Dr Dan Bose

School of Biosciences

Sir Henry Dale Fellow

Daniel Bose
Profile picture of Daniel Bose
d.bose@sheffield.ac.uk
+44 114 222 2838
Firth Court

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Dr Dan Bose
School of Biosciences
Firth Court
Western Bank
Sheffield
S10 2TN
Profile

Career history

  • 2019 - present: Sir Henry Dale Research Fellow, University of Sheffield, Sheffield, UK
  • 2017 - 2019: Research Fellow, University of Sheffield, Sheffield, UK
  • 2011 - 2016: Postdoctoral Research Associate, University of Pennsylvania, Philadelphia, USA
  • 2009 - 2011: Postdoctoral Research Associate, Imperial College London, London, UK
  • 2004 - 2008: PhD, Imperial College London, London, UK
Research interests

Only a small amount of the genome contains genes that code for proteins. In fact, much of the genome is transcribed into RNA, but the importance of these non-coding RNAs is only just becoming clear. Our research focuses on the mechanism of enhancer RNAs (eRNAs), non-protein coding RNAs transcribed from enhancers. Enhancers are non-coding genetic regulatory elements that regulate cell-type specific gene expression in metazoans; in humans, enhancers are hotspots for mutations in a number of diseases. 

We look at how the unique sequence and structure of eRNAs allows them to control gene expression in enhancer-specific ways and what happens when this process goes wrong, for example in diseases such as ALS where enhancers are hotspots for mutations. We integrate multidisciplinary techniques such as cryo-EM with molecular biology and functional genomics approaches to build a picture of diverse features of eRNA function and how they interact with the epigenetic-machines that control gene expression  across a variety of scales. 

Publications

Show: Featured publications All publications

Journal articles

  • Catizone AN, Uzunbas GK, Celadova P, Kuang S, Bose D & Sammons MA (2020) . Nucleic Acids Research, 48(8), 4195-4213.
  • Bose DA, Donahue G, Reinberg D, Shiekhattar R, Bonasio R & Berger SL (2017) . Cell, 168(1-2), 135-149.e22.
  • Saravanan M, Wuerges J, Bose D, McCormack EA, Cook NJ, Zhang X & Wigley DB (2012) . Proceedings of the National Academy of Sciences, 109(51), 20883-20888.
  • Klein BJ, Bose D, Baker KJ, Yusoff ZM, Zhang X & Murakami KS (2011) . Proceedings of the National Academy of Sciences, 108(2), 546-550.
  • Bose D, Pape T, Burrows PC, Rappas M, Wigneshweraraj SR, Buck M & Zhang X (2008) . Molecular Cell, 32(3), 337-346.

