Dr Emily Noël

School of Biosciences

Senior Lecturer

British Heart Foundation Intermediate Basic Science Research Fellow, Emily Noël
Profile picture of British Heart Foundation Intermediate Basic Science Research Fellow, Emily Noël
e.s.noel@sheffield.ac.uk
C21, Firth Court

Full contact details

Dr Emily Noël
School of Biosciences
C21
Firth Court
Western Bank
Sheffield
S10 2TN
Profile

Brief career history

  • 2017-Present: British Heart Foundation Intermediate Basic Science Research Fellow, University of Sheffield, UK
  • 2015-2017: Independent Research Fellow, University of Sheffield, UK
  • 2009-2015: Postdoctoral Research Scientist, Bakkers Lab, Hubrecht Institute, Utrecht, NL
  • 2005-2009: PhD Student, Ober Lab, National Institute for Medical Research, London, UK
  • 2001-2004: BSc Biochemistry, University of Warwick
Research interests

The heart is a highly complex organ that forms very early during embryonic development from a simple linear tube. Problems with heart development often result in babies being born with congenital heart defects, a spectrum of structural heart malformations which affect around 1% of live births. Studying how hearts form when an organism is developing helps us better understand why this process sometimes goes wrong.

Our lab uses zebrafish to understand how the developing heart undergoes complex morphological rearrangements. We are particularly interested in how cells interact with their cellular neighbours or the extracellular matrix in different regions of the heart, and how these regionalised interactions support heart form and function as the embryo develops.

We use a variety of genetic and imaging techniques in zebrafish to link cellular processes/signalling, extracellular matrix composition, and heart morphology and function. These include establishing genetic models through targeted gene editing using CRISPR-Cas9, live light-sheet imaging of transgenic lines with fluorescent tissues or reporters, and quantitative image analyses.

Publications

Show: Featured publications All publications

Journal articles

  • Bowley G, Kugler E, Wilkinson R, Lawrie A, Eeden F, Chico TJA, Evans PC, Noël ES & Serbanovic‐Canic J (2022) . British Journal of Pharmacology, 179(5), 900-917.
  • Derrick CJ, Sánchez-Posada J, Hussein F, Tessadori F, Pollitt EJG, Savage AM, Wilkinson RN, Chico TJ, van Eeden FJ, Bakkers J & Noël ES (2022) . Cardiovascular Research, 118(1), 226-240.
  • Derrick CJ, Pollitt EJG, Sevilla Uruchurtu AS, Hussein F, Grierson AJ & Noël ES (2021) . Development, 148(20).
  • Derrick CJ & Noël ES (2021) . Development, 148(5).
  • Noël ES, Momenah TS, Al-Dagriri K, Al-Suwaid A, Al-Shahrani S, Jiang H, Willekers S, Oostveen YY, Chocron S, Postma AV , Bhuiyan ZA et al (2016) . Human Mutation, 37(2), 194-200.
  • Junker JP, Noël ES, Guryev V, Peterson KA, Shah G, Huisken J, McMahon AP, Berezikov E, Bakkers J & van Oudenaarden A (2014) . Cell, 159(3), 662-675.
  • Smith KA, Noel E, Thurlings I, Rehmann H, Chocron S & Bakkers J (2011) . PLoS Genetics, 7(9).
  • Noël ES & Bakkers J () . eLife, 6.
  • Noël ES, Verhoeven M, Lagendijk AK, Tessadori F, Smith K, Choorapoikayil S, den Hertog J & Bakkers J () . Nature Communications, 4(1).

