Dr Anne-Gaelle Borycki

School of Biosciences

Senior Lecturer

a.g.borycki@sheffield.ac.uk
D19, Firth Court

Full contact details

Dr Anne-Gaelle Borycki
School of Biosciences
D19
Firth Court
Western Bank
Sheffield
S10 2TN
Profile
  • 2011-present: Senior Lecturer, School of Biosciences
  • 2000-2010: Lecturer, Department of Biomedical Science
  • 1994-2000: Post-doctoral Fellow at the University of Pennsylvania Medical School in Philadelphia - USA (Advisor: Prof: Charles P. Emerson, Jr)
  • 1992-1994: Post-doctoral Fellow at Gustave Roussy Institute for Cancer Research in Villejuif - France (Advisor: Dr. Serge A. Leibovitch)
  • 1992: Ph.D in Molecular Biology from University of Science, Paris - France (Supervisor: Dr. Serge A. Leibovitch)
  • 1987: M.Sc in Biochemistry from University of Science, Paris - France
  • 1986: B.Sc. in Biochemistry from University of Science, Paris - France
Research interests

The Borycki lab uses primarily mouse genetics to study how the extra-cellular matrix, Sonic hedgehog signaling and cellular structures such as the primary cilum contribute to the regulation of satellite cell activity and to skeletal muscle regeneration.

Satellite cell biology and skeletal muscle regeneration

Satellite cells are skeletal muscle-specific stem cells that reside in a sub-laminal position at the periphery of myofibres. Satellite cells are normally quiescent, but become activated and expand rapidly to produce new muscle progenitor cells that differentiate and fuse to damaged fibres to repair diseased or injured muscles. Therefore, satellite cells hold the promise to be harnessed for the treatment of muscular dystrophies or age-related sarcopenia. However, the use of satellite cells for therapeutic purpose requires prior knowledge of their biology.

Research in our lab focuses on several aspects of satellite cell biology: 

  • The satellite cell niche, and in particular the role played by the extra-cellular matrix and its receptors in the control of adult myogenesis. We have recently demonstrated a remodelling of the extra-cellular matrix at the satellite cell niche during muscle regeneration. Current research aims at translating these findings to develop better in vitro conditions for the expansion of satellite cells.
  • The signalling events that regulate satellite cell behaviour; We have uncovered a role for Sonic hedgehog signalling in the control of satellite cell progression through the cell cycle during muscle regeneration. Future work will focus on the implications of these findings in muscle tumours.
  • The requirement for primary cilia for cell signalling and for mechanotransduction in injured muscles.

To investigate these issues, we use a combination of ex-vivo and in-vivo approaches in the mouse, as well as mouse genetic tools such as conditional knockout, transgenic reporter, and gain-of-function mutant lines.

Our current external collaborations include:

Peter Zammit (UCL), Jennifer Morgan (UCL), Paolo de Coppi (UCL), James Briscoe (Crick Institute), Olivier Lefebvre (Strasbourg).

Publications

Show: Featured publications All publications

Journal articles

  • Rayagiri SS, Ranaldi D, Raven A, Mohamad Azhar IF, Lefebvre O, Zammit PS & Borycki AG (2018) . Nature Communications, 9.
  • Pickering J, Cunliffe VT, Van Eeden F & Borycki A-G (2017) . Matrix Biology, 62, 58-74.
  • Jaafar Marican H, Cruz-Migoni S & Borycki AG (2016) . Stem Cell Reports, 6(6), 798-805.
  • Borycki AG (2013) . Cell Adhesion and Migration, 7(1), 72-81.
  • Anderson C, Williams VC, Moyon B, Daubas P, Tajbakhsh S, Buckingham ME, Shiroishi T, Hughes SM & Borycki AG (2012) . Genes and Development, 26(18), 2103-2117.
  • Anderson C, Thorsteinsdóttir S & Borycki A-G (2009) . Development, 136(20), 3495-3504.