All publications

Journal articles

  • Cooper F, Souilhol C, Haston S, Gray S, Boswell K, Gogolou A, Frith TJR, Stavish D, James BM, Bose D , Dale JK et al (2024) . Development, 151(3).
  • Seehra RS, Warrington SJ, Allouis BHK, Sheard TMD, Spencer ME, Shakespeare T, Cadby A, Bose D, Strutt D & Jayasinghe I (2023) . Cell Reports Physical Science, 4(12).
  • Gelder K & Bose D (2023) . BioEssays, 45(10).
  • Harrison LJ & Bose D (2022) . Development, 149(16).
  • Cooper-Knock J, Zhang S, Kenna KP, Moll T, Franklin JP, Allen S, Nezhad HG, Iacoangeli A, Yacovzada NY, Eitan C , Hornstein E et al (2021) . Cell Rep, 34(5), 108730.
  • Cooper-Knock J, Zhang S, Kenna KP, Moll T, Franklin JP, Allen S, Nezhad HG, Iacoangeli A, Yacovzada NY, Eitan C , Hornstein E et al (2020) . Cell Reports, 33(9).
  • Catizone AN, Uzunbas GK, Celadova P, Kuang S, Bose D & Sammons MA (2020) . Nucleic Acids Research, 48(8), 4195-4213.
  • Bose DA & Berger SL (2017) . RNA Biology, 14(12), 1655-1659.
  • Bose DA, Donahue G, Reinberg D, Shiekhattar R, Bonasio R & Berger SL (2017) . Cell, 168(1-2), 135-149.e22.
  • Sawicka M, Wanrooij PH, Darbari VC, Tannous E, Hailemariam S, Bose D, Makarova AV, Burgers PM & Zhang X (2016) . Journal of Biological Chemistry, 291, 13436-13447.
  • Saravanan M, Wuerges J, Bose D, McCormack EA, Cook NJ, Zhang X & Wigley DB (2012) . Proceedings of the National Academy of Sciences, 109(51), 20883-20888.
  • Jovanovic M, Burrows PC, Bose D, Cámara B, Wiesler S, Zhang X, Wigneshweraraj S, Weinzierl ROJ & Buck M (2011) . Journal of Biological Chemistry, 286(16), 14469-14479.
  • Klein BJ, Bose D, Baker KJ, Yusoff ZM, Zhang X & Murakami KS (2011) . Proceedings of the National Academy of Sciences, 108(2), 546-550.
  • Melero R, Rajagopalan S, Lázaro M, Joerger AC, Brandt T, Veprintsev DB, Lasso G, Gil D, Scheres SHW, Carazo JM , Fersht AR et al (2011) . Proceedings of the National Academy of Sciences, 108(2), 557-562.
  • Ghosh T, Bose D & Zhang X (2010) . FEMS Microbiology Reviews, 34(5), 611-627.
  • Sweeney TR, Cisnetto V, Bose D, Bailey M, Wilson JR, Zhang X, Belsham GJ & Curry S (2010) . Journal of Biological Chemistry, 285(32), 24347-24359.
  • Bose D, Pape T, Burrows PC, Rappas M, Wigneshweraraj SR, Buck M & Zhang X (2008) . Molecular Cell, 32(3), 337-346.
  • Burrows PC, Wigneshweraraj S, Bose D, Joly N, Schumacher J, Rappas M, Pape T, Stockley PG, Zhang X & Buck M (2008) . Biochemical Society Transactions, 36(4), 776-779.
  • Wigneshweraraj S, Bose D, Burrows PC, Joly N, Schumacher J, Rappas M, Pape T, Zhang X, Stockley P, Severinov K & Buck M (2008) . Molecular Microbiology, 68(3), 538-546.
  • Bose D, Joly N, Pape T, Rappas M, Schumacher J, Buck M & Zhang X (2008) . Biochemical Society Transactions, 36(1), 83-88.
  • Rappas M, Bose D & Zhang X (2007) . Current Opinion in Structural Biology, 17(1), 110-116.
  • Buck M, Bose D, Burrows P, Cannon W, Joly N, Pape T, Rappas M, Schumacher J, Wigneshweraraj S & Zhang X (2006) . Biochemical Society Transactions, 34(6), 1067-1071.

Conference proceedings

  • Wigneshweraraj S, Burrows P, Bose D, Cannon W, Joly N, Rappas M, Schumacher J, Zhang X & Buck M (2008) THE MECHANISTIC BASIS OF nif GENE ACTIVATION. BIOLOGICAL NITROGEN FIXATION: TOWARDS POVERTY ALLEVIATION THROUGH SUSTAINABLE AGRICULTURE, Vol. 42 (pp 339-+)

Preprints

  • Shakespeare T, Seehra RS, Rodriguez NF, Atuanya N, Sheard TMD, Köhler R, Bose D, Woodman P, Ciani B & Jayasinghe I (2025) , Cold Spring Harbor Laboratory.
  • Gelder KL, Carruthers NA, Gilbert G, Harrison L, Evans T, Ball SS, Dunning M, Craggs TD, Twelvetrees AE & Bose DA (2024) , Cold Spring Harbor Laboratory.
  • Cooper F, Souilhol C, Haston S, Gray S, Boswell K, Gogolou A, Frith T, Stavish D, James BM, Bose D , Dale JK et al (2023) , Cold Spring Harbor Laboratory.
  • Catizone AN, Uzunbas GK, Celadova P, Kuang S, Bose D & Sammons MA (2019) , Cold Spring Harbor Laboratory.
  • Cooper-Knock J, Zhang S, Kenna KP, Moll T, Franklin J, Allen S, Nezhad HG, Yacovzada NS, Eitan C, Hornstein E , Ehilak E et al () .
Research group

PhD studentships

We always want to hear from students interested in our research. Funded PhD studentships will be advertised here as they become available. Well qualified and motivated graduates should contact me directly to discuss potential projects and options for funding.

Sources of PhD support:

  • BBSRC White Rose Doctoral Training Program
  • MRC DiMeN Doctoral Training Partnership
  • Joint China Scholarship Council Postdoctoral fellowships

We welcome applications from talented scientists with diverse research backgrounds. Our multidisciplinary research means we can provide training for researchers with a strong track record who are motivated to gain experience and develop skills in different areas and techniques.

Project students and internships

Students wishing to apply for summer internships are welcome and should send a CV describing their motivations and interests.

Teaching activities

Level 1 Modules

  • MBB162: Genetics

Level 2 Modules

  • MBB265: Practical molecular bioscience

Level 3 Modules

  • MBB346: Genetic pathways from zygote to organism
  • MBB325: The world of RNA

Links