All publications

Journal articles

  • Sánchez-Posada J, Derrick CJ & Noël ES (2025) . PLOS Biology, 23(1).
  • Bowley G, Irving S, Hoefer I, Wilkinson R, Pasterkamp G, Darwish HMS, White S, Francis SE, Chico T, Noel E , Serbanovic-Canic J et al (2024) . Scientific Reports, 14(1).
  • Pollitt EJG, Sánchez-Posada J, Snashall CM, Derrick CJ & Noël ES (2024) . Development, 151(13).
  • Bowley G, Kugler E, Wilkinson R, Lawrie A, Eeden F, Chico TJA, Evans PC, Noël ES & Serbanovic‐Canic J (2022) . British Journal of Pharmacology, 179(5), 900-917.
  • Derrick CJ, Sánchez-Posada J, Hussein F, Tessadori F, Pollitt EJG, Savage AM, Wilkinson RN, Chico TJ, van Eeden FJ, Bakkers J & Noël ES (2022) . Cardiovascular Research, 118(1), 226-240.
  • Derrick CJ, Pollitt EJG, Sevilla Uruchurtu AS, Hussein F, Grierson AJ & Noël ES (2021) . Development, 148(20).
  • Derrick CJ & Noël ES (2021) . Development, 148(5).
  • Campbell K, Noël ES, Fletcher AG & Bulgakova NA (2020) . Philosophical Transactions of the Royal Society B: Biological Sciences, 375(1809).
  • Han MK, Hoijman E, Nöel E, Garric L, Bakkers J & de Rooij J (2016) . Biology Open, 2016(5), 1461-1472.
  • Noël ES, Momenah TS, Al-Dagriri K, Al-Suwaid A, Al-Shahrani S, Jiang H, Willekers S, Oostveen YY, Chocron S, Postma AV , Bhuiyan ZA et al (2016) . Human Mutation, 37(2), 194-200.
  • Wu C-C, Kruse F, Vasudevarao MD, Junker JP, Zebrowski DC, Fischer K, Noël ES, Grün D, Berezikov E, Engel FB , van Oudenaarden A et al (2016) . Developmental Cell, 36(1), 36-49.
  • Tessadori F, Noël ES, Rens EG, Magliozzi R, Evers-van Gogh IJA, Guardavaccaro D, Merks RMH & Bakkers J (2015) . Developmental Cell, 32(5), 631-639.
  • Junker JP, Noël ES, Guryev V, Peterson KA, Shah G, Huisken J, McMahon AP, Berezikov E, Bakkers J & van Oudenaarden A (2014) . Cell, 159(3), 662-675.
  • Bonetti M, Paardekooper Overman J, Tessadori F, Noël E, Bakkers J & den Hertog J (2014) . Development, 141(9), 1961-1970.
  • Smith KA, Noel E, Thurlings I, Rehmann H, Chocron S & Bakkers J (2011) . PLoS Genetics, 7(9).
  • Mas JC, Noël ES & Ober EA (2011) , 401-428.
  • Noël ES, Reis MD, Arain Z & Ober EA (2010) . Gene Expression Patterns, 10(6), 237-243.
  • Noël ES, Casal-Sueiro A, Busch-Nentwich E, Verkade H, Dong PDS, Stemple DL & Ober EA (2008) . Developmental Biology, 322(2), 237-250.
  • Noël ES & Bakkers J () . eLife, 6.
  • Noël ES, Verhoeven M, Lagendijk AK, Tessadori F, Smith K, Choorapoikayil S, den Hertog J & Bakkers J () . Nature Communications, 4(1).

Book chapters

  • Noël ES (2024) , Current Topics in Developmental Biology (pp. 121-156). Elsevier

Conference proceedings

  • Sanchez-Posada J & Noel ES (2022) morphoHeart: A novel tool to capture, quantify and link 3D asymmetric heart morphogenesis with spatiotemporal extracellular matrix dynamics in zebrafish cardiac development. JOURNAL OF ANATOMY, Vol. 240(4) (pp 785-786)
  • Derrick CJ, Hussein F, Pollitt EJG & Noel ES (2021) Laminins regulate cardiac growth through restricting second heart field addition. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 102(2) (pp 126-126)
  • Carr PL, Jiang Z, Savage AM, Noël ES, Wilkinson RN & Lawrie A (2019) . C49. TICKET TO RIDE: EXPERIMENTAL MODELS OF PAH (pp A5038-A5038)

Preprints

  • Jin Jie CC, Santos-Oliván D, Ramel M-C, Sánchez-Posada J, Andrews TGR, Paizakis P, Noël ES, Torres-Sánchez A & Priya R (2025) , Cold Spring Harbor Laboratory.
  • Pollitt EJG, Derrick CJ, Sánchez-Posada J & Noël ES (2023) , Cold Spring Harbor Laboratory.
  • Derrick CJ, Pollitt EJG, Uruchurtu ASS, Hussein F & Noёl ES (2021) , Cold Spring Harbor Laboratory.
  • Derrick CJ, Sánchez-Posada J, Hussein F, Tessadori F, Pollitt EJG, Savage AM, Wilkinson RN, Chico TJ, van Eeden FJ, Bakkers J & Noël ES (2019) , Cold Spring Harbor Laboratory.
Research group
Grants
  • British Heart Foundation
  • Academy of Medical Sciences/Wellcome Trust
  • Rosetrees Trust
Teaching activities
  • BMS110 Research Topics in Biomedicine
  • BMS242/3 Advanced Concepts in Developmental Biology
  • BMS356 Biomedical Technology & Drug Discovery
  • BMS336 Modelling Human Disease
  • BMS397 Laboratory Research Project
  • L4/MSc Dissertation and Laboratory Research Supervision

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