All publications

Journal articles

  • Rayagiri SS, Ranaldi D, Raven A, Mohamad Azhar IF, Lefebvre O, Zammit PS & Borycki AG (2018) . Nature Communications, 9.
  • Pickering J, Cunliffe VT, Van Eeden F & Borycki A-G (2017) . Matrix Biology, 62, 58-74.
  • Jaafar Marican H, Cruz-Migoni S & Borycki AG (2016) . Stem Cell Reports, 6(6), 798-805.
  • Borycki AG (2013) . Cell Adhesion and Migration, 7(1), 72-81.
  • Anderson C, Williams VC, Moyon B, Daubas P, Tajbakhsh S, Buckingham ME, Shiroishi T, Hughes SM & Borycki AG (2012) . Genes and Development, 26(18), 2103-2117.
  • Balczerski B, Zakaria S, Tucker AS, Borycki AG, Koyama E, Pacifici M & Francis-West P (2012) Distinct spatiotemporal roles of hedgehog signalling during chick and mouse cranial base and axial skeleton development. Developmental Biology.
  • Van Hateren NJ, Das RM, Hautbergue GM, Borycki A-G, Placzek M & Wilson SA (2011) . Development, 138(10), 1893-1902.
  • Coy S, Caamaño JH, Carvajal J, Cleary ML & Borycki A-G (2011) . Molecular and Cellular Biology, 31(7), 1432-1443.
  • Coy SE & Borycki AG (2010) . Developmental Dynamics, 239(4), 1234-1245.
  • Anderson C, Thorsteinsdóttir S & Borycki A-G (2009) . Development, 136(20), 3495-3504.
  • Anderson C, Winder SJ & Borycki A-G (2007) . Dev Dyn, 236(9), 2627-2635.
  • Van Hateren N, Shenton T & Borycki AG (2006) . Developmental Dynamics, 235(2), 490-495.
  • Van Hateren N, Belsham A, Randall V & Borycki AG (2005) . Gene Expression Patterns, 5(6), 817-823.
  • McDermott A, Gustafsson M, Elsam T, Hui CC, Emerson CP & Borycki AG (2005) . Development, 132(2), 345-357.
  • Borycki A, Brown AM & Emerson CP (2000) . Development, 127(10), 2075-2087.
  • Borycki AG & Emerson CP (2000) . Methods in Molecular Biology Clifton N J, 137, 351-357.
  • Noden DM, Marcucio R, Borycki AG & Emerson CP (1999) . Developmental Dynamics, 216(2), 96-112.
  • Borycki AG, Brunk B, Tajbakhsh S, Buckingham M, Chiang C & Emerson CP (1999) . Development, 126(18), 4053-4063.
  • Borycki AG, Li J, Jin F, Emerson CP & Epstein JA (1999) . Development, 126(8), 1665-1674.
  • Borycki AG & Emerson CP (1999) . Current Topics in Developmental Biology, 48(C), 165-224.
  • Borycki AG, Mendham L & Emerson CP (1998) . Development, 125(4), 777-790.
  • Borycki AG & Emerson CP (1997) . Current Biology, 7(10), R620-R623.
  • Borycki AG, Strunk KE, Savary R & Emerson CP (1997) . Developmental Biology, 185(2), 185-200.
  • Borycki AG, Foucrier J, Saffar L & Leibovitch SA (1995) Repression of the CSF-1 receptor (c-fms proto-oncogene product) by antisense transfection induces G1-growth arrest in L6α1 rat myoblasts. Oncogene, 10(9), 1799-1811.
  • Borycki AG, Smadja F, Stanley R & Leibovitch SA (1995) . Experimental Cell Research, 218(1), 213-222.
  • Borycki A, Lenormund J, Guillier M & Leibovitch SA (1993) . Biochim Biophys Acta, 1174(2), 143-152.
  • Borycki A-G, Guillier M, Leibovitch M-P & Leibovitch SA (1992) . Growth Factors, 6(4), 209-218.
  • Borycki AG, Guillier M, Leibovitch MP & Leibovitch SA (1992) . Growth Factors, 6(3), 209-218.
  • HAREL J, LEIBOVITCH MP, GUILLIER M, BORYCKI AG & LEIBOVITCH SA (1989) . Annals of the New York Academy of Sciences, 567(1), 187-207.
  • Leibovitch SA, Leibovitch MP, Borycki AG & Harel J (1989) Expression of CSF-1-receptor-related proteins in muscular stem cells. Oncogene Research, 4(2), 157-162.

Book chapters

  • Khan HA, Van Hateren N & Borycki A-G (2024) , Methods in Molecular Biology (pp. 89-101). Springer US
  • Müller F & Borycki AG (2007) (pp. 231-250).
  • Cruz‐Migoni SB & Borycki A () Wiley

Conference proceedings

  • Pickering J, Watson M, Milano A, Pervolaraki E & Borycki A-G (2009) . MECHANISMS OF DEVELOPMENT, Vol. 126 (pp S315-S315)
  • Anderson C, Thorsteinsdottir S & Borycki A-G (2009) . MECHANISMS OF DEVELOPMENT, Vol. 126 (pp S196-S197)

Preprints

  • Cruz-Migoni SB, Imran KM, Wahid A, Rahman O, Briscoe J & Borycki A-G (2019) , Cold Spring Harbor Laboratory.
Grants
  • Funding
  • Wellcome Trust
  • BBSRC
  • MRC
  • European Union
  • AFM (Association Francaise contre les Myopathies)
Teaching activities

Undergraduate and postgraduate taught modules

Undergraduate:

  • BMS109-108 Physiology with Pharmacology
  • BMS110 Research Topics in Biomedicine
  • BMS242/243 Principles of Developmental Biology (Co-ordinator)
  • Level 3 Practical and Dissertation Modules

Postgraduate:

  • BMS6053 Critical Analysis of Current Science (Co-ordinator)
  • Level 4 Tutor
Professional activities and memberships
  • Member of the EU-funded Network of Excellence "Cells into Organs"
  • Member and Research Program coordinator of the EU-funded Network of Excellence "MYORES"
  • Panel member since 2007, Muscle Biology Committee, AFM (Association Francaise contre les Myopathies)
PhD Studentship Opportunities

We advertise PhD opportunities (Funded or Self-Funded) on FindAPhD.com

For further information and details of other projects on offer, please see the department PhD Opportunities page: