hennecke G, Vacaru AM, Vakeel P, Knoll G, Schafer K, Bos E, Den Hertog J , Peters PJ et al (2007) Integrin-linked kinase and laminin alpha 4 mutations cause human cardiomyopathy. CIRCULATION, Vol. 116(16) (pp 221-221)
  • Van Rooijen E, Van Rooijen C, Voest EE, Giles RH & Van Eeden F (2006) Proper vascular development and heart morphogenesis require tumor suppressor VHL in zebrafish development.. CANCER RESEARCH, Vol. 66(8)

Preprints

  • Baranasic D, Hörtenhuber M, Balwierz P, Zehnder T, Mukarram AK, Nepal C, Varnai C, Hadzhiev Y, Jimenez-Gonzalez A, Li N , Wragg J et al (2021) , Cold Spring Harbor Laboratory.
  • Derrick CJ, Sánchez-Posada J, Hussein F, Tessadori F, Pollitt EJG, Savage AM, Wilkinson RN, Chico TJ, van Eeden FJ, Bakkers J & Noël ES (2019) , Cold Spring Harbor Laboratory.
  • Kim HR, Santhakumar K, Markham E, Baldera D, Bryant HE, El-Khamisy SF & van Eeden FJ (2019) , Cold Spring Harbor Laboratory.
  • Marchi D, Santhakumar K, Markham E, Li N, Storbeck K-H, Krone N, Cunliffe VT & van Eeden FJM (2019) , Cold Spring Harbor Laboratory.
Grants
  • EU FP7
  • EU Trancyst
  • HEFCE
Teaching activities

Undergraduate:

  • BMS109 Lab Skills & Skills Sessions
  • BMS110 Research Topics in Biomedicine
  • BMS242/243 Principles of Developmental Biology
  • BMS243/247 Stem Cells
  • BMS336 Modelling Human Disease and Dysfunction
  • Level 3 Practical and Dissertation Modules

Masters (MSc):

  • BMS6083 Practical Developmental Genetics (Co-ordinator)
Professional activities and memberships
  • Invited teacher at regular EMBO courses at the MPI in Tübingen (recently also Sheffield)
  • Presenter at open science days and public lectures in Utrecht/Wageningen
  • International collaboration on TILLING with Hubrecht Laboratory Utrecht/Sanger Inst. Cambridge
  • Invited speaker at: ZDM8, Boston,  Aug 2015; Zebrafish PI Meeting Ein gedi 2014; BSDB meeting 2013; European zebrafish meeting Barcelona 2013
  • Reviewer for: BBSRC, Development, FNRS, Swiss research council, Singapore, Hong-Kong and many others

Links